HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 7 matching records:

Displaying record number 58700

HXB2 Location  Gag(22-30)   Gag Epitope Map
View variants at this location
Epitope RPGGKKHYM   Epitope Alignment
Variants
RPGGKKrYM   escape documented in this paper
RPGGKKHYk   observed variant
RPGGKKHYr   observed variant
Epitope Name p17-RM9
Species (MHC/HLA human(B*42:01, B*42:02)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3110
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKrYM
Mutations H/R
Epitope Location H7R
HXB2 Location H28R
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note p17-RM9 mutation, RPGGKKrYM, is selected in 13% HLA-B*4201 (8% have wt RM9), 10% HLA-B*4202 (31% have wt RM9) and 8% on-HLA-B*42 (46% have wt RM9) subjects. The authors designate this variant as an escape when presented by HLAs-B*4201 and -B*4202.


Variant ID.  3111
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKHYk
Mutations M/K
Epitope Location M9K
HXB2 Location M30K
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note p17-RM9 mutation, RPGGKKHYk, is selected in 9% HLA-B*4201 (8% have wt RM9), 5% HLA-B*4202 (31% have wt RM9) and 2% on-HLA-B*42 (46% have wt RM9) subjects.


Variant ID.  3112
Epitope Seq.  RPGGKKHYM
Variant Seq.  RPGGKKHYr
Mutations M/R
Epitope Location M9R
HXB2 Location M30R
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note p17-RM9 mutation, RPGGKKHYr, is selected in 4% HLA-B*4201 (8% have wt RM9), 0% HLA-B*4202 (31% have wt RM9) and 1% on-HLA-B*42 (46% have wt RM9) subjects.

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 58675

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPxDLNTML   escape documented in this paper
Epitope Name Gag-TL9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3113
Epitope Seq.  TPQDLNTML
Variant Seq.  TPxDLNTML
Mutations Q/X
Epitope Location Q3X
HXB2 Location Q182X
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, HLA binding, Sequence
Note p24-TL9 mutation, TPxDLNTML, is selected in 21% HLA-B*4201 (75% have wt TL9), 15% HLA-B*4202 (82% have wt TL9) and 5% HLA-B*42-negative (89% have wt TL9) subjects. Mutant TPlDLNTML is designated as an escape by the authors when presented by HLA-B*4201.

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 58723

HXB2 Location  Pol(426-434)   Pol Epitope Map
View variants at this location
Epitope YPGIKVRQL   Epitope Alignment
Variants
YaGIKVRQL   escape documented in this paper
YPGIrVRQL   observed variant
YPGIKVRgL   escape documented in this paper
YPGIKVRrL   escape documented in this paper
YqGIKVRQL   escape documented in this paper
YPkIKVRQL   observed variant
YPGIKVsQL   observed variant
YPGIKVkkL   escape documented in this paper
Epitope Name RT-YL9
Species (MHC/HLA human(B*42:01, B*42:02)

Variant Details

Showing all: 8 variant(s).


Variant ID.  3119
Epitope Seq.  YPGIKVRQL
Variant Seq.  YaGIKVRQL
Mutations P/A
Epitope Location P2A
HXB2 Location P427A
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RT-YL9 mutation, YaGIKVRQL, is selected in 20% HLA-B*4201 (4% have wt YL9) subjects. The authors designate mutant YaGIKVRQL as an escape when presented by HLA-B*4201.


Variant ID.  3120
Epitope Seq.  YPGIKVRQL
Variant Seq.  YPGIrVRQL
Mutations K/R
Epitope Location K5R
HXB2 Location K430R
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RT-YL9 mutation, YPGIrVRQL, is selected in 14% HLA-B*4202 (0% have wt YL9) subjects.


Variant ID.  3121
Epitope Seq.  YPGIKVRQL
Variant Seq.  YPGIKVRgL
Mutations Q/G
Epitope Location Q8G
HXB2 Location Q433G
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RT-YL9 mutation, YPGIKVRgL, is selected in 14% HLA-B*4202 (0% have wt YL9) subjects. The authors designate mutant YPGIKVRgL as an escape when presented by HLA-B*4202.


Variant ID.  3122
Epitope Seq.  YPGIKVRQL
Variant Seq.  YPGIKVRrL
Mutations Q/R
Epitope Location Q8R
HXB2 Location Q433R
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RT-YL9 mutation, YPGIKVRrL, is selected in 14% HLA-B*4202 (0% have wt YL9) subjects. The authors designate mutant YPGIKVRrL as an escape when presented by HLA-B*4202.


Variant ID.  3123
Epitope Seq.  YPGIKVRQL
Variant Seq.  YqGIKVRQL
Mutations P/Q
Epitope Location P2Q
HXB2 Location P427Q
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RT-YL9 mutation, YqGIKVRQ, is selected in 14% HLA-B*4202 (0% have wt YL9) subjects. The authors designate mutant YqGIKVRQ as an escape when presented by HLA-B*4202.


