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Found 11 matching records:

Displaying record number 53687

HXB2 Location Gag(22-31) Gag Epitope Map
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Epitope

RPGGKKKYKL

Epitope Alignment

Variants

RPGGnKKYKL observed variant

Species (MHC/HLA) human(Cw4)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`326`
Epitope Seq.	`RPGGKKKYKL`
Variant Seq.	`RPGGnKKYKL`
Mutations	K/N
Epitope Location	K5N
HXB2 Location	K26N
Mutation Type	OV: observed variant
Note	Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Geels2005 Mark J. Geels, Sheri A. Dubey, Kiersten Anderson, Elly Baan, Margreet Bakker, Georgios Pollakis, William A. Paxton, John W. Shiver, and Jaap Goudsmit. Broad Cross-Clade T-Cell Responses to Gag in Individuals Infected with Human Immunodeficiency Virus Type 1 Non-B Clades (A to G): Importance of HLA Anchor Residue Conservation. J. Virol., 79(17):11247-11258, Sep 2005. PubMed ID: 16103177. Show all entries for this paper.

Displaying record number 53683

HXB2 Location Gag(24-31) Gag Epitope Map
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Epitope

GGKKKYKL

Epitope Alignment

Variants

GGKKKYKm observed variant

Species (MHC/HLA) human(B8)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`327`
Epitope Seq.	`GGKKKYKL`
Variant Seq.	`GGKKKYKm`
Mutations	L/M
Epitope Location	L8M
HXB2 Location	L31M
Mutation Type	OV: observed variant
Note	Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Displaying record number 53684

HXB2 Location Gag(71-79) Gag Epitope Map
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Epitope

GSEELRSLY

Epitope Alignment

Variants

GtEgikSLh observed variant

Species (MHC/HLA) human(A1)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`328`
Epitope Seq.	`GSEELRSLY`
Variant Seq.	`GtEgikSLh`
Mutations	S/T E/G L/I R/K Y/H
Epitope Location	S2T E4G L5I R6K Y9H
HXB2 Location	S72T E74G L75I R76K Y79H
Mutation Type	OV: observed variant
Note	Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Displaying record number 53685

HXB2 Location Gag(74-82) Gag Epitope Map
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Epitope

ELRSLYNTV

Epitope Alignment

Variants

gikSLhNTV observed variant

Species (MHC/HLA) human(B8)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`329`
Epitope Seq.	`ELRSLYNTV`
Variant Seq.	`gikSLhNTV`
Mutations	E/G L/I R/K Y/H
Epitope Location	E1G L2I R3K Y6H
HXB2 Location	E74G L75I R76K Y79H
Mutation Type	OV: observed variant
Note	Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Displaying record number 53675

HXB2 Location Gag(147-155) Gag Epitope Map
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Epitope

ISPRTLNAW

Epitope Alignment

Variants

lSPRTLNAW observed variant

Species (MHC/HLA) human(B58)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`330`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`lSPRTLNAW`
Mutations	I/L
Epitope Location	I1L
HXB2 Location	I147L
Mutation Type	OV: observed variant
Note	Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Displaying record number 53705

HXB2 Location Gag(180-191) Gag Epitope Map
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Epitope

TPQDLNQMLNTV

Epitope Alignment

Variants

TPQDLNtMLNTV observed variant

Species (MHC/HLA) human(B58)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`331`
Epitope Seq.	`TPQDLNQMLNTV`
Variant Seq.	`TPQDLNtMLNTV`
Mutations	Q/T
Epitope Location	Q7T
HXB2 Location	Q186T
Mutation Type	OV: observed variant
Note	Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Displaying record number 53681

HXB2 Location Gag(203-212) Gag Epitope Map
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Epitope

ETINEEAAEW

Epitope Alignment

Variants

dTINEEAAEW observed variant

Species (MHC/HLA) human(B53, B58)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`332`
Epitope Seq.	`ETINEEAAEW`
Variant Seq.	`dTINEEAAEW`
Mutations	E/D
Epitope Location	E1D
HXB2 Location	E203D
Mutation Type	OV: observed variant
Note	Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Displaying record number 53676

HXB2 Location Gag(241-249) Gag Epitope Map
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Epitope

STLQEQIGW

Epitope Alignment

Variants

STLQEQIaW observed variant

Species (MHC/HLA) human(B58)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`333`
Epitope Seq.	`STLQEQIGW`
Variant Seq.	`STLQEQIaW`
Mutations	G/A
Epitope Location	G8A
HXB2 Location	G248A
Mutation Type	OV: observed variant
Note	Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Displaying record number 53688

HXB2 Location Gag(306-316) Gag Epitope Map
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Epitope

AEQASQDVKNW

Epitope Alignment

Variants

AEQASQeVKNW observed variant

Species (MHC/HLA) human(B44)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`334`
Epitope Seq.	`AEQASQDVKNW`
Variant Seq.	`AEQASQeVKNW`
Mutations	D/E
Epitope Location	D7E
HXB2 Location	D312E
Mutation Type	OV: observed variant
Note	Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Displaying record number 53674

HXB2 Location Gag(308-316) Gag Epitope Map
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Epitope

QASQEVKNW

Epitope Alignment

Variants

QASQdVKNW observed variant

Species (MHC/HLA) human(B53, Cw4)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`335`
Epitope Seq.	`QASQEVKNW`
Variant Seq.	`QASQdVKNW`
Mutations	E/D
Epitope Location	E5D
HXB2 Location	E312D
Mutation Type	OV: observed variant
Note	Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.

References

Displaying record number 53682

HXB2 Location Gag(421-432) Gag Epitope Map
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Epitope

HQMKDCNERQAN

Epitope Alignment

Variants

HQMKDCNtR(qg)QAN observed variant

Species (MHC/HLA) human(A2)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2280`
Epitope Seq.	`HQMKDCNERQAN`
Variant Seq.	`HQMKDCNtR(qg)QAN`
Mutations	E/T -/Q -/G
Epitope Location	E8T -(9.1)Q -(9.2)G
HXB2 Location	E428T -(429.1)Q -(429.2)G
Mutation Type	OV: observed variant
Note	Cross-clade T cell responses are frequently induced in individuals infected with different HIV-1 clades. There was an inverse correlation between the height of responses and epitope sequence divergence. For Gag epitopes, the magnitude of the response was directly linked to the homology between HLA anchor residues.