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Found 5 matching records:

Displaying record number 57682

HXB2 Location  Gag(20-29)   Gag Epitope Map
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Epitope RLRPGGKKKY   Epitope Alignment
Variants
RLRPGGKKhY   susceptible form; subtype-specific susceptible form
RLRPGGKKrY   susceptible form; subtype-specific susceptible form
RLRPGGKKqY   susceptible form; subtype-specific susceptible form
qLRPGGKKrY   susceptible form; subtype-specific susceptible form
Epitope Name EnvRY10
Species (MHC/HLA human(A3)

Variant Details

Showing all: 4 variant(s).


Variant ID.  2678
Epitope Seq.  RLRPGGKKKY
Variant Seq.  RLRPGGKKhY
Mutations K/H
Epitope Location K9H
HXB2 Location K28H
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype B, C
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant RLRPGGKKhY was found at frequencies of 2 and 48 in clades B and C respectively.


Variant ID.  2679
Epitope Seq.  RLRPGGKKKY
Variant Seq.  RLRPGGKKrY
Mutations K/R
Epitope Location K9R
HXB2 Location K28R
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype B, C
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant RLRPGGKKrY was found at frequencies of 9 and 14 in clades B and C respectively.


Variant ID.  2680
Epitope Seq.  RLRPGGKKKY
Variant Seq.  RLRPGGKKqY
Mutations K/Q
Epitope Location K9Q
HXB2 Location K28Q
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype A, B, C, D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant RLRPGGKKqY was found at frequencies of 5, 11, 8 and 5 in clades A, B, C and D respectively.


Variant ID.  2681
Epitope Seq.  RLRPGGKKKY
Variant Seq.  qLRPGGKKrY
Mutations R/Q K/R
Epitope Location R1Q K9R
HXB2 Location R20Q K28R
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant qLRPGGKKrY was found at a frequency of 23 in clade D.

References

Koup2010 Richard A. Koup, Mario Roederer, Laurie Lamoreaux, Jennifer Fischer, Laura Novik, Martha C. Nason, Brenda D. Larkin, Mary E. Enama, Julie E. Ledgerwood, Robert T. Bailer, John R. Mascola, Gary J. Nabel, Barney S. Graham, VRC 009 Study Team, and VRC 010 Study Team. Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses. PLoS One, 5(2):e9015, 2010. PubMed ID: 20126394. Show all entries for this paper.


Displaying record number 57676

HXB2 Location  Gag(240-249)   Gag Epitope Map
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Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSnLQEQIGW   susceptible form; subtype-specific susceptible form
TSTLQEQIaW   susceptible form; subtype-specific susceptible form
TSTpQEQIGW   susceptible form; subtype-specific susceptible form
Species (MHC/HLA human(B57)

Variant Details

Showing all: 3 variant(s).


Variant ID.  2672
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIGW
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype B, D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant TSnLQEQIGW was found at a frequency of 3 and 5 in clades B and D respectively.


Variant ID.  2673
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIaW
Mutations G/A
Epitope Location G9A
HXB2 Location G248A
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype A, B, C, D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant TSTLQEQIaW was found at frequencies of 5, 8, 63 and 36 in clades A, B, C and D respectively.


Variant ID.  2674
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTpQEQIGW
Mutations L/P
Epitope Location L4P
HXB2 Location L243P
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype A, B, C, D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant TSTpQEQIGW was found at a frequency of 42 in clade A.

References

Koup2010 Richard A. Koup, Mario Roederer, Laurie Lamoreaux, Jennifer Fischer, Laura Novik, Martha C. Nason, Brenda D. Larkin, Mary E. Enama, Julie E. Ledgerwood, Robert T. Bailer, John R. Mascola, Gary J. Nabel, Barney S. Graham, VRC 009 Study Team, and VRC 010 Study Team. Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses. PLoS One, 5(2):e9015, 2010. PubMed ID: 20126394. Show all entries for this paper.


Displaying record number 57678

HXB2 Location  gp160(37-46)   gp160 Epitope Map
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Epitope TVYYGVPVWK   Epitope Alignment
Variants
TVYYGVPVWr   susceptible form; subtype-specific susceptible form
TVYYGVPVWt   susceptible form; subtype-specific susceptible form
aVYYGVPVWK   susceptible form; subtype-specific susceptible form
Epitope Name EnvTK10
Species (MHC/HLA human(A3)

Variant Details

Showing all: 3 variant(s).


Variant ID.  2675
Epitope Seq.  TVYYGVPVWK
Variant Seq.  TVYYGVPVWr
Mutations K/R
Epitope Location K10R
HXB2 Location K46R
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype A, B, C, D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant TVYYGVPVWr was found at a frequency of 36, 6, 19 and 4 in clades A, B, C and D respectively.


