HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 9 matching records:

Displaying record number 54625

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KgFnPEVIPMF   observed variant
KnFSPEVIPMF   observed variant
KsFSPEVIPMF   observed variant
KgFSPEVIPMF   observed variant
KgFkPEVIPMF   observed variant
KsFSPEtIPMF   observed variant
Epitope Name KF11
Species (MHC/HLA human(B*57:01, B*57:03)

Variant Details

Showing all: 6 variant(s).


Variant ID.  219
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFnPEVIPMF
Mutations A/G S/N
Epitope Location A2G S4N
HXB2 Location A163G S165N
Mutation Type OV: observed variant
Epitope Subtype C
Note Epitope highly variant in African cohort when restricted by B*5703 but highly conserved in B*5701 European cohort.


Variant ID.  220
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KnFSPEVIPMF
Mutations A/N
Epitope Location A2N
HXB2 Location A163N
Mutation Type OV: observed variant
Epitope Subtype C
Note Epitope highly variant in African cohort when restricted by B*5703 but highly conserved in B*5701 European cohort.


Variant ID.  221
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KsFSPEVIPMF
Mutations A/S
Epitope Location A2S
HXB2 Location A163S
Mutation Type OV: observed variant
Epitope Subtype C
Note Epitope highly variant in African cohort when restricted by B*5703 but highly conserved in B*5701 European cohort.


Variant ID.  222
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFSPEVIPMF
Mutations A/G
Epitope Location A2G
HXB2 Location A163G
Mutation Type OV: observed variant
Epitope Subtype C
Note Epitope highly variant in African cohort when restricted by B*5703 but highly conserved in B*5701 European cohort.


Variant ID.  223
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFkPEVIPMF
Mutations A/G S/K
Epitope Location A2G S4K
HXB2 Location A163G S165K
Mutation Type OV: observed variant
Epitope Subtype C
Note Epitope highly variant in African cohort when restricted by B*5703 but highly conserved in B*5701 European cohort.


Variant ID.  224
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KsFSPEtIPMF
Mutations A/S V/T
Epitope Location A2S V7T
HXB2 Location A163S V168T
Mutation Type OV: observed variant
Epitope Subtype C
Note Epitope highly variant in African cohort when restricted by B*5703 but highly conserved in B*5701 European cohort.

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 54622

HXB2 Location  Gag(180-188)   Gag Epitope Map
View variants at this location
Epitope TPQDLNTML   Epitope Alignment
Variants
TPeDLNTML   observed variant
TPsDLNsML   observed variant
TPQDLNmML   observed variant
TPsDLNTMf   observed variant
TPQDLNaML   observed variant
TPrDLNmML   observed variant
TPaDLNTML   observed variant
TPrDLNTML   observed variant
TPgDLNTML   observed variant
TPQDLNTfL   observed variant
Epitope Name TL9
Species (MHC/HLA human(B*81:01)

Variant Details

Showing all: 10 variant(s).


Variant ID.  225
Epitope Seq.  TPQDLNTML
Variant Seq.  TPeDLNTML
Mutations Q/E
Epitope Location Q3E
HXB2 Location Q182E
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Note Found in African cohort


Variant ID.  226
Epitope Seq.  TPQDLNTML
Variant Seq.  TPsDLNsML
Mutations Q/S T/S
Epitope Location Q3S T7S
HXB2 Location Q182S T186S
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Note Found in African cohort


Variant ID.  227
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNmML
Mutations T/M
Epitope Location T7M
HXB2 Location T186M
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Note Found in African cohort


Variant ID.  228
Epitope Seq.  TPQDLNTML
Variant Seq.  TPsDLNTMf
Mutations Q/S L/F
Epitope Location Q3S L9F
HXB2 Location Q182S L188F
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Note Found in African cohort


Variant ID.  229
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNaML
Mutations T/A
Epitope Location T7A
HXB2 Location T186A
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Note Found in African cohort


Variant ID.  230
Epitope Seq.  TPQDLNTML
Variant Seq.  TPrDLNmML
Mutations Q/R T/M
Epitope Location Q3R T7M
HXB2 Location Q182R T186M
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Note Found in African cohort


Variant ID.  231
Epitope Seq.  TPQDLNTML
Variant Seq.  TPaDLNTML
Mutations Q/A
Epitope Location Q3A
HXB2 Location Q182A
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Note Found in African cohort


