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Found 1 matching record:

Displaying record number 52191

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KgFnPEVIPMF   subtype-specific susceptible form
KAlSPEVIPMF   subtype-specific susceptible form
KAFSPEVIPvF   subtype-specific susceptible form
KAFnPEiIPMF   subtype-specific susceptible form
KAFSPEiIPMF   subtype-specific susceptible form
KAFSqEVIPMF   diminished response; subtype-specific susceptible form
rgFSPEVIPMF   observed variant
rgsSPEVIPMF   observed variant
Epitope Name KAFS
Species (MHC/HLA human(B*57:01, B*57:03)

Variant Details

Showing all: 8 variant(s).


Variant ID.  347
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFnPEVIPMF
Mutations A/G S/N
Epitope Location A2G S4N
HXB2 Location A163G S165N
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A, AC
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding
Note Variant found in clades A and AC. B*5701 CTL clones recognized this variant and displayed similar levels of lytic activity as against the wt at time 0 but 50% of activity at 24h later. This variant was presented more efficiently by B*5703 than by B*5701. The variant reacted with 100% of CTLs but failed to induce significant IFN-gamma secretion in 2 of the patients, indicating that this variant is unable to activate all downstream effector functions. However, it induced IFN-gamma in some patients' PBMCs.


Variant ID.  348
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAlSPEVIPMF
Mutations F/L
Epitope Location F3L
HXB2 Location F164L
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding
Note Variant found in clade A. It was recognized by CTLs and induced lysis of peptide-pulsed targets. The variant induced IFN-gamma secretion in PBMCs from 5 patients and did not induce secretion in PBMCs from 1 patient.


Variant ID.  349
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPEVIPvF
Mutations M/V
Epitope Location M10V
HXB2 Location M171V
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding
Note Variant found in clade A. It was recognized by CTLs and induced lysis of peptide-pulsed targets. The variant induced IFN-gamma secretion in PBMCs from all patients.


Variant ID.  350
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFnPEiIPMF
Mutations S/N V/I
Epitope Location S4N V7I
HXB2 Location S165N V168I
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype O group
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding
Note Variant found in group O. It was recognized by CTLs and induced lysis of peptide-pulsed targets. The variant induced IFN-gamma secretion in PBMCs from 4 patients and did not induce secretion in PBMCs from 2 patients.


Variant ID.  351
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPEiIPMF
Mutations V/I
Epitope Location V7I
HXB2 Location V168I
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype AC
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding
Note Variant found in clade A/C. It was recognized by CTLs and induced lysis of peptide-pulsed targets. The variant induced IFN-gamma secretion in PBMCs from all patients.


Variant ID.  352
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSqEVIPMF
Mutations P/Q
Epitope Location P5Q
HXB2 Location P166Q
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype AC
Method CD8 T-cell Elispot - IFNy, Chromium-release assay, Tetramer binding
Note Variant found in clade A /C. It induced IFN-gamma production in 3/6 patients' PBMC but it demonstrated a diminished capacity to sensitize target cells for lysis. This variant was a weak ligand.


Variant ID.  353
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  rgFSPEVIPMF
Mutations K/R A/G
Epitope Location K1R A2G
HXB2 Location K162R A163G
Mutation Type OV: observed variant
Note Variant found in one patient in 10/11 clones.


Variant ID.  354
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  rgsSPEVIPMF
Mutations K/R A/G F/S
Epitope Location K1R A2G F3S
HXB2 Location K162R A163G F164S
Mutation Type OV: observed variant
Note Variant found in one patient in 1/11 clones.

References

Gillespie2002 Geraldine M. A. Gillespie, Rupert Kaul, Tao Dong, Hong-Bing Yang, Tim Rostron, Job J. Bwayo, Peter Kiama, Tim Peto, Francis A. Plummer, Andrew J. McMichael, and Sarah L. Rowland-Jones. Cross-Reactive Cytotoxic T Lymphocytes against a HIV-1 P24 Epitope in Slow Progressors with B*57. AIDS, 16(7):961-972, 3 May 2002. PubMed ID: 11953462. Show all entries for this paper.


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