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Found 11 matching records:

Displaying record number 1649

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLFNTVATL   Epitope Alignment
Variants
SLyNTVATL   susceptible form
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  670
Epitope Seq.  SLFNTVATL
Variant Seq.  SLyNTVATL
Mutations F/Y
Epitope Location F3Y
HXB2 Location F79Y
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This epitope and the variant were recognized by 22/26 HLA-A2+ infected women but only by 1/10 HIV-exposed, persistently seronegative women (HEPS). Responses to the epitope and the variant were much higher after HIV-1 seroconversion in previous HEPS.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1676

HXB2 Location  Gag(183-191)   Gag Epitope Map
View variants at this location
Epitope DLNMMLNIV   Epitope Alignment
Variants
DLNMtLNvV   susceptible form
Species (MHC/HLA human(B14)

Variant Details

Showing all: 1 variant(s).


Variant ID.  677
Epitope Seq.  DLNMMLNIV
Variant Seq.  DLNMtLNvV
Mutations M/T I/V
Epitope Location M5T I8V
HXB2 Location M187T I190V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This epitope and the variant were recognized by 3/7 HIV infected women and by 4/4 HIV-exposed, persistently seronegative women.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1681

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KRWIImGLNK   susceptible form
Species (MHC/HLA human(B27)

Variant Details

Showing all: 1 variant(s).


Variant ID.  675
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Responses to the epitope and the variant were much higher after HIV-1 seroconversion of previous HEPS.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1680

HXB2 Location  Gag(293-302)   Gag Epitope Map
View variants at this location
Epitope FRDYVDRFYK   Epitope Alignment
Variants
FRDYVDRFfK   susceptible form
Species (MHC/HLA human(B18)

Variant Details

Showing all: 1 variant(s).


Variant ID.  679
Epitope Seq.  FRDYVDRFYK
Variant Seq.  FRDYVDRFfK
Mutations Y/F
Epitope Location Y9F
HXB2 Location Y301F
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This epitope and the variant were recognized by 1/9 HIV infected women and by 3/4 HIV-exposed, persistently seronegative women.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1675

HXB2 Location  Gag(298-306)   Gag Epitope Map
View variants at this location
Epitope DRFFKTLRA   Epitope Alignment
Variants
DRFwKTLRA   susceptible form
Species (MHC/HLA human(B14)

Variant Details

Showing all: 1 variant(s).


Variant ID.  676
Epitope Seq.  DRFFKTLRA
Variant Seq.  DRFwKTLRA
Mutations F/W
Epitope Location F4W
HXB2 Location F301W
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This epitope and the variant were recognized by 6/7 HIV infected women but not by HIV-exposed, persistently seronegative women.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1689

HXB2 Location  Gag(309-317)   Gag Epitope Map
View variants at this location
Epitope ATQEVKNWM   Epitope Alignment
Variants
AsQEVKNWM   susceptible form
Species (MHC/HLA human(B53)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2190
Epitope Seq.  ATQEVKNWM
Variant Seq.  AsQEVKNWM
Mutations T/S
Epitope Location T2S
HXB2 Location T310S
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This epitope and the variant were recognized by 5/9 HIV infected women and by 1/2 HIV-exposed, persistently seronegative women.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1684

HXB2 Location  Pol(330-338)   Pol Epitope Map
View variants at this location
Epitope HPDIVIYQY   Epitope Alignment
Variants
nPDIVIYQY   susceptible form
Species (MHC/HLA human(B35)

Variant Details

Showing all: 1 variant(s).


Variant ID.  673
Epitope Seq.  HPDIVIYQY
Variant Seq.  nPDIVIYQY
Mutations H/N
Epitope Location H1N
HXB2 Location H330N
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This epitope and the variant were recognized by 1/4 HIV infected women and by 2/3 HIV-exposed, persistently seronegative women. Responses to the epitope and the variant were much higher before HIV-1 seroconversion of previous HEPS.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1648

HXB2 Location  Pol(464-472)   Pol Epitope Map
View variants at this location
Epitope ILKDPVHGV   Epitope Alignment
Variants
ILKePVHGV   susceptible form
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  671
Epitope Seq.  ILKDPVHGV
Variant Seq.  ILKePVHGV
Mutations D/E
Epitope Location D4E
HXB2 Location D467E
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This epitope and the variant were recognized by 14/25 HIV infected women and by 7/10 HIV-exposed, persistently seronegative women. Responses to the epitope and the variant were much higher before HIV-1 seroconversion of previous HEPS.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1660

HXB2 Location  gp160(586-593)   gp160 Epitope Map
View variants at this location
Epitope YLRDQQLL   Epitope Alignment
Variants
YLkDQQLL   susceptible form
Species (MHC/HLA human(A24)

Variant Details

Showing all: 1 variant(s).


Variant ID.  672
Epitope Seq.  YLRDQQLL
Variant Seq.  YLkDQQLL
Mutations R/K
Epitope Location R3K
HXB2 Location R588K
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This epitope and the variant were recognized by 10/10 HIV infected women and by 3/4 HIV-exposed, persistently seronegative women.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1669

HXB2 Location  Nef(128-137)   Nef Epitope Map
View variants at this location
Epitope TPGPGVRYPL   Epitope Alignment
Variants
TPGPGiRYPL   susceptible form
Species (MHC/HLA human(B7)

Variant Details

Showing all: 1 variant(s).


Variant ID.  674
Epitope Seq.  TPGPGVRYPL
Variant Seq.  TPGPGiRYPL
Mutations V/I
Epitope Location V6I
HXB2 Location V133I
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This epitope and the variant were recognized by 5/6 HIV infected women and by 4/5 HIV-exposed, persistently seronegative women. Responses to the epitope and the variant were much higher after HIV-1 seroconversion of previous HEPS.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


Displaying record number 1679

HXB2 Location  Nef(135-143)   Nef Epitope Map
View variants at this location
Epitope YPLTFGWCY   Epitope Alignment
Variants
YPLTFGWCf   susceptible form
Species (MHC/HLA human(B18, B49)

Variant Details

Showing all: 1 variant(s).


Variant ID.  678
Epitope Seq.  YPLTFGWCY
Variant Seq.  YPLTFGWCf
Mutations Y/F
Epitope Location Y9F
HXB2 Location Y143F
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note This epitope and the variant were recognized by 8/9 HIV infected women and by 1/4 HIV-exposed, persistently seronegative women.

References

Kaul2001a R. Kaul, T. Dong, F. A. Plummer, J. Kimani, T. Rostron, P. Kiama, E. Njagi, E. Irungu, B. Farah, J. Oyugi, R. Chakraborty, K. S. MacDonald, J. J. Bwayo, A. McMichael, and S. L. Rowland-Jones. CD8(+) lymphocytes respond to different HIV epitopes in seronegative and infected subjects. J. Clin. Invest., 107(10):1303-10, May 2001. URL: http://www.jci.org/cgi/content/full/107/10/1303. PubMed ID: 11375420. Show all entries for this paper.


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