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Found 11 matching records:

Displaying record number 53687

HXB2 Location  Gag(22-31)   Gag Epitope Map
View variants at this location
Epitope RPGGKKKYKL   Epitope Alignment
Variants
RPGGnKKYKL   observed variant
Species (MHC/HLA human(Cw4)

Variant Details

Showing all: 1 variant(s).


Variant ID.  326
Epitope Seq.  RPGGKKKYKL
Variant Seq.  RPGGnKKYKL
Mutations K/N
Epitope Location K5N
HXB2 Location K26N
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 53683

HXB2 Location  Gag(24-31)   Gag Epitope Map
View variants at this location
Epitope GGKKKYKL   Epitope Alignment
Variants
GGKKKYKm   observed variant
Species (MHC/HLA human(B8)

Variant Details

Showing all: 1 variant(s).


Variant ID.  327
Epitope Seq.  GGKKKYKL
Variant Seq.  GGKKKYKm
Mutations L/M
Epitope Location L8M
HXB2 Location L31M
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 53684

HXB2 Location  Gag(71-79)   Gag Epitope Map
View variants at this location
Epitope GSEELRSLY   Epitope Alignment
Variants
GtEgikSLh   observed variant
Species (MHC/HLA human(A1)

Variant Details

Showing all: 1 variant(s).


Variant ID.  328
Epitope Seq.  GSEELRSLY
Variant Seq.  GtEgikSLh
Mutations S/T E/G L/I R/K Y/H
Epitope Location S2T E4G L5I R6K Y9H
HXB2 Location S72T E74G L75I R76K Y79H
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 53685

HXB2 Location  Gag(74-82)   Gag Epitope Map
View variants at this location
Epitope ELRSLYNTV   Epitope Alignment
Variants
gikSLhNTV   observed variant
Species (MHC/HLA human(B8)

Variant Details

Showing all: 1 variant(s).


Variant ID.  329
Epitope Seq.  ELRSLYNTV
Variant Seq.  gikSLhNTV
Mutations E/G L/I R/K Y/H
Epitope Location E1G L2I R3K Y6H
HXB2 Location E74G L75I R76K Y79H
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 53675

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   observed variant
Species (MHC/HLA human(B58)

Variant Details

Showing all: 1 variant(s).


Variant ID.  330
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 53705

HXB2 Location  Gag(180-191)   Gag Epitope Map
View variants at this location
Epitope TPQDLNQMLNTV   Epitope Alignment
Variants
TPQDLNtMLNTV   observed variant
Species (MHC/HLA human(B58)

Variant Details

Showing all: 1 variant(s).


Variant ID.  331
Epitope Seq.  TPQDLNQMLNTV
Variant Seq.  TPQDLNtMLNTV
Mutations Q/T
Epitope Location Q7T
HXB2 Location Q186T
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 53681

HXB2 Location  Gag(203-212)   Gag Epitope Map
View variants at this location
Epitope ETINEEAAEW   Epitope Alignment
Variants
dTINEEAAEW   observed variant
Species (MHC/HLA human(B53, B58)

Variant Details

Showing all: 1 variant(s).


Variant ID.  332
Epitope Seq.  ETINEEAAEW
Variant Seq.  dTINEEAAEW
Mutations E/D
Epitope Location E1D
HXB2 Location E203D
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 53676

HXB2 Location  Gag(241-249)   Gag Epitope Map
View variants at this location
Epitope STLQEQIGW   Epitope Alignment
Variants
STLQEQIaW   observed variant
Species (MHC/HLA human(B58)

Variant Details

Showing all: 1 variant(s).


Variant ID.  333
Epitope Seq.  STLQEQIGW
Variant Seq.  STLQEQIaW
Mutations G/A
Epitope Location G8A
HXB2 Location G248A
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 53688

HXB2 Location  Gag(306-316)   Gag Epitope Map
View variants at this location
Epitope AEQASQDVKNW   Epitope Alignment
Variants
AEQASQeVKNW   observed variant
Species (MHC/HLA human(B44)

Variant Details

Showing all: 1 variant(s).


Variant ID.  334
Epitope Seq.  AEQASQDVKNW
Variant Seq.  AEQASQeVKNW
Mutations D/E
Epitope Location D7E
HXB2 Location D312E
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 53674

HXB2 Location  Gag(308-316)   Gag Epitope Map
View variants at this location
Epitope QASQEVKNW   Epitope Alignment
Variants
QASQdVKNW   observed variant
Species (MHC/HLA human(B53, Cw4)

Variant Details

Showing all: 1 variant(s).


Variant ID.  335
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQdVKNW
Mutations E/D
Epitope Location E5D
HXB2 Location E312D
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


Displaying record number 53682

HXB2 Location  Gag(421-432)   Gag Epitope Map
View variants at this location
Epitope HQMKDCNERQAN   Epitope Alignment
Variants
HQMKDCNtR(qg)QAN   observed variant
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2280
Epitope Seq.  HQMKDCNERQAN
Variant Seq.  HQMKDCNtR(qg)QAN
Mutations E/T -/Q -/G
Epitope Location E8T -(9.1)Q -(9.2)G
HXB2 Location E428T -(429.1)Q -(429.2)G
Mutation Type OV: observed variant
Note Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.


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