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Found 2 matching records:

Displaying record number 61245

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPQDLNsML   HLA association; observed variant
TPsDLNsML   HLA association; observed variant
TPaDLNTML   HLA association; observed variant
TPtDLNTML   HLA association; observed variant
TPgDLNTML   HLA association; observed variant
Epitope Name TL9, TL9T7
Species (MHC/HLA human(B*42:01, B*81:01)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3755
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNsML
Mutations T/S
Epitope Location T7S
HXB2 Location T186S
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B, C, D, F, G, J, K
Variant Subtype C
Method Other
Note Variant TL9S7, TPQDLNsML, is present in 5% of B*42-/B*81- subjects; 57.1% of B*81+ subjects. Thus T3S substitution is predominantly selected in the presence of B*81. A second substitution at Q3S is observed in association with coexpression of a second TL9 presenting allele, either B*07 or B*42. In 5/6 TL9S7 variant viruses, upstream E177D or downstream T190I/A were seen. Different substitutions at P3 were associated with presence of B*42 allele, where Q3T, Q3G, Q3A or Q3S were isolated from B*53 or B*81-expressing subjects.


Variant ID.  3756
Epitope Seq.  TPQDLNTML
Variant Seq.  TPsDLNsML
Mutations Q/S T/S
Epitope Location Q3S T7S
HXB2 Location Q182S T186S
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B, C, D, F, G, J, K
Variant Subtype C
Method Other
Note Variant TL9S3S7, TPsDLNsML, is present in 2.5% of B*81-/B*42- subjects; 28.6% of B*81+; and 14.3% of B*42+ subjects.


Variant ID.  3757
Epitope Seq.  TPQDLNTML
Variant Seq.  TPaDLNTML
Mutations Q/A
Epitope Location Q3A
HXB2 Location Q182A
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B, C, D, F, G, J, K
Variant Subtype C
Method Other
Note Variant, TPaDLNTML, is present in 7.1% of B*42+ subjects; 2.5% of B*42-/B*81- subjects.


Variant ID.  3758
Epitope Seq.  TPQDLNTML
Variant Seq.  TPtDLNTML
Mutations Q/T
Epitope Location Q3T
HXB2 Location Q182T
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B, C, D, F, G, J, K
Variant Subtype C
Method Other
Note Variant TL9T3, TPtDLNTML, is present in 28.6% of B*42+ subjects.


Variant ID.  3759
Epitope Seq.  TPQDLNTML
Variant Seq.  TPgDLNTML
Mutations Q/G
Epitope Location Q3G
HXB2 Location Q182G
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype B, C, D, F, G, J, K
Variant Subtype C
Method Other
Note Variant TPgDLNTML, is present in 7.1% of B*42+ subjects.

References

Geldmacher2009 Christof Geldmacher, Ian S. Metzler, Sodsai Tovanabutra, Tedi E. Asher, Emma Gostick, David R. Ambrozak, Constantinos Petrovas, Alexandra Schuetz, Njabulo Ngwenyama, Gustavo Kijak, Leonard Maboko, Michael Hoelscher, Francine McCutchan, David A. Price, Daniel C. Douek, and Richard A. Koup. Minor Viral and Host Genetic Polymorphisms Can Dramatically Impact the Biologic Outcome of an Epitope-Specific CD8 T-Cell Response. Blood, 114(8):1553-1562, 20 Aug 2009. PubMed ID: 19542300. Show all entries for this paper.


Displaying record number 61246

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNMML   Epitope Alignment
Variants
iPQDLNMML   HLA association; observed variant
iPhDLNMML   HLA association; observed variant
TPsDLNMML   HLA association; observed variant
TPhDLNMML   HLA association; observed variant
TPQDLNvML   HLA association; observed variant
TPgDLNMML   HLA association; observed variant
TPQDLNtML   HLA association; observed variant
Epitope Name TL9M7
Species (MHC/HLA human(B*42:01, B*81:01)

Variant Details

Showing all: 7 variant(s).


