HIV molecular immunology database
Found 8 matching records:
HXB2 Location | Gag(22-29) | Gag Epitope Map
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Epitope |
RPGGKKHY
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Epitope Alignment | |||||||
Variants |
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Species (MHC/HLA) | human(B42, B7) |
Showing all: 2 variant(s).
Variant ID. | 337 |
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Epitope Seq. | RPGGKKHY |
Variant Seq. | RPGGKKkY |
Mutations | H/K |
Epitope Location | H7K |
HXB2 Location | H28K |
Mutation Type | DR: diminished response |
Epitope Subtype | C |
Variant Subtype | D |
Note | The wild type epitope sequence was a subtype C peptide, the variant found in subtype D. CTL response in 56 individuals from Tanzania was strongest for subtype D peptide, and lower for subtype C, due to point mutation effect. |
Variant ID. | 338 |
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Epitope Seq. | RPGGKKHY |
Variant Seq. | RPGGKKqY |
Mutations | H/Q |
Epitope Location | H7Q |
HXB2 Location | H28Q |
Mutation Type | DR: diminished response |
Epitope Subtype | C |
Variant Subtype | A |
Note | The wild type epitope sequence was a subtype C peptide, the variant found in subtype A. CTL response in 56 individuals from Tanzania was strongest for subtype D peptide, and lower for subtype A, due to point mutation effect. |
Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.
HXB2 Location | Gag(28-36) | Gag Epitope Map
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Epitope |
HYMLKHIVW
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Epitope Alignment | |||||||
Variants |
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Species (MHC/HLA) | human(A*23:01) |
Showing all: 2 variant(s).
Variant ID. | 339 |
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Epitope Seq. | HYMLKHIVW |
Variant Seq. | kYrLKHlVW |
Mutations | H/K M/R I/L |
Epitope Location | H1K M3R I7L |
HXB2 Location | H28K M30R I34L |
Mutation Type | DR: diminished response |
Epitope Subtype | C |
Variant Subtype | D |
Note | The wild type epitope sequence was a subtype C peptide, the variant found in subtype D. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and lower for subtype D, due to point mutation effect. |
Variant ID. | 340 |
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Epitope Seq. | HYMLKHIVW |
Variant Seq. | qYrmKHlVW |
Mutations | H/Q M/R L/M I/L |
Epitope Location | H1Q M3R L4M I7L |
HXB2 Location | H28Q M30R L31M I34L |
Mutation Type | DR: diminished response |
Epitope Subtype | C |
Variant Subtype | A |
Note | The wild type epitope sequence was a subtype C peptide, the variant found in subtype A. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and lower for subtype A, due to point mutation effect. |
Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.
HXB2 Location | Gag(77-85) | Gag Epitope Map
View variants at this location |
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Epitope |
SLYNTVATL
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(A2, A68) |
Showing all: 1 variant(s).
Variant ID. | 341 |
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Epitope Seq. | SLYNTVATL |
Variant Seq. | SLfNTiATL |
Mutations | Y/F V/I |
Epitope Location | Y3F V6I |
HXB2 Location | Y79F V82I |
Mutation Type | DR: diminished response |
Epitope Subtype | C |
Variant Subtype | A, D |
Note | The wild type epitope sequence was a subtype C peptide, the variant common to subtypes A and D. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and lower for subtypes A and D, due to point mutation effect. |
Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.
HXB2 Location | Gag(147-155) | Gag Epitope Map
View variants at this location |
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Epitope |
ISPRTLNAW
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(B57, B58) |
Showing all: 1 variant(s).
Variant ID. | 342 |
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Epitope Seq. | ISPRTLNAW |
Variant Seq. | lSPRTLNAW |
Mutations | I/L |
Epitope Location | I1L |
HXB2 Location | I147L |
Mutation Type | DR: diminished response |
Epitope Subtype | C |
Variant Subtype | A, D |
Note | The wild type epitope sequence was a subtype C peptide, the variant common to subtypes A and D. CTL response in 56 individuals from Tanzania was strongest for subtypes A and D peptides, and much lower for subtype C, due to point mutation and/or frame-of-epitope effect. |
Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.
