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Found 7 matching records:

Displaying record number 58700

HXB2 Location Gag(22-30) Gag Epitope Map
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RPGGKKHYM

`RPGGKKrYM`		escape documented in this paper
`RPGGKKHYk`		observed variant
`RPGGKKHYr`		observed variant

Epitope Name p17-RM9

Species (MHC/HLA) human(B*42:01, B*42:02)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`3110`
Epitope Seq.	`RPGGKKHYM`
Variant Seq.	`RPGGKKrYM`
Mutations	H/R
Epitope Location	H7R
HXB2 Location	H28R
Mutation Type	E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	p17-RM9 mutation, RPGGKKrYM, is selected in 13% HLA-B4201 (8% have wt RM9), 10% HLA-B4202 (31% have wt RM9) and 8% on-HLA-B42 (46% have wt RM9) subjects. The authors designate this variant as an escape when presented by HLAs-B4201 and -B*4202.

Variant ID.	`3111`
Epitope Seq.	`RPGGKKHYM`
Variant Seq.	`RPGGKKHYk`
Mutations	M/K
Epitope Location	M9K
HXB2 Location	M30K
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	p17-RM9 mutation, RPGGKKHYk, is selected in 9% HLA-B4201 (8% have wt RM9), 5% HLA-B4202 (31% have wt RM9) and 2% on-HLA-B*42 (46% have wt RM9) subjects.

Variant ID.	`3112`
Epitope Seq.	`RPGGKKHYM`
Variant Seq.	`RPGGKKHYr`
Mutations	M/R
Epitope Location	M9R
HXB2 Location	M30R
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	p17-RM9 mutation, RPGGKKHYr, is selected in 4% HLA-B4201 (8% have wt RM9), 0% HLA-B4202 (31% have wt RM9) and 1% on-HLA-B*42 (46% have wt RM9) subjects.

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.

Displaying record number 58675

HXB2 Location Gag(180-188) Gag Epitope Map
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Epitope

TPQDLNTML

Epitope Alignment

Variants

TPxDLNTML escape documented in this paper

Epitope Name Gag-TL9

Species (MHC/HLA) human(B*42:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3113`
Epitope Seq.	`TPQDLNTML`
Variant Seq.	`TPxDLNTML`
Mutations	Q/X
Epitope Location	Q3X
HXB2 Location	Q182X
Mutation Type	E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note	p24-TL9 mutation, TPxDLNTML, is selected in 21% HLA-B4201 (75% have wt TL9), 15% HLA-B4202 (82% have wt TL9) and 5% HLA-B42-negative (89% have wt TL9) subjects. Mutant TPlDLNTML is designated as an escape by the authors when presented by HLA-B4201.

References

Displaying record number 58723

HXB2 Location Pol(426-434) Pol Epitope Map
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Epitope

YPGIKVRQL

Epitope Alignment

Variants

`YaGIKVRQL`		escape documented in this paper
`YPGIrVRQL`		observed variant
`YPGIKVRgL`		escape documented in this paper
`YPGIKVRrL`		escape documented in this paper
`YqGIKVRQL`		escape documented in this paper
`YPkIKVRQL`		observed variant
`YPGIKVsQL`		observed variant
`YPGIKVkkL`		escape documented in this paper

Epitope Name RT-YL9

Species (MHC/HLA) human(B*42:01, B*42:02)

Variant Details

Showing all: 8 variant(s).

Variant ID.	`3119`
Epitope Seq.	`YPGIKVRQL`
Variant Seq.	`YaGIKVRQL`
Mutations	P/A
Epitope Location	P2A
HXB2 Location	P427A
Mutation Type	E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RT-YL9 mutation, YaGIKVRQL, is selected in 20% HLA-B4201 (4% have wt YL9) subjects. The authors designate mutant YaGIKVRQL as an escape when presented by HLA-B4201.

Variant ID.	`3120`
Epitope Seq.	`YPGIKVRQL`
Variant Seq.	`YPGIrVRQL`
Mutations	K/R
Epitope Location	K5R
HXB2 Location	K430R
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RT-YL9 mutation, YPGIrVRQL, is selected in 14% HLA-B*4202 (0% have wt YL9) subjects.

Variant ID.	`3121`
Epitope Seq.	`YPGIKVRQL`
Variant Seq.	`YPGIKVRgL`
Mutations	Q/G
Epitope Location	Q8G
HXB2 Location	Q433G
Mutation Type	E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RT-YL9 mutation, YPGIKVRgL, is selected in 14% HLA-B4202 (0% have wt YL9) subjects. The authors designate mutant YPGIKVRgL as an escape when presented by HLA-B4202.

Variant ID.	`3122`
Epitope Seq.	`YPGIKVRQL`
Variant Seq.	`YPGIKVRrL`
Mutations	Q/R
Epitope Location	Q8R
HXB2 Location	Q433R
Mutation Type	E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RT-YL9 mutation, YPGIKVRrL, is selected in 14% HLA-B4202 (0% have wt YL9) subjects. The authors designate mutant YPGIKVRrL as an escape when presented by HLA-B4202.

