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Search the Epitope Variant and Escape Mutation Database


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Displaying record number 61471

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
SLfNTiAvL   escape documented in this paper
Epitope Name SL9
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 1 variant(s).

Variant ID.  3909
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiAvL
Mutations Y/F V/I T/V
Epitope Location Y3F V6I T8V
HXB2 Location Y79F V82I T84V
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note Triple mutant, SLfNTiAvL-HIV when infected into LRA-treated CD4+ T cells, was not recognizable by non-mutant-SL9-recognizing CTL.


Jones2016 R. Brad Jones, Stefanie Mueller, Rachel O'Connor, Katherine Rimpel, Derek D. Sloan, Dan Karel, Hing C. Wong, Emily K. Jeng, Allison S. Thomas, James B. Whitney, So-Yon Lim, Colin Kovacs, Erika Benko, Sara Karandish, Szu-Han Huang, Maria J. Buzon, Mathias Lichterfeld, Alivelu Irrinki, Jeffrey P. Murry, Angela Tsai, Helen Yu, Romas Geleziunas, Alicja Trocha, Mario A. Ostrowski, Darrell J. Irvine, and Bruce D. Walker. A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes. PLoS Pathog., 12(4):e1005545, Apr 2016. PubMed ID: 27082643. Show all entries for this paper.

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