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Displaying record number 54497

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTVAaL   susceptible form
lLYNTVATL   susceptible form
SLYNTVAsL   susceptible form
SLYNTpATL   susceptible form
lLYNTVAaL   susceptible form
lLYNTVAsL   susceptible form
lLYNTVlTL   susceptible form
SLYNTsAaL   susceptible form
lLYNTpATL   susceptible form
SLYNTpAaL   susceptible form
SLYNTpAsL   susceptible form
SLhNwslaL   susceptible form
SLwNwplaL   susceptible form
SLwNwplsL   susceptible form
SLhNwplaL   susceptible form
SLhNwplsL   susceptible form
lLwNTslaL   susceptible form
lLwNwslaL   susceptible form
lLwNwslsL   susceptible form
lLwNwplaL   susceptible form
lLhNwslaL   susceptible form
lLhNwplsL   susceptible form
SLfNTVATL   escape documented in this paper; susceptible form
SLfNTVAvL   diminished response; escape documented in this paper
SLfNTiAvL   escape documented in this paper; susceptible form
SLYNTiATL   diminished response; susceptible form
SLYNTiAvL   diminished response; susceptible form
SvYNTVATL   diminished response; susceptible form
SLYNTVAvL   diminished response; susceptible form
Epitope Name SL9
Species (MHC/HLA human, mouse(A2)

Variant Details

Showing all: 29 variant(s).


Variant ID.  596
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVAaL
Mutations T/A
Epitope Location T8A
HXB2 Location T84A
Mutation Type SF: susceptible form
Note This synthesized variant was recognized by CTLs from 8/9 individuals. The variant was more immunogenic than the wt, reduced IL-2-mediated activation induced cell death that the wt CTLs were susceptible to, and induced broad response to several SL9 variants.


Variant ID.  597
Epitope Seq.  SLYNTVATL
Variant Seq.  lLYNTVATL
Mutations S/L
Epitope Location S1L
HXB2 Location S77L
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 6/8 donors.


Variant ID.  598
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVAsL
Mutations T/S
Epitope Location T8S
HXB2 Location T84S
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 7/8 donors.


Variant ID.  599
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTpATL
Mutations V/P
Epitope Location V6P
HXB2 Location V82P
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.


Variant ID.  600
Epitope Seq.  SLYNTVATL
Variant Seq.  lLYNTVAaL
Mutations S/L T/A
Epitope Location S1L T8A
HXB2 Location S77L T84A
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 5/8 donors.


Variant ID.  601
Epitope Seq.  SLYNTVATL
Variant Seq.  lLYNTVAsL
Mutations S/L T/S
Epitope Location S1L T8S
HXB2 Location S77L T84S
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 6/8 donors.


Variant ID.  602
Epitope Seq.  SLYNTVATL
Variant Seq.  lLYNTVlTL
Mutations S/L A/L
Epitope Location S1L A7L
HXB2 Location S77L A83L
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 2/8 donors.


Variant ID.  603
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTsAaL
Mutations V/S T/A
Epitope Location V6S T8A
HXB2 Location V82S T84A
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.


Variant ID.  604
Epitope Seq.  SLYNTVATL
Variant Seq.  lLYNTpATL
Mutations S/L V/P
Epitope Location S1L V6P
HXB2 Location S77L V82P
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.


Variant ID.  605
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTpAaL
Mutations V/P T/A
Epitope Location V6P T8A
HXB2 Location V82P T84A
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.


Variant ID.  606
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTpAsL
Mutations V/P T/S
Epitope Location V6P T8S
HXB2 Location V82P T84S
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 2/8 donors.


Variant ID.  607
Epitope Seq.  SLYNTVATL
Variant Seq.  SLhNwslaL
Mutations Y/H T/W V/S A/L T/A
Epitope Location Y3H T5W V6S A7L T8A
HXB2 Location Y79H T81W V82S A83L T84A
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.


Variant ID.  608
Epitope Seq.  SLYNTVATL
Variant Seq.  SLwNwplaL
Mutations Y/W T/W V/P A/L T/A
Epitope Location Y3W T5W V6P A7L T8A
HXB2 Location Y79W T81W V82P A83L T84A
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.


Variant ID.  609
Epitope Seq.  SLYNTVATL
Variant Seq.  SLwNwplsL
Mutations Y/W T/W V/P A/L T/S
Epitope Location Y3W T5W V6P A7L T8S
HXB2 Location Y79W T81W V82P A83L T84S
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.


Variant ID.  610
Epitope Seq.  SLYNTVATL
Variant Seq.  SLhNwplaL
Mutations Y/H T/W V/P A/L T/A
Epitope Location Y3H T5W V6P A7L T8A
HXB2 Location Y79H T81W V82P A83L T84A
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.


Variant ID.  611
Epitope Seq.  SLYNTVATL
Variant Seq.  SLhNwplsL
Mutations Y/H T/W V/P A/L T/S
Epitope Location Y3H T5W V6P A7L T8S
HXB2 Location Y79H T81W V82P A83L T84S
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.


Variant ID.  612
Epitope Seq.  SLYNTVATL
Variant Seq.  lLwNTslaL
Mutations S/L Y/W V/S A/L T/A
Epitope Location S1L Y3W V6S A7L T8A
HXB2 Location S77L Y79W V82S A83L T84A
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 3/8 donors.