HXB2 Location | Gag(180-188) | Gag Epitope Map
View variants at this location |
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Epitope |
TPQDLNTML
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(B42, B7, B81) |
Showing all: 1 variant(s).
Variant ID. | 343 |
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Epitope Seq. | TPQDLNTML |
Variant Seq. | TPQDLNmML |
Mutations | T/M |
Epitope Location | T7M |
HXB2 Location | T186M |
Mutation Type | DR: diminished response |
Epitope Subtype | C, D |
Variant Subtype | A |
Note | The wild type epitope sequence was common to subtypes C and D, the variant to subtype A. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and much lower for subtype A, due to point mutation effect. The response was also lower for subtype D, due to frame-of-epitope effect. |
Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.
HXB2 Location | Gag(291-301) | Gag Epitope Map
View variants at this location |
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Epitope |
EPFRDYVDRFF
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(B81) |
Showing all: 1 variant(s).
Variant ID. | 344 |
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Epitope Seq. | EPFRDYVDRFF |
Variant Seq. | EPFRDYVDRFy |
Mutations | F/Y |
Epitope Location | F11Y |
HXB2 Location | F301Y |
Mutation Type | DR: diminished response |
Epitope Subtype | A, C |
Variant Subtype | D |
Note | The wild type epitope sequence was common to subtypes C and A, the variant to subtype D. CTL response in 56 individuals from Tanzania was strongest for subtypes C and A peptides, and much lower for subtype D, due to point mutation effect. |
Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.
HXB2 Location | Gag(296-304) | Gag Epitope Map
View variants at this location |
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Epitope |
YVDRFFKTL
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(B*15:10) |
Showing all: 1 variant(s).
Variant ID. | 345 |
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Epitope Seq. | YVDRFFKTL |
Variant Seq. | YVDRFyKTL |
Mutations | F/Y |
Epitope Location | F6Y |
HXB2 Location | F301Y |
Mutation Type | DR: diminished response |
Epitope Subtype | A, C |
Variant Subtype | D |
Note | The wild type epitope sequence was common to subtypes C and A, the variant to subtype D. CTL response in 56 individuals from Tanzania was strongest for subtype C peptide, and much lower for subtype D, due to point mutation effect. The response was somewhat lower for subtype A peptide due to frame-of-epitope effect. |
Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.
HXB2 Location | Gag(355-363) | Gag Epitope Map
View variants at this location |
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Epitope |
GPSHKARVL
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Epitope Alignment | ||||
Variants |
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Species (MHC/HLA) | human(B42, B7, B81) |
Showing all: 1 variant(s).
Variant ID. | 346 |
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Epitope Seq. | GPSHKARVL |
Variant Seq. | GPgHKARVL |
Mutations | S/G |
Epitope Location | S3G |
HXB2 Location | S357G |
Mutation Type | DR: diminished response |
Epitope Subtype | D |
Variant Subtype | A, C |
Note | The wild type epitope sequence was a subtype D peptide, the variant common to subtypes C and A. CTL response in 56 individuals from Tanzania was strongest for subtype D peptide, and much lower for subtypes C and A, due to point mutation and/or frame-of-epitope effect. |
Geldmacher2007 Christof Geldmacher, Jeffrey R. Currier, Martina Gerhardt, Antelmo Haule, Leonard Maboko, Deborah Birx, Clive Gray, Andreas Meyerhans, Josephine Cox, and Michael Hoelscher. In a Mixed Subtype Epidemic, the HIV-1 Gag-Specific T-Cell Response Is Biased Towards the Infecting Subtype. AIDS, 21(2):135-143, 11 Jan 2007. PubMed ID: 17197803. Show all entries for this paper.