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Found 11 matching records:

Displaying record number 53748

HXB2 Location  Gag(20-29)   Gag Epitope Map
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Epitope RLRPGGKKKY   Epitope Alignment
Variants
RLRPGGrKKY   susceptible form
Epitope Name RY10
Species (MHC/HLA human(B62)

Variant Details

Showing all: 1 variant(s).


Variant ID.  752
Epitope Seq.  RLRPGGKKKY
Variant Seq.  RLRPGGrKKY
Mutations K/R
Epitope Location K7R
HXB2 Location K26R
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note Variant was detected over a 5 year time period in a patient. The variant was better recognized than the wt epitope by patient CTLs.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53755

HXB2 Location  Gag(77-85)   Gag Epitope Map
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Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTiATL   escape documented in this paper
SLfNTiAaL   observed variant
SLfNTVAvL   escape documented in this paper
SLfsTVAvL   observed variant
SLfNTVAvp   observed variant
SLfNTiAvL   observed variant
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing all: 6 variant(s).


Variant ID.  753
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiATL
Mutations Y/F V/I
Epitope Location Y3F V6I
HXB2 Location Y79F V82I
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note Variant was found in the beginning and at the end of a 7 year period in a patient. It was not recognized by patient CTLs.


Variant ID.  754
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiAaL
Mutations Y/F V/I T/A
Epitope Location Y3F V6I T8A
HXB2 Location Y79F V82I T84A
Mutation Type OV: observed variant
Note Variant was found in 1/22 clones at the beginning of a 7 year period in a patient.


Variant ID.  755
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVAvL
Mutations Y/F T/V
Epitope Location Y3F T8V
HXB2 Location Y79F T84V
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note Variant dominated in the middle of a 7 year period in a patient. It was not recognized by patient CTLs.


Variant ID.  756
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfsTVAvL
Mutations Y/F N/S T/V
Epitope Location Y3F N4S T8V
HXB2 Location Y79F N80S T84V
Mutation Type OV: observed variant
Note Variant was found in 1/28 clones at the middle of a 7 year period in a patient.


Variant ID.  757
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVAvp
Mutations Y/F T/V L/P
Epitope Location Y3F T8V L9P
HXB2 Location Y79F T84V L85P
Mutation Type OV: observed variant
Note Variant was found in 1/28 clones at the middle of a 7 year period in a patient.


Variant ID.  758
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiAvL
Mutations Y/F V/I T/V
Epitope Location Y3F V6I T8V
HXB2 Location Y79F V82I T84V
Mutation Type OV: observed variant
Note Variant was found at the end of a 7 year period in a patient.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53749

HXB2 Location  Gag(260-267)   Gag Epitope Map
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Epitope EIYKRWII   Epitope Alignment
Variants
dIYKRWII   susceptible form
Epitope Name EI8
Species (MHC/HLA human(B8)

Variant Details

Showing all: 1 variant(s).


Variant ID.  759
Epitope Seq.  EIYKRWII
Variant Seq.  dIYKRWII
Mutations E/D
Epitope Location E1D
HXB2 Location E260D
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note This variant was the only form of the epitope detected over a 5 year time period in a patient. The variant was equally well recognized by patient CTLs as the wt consensus B epitope.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53758

HXB2 Location  Gag(275-282)   Gag Epitope Map
View variants at this location
Epitope RMYSPTSI   Epitope Alignment
Variants
RMYSPvSI   diminished response
RMYSPvgI   observed variant
RMYSPvSt   observed variant
RMYSPsSI   observed variant
RvYSPTSI   observed variant
Epitope Name RI8
Species (MHC/HLA human(B52)

Variant Details

Showing all: 5 variant(s).


Variant ID.  760
Epitope Seq.  RMYSPTSI
Variant Seq.  RMYSPvSI
Mutations T/V
Epitope Location T6V
HXB2 Location T280V
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note Variant dominated in the beginning of a 7 year period in a patient and reverted to wt later on. The variant was less well recognized by patient CTLs compared to the wt form.


