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Found 9 matching records:

Displaying record number 59314

HXB2 Location  Gag(22-30)   Gag Epitope Map
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Epitope RPGGKKHYM   Epitope Alignment
Variants
{IsL}RPGGKKHYM   escape documented in this paper; observed variant
RPGGKKqYM   diminished response; escape documented in this paper; observed variant
RPGGKKsYM   diminished response; escape documented in this paper; observed variant
RPGGKKrYM   diminished response; escape documented in this paper; observed variant
RPGGKKHYk   diminished response; escape documented in this paper; observed variant
Epitope Name Gag-RM9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3477
Epitope Seq.  {IRL}RPGGKKHYM
Variant Seq.  {IsL}RPGGKKHYM
Mutations R/S
Epitope Location R-2S
HXB2 Location R20S
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 5% of B*4201+ and 2% of B*4201- subjects (n=1767) carried this upstream escape variant, {IsL}RPGGKKHYM.


Variant ID.  3478
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKqYM
Mutations H/Q
Epitope Location H7Q
HXB2 Location H28Q
Mutation Type DR: diminished response
E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 29% of B*4201+ and 13% of B*4201- subjects (n=1765) carried this escape variant, RPGGKKqYM.


Variant ID.  3479
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKsYM
Mutations H/S
Epitope Location H7S
HXB2 Location H28S
Mutation Type DR: diminished response
E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 6% of B*4201+ and 2% of B*4201- subjects (n=1765) carried this escape variant, RPGGKKsYM.


Variant ID.  3480
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKrYM
Mutations H/R
Epitope Location H7R
HXB2 Location H28R
Mutation Type DR: diminished response
E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 22% of B*4201+ and 13% of B*4201- subjects (n=1765) carried this escape variant, RPGGKKrYM.


Variant ID.  3481
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKHYk
Mutations M/K
Epitope Location M9K
HXB2 Location M30K
Mutation Type DR: diminished response
E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 14% of B*4201+ and 7% of B*4201- subjects (n=1765) carried this escape variant, RPGGKKHYk.

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 59433

HXB2 Location  Gag(180-188)   Gag Epitope Map
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Epitope TPQDLNTML   Epitope Alignment
Variants
TPtDLNTML   escape documented in this paper; observed variant
Epitope Name Gag-TL9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3482
Epitope Seq.  TPQDLNTML
Variant Seq.  TPtDLNTML
Mutations Q/T
Epitope Location Q3T
HXB2 Location Q50T
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 9% of B*4201+ and 1% of B*4201- subjects (n=1857) carried this escape variant, TPtDLNTML.

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 59434

HXB2 Location  Gag(385-393)   Gag Epitope Map
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Epitope GPKRIVKCF   Epitope Alignment
Variants
GsKRIVKCF   escape documented in this paper; observed variant
GPrRIVKCF   escape documented in this paper; observed variant
Epitope Name Gag-GF9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3483
Epitope Seq.  GPKRIVKCF
Variant Seq.  GsKRIVKCF
Mutations P/S
Epitope Location P2S
HXB2 Location P23S
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 46% of B*4201+ and 29% of B*4201- subjects (n=1857) carried this escape variant, GsKRIVKCF.


Variant ID.  3484
Epitope Seq.  GPKRIVKCF
Variant Seq.  GPrRIVKCF
Mutations K/R
Epitope Location K3R
HXB2 Location K24R
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Other, Tetramer binding
Note 43% of B*4201+ and 34% of B*4201- subjects (n=1857) carried this escape variant, GPrRIVKCF.

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 59435

HXB2 Location  Pol(426-434)   Pol Epitope Map
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Epitope YPGIKVRQL   Epitope Alignment
Variants
YsGIKVRQL   escape documented in this paper; observed variant
YaGIKVRQL   escape documented in this paper; observed variant
YqGIKVRQL   escape documented in this paper; observed variant
YPGvKVRQL   escape documented in this paper; observed variant
YPGIKVRnL   escape documented in this paper; observed variant
YPGIKVRQL{CrL}   escape documented in this paper; observed variant
Epitope Name RT-YL9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 6 variant(s).


Variant ID.  3485
Epitope Seq.  YPGIKVRQL
Variant Seq.  YsGIKVRQL
Mutations P/S
Epitope Location P2S
HXB2 Location P272S
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 24% of B*4201+ and 5% of B*4201- subjects (n=1857) carried this escape variant, YsGIKVRQL.


Variant ID.  3486
Epitope Seq.  YPGIKVRQL
Variant Seq.  YaGIKVRQL
Mutations P/A
Epitope Location P2A
HXB2 Location P272A
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 31% of B*4201+ and 11% of B*4201- subjects (n=1857) carried this escape variant, YaGIKVRQL.


Variant ID.  3487
Epitope Seq.  YPGIKVRQL
Variant Seq.  YqGIKVRQL
Mutations P/Q
Epitope Location P2Q
HXB2 Location P272Q
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 4% of B*4201+ and 1% of B*4201- subjects (n=1857) carried this escape variant, YqGIKVRQL.


Variant ID.  3488
Epitope Seq.  YPGIKVRQL
Variant Seq.  YPGvKVRQL
Mutations I/V
Epitope Location I4V
HXB2 Location I274V
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 10% of B*4201+ and 1% of B*4201- subjects (n=1857) carried this escape variant, YPGvKVRQL.


Variant ID.  3489
Epitope Seq.  YPGIKVRQL
Variant Seq.  YPGIKVRnL
Mutations Q/N
Epitope Location Q8N
HXB2 Location Q278N
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 5% of B*4201+ and 2% of B*4201- subjects (n=1857) carried this escape variant, YPGIKVRnL.