Variant ID.	`3123`
Epitope Seq.	`YPGIKVRQL`
Variant Seq.	`YqGIKVRQL`
Mutations	P/Q
Epitope Location	P2Q
HXB2 Location	P427Q
Mutation Type	E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RT-YL9 mutation, YqGIKVRQ, is selected in 14% HLA-B4202 (0% have wt YL9) subjects. The authors designate mutant YqGIKVRQ as an escape when presented by HLA-B4202.

Variant ID.	`3124`
Epitope Seq.	`YPGIKVRQL`
Variant Seq.	`YPkIKVRQL`
Mutations	G/K
Epitope Location	G3K
HXB2 Location	G428K
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RT-YL9 mutation, YPkIKVRQL, is selected in 14% HLA-B*4202 (0% have wt YL9) subjects.

Variant ID.	`3125`
Epitope Seq.	`YPGIKVRQL`
Variant Seq.	`YPGIKVsQL`
Mutations	R/S
Epitope Location	R7S
HXB2 Location	R432S
Mutation Type	OV: observed variant
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RT-YL9 mutation, YPGIKVsQL, is selected in 14% HLA-B*4202 (0% have wt YL9) subjects.

Variant ID.	`3126`
Epitope Seq.	`YPGIKVRQL`
Variant Seq.	`YPGIKVkkL`
Mutations	R/K Q/K
Epitope Location	R7K Q8K
HXB2 Location	R432K Q433K
Mutation Type	E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	RT-YL9 mutation, YPGIKVkkL, is selected in 14% HLA-B4202 (0% have wt YL9) subjects. The authors designate mutant YPGIKVkkL as an escape when presented by HLA-B4202.

References

Displaying record number 58708

HXB2 Location Pol(743-751) Pol Epitope Map
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Epitope

LPPIVAKEI

Epitope Alignment

Variants

`LPPxVAKEI`		escape documented in this paper
`LPPIVAxEI`		escape documented in this paper

Epitope Name Int-LI9

Species (MHC/HLA) human(B*42:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`3117`
Epitope Seq.	`LPPIVAKEI`
Variant Seq.	`LPPxVAKEI`
Mutations	I/X
Epitope Location	I4X
HXB2 Location	I746X
Mutation Type	E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	Epitope Int-LI9 carries escape mutations at position 4, LPPxVAKEI. The authors designate it an escape when presented by HLA-B*4201.

Variant ID.	`3118`
Epitope Seq.	`LPPIVAKEI`
Variant Seq.	`LPPIVAxEI`
Mutations	K/X
Epitope Location	K7X
HXB2 Location	K749X
Mutation Type	E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	Sequence
Note	Epitope Int-LI9 carries escape mutations at position 7, LPPIVAxEI. The authors designate it an escape when presented by HLA-B*4201.

References

Displaying record number 58707

HXB2 Location Pol(982-990) Pol Epitope Map
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Epitope

IIKDYGKQM

Epitope Alignment

Variants

IIxDYGKQM escape documented in this paper

Epitope Name Int-IM9

Species (MHC/HLA) human(B*42:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3116`
Epitope Seq.	`IIKDYGKQM`
Variant Seq.	`IIxDYGKQM`
Mutations	K/X
Epitope Location	K3X
HXB2 Location	K984X
Mutation Type	E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Novel epitope, IM9 does accumulate mutations at position 3, IIxDYGKQM. The authors designate this variant as an escape when presented by HLA-B*4201.

References

Displaying record number 58709

HXB2 Location Vif(48-58) Vif Epitope Map
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Epitope

HPKVSSEVHIA

Epitope Alignment

Variants

xPKVSSEVHIa escape documented in this paper

Epitope Name Vif-HI10

Species (MHC/HLA) human(B*42:01)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3115`
Epitope Seq.	`HPKVSSEVHIa`
Variant Seq.	`xPKVSSEVHIa`
Mutations	H/X
Epitope Location	H1X
HXB2 Location	H48X
Mutation Type	E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Mutations at position 1, xPKVSSEVHIa, were detected. The authors designate this variant as an escape when presented by HLA-B*4201.

References

Displaying record number 58710

HXB2 Location Vpr(34-42) Vpr Epitope Map
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Epitope

FPRPWLHGL

Epitope Alignment

Variants

FPRPWLHxL escape documented in this paper

Epitope Name Vpr-FL9

Species (MHC/HLA) human(B*42:01, B*42:02)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3114`
Epitope Seq.	`FPRPWLHGL`
Variant Seq.	`FPRPWLHxL`
Mutations	G/X
Epitope Location	G8X
HXB2 Location	G41X
Mutation Type	E: escape documented in this paper
Epitope Subtype	C
Variant Subtype	C
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Mutations at position 8 in Vpr-FL9, FPRPWLHxL, were detected, but only for HLA-B4201-positive subjects (75% of B4201 subjects). The authors designate this variant as an escape when presented by HLA-B*4201.