Variant ID.  761
Epitope Seq.  RMYSPTSI
Variant Seq.  RMYSPvgI
Mutations T/V S/G
Epitope Location T6V S7G
HXB2 Location T280V S281G
Mutation Type OV: observed variant
Note Variant was found in 1/8 clones at the beginning of a 7 year period in a patient.


Variant ID.  762
Epitope Seq.  RMYSPTSI
Variant Seq.  RMYSPvSt
Mutations T/V I/T
Epitope Location T6V I8T
HXB2 Location T280V I282T
Mutation Type OV: observed variant
Note Variant was found in 1/15 clones at the middle of a 7 year period in a patient.


Variant ID.  763
Epitope Seq.  RMYSPTSI
Variant Seq.  RMYSPsSI
Mutations T/S
Epitope Location T6S
HXB2 Location T280S
Mutation Type OV: observed variant
Note Variant was found in 3/15 clones at the middle of a 7 year period in a patient.


Variant ID.  764
Epitope Seq.  RMYSPTSI
Variant Seq.  RvYSPTSI
Mutations M/V
Epitope Location M2V
HXB2 Location M276V
Mutation Type OV: observed variant
Note Variant was found in 1/13 clones at the middle of a 7 year period in a patient.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53759

HXB2 Location  Gag(298-306)   Gag Epitope Map
View variants at this location
Epitope DRFYKTLRA   Epitope Alignment
Variants
DRFYrTLRA   diminished response
DRFYrTpRA   observed variant
kRFYKTLRA   observed variant
DRFcKTLRA   observed variant
DRFYKTLgA   observed variant
Epitope Name DA9
Species (MHC/HLA human(B14)

Variant Details

Showing all: 5 variant(s).


Variant ID.  765
Epitope Seq.  DRFYKTLRA
Variant Seq.  DRFYrTLRA
Mutations K/R
Epitope Location K5R
HXB2 Location K302R
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note Variant dominated in the beginning of a 7 year period in a patient and reverted to wt later on. The variant was less well recognized by patient CTLs compared to the wt form.


Variant ID.  766
Epitope Seq.  DRFYKTLRA
Variant Seq.  DRFYrTpRA
Mutations K/R L/P
Epitope Location K5R L7P
HXB2 Location K302R L304P
Mutation Type OV: observed variant
Note Variant was found in 2/8 clones at the beginning of a 7 year period in a patient.


Variant ID.  767
Epitope Seq.  DRFYKTLRA
Variant Seq.  kRFYKTLRA
Mutations D/K
Epitope Location D1K
HXB2 Location D298K
Mutation Type OV: observed variant
Note Variant was found in 1/13 clones at the middle of a 7 year period in a patient.


Variant ID.  768
Epitope Seq.  DRFYKTLRA
Variant Seq.  DRFcKTLRA
Mutations Y/C
Epitope Location Y4C
HXB2 Location Y301C
Mutation Type OV: observed variant
Note Variant was found in 5/13 clones at the middle of a 7 year period in a patient.


Variant ID.  769
Epitope Seq.  DRFYKTLRA
Variant Seq.  DRFYKTLgA
Mutations R/G
Epitope Location R8G
HXB2 Location R305G
Mutation Type OV: observed variant
Note Variant was found in 1/13 clones at the middle of a 7 year period in a patient.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53756

HXB2 Location  Gag(305-313)   Gag Epitope Map
View variants at this location
Epitope RAEQASQEV   Epitope Alignment
Variants
RAEQAtQEV   diminished response
RAEQASQdV   escape documented in this paper
RAEQAtQdV   observed variant
RAEQAShdV   observed variant
RAErAtQEV   observed variant
gAEQASQdV   observed variant
RAEhASQdV   observed variant
RAEQAlQdV   observed variant
Epitope Name RV9
Species (MHC/HLA human(Cw8)

Variant Details

Showing all: 8 variant(s).


