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Found 9 matching records:

Displaying record number 57959

HXB2 Location  Gag(77-85)   Gag Epitope Map
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Epitope SLYNTVVTL   Epitope Alignment
Variants
SLYNTVaTL   susceptible form
Epitope Name SL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2690
Epitope Seq.  SLYNTVVTL
Variant Seq.  SLYNTVaTL
Mutations V/A
Epitope Location V7A
HXB2 Location V83A
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note SLYNTVVTL underwent adaptation to neo-epitope SLYNTVaTL. 4 subjects had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 57960

HXB2 Location  Gag(355-363)   Gag Epitope Map
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Epitope GPSHKARVL   Epitope Alignment
Variants
GPgHKARVL   susceptible form
Epitope Name GL9
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2691
Epitope Seq.  GPSHKARVL
Variant Seq.  GPgHKARVL
Mutations S/G
Epitope Location S3G
HXB2 Location S357G
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note GPSHKARVL underwent adaptation to neo-epitope GPgHKARVL. 5 subjects had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 57957

HXB2 Location  Pol(724-734)   Pol Epitope Map
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Epitope QEEHERYHSNW   Epitope Alignment
Variants
QEEHEkYHSNW   susceptible form
Epitope Name QW11
Species (MHC/HLA human(B*44:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2688
Epitope Seq.  QEEHERYHSNW
Variant Seq.  QEEHEkYHSNW
Mutations R/K
Epitope Location R6K
HXB2 Location R729K
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note QEEHERYHSNW underwent adaptation to neo-epitope QEEHEkYHSNW. 2 subjects had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 57955

HXB2 Location  Pol(838-847)   Pol Epitope Map
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Epitope STTVKAACWW   Epitope Alignment
Variants
STaVKAACWW   escape documented in this paper; literature escape
SnTVKAACWW   escape documented in this paper; literature escape
Epitope Name SW10
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2685
Epitope Seq.  STTVKAACWW
Variant Seq.  STaVKAACWW
Mutations T/A
Epitope Location T3A
HXB2 Location T840A
Mutation Type E: escape documented in this paper
LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note STTVKAACWW underwent classical escape, with adapted forms STaVKAACWW and SnTVKAACWW having abrogated EliSpot responses.


Variant ID.  2686
Epitope Seq.  STTVKAACWW
Variant Seq.  SnTVKAACWW
Mutations T/N
Epitope Location T2N
HXB2 Location T839N
Mutation Type E: escape documented in this paper
LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note STTVKAACWW underwent classical escape, with adapted forms STaVKAACWW and SnTVKAACWW having abrogated EliSpot responses.

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 57962

HXB2 Location  Vpr(59-67)   Vpr Epitope Map
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Epitope ALIRILQQL   Epitope Alignment
Variants
AiIRILQQL   susceptible form
Epitope Name AL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2693
Epitope Seq.  ALIRILQQL
Variant Seq.  AiIRILQQL
Mutations L/I
Epitope Location L2I
HXB2 Location L60I
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note ALIRILQQL underwent adaptation to neo-epitope AiIRILQQL. 1 subject had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 57954

HXB2 Location  Nef(90-97)   Nef Epitope Map
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Epitope FLKEKGGL   Epitope Alignment
Variants
FLKEqGGL   escape documented in this paper; literature escape; non-susceptible form
FLKEeGGL   escape documented in this paper; literature escape; non-susceptible form
FLKEnGGL   escape documented in this paper; literature escape; non-susceptible form; susceptible form
Epitope Name FL8
Species (MHC/HLA human(B*08:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  2682
Epitope Seq.  FLKEKGGL
Variant Seq.  FLKEqGGL
Mutations K/Q
Epitope Location K5Q
HXB2 Location K94Q
Mutation Type E: escape documented in this paper
LE: literature escape
NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note FLKEKGGL underwent classical escape, with adapted forms FLKEqGGL, FLKEeGGL, and FLKEnGGL having abrogated EliSpot responses.


Variant ID.  2683
Epitope Seq.  FLKEKGGL
Variant Seq.  FLKEeGGL
Mutations K/E
Epitope Location K5E
HXB2 Location K94E
Mutation Type E: escape documented in this paper
LE: literature escape
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note FLKEKGGL underwent classical escape, with adapted forms FLKEqGGL, FLKEeGGL, and FLKEnGGL having abrogated EliSpot responses.


Variant ID.  2684
Epitope Seq.  FLKEKGGL
Variant Seq.  FLKEnGGL
Mutations K/N
Epitope Location K5N
HXB2 Location K94N
Mutation Type E: escape documented in this paper
LE: literature escape
NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note FLKEKGGL underwent classical escape, with adapted forms FLKEqGGL, FLKEeGGL, and FLKEnGGL having abrogated EliSpot responses. Longitudinal study of an acute subtype A infection in a B*08-positive patient revealed early responses to FLKEKGGL and its variant, FLKEnGGL. The patient's sequences were the non-adapted form and remained invariant despite high-magnitude responses.

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 57956

HXB2 Location  Nef(105-115)   Nef Epitope Map
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Epitope KRQDILDWVY   Epitope Alignment
Variants
KRQeILDWVY   susceptible form
Epitope Name KY11
Species (MHC/HLA human(C*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2687
Epitope Seq.  KRQDILDWVY
Variant Seq.  KRQeILDWVY
Mutations D/E
Epitope Location D4E
HXB2 Location D108E
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note KRQDILDWVY underwent adaptation to neo-epitope KRQeILDWVY. 8 subjects had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 57958

HXB2 Location  Nef(128-137)   Nef Epitope Map
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Epitope TPGPGIRYPL   Epitope Alignment
Variants
TPGPGvRYPL   susceptible form
Epitope Name TL10
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2689
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRYPL
Mutations I/V
Epitope Location I6V
HXB2 Location I133V
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy
Note TPGPGIRYPL underwent adaptation to neo-epitope TPGPGvRYPL. 6 subjects had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


Displaying record number 57961

HXB2 Location  Nef(183-191)   Nef Epitope Map
View variants at this location
Epitope WKFDSRLAF   Epitope Alignment
Variants
WrFDSRLAF   susceptible form
Epitope Name WF9
Species (MHC/HLA human(B*15:03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2692
Epitope Seq.  WKFDSRLAF
Variant Seq.  WrFDSRLAF
Mutations K/R
Epitope Location K2R
HXB2 Location K184R
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study
Note WKFDSRLAF underwent adaptation to neo-epitope WrFDSRLAF. 1 subject had higher EliSpot responses to the neo-epitope than to the non-adapted form.

References

Keane2012 Niamh M. Keane, Steven G. Roberts, Coral-Ann M. Almeida, Tanya Krishnan, Abha Chopra, Emma Demaine, Rebecca Laird, Monika Tschochner, Jonathan M. Carlson, Simon Mallal, David Heckerman, Ian James, and Mina John. High-Avidity, High-IFN-gamma-Producing CD8 T-Cell Responses following Immune Selection during HIV-1 Infection. Immunol. Cell Biol., 90(2):224-234, Feb 2012. PubMed ID: 21577229. Show all entries for this paper.


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