Variant ID.  2676
Epitope Seq.  TVYYGVPVWK
Variant Seq.  TVYYGVPVWt
Mutations K/T
Epitope Location K10T
HXB2 Location K46T
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant TVYYGVPVWt was found at a frequency of 7 in clade C.


Variant ID.  2677
Epitope Seq.  TVYYGVPVWK
Variant Seq.  aVYYGVPVWK
Mutations T/A
Epitope Location T1A
HXB2 Location T37A
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype C, D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant aVYYGVPVWK was found frequencies of 1 and 2 in clades C and D.

References

Koup2010 Richard A. Koup, Mario Roederer, Laurie Lamoreaux, Jennifer Fischer, Laura Novik, Martha C. Nason, Brenda D. Larkin, Mary E. Enama, Julie E. Ledgerwood, Robert T. Bailer, John R. Mascola, Gary J. Nabel, Barney S. Graham, VRC 009 Study Team, and VRC 010 Study Team. Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses. PLoS One, 5(2):e9015, 2010. PubMed ID: 20126394. Show all entries for this paper.


Displaying record number 57651

HXB2 Location  gp160(218-226)   gp160 Epitope Map
View variants at this location
Epitope CAPAGFAIL   Epitope Alignment
Variants
CtPAGFAIL   susceptible form; subtype-specific susceptible form
CAPAGyAIL   susceptible form; subtype-specific susceptible form
Epitope Name EnvCL9
Species (MHC/HLA human

Variant Details

Showing all: 2 variant(s).


Variant ID.  2666
Epitope Seq.  CAPAGFAIL
Variant Seq.  CtPAGFAIL
Mutations A/T
Epitope Location A2T
HXB2 Location A219T
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype A, B, C
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant CtPAGFAIL was found at a frequency of 5, 17 and 1 in clades A, B and C respectively.


Variant ID.  2667
Epitope Seq.  CAPAGFAIL
Variant Seq.  CAPAGyAIL
Mutations F/Y
Epitope Location F6Y
HXB2 Location F223Y
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype A, B, C, D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant CAPAGyAIL was found at a frequency of 3, 1, 82 and 13 in clades A, B, C and D respectively.

References

Koup2010 Richard A. Koup, Mario Roederer, Laurie Lamoreaux, Jennifer Fischer, Laura Novik, Martha C. Nason, Brenda D. Larkin, Mary E. Enama, Julie E. Ledgerwood, Robert T. Bailer, John R. Mascola, Gary J. Nabel, Barney S. Graham, VRC 009 Study Team, and VRC 010 Study Team. Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses. PLoS One, 5(2):e9015, 2010. PubMed ID: 20126394. Show all entries for this paper.


Displaying record number 57675

HXB2 Location  gp160(419-427)   gp160 Epitope Map
View variants at this location
Epitope RIKQIINMW   Epitope Alignment
Variants
RIKQIvNMW   susceptible form; subtype-specific susceptible form
kIKQIINMW   susceptible form; subtype-specific susceptible form
RIKQIINrW   susceptible form; subtype-specific susceptible form
Epitope Name EnvRW9
Species (MHC/HLA human

Variant Details

Showing all: 3 variant(s).


Variant ID.  2669
Epitope Seq.  RIKQIINMW
Variant Seq.  RIKQIvNMW
Mutations I/V
Epitope Location I6V
HXB2 Location I424V
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype A, B, C, D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant RIKQIvNMW was found at a frequency of 2, 11, 5 and 6 in clades A, B, C and D respectively.


Variant ID.  2670
Epitope Seq.  RIKQIINMW
Variant Seq.  kIKQIINMW
Mutations R/K
Epitope Location R1K
HXB2 Location R419K
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype A, B, C, D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant kIKQIINMW was found at a frequency of 4, 3, 7 and 2 in clades A, B, C and D respectively.


Variant ID.  2671
Epitope Seq.  RIKQIINMW
Variant Seq.  RIKQIINrW
Mutations M/R
Epitope Location M8R
HXB2 Location M426R
Mutation Type SF: susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, B, C, D
Variant Subtype A, B, C, D
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Variant RIKQIINrW was found at a frequency of 11 and 2 in clades B and C respectively.

References

Koup2010 Richard A. Koup, Mario Roederer, Laurie Lamoreaux, Jennifer Fischer, Laura Novik, Martha C. Nason, Brenda D. Larkin, Mary E. Enama, Julie E. Ledgerwood, Robert T. Bailer, John R. Mascola, Gary J. Nabel, Barney S. Graham, VRC 009 Study Team, and VRC 010 Study Team. Priming Immunization with DNA Augments Immunogenicity of Recombinant Adenoviral Vectors for Both HIV-1 Specific Antibody and T-Cell Responses. PLoS One, 5(2):e9015, 2010. PubMed ID: 20126394. Show all entries for this paper.


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