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Found 2 matching records:

Displaying record number 58174

HXB2 Location  Gag(140-147)   Gag Epitope Map
View variants at this location
Epitope GQMVHQAI   Epitope Alignment
Variants
GQMVHQpI   HLA association; escape documented in this paper
Epitope Name GI8
Species (MHC/HLA human(B*48:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2781
Epitope Seq.  GQMVHQAI
Variant Seq.  GQMVHQpI
Mutations A/P
Epitope Location A7P
HXB2 Location A146P
Mutation Type A: HLA association
E: escape documented in this paper
Method Intracellular cytokine staining
Note Variant GQMVHQpI, A146P, was shown to be an escape and was strongly associated with HLA allele B*4801 among HIV-1 infected Japanese.

References

Kawashima2009 Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung'u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi, and Philip Goulder. Adaptation of HIV-1 to Human Leukocyte Antigen Class I. Nature, 458(7238):641-645, 2 Apr 2009. PubMed ID: 19242411. Show all entries for this paper.

Naruto2011 Takuya Naruto, Hayato Murakoshi, Takayuki Chikata, Madoka Koyanagi, Yuka Kawashima, Hiroyuki Gatanaga, Shinichi Oka, and Masafumi Takiguchi. Selection of HLA-B57-Associated Gag A146P Mutant by HLA-B*48:01-Restricted Gag140-147-Specific CTLs in Chronically HIV-1-Infected Japanese. Microbes Infect., 13(8-9):766-770, Aug 2011. PubMed ID: 21473930. Show all entries for this paper.


Displaying record number 57127

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSt   diminished HLA binding or increased off-rate
TAFTIPSr   diminished HLA binding or increased off-rate
Species (MHC/HLA human(B*51)

Variant Details

Showing all: 2 variant(s).


Variant ID.  2530
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type DHB: diminished HLA binding or increased off-rate
Method Intracellular cytokine staining, Relative replication capacity assay
Note This variant had greatly reduce binding to HLA-B*51 in vitro.


Variant ID.  2531
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSr
Mutations I/R
Epitope Location I8R
HXB2 Location I290R
Mutation Type DHB: diminished HLA binding or increased off-rate
Method Intracellular cytokine staining, Relative replication capacity assay
Note This variant had greatly reduce binding to HLA-B*51 in vitro.

References

Kawashima2009 Yuka Kawashima, Katja Pfafferott, John Frater, Philippa Matthews, Rebecca Payne, Marylyn Addo, Hiroyuki Gatanaga, Mamoru Fujiwara, Atsuko Hachiya, Hirokazu Koizumi, Nozomi Kuse, Shinichi Oka, Anna Duda, Andrew Prendergast, Hayley Crawford, Alasdair Leslie, Zabrina Brumme, Chanson Brumme, Todd Allen, Christian Brander, Richard Kaslow, James Tang, Eric Hunter, Susan Allen, Joseph Mulenga, Songee Branch, Tim Roach, Mina John, Simon Mallal, Anthony Ogwu, Roger Shapiro, Julia G. Prado, Sarah Fidler, Jonathan Weber, Oliver G. Pybus, Paul Klenerman, Thumbi Ndung'u, Rodney Phillips, David Heckerman, P. Richard Harrigan, Bruce D. Walker, Masafumi Takiguchi, and Philip Goulder. Adaptation of HIV-1 to Human Leukocyte Antigen Class I. Nature, 458(7238):641-645, 2 Apr 2009. PubMed ID: 19242411. Show all entries for this paper.


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