Variant ID.  3760
Epitope Seq.  TPQDLNMML
Variant Seq.  iPQDLNMML
Mutations T/I
Epitope Location T1I
HXB2 Location T180I
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype A, CRF01_AE, CRF02_AG
Variant Subtype A, CRF01_AE, CRF02_AG
Method Other
Note Variant, iPQDLNMML, is present in 8.3% of B*42+ subjects; 5% of B*42-/B*81- subjects.


Variant ID.  3761
Epitope Seq.  TPQDLNMML
Variant Seq.  iPhDLNMML
Mutations T/I Q/H
Epitope Location T1I Q3H
HXB2 Location T180I Q182H
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype A, CRF01_AE, CRF02_AG
Variant Subtype A, CRF01_AE, CRF02_AG
Method Other
Note Variant, iPhDLNMML, is present in 2.5% of B*42-/B*81- subjects.


Variant ID.  3762
Epitope Seq.  TPQDLNMML
Variant Seq.  TPsDLNMML
Mutations Q/S
Epitope Location Q3S
HXB2 Location Q182S
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype A, CRF01_AE, CRF02_AG
Variant Subtype A, CRF01_AE, CRF02_AG
Method Other
Note Variant, TPsDLNMML, is present in 8.3% of B*42+ subjects; 2.5% of B*42-/B*81- subjects.


Variant ID.  3763
Epitope Seq.  TPQDLNMML
Variant Seq.  TPhDLNMML
Mutations Q/H
Epitope Location Q3H
HXB2 Location Q182H
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype A, CRF01_AE, CRF02_AG
Variant Subtype A, CRF01_AE, CRF02_AG
Method Other
Note Variant, TPhDLNMML, is present in 2.5% of B*42-/B*81- subjects.


Variant ID.  3764
Epitope Seq.  TPQDLNMML
Variant Seq.  TPQDLNvML
Mutations M/V
Epitope Location M7V
HXB2 Location M186V
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype A, CRF01_AE, CRF02_AG
Variant Subtype A, CRF01_AE, CRF02_AG
Method Other
Note Variant, TPQDLNvML, is present in 5% of B*42-/B*81- subjects.


Variant ID.  3765
Epitope Seq.  TPQDLNMML
Variant Seq.  TPgDLNMML
Mutations Q/G
Epitope Location Q3G
HXB2 Location Q182G
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype A, CRF01_AE, CRF02_AG
Variant Subtype A, CRF01_AE, CRF02_AG
Method Other
Note Variant, TPgDLNMML, is present in 5% of B*42-/B*81- and 11.1% of the B*81+ subjects.


Variant ID.  3766
Epitope Seq.  TPQDLNMML
Variant Seq.  TPQDLNtML
Mutations M/T
Epitope Location M7T
HXB2 Location M186T
Mutation Type A: HLA association
OV: observed variant
Epitope Subtype A, CRF01_AE, CRF02_AG
Variant Subtype A, CRF01_AE, CRF02_AG
Method Other
Note Variant, TPQDLNtML, is present in 2.5% of B*42-/B*81- subjects and 16.7% of B*42+ subjects.

References

Geldmacher2009 Christof Geldmacher, Ian S. Metzler, Sodsai Tovanabutra, Tedi E. Asher, Emma Gostick, David R. Ambrozak, Constantinos Petrovas, Alexandra Schuetz, Njabulo Ngwenyama, Gustavo Kijak, Leonard Maboko, Michael Hoelscher, Francine McCutchan, David A. Price, Daniel C. Douek, and Richard A. Koup. Minor Viral and Host Genetic Polymorphisms Can Dramatically Impact the Biologic Outcome of an Epitope-Specific CD8 T-Cell Response. Blood, 114(8):1553-1562, 20 Aug 2009. PubMed ID: 19542300. Show all entries for this paper.


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