Variant ID.  232
Epitope Seq.  TPQDLNTML
Variant Seq.  TPrDLNTML
Mutations Q/R
Epitope Location Q3R
HXB2 Location Q182R
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Note Found in African cohort


Variant ID.  233
Epitope Seq.  TPQDLNTML
Variant Seq.  TPgDLNTML
Mutations Q/G
Epitope Location Q3G
HXB2 Location Q182G
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Note Found in African cohort


Variant ID.  234
Epitope Seq.  TPQDLNTML
Variant Seq.  TPQDLNTfL
Mutations M/F
Epitope Location M8F
HXB2 Location M187F
Mutation Type OV: observed variant
Epitope Subtype C
Variant Subtype C
Note Found in African cohort

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 54619

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSnLQEQIGW   calculated escape
TSnLQEQIaW   calculated escape
TSTpQEQIGW   observed variant
TSnLQEQIrW   calculated escape
Epitope Name TW10
Species (MHC/HLA human(B*57, B*58)

Variant Details

Showing all: 4 variant(s).


Variant ID.  235
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIGW
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type CE: calculated escape
Epitope Subtype B
Variant Subtype B
Note The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favorable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads.


Variant ID.  236
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIaW
Mutations T/N G/A
Epitope Location T3N G9A
HXB2 Location T242N G248A
Mutation Type CE: calculated escape
Epitope Subtype B
Variant Subtype B
Note The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favorable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads.


Variant ID.  237
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTpQEQIGW
Mutations L/P
Epitope Location L4P
HXB2 Location L243P
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Note Found in European cohort.


Variant ID.  238
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIrW
Mutations T/N G/R
Epitope Location T3N G9R
HXB2 Location T242N G248R
Mutation Type CE: calculated escape
Note This variant was more often found in HLA-B*5703 and HLA-B*5801 patients.

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 54621

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIAW   Epitope Alignment
Variants
TSnLQEQInW   observed variant
TSnLQEQIAW   calculated escape
TSnLQEQItW   calculated escape
TSnLQEQvAW   calculated escape
TSnLaEQIAW   calculated escape
TSnLQEQIgW   calculated escape
TSnLgEQIAW   calculated escape
TSTpQEQIAW   observed variant
TSTtQEQIAW   observed variant
TSsLQEQIAW   observed variant
TSTLQEQIrW   observed variant
TSTLaEQIAW   observed variant
TSTLQEQvAW   observed variant
TSTLQEQmAW   observed variant
Epitope Name TW10
Species (MHC/HLA human(B*57:03, B*58:01)

Variant Details

Showing all: 14 variant(s).


Variant ID.  239
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSnLQEQInW
Mutations T/N A/N
Epitope Location T3N A9N
HXB2 Location T242N A248N
Mutation Type OV: observed variant
Note Found in African and European cohort


Variant ID.  240
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSnLQEQIAW
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type CE: calculated escape
Note This variant was more often found in HLA-B*5703 and HLA-B*5801 patients.


Variant ID.  241
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSnLQEQItW
Mutations T/N A/T
Epitope Location T3N A9T
HXB2 Location T242N A248T
Mutation Type CE: calculated escape
Note This variant was more often found in HLA-B*5703 and HLA-B*5801 patients.


Variant ID.  243
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSnLQEQvAW
Mutations T/N I/V
Epitope Location T3N I8V
HXB2 Location T242N I247V
Mutation Type CE: calculated escape
Note This variant was more often found in HLA-B*5703 patients.


Variant ID.  244
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSnLaEQIAW
Mutations T/N Q/A
Epitope Location T3N Q5A
HXB2 Location T242N Q244A
Mutation Type CE: calculated escape
Note This variant was more often found in HLA-B*5703 patients.


Variant ID.  245
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSnLQEQIgW
Mutations T/N A/G
Epitope Location T3N A9G
HXB2 Location T242N A248G
Mutation Type CE: calculated escape
Note This variant was more often found in HLA-B*5703 and HLA-B*5801 patients.


Variant ID.  246
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSnLgEQIAW
Mutations T/N Q/G
Epitope Location T3N Q5G
HXB2 Location T242N Q244G
Mutation Type CE: calculated escape
Note This variant was more often found in HLA-B*5703 patients.