Variant ID.  3124
Epitope Seq.  YPGIKVRQL
Variant Seq.  YPkIKVRQL
Mutations G/K
Epitope Location G3K
HXB2 Location G428K
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RT-YL9 mutation, YPkIKVRQL, is selected in 14% HLA-B*4202 (0% have wt YL9) subjects.


Variant ID.  3125
Epitope Seq.  YPGIKVRQL
Variant Seq.  YPGIKVsQL
Mutations R/S
Epitope Location R7S
HXB2 Location R432S
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RT-YL9 mutation, YPGIKVsQL, is selected in 14% HLA-B*4202 (0% have wt YL9) subjects.


Variant ID.  3126
Epitope Seq.  YPGIKVRQL
Variant Seq.  YPGIKVkkL
Mutations R/K Q/K
Epitope Location R7K Q8K
HXB2 Location R432K Q433K
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method Sequence
Note RT-YL9 mutation, YPGIKVkkL, is selected in 14% HLA-B*4202 (0% have wt YL9) subjects. The authors designate mutant YPGIKVkkL as an escape when presented by HLA-B*4202.

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 58708

HXB2 Location  Pol(743-751)   Pol Epitope Map
View variants at this location
Epitope LPPIVAKEI   Epitope Alignment
Variants
LPPxVAKEI   escape documented in this paper
LPPIVAxEI   escape documented in this paper
Epitope Name Int-LI9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3117
Epitope Seq.  LPPIVAKEI
Variant Seq.  LPPxVAKEI
Mutations I/X
Epitope Location I4X
HXB2 Location I746X
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method Sequence
Note Epitope Int-LI9 carries escape mutations at position 4, LPPxVAKEI. The authors designate it an escape when presented by HLA-B*4201.


Variant ID.  3118
Epitope Seq.  LPPIVAKEI
Variant Seq.  LPPIVAxEI
Mutations K/X
Epitope Location K7X
HXB2 Location K749X
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method Sequence
Note Epitope Int-LI9 carries escape mutations at position 7, LPPIVAxEI. The authors designate it an escape when presented by HLA-B*4201.

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 58707

HXB2 Location  Pol(982-990)   Pol Epitope Map
View variants at this location
Epitope IIKDYGKQM   Epitope Alignment
Variants
IIxDYGKQM   escape documented in this paper
Epitope Name Int-IM9
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3116
Epitope Seq.  IIKDYGKQM
Variant Seq.  IIxDYGKQM
Mutations K/X
Epitope Location K3X
HXB2 Location K984X
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Novel epitope, IM9 does accumulate mutations at position 3, IIxDYGKQM. The authors designate this variant as an escape when presented by HLA-B*4201.

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 58709

HXB2 Location  Vif(48-58)   Vif Epitope Map
View variants at this location
Epitope HPKVSSEVHIA   Epitope Alignment
Variants
xPKVSSEVHIa   escape documented in this paper
Epitope Name Vif-HI10
Species (MHC/HLA human(B*42:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3115
Epitope Seq.  HPKVSSEVHIa
Variant Seq.  xPKVSSEVHIa
Mutations H/X
Epitope Location H1X
HXB2 Location H48X
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Mutations at position 1, xPKVSSEVHIa, were detected. The authors designate this variant as an escape when presented by HLA-B*4201.

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Displaying record number 58710

HXB2 Location  Vpr(34-42)   Vpr Epitope Map
View variants at this location
Epitope FPRPWLHGL   Epitope Alignment
Variants
FPRPWLHxL   escape documented in this paper
Epitope Name Vpr-FL9
Species (MHC/HLA human(B*42:01, B*42:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3114
Epitope Seq.  FPRPWLHGL
Variant Seq.  FPRPWLHxL
Mutations G/X
Epitope Location G8X
HXB2 Location G41X
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Mutations at position 8 in Vpr-FL9, FPRPWLHxL, were detected, but only for HLA-B*4201-positive subjects (75% of B*4201 subjects). The authors designate this variant as an escape when presented by HLA-B*4201.

References

Kloverpris2012a Henrik N. Kløverpris, Mikkel Harndahl, Alasdair J. Leslie, Jonathan M. Carlson, Nasreen Ismail, Mary van der Stok, Kuan-Hsiang Gary Huang, Fabian Chen, Lynn Riddell, Dewald Steyn, Dominique Goedhals, Cloete van Vuuren, John Frater, Bruce D. Walker, Mary Carrington, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HIV Control through a Single Nucleotide on the HLA-B Locus. J. Virol., 86(21):11493-11500, Nov 2012. PubMed ID: 22896606. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health