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Search the Epitope Variant and Escape Mutation Database

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Found 4 matching records:

Displaying record number 58674

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
{x}ISPRTLNAW   calculated escape
xSPRTLNAW   calculated escape
Epitope Name ISW9
Species (MHC/HLA)  human(B*57:01, B*57:02, B*57:03, B*58:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.  3093
Epitope Seq.  {A}ISPRTLNAW
Variant Seq.  {x}ISPRTLNAW
Mutations A/X
Epitope Location A-1X
HXB2 Location A146X
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note ISW9 escapes at A146X, {x}ISPRTLNAW, are seen in ˜100% of HLA-B*5703 and -B*5702 positive subjects.

Variant ID.  3094
Epitope Seq.  ISPRTLNAW
Variant Seq.  xSPRTLNAW
Mutations I/X
Epitope Location I2X
HXB2 Location I148X
Mutation Type CE: calculated escape
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note ISW9 escapes at I147X, xSPRTLNAW, are seen in >75% of HLA-B*5703 and -B*5702 positive subjects.

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.

Displaying record number 58684

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KxFSPEVIPMF   observed variant
KAFxPEVIPMF   observed variant
Epitope Name KF11
Species (MHC/HLA)  human(B*57:03)

Variant Details

Showing all: 2 variant(s).

Variant ID.  3100
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KxFSPEVIPMF
Mutations A/X
Epitope Location A2X
HXB2 Location A163X
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note Mutation KxFSPEVIPMF was seen in > 50% of HLA-B*5703-positive subjects.

Variant ID.  3101
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFxPEVIPMF
Mutations S/X
Epitope Location S4X
HXB2 Location S165X
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note Mutation KAFxPEVIPMF was seen in > 30% of HLA-B*5703-positive subjects.

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.

Displaying record number 58688

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIAW   Epitope Alignment
Variants
TSxLQEQIAW   observed variant
TSTLQEQxAW   observed variant
Epitope Name TW10
Species (MHC/HLA)  human(B*57:02, B*57:03, B*58:01)

Variant Details

Showing all: 2 variant(s).

Variant ID.  3102
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSxLQEQIAW
Mutations T/X
Epitope Location T3X
HXB2 Location T242X
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note Mutation TSxLQEQIAW was seen in >75% of both HLA-B*5703 and -B*5702 positive subjects, and in just under 75% of HLA-B*5801 carrying subjects.

Variant ID.  3103
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSTLQEQxAW
Mutations I/X
Epitope Location I8X
HXB2 Location I247X
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Method Sequence
Note Mutation TSTLQEQxAW was seen in ˜25% of HLA-B*5703-positive subjects, and in very few HLA-B*5801 or -B*5702 carrying subjects.

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.

Displaying record number 58690

HXB2 Location  Gag(308-316)   Gag Epitope Map
View variants at this location
Epitope QATQDVKNW   Epitope Alignment
Variants
QAsQDVKNW   escape documented in this paper
QAsQeVKNW   escape documented in this paper
QATQeVKNW   escape documented in this paper
Epitope Name QW9
Species (MHC/HLA)  human(B*57:02, B*57:03, B*58:01)

Variant Details

Showing all: 3 variant(s).

Variant ID.  3104
Epitope Seq.  QATQDVKNW
Variant Seq.  QAsQDVKNW
Mutations T/S
Epitope Location T3S
HXB2 Location T310S
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Mutant QAsQDVKNW was observed and recognized only in HLA-B*5801-positive subjects. Only 10-15% of such B*5801 subjects, however, carried the P3 mutation.

Variant ID.  3105
Epitope Seq.  QATQDVKNW
Variant Seq.  QAsQeVKNW
Mutations T/S D/E
Epitope Location T3S D5E
HXB2 Location T310S D312E
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Mutant QAsQeVKNW was observed and recognized only in HLA-B*5801-positive subjects. Only ˜5% of such B*5801 subjects, however, carried the P3/P5 mutation.

Variant ID.  3106
Epitope Seq.  QATQDVKNW
Variant Seq.  QATQeVKNW
Mutations D/E
Epitope Location D5E
HXB2 Location D312E
Mutation Type E: escape documented in this paper
Epitope Subtype C
Variant Subtype C
Method CD8 T-cell Elispot - IFNy, Sequence
Note Mutant QATQeVKNW was observed and recognized only in HLA-B*5801-positive subjects.

References

Kloverpris2012 Henrik N. Kloverpris, Anette Stryhn, Mikkel Harndahl, Mary van der Stok, Rebecca P. Payne, Philippa C. Matthews, Fabian Chen, Lynn Riddell, Bruce D. Walker, Thumbi Ndung'u, Søren Buus, and Philip Goulder. HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control. J. Virol., 86(2):919-929, Jan 2012. PubMed ID: 22090105. Show all entries for this paper.

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