Variant ID.  247
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSTpQEQIAW
Mutations L/P
Epitope Location L4P
HXB2 Location L243P
Mutation Type OV: observed variant
Note Found in African B*5801 cohort


Variant ID.  248
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSTtQEQIAW
Mutations L/T
Epitope Location L4T
HXB2 Location L243T
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  249
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSsLQEQIAW
Mutations T/S
Epitope Location T3S
HXB2 Location T242S
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  250
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSTLQEQIrW
Mutations A/R
Epitope Location A9R
HXB2 Location A248R
Mutation Type OV: observed variant
Note Found in European cohort


Variant ID.  251
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSTLaEQIAW
Mutations Q/A
Epitope Location Q5A
HXB2 Location Q244A
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  252
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSTLQEQvAW
Mutations I/V
Epitope Location I8V
HXB2 Location I247V
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  253
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TSTLQEQmAW
Mutations I/M
Epitope Location I8M
HXB2 Location I247M
Mutation Type OV: observed variant
Note Found in African B*5703 cohort

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 54618

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
KkWIILGLNK   calculated escape
KRWIImGLNK   calculated escape
KRWvImGLNK   observed variant
KkWIImGLNK   observed variant
KRWIIiGLNK   calculated escape
Epitope Name KK10
Species (MHC/HLA human(B*27)

Variant Details

Showing all: 5 variant(s).


Variant ID.  254
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIILGLNK
Mutations R/K
Epitope Location R2K
HXB2 Location R264K
Mutation Type CE: calculated escape
Note The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads.


Variant ID.  255
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type CE: calculated escape
Note The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. Leucine at position 6 was under strong positive selection pressure.


Variant ID.  256
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWvImGLNK
Mutations I/V L/M
Epitope Location I4V L6M
HXB2 Location I266V L268M
Mutation Type OV: observed variant
Note Found in European cohort


Variant ID.  257
Epitope Seq.  KRWIILGLNK
Variant Seq.  KkWIImGLNK
Mutations R/K L/M
Epitope Location R2K L6M
HXB2 Location R264K L268M
Mutation Type OV: observed variant
Note Found in European cohort


Variant ID.  258
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIIiGLNK
Mutations L/I
Epitope Location L6I
HXB2 Location L268I
Mutation Type CE: calculated escape
Note The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. Leucine at position 6 was under strong positive selection pressure.

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 54623

HXB2 Location  Pol(158-167)   Pol Epitope Map
View variants at this location
Epitope SPIETVPVKL   Epitope Alignment
Variants
SsIETVPVKL   calculated escape
SPIkTVPVKL   calculated escape
SsIkTVPVKL   observed variant
SsIaTVPVKL   observed variant
SsIdTVPVKL   observed variant
StIETVPVKL   observed variant
SPIETVPVmL   observed variant
SPIaTVPVnL   observed variant
Epitope Name SL10
Species (MHC/HLA human(B*81:01)

Variant Details

Showing all: 8 variant(s).


Variant ID.  259
Epitope Seq.  SPIETVPVKL
Variant Seq.  SsIETVPVKL
Mutations P/S
Epitope Location P2S
HXB2 Location P159S
Mutation Type CE: calculated escape
Note This variant from an African cohort was more often found in HLA-B*8101 patients, indicating that some favorable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads.


Variant ID.  260
Epitope Seq.  SPIETVPVKL
Variant Seq.  SPIkTVPVKL
Mutations E/K
Epitope Location E4K
HXB2 Location E161K
Mutation Type CE: calculated escape
Note This variant was more often found in HLA-B*8101 patients, indicating that some favorable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads.