Variant ID.  770
Epitope Seq.  RAEQASQEV
Variant Seq.  RAEQAtQEV
Mutations S/T
Epitope Location S6T
HXB2 Location S310T
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note Variant dominated in the middle of a 7 year period in a patient. The variant was less well recognized by patient CTLs compared to the wt form.


Variant ID.  771
Epitope Seq.  RAEQASQEV
Variant Seq.  RAEQASQdV
Mutations E/D
Epitope Location E8D
HXB2 Location E312D
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note Variant dominated in the beginning of a 7 year period in a patient. The variant was not recognized by patient CTLs.


Variant ID.  772
Epitope Seq.  RAEQASQEV
Variant Seq.  RAEQAtQdV
Mutations S/T E/D
Epitope Location S6T E8D
HXB2 Location S310T E312D
Mutation Type OV: observed variant
Note Variant was found at the middle of a 7 year period in a patient.


Variant ID.  773
Epitope Seq.  RAEQASQEV
Variant Seq.  RAEQAShdV
Mutations Q/H E/D
Epitope Location Q7H E8D
HXB2 Location Q311H E312D
Mutation Type OV: observed variant
Note Variant was found in 1/15 clones at the middle of a 7 year period in a patient.


Variant ID.  774
Epitope Seq.  RAEQASQEV
Variant Seq.  RAErAtQEV
Mutations Q/R S/T
Epitope Location Q4R S6T
HXB2 Location Q308R S310T
Mutation Type OV: observed variant
Note Variant was found in 2/16 clones at the middle of a 7 year period in a patient.


Variant ID.  775
Epitope Seq.  RAEQASQEV
Variant Seq.  gAEQASQdV
Mutations R/G E/D
Epitope Location R1G E8D
HXB2 Location R305G E312D
Mutation Type OV: observed variant
Note Variant was found in 1/13 clones at the middle of a 7 year period in a patient.


Variant ID.  776
Epitope Seq.  RAEQASQEV
Variant Seq.  RAEhASQdV
Mutations Q/H E/D
Epitope Location Q4H E8D
HXB2 Location Q308H E312D
Mutation Type OV: observed variant
Note Variant was found in 1/13 clones at the middle of a 7 year period in a patient.


Variant ID.  777
Epitope Seq.  RAEQASQEV
Variant Seq.  RAEQAlQdV
Mutations S/L E/D
Epitope Location S6L E8D
HXB2 Location S310L E312D
Mutation Type OV: observed variant
Note Variant was found in 1/13 clones at the end of a 7 year period in a patient.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53751

HXB2 Location  Pol(173-181)   Pol Epitope Map
View variants at this location
Epitope GPKVKQWPL   Epitope Alignment
Variants
GPrVKQWPL   susceptible form
GPrVKQgPL   observed variant
Epitope Name GL9
Species (MHC/HLA human(B8)

Variant Details

Showing all: 2 variant(s).


Variant ID.  778
Epitope Seq.  GPKVKQWPL
Variant Seq.  GPrVKQWPL
Mutations K/R
Epitope Location K3R
HXB2 Location K175R
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note Variant persisted throughout a 5-year period in a patient. The variant was equally well recognized by patient CTLs as the wt form.


Variant ID.  779
Epitope Seq.  GPKVKQWPL
Variant Seq.  GPrVKQgPL
Mutations K/R W/G
Epitope Location K3R W7G
HXB2 Location K175R W179G
Mutation Type OV: observed variant
Note Variant was found in 1/8 clones at the end of a 5 year period in a patient.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53752

HXB2 Location  Pol(313-321)   Pol Epitope Map
View variants at this location
Epitope AIFQSSMTK   Epitope Alignment
Variants
AIFQSSMTr   escape documented in this paper
tIFQSSMTr   observed variant
AIFQSSMar   observed variant
Epitope Name AK9
Species (MHC/HLA human(A11)

Variant Details

Showing all: 3 variant(s).


