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Found 2 matching records:

Displaying record number 62010

HXB2 Location Gag(162-172) Gag Epitope Map
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Epitope

KAFSPEVIPMF

Epitope Alignment

Variants

KAFSaEVIPMF TCR related mutation

Epitope Name B*57-KF11

Species (MHC/HLA) human(B*57)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`4200`
Epitope Seq.	`KAFSPEVIPMF`
Variant Seq.	`KAFSaEVIPMF`
Mutations	P/A
Epitope Location	P5A
HXB2 Location	P166A
Mutation Type	TCR: TCR related mutation
Epitope Subtype	B
Variant Subtype	B
Method	Other
Note	Residue P34 is known to make TCR contacts. Upon mutation to P34A, the epitope network score changes to 4.42.

References

Gaiha2019 Gaurav D. Gaiha, Elizabeth J. Rossin, Jonathan Urbach, Christian Landeros, David R. Collins, Chioma Nwonu, Itai Muzhingi, Melis N. Anahtar, Olivia M. Waring, Alicja Piechocka-Trocha, Michael Waring, Daniel P. Worrall, Musie S. Ghebremichael, Ruchi M. Newman, Karen A. Power, Todd M. Allen, James Chodosh, and Bruce D. Walker. Structural Topology Defines Protective CD8+ T Cell Epitopes in the HIV Proteome. Science, 364(6439):480-484, 3 May 2019. PubMed ID: 31048489. Show all entries for this paper.

Displaying record number 62124

HXB2 Location gp160(298-307) gp160 Epitope Map
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Epitope

RPNNNTRKSI

Epitope Alignment

Variants

aPNNNTRKSI TCR related mutation

Epitope Name B*07-RI10

Species (MHC/HLA) human(B*07)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`4201`
Epitope Seq.	`RPNNNTRKSI`
Variant Seq.	`aPNNNTRKSI`
Mutations	R/A
Epitope Location	R1A
HXB2 Location	R298A
Mutation Type	TCR: TCR related mutation
Epitope Subtype	B
Variant Subtype	B
Method	Other, Relative replication capacity assay
Note	Residue R298 is known to make TCR contacts. Upon mutation to R298A, the epitope network score decreases to 2.73.