Variant ID.  3490
Epitope Seq.  YPGIKVRQL{CKL}
Variant Seq.  YPGIKVRQL{CrL}
Mutations K/R
Epitope Location K+2R
HXB2 Location K281R
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 18% of B*4201+ and 7% of B*4201- subjects (n=1857) carried this flanking region escape variant, YPGIKVRQL|CrL.

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 59436

HXB2 Location  Pol(743-751)   Pol Epitope Map
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Epitope LPPIVAKEI   Epitope Alignment
Variants
LPPvVAKEI   escape documented in this paper; observed variant
LPPIVArEI   escape documented in this paper; observed variant
Epitope Name Int-LI9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3491
Epitope Seq.  LPPIVAKEI
Variant Seq.  LPPvVAKEI
Mutations I/V
Epitope Location I4V
HXB2 Location I31V
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 51% of B*4201+ and 17% of B*4201- subjects (n=1857) carried this escape variant, LPPvVAKEI.


Variant ID.  3492
Epitope Seq.  LPPIVAKEI
Variant Seq.  LPPIVArEI
Mutations K/R
Epitope Location K7R
HXB2 Location K34R
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 28% of B*4201+ and 2% of B*4201- subjects (n=1857) carried this escape variant, LPPIVArEI.

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 59437

HXB2 Location  Pol(982-990)   Pol Epitope Map
View variants at this location
Epitope IIKDYGQM   Epitope Alignment
Variants
IIrDYGQM   escape documented in this paper; observed variant
IIKeYGQM   escape documented in this paper; observed variant
IIKDYGQv   escape documented in this paper; observed variant
Epitope Name Int-IM9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3493
Epitope Seq.  IIKDYGQM
Variant Seq.  IIrDYGQM
Mutations K/R
Epitope Location K3R
HXB2 Location K269R
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 79% of B*4201+ and 41% of B*4201- subjects (n=1857) carried this escape variant, IIrDYGQM.


Variant ID.  3494
Epitope Seq.  IIKDYGQM
Variant Seq.  IIKeYGQM
Mutations D/E
Epitope Location D4E
HXB2 Location D270E
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 7% of B*4201+ and 1% of B*4201- subjects (n=1857) carried this escape variant, IIKeYGQM.


Variant ID.  3495
Epitope Seq.  IIKDYGQM
Variant Seq.  IIKDYGQv
Mutations M/V
Epitope Location M8V
HXB2 Location M274V
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 7% of B*4201+ and 1% of B*4201- subjects (n=1857) carried this escape variant, IIKDYGQv.

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 59439

HXB2 Location  Vif(48-57)   Vif Epitope Map
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Epitope HPKVSSEVHI   Epitope Alignment
Variants
nPKVSSEVHI   escape documented in this paper; observed variant
Epitope Name Vif-HI10
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3498
Epitope Seq.  HPKVSSEVHI
Variant Seq.  nPKVSSEVHI
Mutations H/N
Epitope Location H1N
HXB2 Location H34N
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 32% of B*4201+ and 9% of B*4201- subjects (n=1857) carried this escape variant, nPKVSSEVHI.

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 59438

HXB2 Location  Vpr(34-42)   Vpr Epitope Map
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Epitope FPRPWLHGL   Epitope Alignment
Variants
FPRPWLHGi   escape documented in this paper; observed variant
FPRPWLHGL{GQh}   escape documented in this paper; observed variant
Epitope Name Vpr-FL9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3496
Epitope Seq.  FPRPWLHGL
Variant Seq.  FPRPWLHGi
Mutations L/I
Epitope Location L9I
HXB2 Location L42I
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 12% of B*4201+ and 3% of B*4201- subjects (n=1857) carried this escape variant, FPRPWLHGi.


Variant ID.  3497
Epitope Seq.  FPRPWLHGL{GQY}
Variant Seq.  FPRPWLHGL{GQh}
Mutations Y/H
Epitope Location Y+3H
HXB2 Location Y45H
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 61% of B*4201+ and 42% of B*4201- subjects (n=1857) carried this flanking region escape variant, FPRPWLHGL{GQh}.

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


Displaying record number 59440

HXB2 Location  gp160(843-851)   gp160 Epitope Map
View variants at this location
Epitope IPRRIRQGF   Epitope Alignment
Variants
vPRRIRQGF   escape documented in this paper; observed variant
IPtRIRQGF   escape documented in this paper; observed variant
Epitope Name Env-IF9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3499
Epitope Seq.  IPRRIRQGF
Variant Seq.  vPRRIRQGF
Mutations I/V
Epitope Location I1V
HXB2 Location I843V
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 17% of B*4201+ and 4% of B*4201- subjects (n=1857) carried this escape variant, vPRRIRQGF.


Variant ID.  3500
Epitope Seq.  IPRRIRQGF
Variant Seq.  IPtRIRQGF
Mutations R/T
Epitope Location R3T
HXB2 Location R845T
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Other, Tetramer binding
Note 41% of B*4201+ and 22% of B*4201- subjects (n=1857) carried this escape variant, IPtRIRQGF.

References

Kloverpris2015 Henrik N Kløverpris, Reuben McGregor, James E. McLaren, Kristin Ladell, Mikkel Harndahl, Anette Stryhn, Jonathan M. Carlson, Catherine Koofhethile, Bram Gerritsen, Can Keşmir, Fabian Chen, Lynn Riddell, Graz Luzzi, Alasdair Leslie, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, David A. Price, and Philip J. Goulder. CD8+ TCR Bias and Immunodominance in HIV-1 Infection. J. Immunol., 194(11):5329-5345, 1 Jun 2015. PubMed ID: 25911754. Show all entries for this paper.


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