Variant ID.  262
Epitope Seq.  SPIETVPVKL
Variant Seq.  SsIkTVPVKL
Mutations P/S E/K
Epitope Location P2S E4K
HXB2 Location P159S E161K
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  263
Epitope Seq.  SPIETVPVKL
Variant Seq.  SsIaTVPVKL
Mutations P/S E/A
Epitope Location P2S E4A
HXB2 Location P159S E161A
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  264
Epitope Seq.  SPIETVPVKL
Variant Seq.  SsIdTVPVKL
Mutations P/S E/D
Epitope Location P2S E4D
HXB2 Location P159S E161D
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  265
Epitope Seq.  SPIETVPVKL
Variant Seq.  StIETVPVKL
Mutations P/T
Epitope Location P2T
HXB2 Location P159T
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  266
Epitope Seq.  SPIETVPVKL
Variant Seq.  SPIETVPVmL
Mutations K/M
Epitope Location K9M
HXB2 Location K166M
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  267
Epitope Seq.  SPIETVPVKL
Variant Seq.  SPIaTVPVnL
Mutations E/A K/N
Epitope Location E4A K9N
HXB2 Location E161A K166N
Mutation Type OV: observed variant
Note Found in African cohort

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 54617

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSt   calculated escape
TAFTIPSm   observed variant
TAFTIPSr   observed variant
TAFTvPSt   observed variant
Epitope Name TI8
Species (MHC/HLA human(B*51)

Variant Details

Showing all: 4 variant(s).


Variant ID.  268
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type CE: calculated escape
Note The variant appears very soon after seroconversion, and was present in 7/8 HLA-matched and 21/57 HLA-unmatched patients. Position 8 was under strong positive selection pressure.


Variant ID.  269
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSm
Mutations I/M
Epitope Location I8M
HXB2 Location I290M
Mutation Type OV: observed variant
Note Found in European cohort


Variant ID.  270
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSr
Mutations I/R
Epitope Location I8R
HXB2 Location I290R
Mutation Type OV: observed variant
Note Found in European cohort


Variant ID.  271
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTvPSt
Mutations I/V I/T
Epitope Location I5V I8T
HXB2 Location I287V I290T
Mutation Type OV: observed variant
Note Found in European cohort

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 54624

HXB2 Location  Nef(71-79)   Nef Epitope Map
View variants at this location
Epitope RPQVPLRPM   Epitope Alignment
Variants
RPQVPvRPM   calculated escape
RPQVPtRPM   observed variant
RPQVPmRPM   observed variant
RPQmPLRPM   observed variant
kPQVPvRPM   observed variant
RPQVPiRPM   observed variant
tPQVPIRPM   observed variant
Epitope Name RM9
Species (MHC/HLA human(B*81:01)

Variant Details

Showing all: 7 variant(s).


Variant ID.  272
Epitope Seq.  RPQVPLRPM
Variant Seq.  RPQVPvRPM
Mutations L/V
Epitope Location L6V
HXB2 Location L76V
Mutation Type CE: calculated escape
Note This variant was more often found in HLA-B*8101 patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads.


Variant ID.  273
Epitope Seq.  RPQVPLRPM
Variant Seq.  RPQVPtRPM
Mutations L/T
Epitope Location L6T
HXB2 Location L76T
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  274
Epitope Seq.  RPQVPLRPM
Variant Seq.  RPQVPmRPM
Mutations L/M
Epitope Location L6M
HXB2 Location L76M
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  275
Epitope Seq.  RPQVPLRPM
Variant Seq.  RPQmPLRPM
Mutations V/M
Epitope Location V4M
HXB2 Location V74M
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  276
Epitope Seq.  RPQVPLRPM
Variant Seq.  kPQVPvRPM
Mutations R/K L/V
Epitope Location R1K L6V
HXB2 Location R71K L76V
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  277
Epitope Seq.  RPQVPLRPM
Variant Seq.  RPQVPiRPM
Mutations L/I
Epitope Location L6I
HXB2 Location L76I
Mutation Type OV: observed variant
Note Found in African cohort


Variant ID.  278
Epitope Seq.  RPQVPLRPM
Variant Seq.  tPQVPIRPM
Mutations R/T L/I
Epitope Location R1T L6I
HXB2 Location R71T L76I
Mutation Type OV: observed variant
Note Found in African cohort

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Displaying record number 54620

HXB2 Location  Nef(116-125)   Nef Epitope Map
View variants at this location
Epitope HTQGYFPDWQ   Epitope Alignment
Variants
nTQGYFPDWQ   calculated escape
Epitope Name HQ10
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  279
Epitope Seq.  HTQGYFPDWQ
Variant Seq.  nTQGYFPDWQ
Mutations H/N
Epitope Location H1N
HXB2 Location H116N
Mutation Type CE: calculated escape
Note The variant was found in 100% of HLA-matched and in 28.8% of HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads.

References

Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health