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Found 2 matching records:

Displaying record number 104

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTVATL   susceptible form
SLYNTiATL   susceptible form
SLYNTVAvL   susceptible form
SLYNaVATL   susceptible form
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing all: 4 variant(s).


Variant ID.  408
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type SF: susceptible form
Method Chromium-release assay
Note No variants were found in the patient, but this synthetic variant was tested against patient CTLs. The variant was recognized by CTLs and induced target specific lysis.


Variant ID.  409
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type SF: susceptible form
Method Chromium-release assay
Note No variants were found in the patient, but this synthetic variant was tested against patient CTLs. The variant was recognized by CTLs and induced target specific lysis.


Variant ID.  410
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVAvL
Mutations T/V
Epitope Location T8V
HXB2 Location T84V
Mutation Type SF: susceptible form
Method Chromium-release assay
Note No variants were found in the patient, but this synthetic variant was tested against patient CTLs. The variant was recognized by CTLs and induced target specific lysis.


Variant ID.  411
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNaVATL
Mutations T/A
Epitope Location T5A
HXB2 Location T81A
Mutation Type SF: susceptible form
Method Chromium-release assay
Note No variants were found in the patient, but this synthetic variant was tested against patient CTLs. The variant was recognized by CTLs and induced target specific lysis.

References

Harrer1998 T. Harrer, E. Harrer, P. Barbosa, F. Kaufmann, R. Wagner, S. Bruggemann, J. R. Kalden, M. Feinberg, R. P. Johnson, S. Buchbinder, and B. D. Walker. Recognition of Two Overlapping CTL Epitopes in HIV-1 p17 by CTL from a Long-Term Nonprogressing HIV-1-Infected Individual. J. Immunol., 161:4875-4881, 1998. PubMed ID: 9794421. Show all entries for this paper.


Displaying record number 107

HXB2 Location  Gag(84-91)   Gag Epitope Map
View variants at this location
Epitope TLYCVHQR   Epitope Alignment
Variants
TLYCVHQk   susceptible form
TLYCVHQq   diminished response
TLYCVHeR   escape documented in this paper
Species (MHC/HLA human(A11)

Variant Details

Showing all: 3 variant(s).


Variant ID.  412
Epitope Seq.  TLYCVHQR
Variant Seq.  TLYCVHQk
Mutations R/K
Epitope Location R8K
HXB2 Location R91K
Mutation Type SF: susceptible form
Method Chromium-release assay
Note Variant found in patient. It was recognized by patient CTLs and induced target specific lysis.


Variant ID.  413
Epitope Seq.  TLYCVHQR
Variant Seq.  TLYCVHQq
Mutations R/Q
Epitope Location R8Q
HXB2 Location R91Q
Mutation Type DR: diminished response
Method Chromium-release assay
Note Variant found in patient. It was recognized by patient CTLs but less than the R/K variant, and only induced target specific lysis at high concentrations. This mutation did not abrogate virus replication.


Variant ID.  414
Epitope Seq.  TLYCVHQR
Variant Seq.  TLYCVHeR
Mutations Q/E
Epitope Location Q7E
HXB2 Location Q90E
Mutation Type E: escape documented in this paper
Method Chromium-release assay
Note Variant found in patient. It was not able to induce target specific lysis. This mutation did not abrogate virus replication.

References

Harrer1998 T. Harrer, E. Harrer, P. Barbosa, F. Kaufmann, R. Wagner, S. Bruggemann, J. R. Kalden, M. Feinberg, R. P. Johnson, S. Buchbinder, and B. D. Walker. Recognition of Two Overlapping CTL Epitopes in HIV-1 p17 by CTL from a Long-Term Nonprogressing HIV-1-Infected Individual. J. Immunol., 161:4875-4881, 1998. PubMed ID: 9794421. Show all entries for this paper.


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