HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 8 matching records:

Displaying record number 54602

HXB2 Location  Gag(22-29)   Gag Epitope Map
View variants at this location
Epitope RPGGKKHY   Epitope Alignment
Variants
RPGGKKkY   diminished response
RPGGKKqY   diminished response
Species (MHC/HLA human(B42, B7)

Variant Details

Showing all: 2 variant(s).


Variant ID.  337
Epitope Seq.  RPGGKKHY
Variant Seq.  RPGGKKkY
Mutations H/K
Epitope Location H7K
HXB2 Location H28K
Mutation Type DR: diminished response
Epitope Subtype C
Variant Subtype D
Note The wild type epitope sequence was a subtype C peptide, the variant found in subtype D. CTL response in 56 individuals from Tanzania was strongest for subtype D peptide, and lower for subtype C, due to point mutation effect.


Variant ID.  338
Epitope Seq.  RPGGKKHY
Variant Seq.  RPGGKKqY
Mutations H/Q
Epitope Location H7Q
HXB2 Location H28Q
Mutation Type DR: diminished response
Epitope Subtype C
Variant Subtype A
Note The wild type epitope sequence was a subtype C peptide, the variant found in subtype A. CTL response in 56 individuals from Tanzania was strongest for subtype D peptide, and lower for subtype A, due to point mutation effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


Displaying record number 54596

HXB2 Location  Gag(28-36)   Gag Epitope Map
View variants at this location
Epitope HYMLKHIVW   Epitope Alignment
Variants
kYrLKHlVW   diminished response
qYrmKHlVW   diminished response
Species (MHC/HLA human(A*23:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  339
Epitope Seq.  HYMLKHIVW
Variant Seq.  kYrLKHlVW
Mutations H/K M/R I/L
Epitope Location H1K M3R I7L
HXB2 Location H28K M30R I34L
Mutation Type DR: diminished response
Epitope Subtype C
Variant Subtype D
Note The wild type epitope sequence was a subtype C peptide, the variant found in subtype D. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and lower for subtype D, due to point mutation effect.


Variant ID.  340
Epitope Seq.  HYMLKHIVW
Variant Seq.  qYrmKHlVW
Mutations H/Q M/R L/M I/L
Epitope Location H1Q M3R L4M I7L
HXB2 Location H28Q M30R L31M I34L
Mutation Type DR: diminished response
Epitope Subtype C
Variant Subtype A
Note The wild type epitope sequence was a subtype C peptide, the variant found in subtype A. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and lower for subtype A, due to point mutation effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


Displaying record number 54597

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTiATL   diminished response
Species (MHC/HLA human(A2, A68)

Variant Details

Showing all: 1 variant(s).


Variant ID.  341
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiATL
Mutations Y/F V/I
Epitope Location Y3F V6I
HXB2 Location Y79F V82I
Mutation Type DR: diminished response
Epitope Subtype C
Variant Subtype A, D
Note The wild type epitope sequence was a subtype C peptide, the variant common to subtypes A and D. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and lower for subtypes A and D, due to point mutation effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


Displaying record number 54598

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   diminished response
Species (MHC/HLA human(B57, B58)

Variant Details

Showing all: 1 variant(s).


Variant ID.  342
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type DR: diminished response
Epitope Subtype C
Variant Subtype A, D
Note The wild type epitope sequence was a subtype C peptide, the variant common to subtypes A and D. CTL response in 56 individuals from Tanzania was strongest for subtypes A and D peptides, and much lower for subtype C, due to point mutation and/or frame-of-epitope effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


Displaying record number 54594

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPQDLNmML   diminished response
Species (MHC/HLA human(B42, B7, B81)

Variant Details

Showing all: 1 variant(s).


Variant ID.  343
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNmML
Mutations T/M
Epitope Location T7M
HXB2 Location T186M
Mutation Type DR: diminished response
Epitope Subtype C, D
Variant Subtype A
Note The wild type epitope sequence was common to subtypes C and D, the variant to subtype A. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and much lower for subtype A, due to point mutation effect. The response was also lower for subtype D, due to frame-of-epitope effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


Displaying record number 54600

HXB2 Location  Gag(291-301)   Gag Epitope Map
View variants at this location
Epitope EPFRDYVDRFF   Epitope Alignment
Variants
EPFRDYVDRFy   diminished response
Species (MHC/HLA human(B81)

Variant Details

Showing all: 1 variant(s).


Variant ID.  344
Epitope Seq.  EPFRDYVDRFF
Variant Seq.  EPFRDYVDRFy
Mutations F/Y
Epitope Location F11Y
HXB2 Location F301Y
Mutation Type DR: diminished response
Epitope Subtype A, C
Variant Subtype D
Note The wild type epitope sequence was common to subtypes C and A, the variant to subtype D. CTL response in 56 individuals from Tanzania was strongest for subtypes C and A peptides, and much lower for subtype D, due to point mutation effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


Displaying record number 54595

HXB2 Location  Gag(296-304)   Gag Epitope Map
View variants at this location
Epitope YVDRFFKTL   Epitope Alignment
Variants
YVDRFyKTL   diminished response
Species (MHC/HLA human(B*15:10)

Variant Details

Showing all: 1 variant(s).


Variant ID.  345
Epitope Seq.  YVDRFFKTL
Variant Seq.  YVDRFyKTL
Mutations F/Y
Epitope Location F6Y
HXB2 Location F301Y
Mutation Type DR: diminished response
Epitope Subtype A, C
Variant Subtype D
Note The wild type epitope sequence was common to subtypes C and A, the variant to subtype D. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and much lower for subtype D, due to point mutation effect. The response was somewhat lower for subtype A peptide due to frame-of-epitope effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


Displaying record number 54601

HXB2 Location  Gag(355-363)   Gag Epitope Map
View variants at this location
Epitope GPSHKARVL   Epitope Alignment
Variants
GPgHKARVL   diminished response
Species (MHC/HLA human(B42, B7, B81)

Variant Details

Showing all: 1 variant(s).


Variant ID.  346
Epitope Seq.  GPSHKARVL
Variant Seq.  GPgHKARVL
Mutations S/G
Epitope Location S3G
HXB2 Location S357G
Mutation Type DR: diminished response
Epitope Subtype D
Variant Subtype A, C
Note The wild type epitope sequence was a subtype D peptide, the variant common to subtypes C and A. CTL response in 56 individuals from Tanzania was strongest for subtype D peptide, and much lower for subtypes C and A, due to point mutation and/or frame-of-epitope effect.

References

Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health