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Found 2 matching records:

Displaying record number 62010

HXB2 Location  Gag(162-172)   Gag Epitope Map
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Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KAFSaEVIPMF   TCR related mutation
Epitope Name B*57-KF11
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4200
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSaEVIPMF
Mutations P/A
Epitope Location P5A
HXB2 Location P166A
Mutation Type TCR: TCR related mutation
Epitope Subtype B
Variant Subtype B
Method Other
Note Residue P34 is known to make TCR contacts. Upon mutation to P34A, the epitope network score changes to 4.42.

References

Gaiha2019 Gaurav D. Gaiha, Elizabeth J. Rossin, Jonathan Urbach, Christian Landeros, David R. Collins, Chioma Nwonu, Itai Muzhingi, Melis N. Anahtar, Olivia M. Waring, Alicja Piechocka-Trocha, Michael Waring, Daniel P. Worrall, Musie S. Ghebremichael, Ruchi M. Newman, Karen A. Power, Todd M. Allen, James Chodosh, and Bruce D. Walker. Structural Topology Defines Protective CD8+ T Cell Epitopes in the HIV Proteome. Science, 364(6439):480-484, 3 May 2019. PubMed ID: 31048489. Show all entries for this paper.


Displaying record number 62124

HXB2 Location  gp160(298-307)   gp160 Epitope Map
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Epitope RPNNNTRKSI   Epitope Alignment
Variants
aPNNNTRKSI   TCR related mutation
Epitope Name B*07-RI10
Species (MHC/HLA human(B*07)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4201
Epitope Seq.  RPNNNTRKSI
Variant Seq.  aPNNNTRKSI
Mutations R/A
Epitope Location R1A
HXB2 Location R298A
Mutation Type TCR: TCR related mutation
Epitope Subtype B
Variant Subtype B
Method Other, Relative replication capacity assay
Note Residue R298 is known to make TCR contacts. Upon mutation to R298A, the epitope network score decreases to 2.73.

References

Gaiha2019 Gaurav D. Gaiha, Elizabeth J. Rossin, Jonathan Urbach, Christian Landeros, David R. Collins, Chioma Nwonu, Itai Muzhingi, Melis N. Anahtar, Olivia M. Waring, Alicja Piechocka-Trocha, Michael Waring, Daniel P. Worrall, Musie S. Ghebremichael, Ruchi M. Newman, Karen A. Power, Todd M. Allen, James Chodosh, and Bruce D. Walker. Structural Topology Defines Protective CD8+ T Cell Epitopes in the HIV Proteome. Science, 364(6439):480-484, 3 May 2019. PubMed ID: 31048489. Show all entries for this paper.


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