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Found 2 matching records:

Displaying record number 53008

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTVATL   diminished HLA binding or increased off-rate; escape documented in this paper
SLfNTVAvL   escape documented in this paper; TCR related mutation
SLYNTVvTL   inferred escape
SLfNTiATL   inferred escape
SLYNTiAvL   escape documented in this paper; TCR related mutation
SLhNTVAvL   diminished HLA binding or increased off-rate; escape documented in this paper
SLYNTVAvL   diminished HLA binding or increased off-rate; escape documented in this paper
Epitope Name SL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing all: 7 variant(s).


Variant ID.  486
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Note This variant was found in one patient and elicited <50% the response to the wt while it elicited strong response in another patient. Likely mechanism of escape was loss of HLA binding.


Variant ID.  487
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVAvL
Mutations Y/F T/V
Epitope Location Y3F T8V
HXB2 Location Y79F T84V
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Note This variant was found in two patients and elicited <50% the response to the wt in both patients. Likely mechanism of escape was loss of T cell recognition.


Variant ID.  488
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVvTL
Mutations A/V
Epitope Location A7V
HXB2 Location A83V
Mutation Type IE: inferred escape
Note Variant found in one patient. Decline of CTL responses.


Variant ID.  489
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiATL
Mutations Y/F V/I
Epitope Location Y3F V6I
HXB2 Location Y79F V82I
Mutation Type IE: inferred escape
Note Variant found in one patient. Decline of CTL responses.


Variant ID.  490
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiAvL
Mutations V/I T/V
Epitope Location V6I T8V
HXB2 Location V82I T84V
Mutation Type E: escape documented in this paper
TCR: TCR related mutation
Note This variant was found in two patients and elicited <50% the response to the index peptide in both patients. The likely mechanism of escape was loss of T cell recognition.


Variant ID.  491
Epitope Seq.  SLYNTVATL
Variant Seq.  SLhNTVAvL
Mutations Y/H T/V
Epitope Location Y3H T8V
HXB2 Location Y79H T84V
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Note This variant was found in one patient and elicited <25% the response to the wt in two patients. Likely mechanism of escape was loss of HLA binding.


Variant ID.  492
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVAvL
Mutations T/V
Epitope Location T8V
HXB2 Location T84V
Mutation Type DHB: diminished HLA binding or increased off-rate
E: escape documented in this paper
Note This variant was found in three patients and elicited <50% the response to the wt in two patients. Likely mechanism of escape was loss of HLA binding.

References

Jamieson2003 Beth D. Jamieson, Otto O. Yang, Lance Hultin, Mary Ann Hausner, Patricia Hultin, Jose Matud, Kevin Kunstman, Scott Killian, John Altman, Kristina Kommander, Bette Korber, Janis Giorgi, and Steven Wolinsky. Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses. J. Immunol., 171(10):5372-5379, 15 Nov 2003. PubMed ID: 14607940. Show all entries for this paper.


Displaying record number 53009

HXB2 Location  Pol(464-472)   Pol Epitope Map
View variants at this location
Epitope ILKEPVHGV   Epitope Alignment
Variants
ILKEPVHGa   inferred escape
ILKEPiHGa   inferred escape
ILrEPVHGV   inferred escape
ILKEPVHea   inferred escape
ILKgPVHGa   inferred escape
ILeEPVHGa   inferred escape
ILrEPVHGa   inferred escape
Epitope Name IV9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing all: 7 variant(s).


Variant ID.  493
Epitope Seq.  ILKEPVHGV
Variant Seq.  ILKEPVHGa
Mutations V/A
Epitope Location V9A
HXB2 Location V472A
Mutation Type IE: inferred escape
Note This variant was found in all three patients, being the initial and the last variant in one of the patients. It preceded loss of the IV9 specific CTLs.


Variant ID.  494
Epitope Seq.  ILKEPVHGV
Variant Seq.  ILKEPiHGa
Mutations V/I V/A
Epitope Location V6I V9A
HXB2 Location V469I V472A
Mutation Type IE: inferred escape
Note This variant was found in one of the patients. It preceded loss of the IV9 specific CTLs.


Variant ID.  495
Epitope Seq.  ILKEPVHGV
Variant Seq.  ILrEPVHGV
Mutations K/R
Epitope Location K3R
HXB2 Location K466R
Mutation Type IE: inferred escape
Note This variant was found in two of the patients. It preceded loss of the IV9 specific CTLs.


Variant ID.  496
Epitope Seq.  ILKEPVHGV
Variant Seq.  ILKEPVHea
Mutations G/E V/A
Epitope Location G8E V9A
HXB2 Location G471E V472A
Mutation Type IE: inferred escape
Note This variant was found in one of the patients. It preceded loss of the IV9 specific CTLs.


Variant ID.  497
Epitope Seq.  ILKEPVHGV
Variant Seq.  ILKgPVHGa
Mutations E/G V/A
Epitope Location E4G V9A
HXB2 Location E467G V472A
Mutation Type IE: inferred escape
Note This variant was found in one of the patients. It preceded loss of the IV9 specific CTLs.


Variant ID.  498
Epitope Seq.  ILKEPVHGV
Variant Seq.  ILeEPVHGa
Mutations K/E V/A
Epitope Location K3E V9A
HXB2 Location K466E V472A
Mutation Type IE: inferred escape
Note This variant was found in one of the patients. It preceded loss of the IV9 specific CTLs.


Variant ID.  499
Epitope Seq.  ILKEPVHGV
Variant Seq.  ILrEPVHGa
Mutations K/R V/A
Epitope Location K3R V9A
HXB2 Location K466R V472A
Mutation Type IE: inferred escape
Note This variant was found in one of the patients. It preceded loss of the IV9 specific CTLs.

References

Jamieson2003 Beth D. Jamieson, Otto O. Yang, Lance Hultin, Mary Ann Hausner, Patricia Hultin, Jose Matud, Kevin Kunstman, Scott Killian, John Altman, Kristina Kommander, Bette Korber, Janis Giorgi, and Steven Wolinsky. Epitope Escape Mutation and Decay of Human Immunodeficiency Virus Type 1-Specific CTL Responses. J. Immunol., 171(10):5372-5379, 15 Nov 2003. PubMed ID: 14607940. Show all entries for this paper.


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