Variant ID.  780
Epitope Seq.  AIFQSSMTK
Variant Seq.  AIFQSSMTr
Mutations K/R
Epitope Location K9R
HXB2 Location K321R
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note Variant persisted throughout a 5-year period in a patient. The variant was not recognized by patient CTLs.


Variant ID.  781
Epitope Seq.  AIFQSSMTK
Variant Seq.  tIFQSSMTr
Mutations A/T K/R
Epitope Location A1T K9R
HXB2 Location A313T K321R
Mutation Type OV: observed variant
Note Variant was found in 1/15 clones at the end of a 5 year period in a patient.


Variant ID.  782
Epitope Seq.  AIFQSSMTK
Variant Seq.  AIFQSSMar
Mutations T/A K/R
Epitope Location T8A K9R
HXB2 Location T320A K321R
Mutation Type OV: observed variant
Note Variant was found in 1/15 clones at the end of a 5 year period in a patient.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53753

HXB2 Location  Pol(415-426)   Pol Epitope Map
View variants at this location
Epitope LVGKLNWASQIY   Epitope Alignment
Variants
LVGKLNWASQIh   observed variant
Epitope Name LY12
Species (MHC/HLA human(B62)

Variant Details

Showing all: 1 variant(s).


Variant ID.  783
Epitope Seq.  LVGKLNWASQIY
Variant Seq.  LVGKLNWASQIh
Mutations Y/H
Epitope Location Y12H
HXB2 Location Y426H
Mutation Type OV: observed variant
Note Variant was found in 1/6 clones at the beginning of a 5 year period in a patient.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53761

HXB2 Location  gp160(584-592)   gp160 Epitope Map
View variants at this location
Epitope ERYLKDQQL   Epitope Alignment
Variants
ERYLqDQQL   diminished response
Epitope Name EL9
Species (MHC/HLA human(B14)

Variant Details

Showing all: 1 variant(s).


Variant ID.  784
Epitope Seq.  ERYLKDQQL
Variant Seq.  ERYLqDQQL
Mutations K/Q
Epitope Location K5Q
HXB2 Location K588Q
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note This variant was the only form of the epitope detected over a 6-year period in a patient. The variant was much less well recognized by patient CTLs compared to the wt form.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


Displaying record number 53754

HXB2 Location  gp160(586-593)   gp160 Epitope Map
View variants at this location
Epitope YLKDQQLL   Epitope Alignment
Variants
YLrDQQLL   observed variant
YLKgQQLL   observed variant
Epitope Name YL8
Species (MHC/HLA human(B8)

Variant Details

Showing all: 2 variant(s).


Variant ID.  785
Epitope Seq.  YLKDQQLL
Variant Seq.  YLrDQQLL
Mutations K/R
Epitope Location K3R
HXB2 Location K588R
Mutation Type OV: observed variant
Note Variant was found in 1/9 clones at the beginning of a 5 year period in a patient.


Variant ID.  786
Epitope Seq.  YLKDQQLL
Variant Seq.  YLKgQQLL
Mutations D/G
Epitope Location D4G
HXB2 Location D589G
Mutation Type OV: observed variant
Note Variant was found in 1/8 clones at the end of a 5 year period in a patient.

References

Koibuchi2005a Tomohiko Koibuchi, Todd M. Allen, Mathias Lichterfeld, Stanley K. Mui, Kristin M. O'Sullivan, Alicja Trocha, Spyros A. Kalams, R. Paul Johnson, and Bruce D. Walker. Limited Sequence Evolution within Persistently Targeted CD8 Epitopes in Chronic Human Immunodeficiency Virus Type 1 Infection. J. Virol., 79(13):8171-8181, Jul 2005. PubMed ID: 15956562. Show all entries for this paper.


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