HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 8 matching records:

Displaying record number 59012

HXB2 Location  Gag(22-30)   Gag Epitope Map
View variants at this location
Epitope RPGGKKHYM   Epitope Alignment
Variants
RPGGKKkYk   subtype-specific non-susceptible form
Epitope Name RM9-p17
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3219
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKkYk
Mutations H/K M/K
Epitope Location H7K M9K
HXB2 Location H28K M30K
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, HLA binding
Note Epitope RK9, RPGGKKkYk, the B-clade consensus epitope differs at H7K and M9K, and is not recognized by HLA-B*0702. RK9 is unstable in complex with HLA-B*0702; and its binding affinity is Kd = >20,000 nM. RK9 is contained within OLP3, EKIRLRPGGKKkYkLKHI.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 59039

HXB2 Location  Gag(355-363)   Gag Epitope Map
View variants at this location
Epitope GPSHKARVL   Epitope Alignment
Variants
GPgHKARVL   subtype-specific susceptible form
Epitope Name GL9-p24
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3220
Epitope Seq.  GPSHKARVL
Variant Seq.  GPgHKARVL
Mutations S/G
Epitope Location S3G
HXB2 Location S24G
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, HLA binding
Note GL9-3G, GPgHKARVL, (3G), a B-clade Gag variant of C-clade GPSHKARVL was cross-recognized to equal extents as its C-clade variant, (3S), at 55% and 29% in C- or B-clade infected cohorts. The B-clade consensus epitope differs at S3G and its binding affinity to B*0702 was Kd = 342 nM. GL9-3G is contained within OLP48, ACQGVGGPgHKARVLAEA.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 59051

HXB2 Location  Pol(743-751)   Pol Epitope Map
View variants at this location
Epitope LPPVVAKEI   Epitope Alignment
Variants
LPPiVAKEI   subtype-specific non-susceptible form
Epitope Name LI9-Int
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3224
Epitope Seq.  LPPVVAKEI
Variant Seq.  LPPiVAKEI
Mutations V/I
Epitope Location V4I
HXB2 Location V746I
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype C
Method HLA binding
Note C-clade variant of LI9-Int, LPPiVAKEI, is not recognized by any C-clade infected individuals. It's binding coefficient for HLA-B*0702 is 2,128 nM..

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 59041

HXB2 Location  Vif(48-57)   Vif Epitope Map
View variants at this location
Epitope HPRISSEVHI   Epitope Alignment
Variants
HPkISSEVHI   subtype-specific non-susceptible form
Epitope Name HI10-Vif
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3221
Epitope Seq.  HPRISSEVHI
Variant Seq.  HPkISSEVHI
Mutations R/K
Epitope Location R3K
HXB2 Location R50K
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype C
Method HLA binding
Note C-clade variant of Vif-HI10, HPkISSEVHI, is not recognized by any C-clade infected individuals. It's binding coefficient for HLA-B*0702 is 178 nM..

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 59052

HXB2 Location  Vpr(34-42)   Vpr Epitope Map
View variants at this location
Epitope FPRIWLHSL   Epitope Alignment
Variants
FPRpWLHgL   subtype-specific susceptible form
Epitope Name FL9-Vpr
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3225
Epitope Seq.  FPRIWLHSL
Variant Seq.  FPRpWLHgL
Mutations I/P S/G
Epitope Location I4P S8G
HXB2 Location I37P S41G
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype C
Method HLA binding
Note Variant FL9, FPRpWLHgL, a C-clade Vpr epitope was targeted by C-clade infected subjects more robustly than the B-clade variant FL9. The affinity of C-clade FL9 to B*0702 was Kd = 6 nM. Clade-C FL9 is contained within OLP281, ELKQEAVRHFPRpWLHgL.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 59053

HXB2 Location  gp160(843-851)   gp160 Epitope Map
View variants at this location
Epitope IPRRIRQGL   Epitope Alignment
Variants
IPRRIRQGf   subtype-specific susceptible form
Epitope Name IL9-Env
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3226
Epitope Seq.  IPRRIRQGL
Variant Seq.  IPRRIRQGf
Mutations L/F
Epitope Location L9F
HXB2 Location L851F
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype C
Method HLA binding
Note Variant IF9, IPRRIRQGf, a C-clade Env epitope was targeted by B-clade infected subjects more robustly than the C-clade variant IF9. The affinity of C-clade IF9 to B*0702 was Kd = 33 nM. Clade-C IF9 is contained within OLP401, NIPRRIRQGfEaALq.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 59046

HXB2 Location  Nef(77-85)   Nef Epitope Map
View variants at this location
Epitope RPMTYKAAV   Epitope Alignment
Variants
RPMTYKAAf   subtype-specific susceptible form
Epitope Name RV9-Nef
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3222
Epitope Seq.  RPMTYKAAV
Variant Seq.  RPMTYKAAf
Mutations V/F
Epitope Location V9F
HXB2 Location V85F
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype C
Method HLA binding
Note Variant RF9, RPMTYKAAf, a C-clade Nef epitope was targeted by C-clade infected subjects more robustly than the B-clade variant RV9. The affinity of RF9 to B*0702 was Kd = 7 nM. Clade-C RF9 is contained within OLP77, QVPLRPMTfKgAfDLSfF.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Displaying record number 59047

HXB2 Location  Nef(128-137)   Nef Epitope Map
View variants at this location
Epitope TPGPGIRYPL   Epitope Alignment
Variants
TPGPGvRYPL   subtype-specific susceptible form
Epitope Name TL10-Nef
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3223
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRYPL
Mutations I/V
Epitope Location I6V
HXB2 Location I133V
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype C
Method HLA binding
Note Variant TL10-Nef, TPGPGvRYPL, a C-clade Nef epitope was targeted by C-clade infected subjects more robustly than the B-clade variant TL10. The affinity of TL10 to B*0702 was Kd = 27 nM. Clade-C TL10 is contained within OLP84, NYTPGPGvRYPLTFGWCF.

References

Kloverpris2014 Henrik N. Kløverpris, Emily Adland, Madoka Koyanagi, Anette Stryhn, Mikkel Harndahl, Philippa C. Matthews, Roger Shapiro, Bruce D. Walker, Thumbi Ndung'u, Christian Brander, Masafumi Takiguchi, Søren Buus, and Philip Goulder. HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. AIDS Res. Hum. Retroviruses, 30(5):468-475, May 2014. PubMed ID: 24010680. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health