Variant ID.  613
Epitope Seq.  SLYNTVATL
Variant Seq.  lLwNwslaL
Mutations S/L Y/W T/W V/S A/L T/A
Epitope Location S1L Y3W T5W V6S A7L T8A
HXB2 Location S77L Y79W T81W V82S A83L T84A
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 2/8 donors.


Variant ID.  614
Epitope Seq.  SLYNTVATL
Variant Seq.  lLwNwslsL
Mutations S/L Y/W T/W V/S A/L T/S
Epitope Location S1L Y3W T5W V6S A7L T8S
HXB2 Location S77L Y79W T81W V82S A83L T84S
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.


Variant ID.  615
Epitope Seq.  SLYNTVATL
Variant Seq.  lLwNwplaL
Mutations S/L Y/W T/W V/P A/L T/A
Epitope Location S1L Y3W T5W V6P A7L T8A
HXB2 Location S77L Y79W T81W V82P A83L T84A
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.


Variant ID.  616
Epitope Seq.  SLYNTVATL
Variant Seq.  lLhNwslaL
Mutations S/L Y/H T/W V/S A/L T/A
Epitope Location S1L Y3H T5W V6S A7L T8A
HXB2 Location S77L Y79H T81W V82S A83L T84A
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.


Variant ID.  617
Epitope Seq.  SLYNTVATL
Variant Seq.  lLhNwplsL
Mutations S/L Y/H T/W V/P A/L T/S
Epitope Location S1L Y3H T5W V6P A7L T8S
HXB2 Location S77L Y79H T81W V82P A83L T84S
Mutation Type SF: susceptible form
Note 74 synthesized SL9 variants were tested for recognition by CTLs from 9 HLA-A2+ donors. This variant was one of the 22 recognized by CTLs. It was recognized by CTLs from 1/8 donors.


Variant ID.  618
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type E: escape documented in this paper
SF: susceptible form
Note This variant was not recognized by SL9-CTLs from one patient while it was recognized by the T/A-variant CTLs from this patient and by SL9- and T/A-CTLs derived from sister cells from another patient.


Variant ID.  619
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVAvL
Mutations Y/F T/V
Epitope Location Y3F T8V
HXB2 Location Y79F T84V
Mutation Type DR: diminished response
E: escape documented in this paper
Note This variant was not recognized by SL9-CTLs from one patient while it was recognized by the T/A-variant CTLs from this patient and by SL9- and T/A-CTLs derived from sister cells from another patient. It was recognized to a lesser extent than the wt.


Variant ID.  620
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiAvL
Mutations Y/F V/I T/V
Epitope Location Y3F V6I T8V
HXB2 Location Y79F V82I T84V
Mutation Type E: escape documented in this paper
SF: susceptible form
Note This variant was not recognized by SL9-CTLs from one patient while it was recognized by the T/A-variant CTLs from this patient and by SL9- and T/A-CTLs derived from sister cells from another patient.


Variant ID.  621
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type DR: diminished response
SF: susceptible form
Note This variant was recognized by SL9-CTLs from one patient while it was recognized to a lesser extent by the T/A-variant CTLs from this patient. It was recognized by SL9- and T/A-CTLs derived from sister cells from another patient.


Variant ID.  622
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiAvL
Mutations V/I T/V
Epitope Location V6I T8V
HXB2 Location V82I T84V
Mutation Type DR: diminished response
SF: susceptible form
Note This variant was recognized by SL9-CTLs from one patient while it was recognized to a lesser extent by the T/A-variant CTLs from this patient. It was recognized by SL9- and T/A-CTLs derived from sister cells from another patient.


Variant ID.  623
Epitope Seq.  SLYNTVATL
Variant Seq.  SvYNTVATL
Mutations L/V
Epitope Location L2V
HXB2 Location L78V
Mutation Type DR: diminished response
SF: susceptible form
Note This variant was recognized by both SL9-CTLs and by the T/A-variant CTLs from this patient, but to somewhat lesser extent than the wt epitope. It was also recognized by SL9- and T/A-CTLs derived from sister cells from another patient.


Variant ID.  2256
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVAvL
Mutations T/V
Epitope Location T8V
HXB2 Location T84V
Mutation Type DR: diminished response
SF: susceptible form
Note This variant was recognized by both SL9-CTLs and by the T/A-variant CTLs from two patients, but to somewhat lesser extent than the wt epitope in one of the patients.

References

Kan-Mitchell2006 June Kan-Mitchell, Melissa Bajcz, Keri L. Schaubert, David A. Price, Jason M. Brenchley, Tedi E. Asher, Daniel C. Douek, Hwee L. Ng, Otto O. Yang, Charles R. Rinaldo, Jr., Jose Miguel Benito, Brygida Bisikirska, Ramakrishna Hegde, Franco M. Marincola, César Boggiano, Dianne Wilson, Judith Abrams, Sylvie E. Blondelle, and Darcy B. Wilson. Degeneracy and Repertoire of the Human HIV-1 Gag p17(77-85) CTL Response. J. Immunol., 176(11):6690-6701, 1 Jun 2006. PubMed ID: 16709828. Show all entries for this paper.


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