HIV molecular immunology database
Found 9 matching records:
HXB2 Location | Gag(162-172) | Gag Epitope Map
View variants at this location |
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Epitope |
KAFSPEVIPMF
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Epitope Alignment | |||||||||||||||||||
Variants |
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Epitope Name | KF11 | ||||||||||||||||||||
Species (MHC/HLA) | human(B*57:01, B*57:03) |
Showing all: 6 variant(s).
Variant ID. | 219 |
---|---|
Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KgFnPEVIPMF |
Mutations | A/G S/N |
Epitope Location | A2G S4N |
HXB2 Location | A163G S165N |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Note | Epitope highly variant in African cohort when restricted by B*5703 but highly conserved in B*5701 European cohort. |
Variant ID. | 220 |
---|---|
Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KnFSPEVIPMF |
Mutations | A/N |
Epitope Location | A2N |
HXB2 Location | A163N |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Note | Epitope highly variant in African cohort when restricted by B*5703 but highly conserved in B*5701 European cohort. |
Variant ID. | 221 |
---|---|
Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KsFSPEVIPMF |
Mutations | A/S |
Epitope Location | A2S |
HXB2 Location | A163S |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Note | Epitope highly variant in African cohort when restricted by B*5703 but highly conserved in B*5701 European cohort. |
Variant ID. | 222 |
---|---|
Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KgFSPEVIPMF |
Mutations | A/G |
Epitope Location | A2G |
HXB2 Location | A163G |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Note | Epitope highly variant in African cohort when restricted by B*5703 but highly conserved in B*5701 European cohort. |
Variant ID. | 223 |
---|---|
Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KgFkPEVIPMF |
Mutations | A/G S/K |
Epitope Location | A2G S4K |
HXB2 Location | A163G S165K |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Note | Epitope highly variant in African cohort when restricted by B*5703 but highly conserved in B*5701 European cohort. |
Variant ID. | 224 |
---|---|
Epitope Seq. | KAFSPEVIPMF |
Variant Seq. | KsFSPEtIPMF |
Mutations | A/S V/T |
Epitope Location | A2S V7T |
HXB2 Location | A163S V168T |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Note | Epitope highly variant in African cohort when restricted by B*5703 but highly conserved in B*5701 European cohort. |
Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.
HXB2 Location | Gag(180-188) | Gag Epitope Map
View variants at this location |
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Epitope |
TPQDLNTML
|
Epitope Alignment | |||||||||||||||||||||||||||||||
Variants |
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Epitope Name | TL9 | ||||||||||||||||||||||||||||||||
Species (MHC/HLA) | human(B*81:01) |
Showing all: 10 variant(s).
Variant ID. | 225 |
---|---|
Epitope Seq. | TPQDLNTML |
Variant Seq. | TPeDLNTML |
Mutations | Q/E |
Epitope Location | Q3E |
HXB2 Location | Q182E |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Variant Subtype | C |
Note | Found in African cohort |
Variant ID. | 226 |
---|---|
Epitope Seq. | TPQDLNTML |
Variant Seq. | TPsDLNsML |
Mutations | Q/S T/S |
Epitope Location | Q3S T7S |
HXB2 Location | Q182S T186S |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Variant Subtype | C |
Note | Found in African cohort |
Variant ID. | 227 |
---|---|
Epitope Seq. | TPQDLNTML |
Variant Seq. | TPQDLNmML |
Mutations | T/M |
Epitope Location | T7M |
HXB2 Location | T186M |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Variant Subtype | C |
Note | Found in African cohort |
Variant ID. | 228 |
---|---|
Epitope Seq. | TPQDLNTML |
Variant Seq. | TPsDLNTMf |
Mutations | Q/S L/F |
Epitope Location | Q3S L9F |
HXB2 Location | Q182S L188F |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Variant Subtype | C |
Note | Found in African cohort |
Variant ID. | 229 |
---|---|
Epitope Seq. | TPQDLNTML |
Variant Seq. | TPQDLNaML |
Mutations | T/A |
Epitope Location | T7A |
HXB2 Location | T186A |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Variant Subtype | C |
Note | Found in African cohort |
Variant ID. | 230 |
---|---|
Epitope Seq. | TPQDLNTML |
Variant Seq. | TPrDLNmML |
Mutations | Q/R T/M |
Epitope Location | Q3R T7M |
HXB2 Location | Q182R T186M |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Variant Subtype | C |
Note | Found in African cohort |
Variant ID. | 231 |
---|---|
Epitope Seq. | TPQDLNTML |
Variant Seq. | TPaDLNTML |
Mutations | Q/A |
Epitope Location | Q3A |
HXB2 Location | Q182A |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Variant Subtype | C |
Note | Found in African cohort |
Variant ID. | 232 |
---|---|
Epitope Seq. | TPQDLNTML |
Variant Seq. | TPrDLNTML |
Mutations | Q/R |
Epitope Location | Q3R |
HXB2 Location | Q182R |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Variant Subtype | C |
Note | Found in African cohort |
Variant ID. | 233 |
---|---|
Epitope Seq. | TPQDLNTML |
Variant Seq. | TPgDLNTML |
Mutations | Q/G |
Epitope Location | Q3G |
HXB2 Location | Q182G |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Variant Subtype | C |
Note | Found in African cohort |
Variant ID. | 234 |
---|---|
Epitope Seq. | TPQDLNTML |
Variant Seq. | TPQDLNTfL |
Mutations | M/F |
Epitope Location | M8F |
HXB2 Location | M187F |
Mutation Type | OV: observed variant |
Epitope Subtype | C |
Variant Subtype | C |
Note | Found in African cohort |
Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.
HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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Epitope |
TSTLQEQIGW
|
Epitope Alignment | |||||||||||||
Variants |
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Epitope Name | TW10 | ||||||||||||||
Species (MHC/HLA) | human(B*57, B*58) |
Showing all: 4 variant(s).
Variant ID. | 235 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIGW |
Mutations | T/N |
Epitope Location | T3N |
HXB2 Location | T242N |
Mutation Type | CE: calculated escape |
Epitope Subtype | B |
Variant Subtype | B |
Note | The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favorable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. |
Variant ID. | 236 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIaW |
Mutations | T/N G/A |
Epitope Location | T3N G9A |
HXB2 Location | T242N G248A |
Mutation Type | CE: calculated escape |
Epitope Subtype | B |
Variant Subtype | B |
Note | The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favorable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. |
Variant ID. | 237 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSTpQEQIGW |
Mutations | L/P |
Epitope Location | L4P |
HXB2 Location | L243P |
Mutation Type | OV: observed variant |
Epitope Subtype | B |
Variant Subtype | B |
Note | Found in European cohort. |
Variant ID. | 238 |
---|---|
Epitope Seq. | TSTLQEQIGW |
Variant Seq. | TSnLQEQIrW |
Mutations | T/N G/R |
Epitope Location | T3N G9R |
HXB2 Location | T242N G248R |
Mutation Type | CE: calculated escape |
Note | This variant was more often found in HLA-B*5703 and HLA-B*5801 patients. |
Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.
HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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Epitope |
TSTLQEQIAW
|
Epitope Alignment | |||||||||||||||||||||||||||||||||||||||||||
Variants |
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Epitope Name | TW10 | ||||||||||||||||||||||||||||||||||||||||||||
Species (MHC/HLA) | human(B*57:03, B*58:01) |
Showing all: 14 variant(s).
Variant ID. | 239 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSnLQEQInW |
Mutations | T/N A/N |
Epitope Location | T3N A9N |
HXB2 Location | T242N A248N |
Mutation Type | OV: observed variant |
Note | Found in African and European cohort |
Variant ID. | 240 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSnLQEQIAW |
Mutations | T/N |
Epitope Location | T3N |
HXB2 Location | T242N |
Mutation Type | CE: calculated escape |
Note | This variant was more often found in HLA-B*5703 and HLA-B*5801 patients. |
Variant ID. | 241 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSnLQEQItW |
Mutations | T/N A/T |
Epitope Location | T3N A9T |
HXB2 Location | T242N A248T |
Mutation Type | CE: calculated escape |
Note | This variant was more often found in HLA-B*5703 and HLA-B*5801 patients. |
Variant ID. | 243 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSnLQEQvAW |
Mutations | T/N I/V |
Epitope Location | T3N I8V |
HXB2 Location | T242N I247V |
Mutation Type | CE: calculated escape |
Note | This variant was more often found in HLA-B*5703 patients. |
Variant ID. | 244 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSnLaEQIAW |
Mutations | T/N Q/A |
Epitope Location | T3N Q5A |
HXB2 Location | T242N Q244A |
Mutation Type | CE: calculated escape |
Note | This variant was more often found in HLA-B*5703 patients. |
Variant ID. | 245 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSnLQEQIgW |
Mutations | T/N A/G |
Epitope Location | T3N A9G |
HXB2 Location | T242N A248G |
Mutation Type | CE: calculated escape |
Note | This variant was more often found in HLA-B*5703 and HLA-B*5801 patients. |
Variant ID. | 246 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSnLgEQIAW |
Mutations | T/N Q/G |
Epitope Location | T3N Q5G |
HXB2 Location | T242N Q244G |
Mutation Type | CE: calculated escape |
Note | This variant was more often found in HLA-B*5703 patients. |
Variant ID. | 247 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSTpQEQIAW |
Mutations | L/P |
Epitope Location | L4P |
HXB2 Location | L243P |
Mutation Type | OV: observed variant |
Note | Found in African B*5801 cohort |
Variant ID. | 248 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSTtQEQIAW |
Mutations | L/T |
Epitope Location | L4T |
HXB2 Location | L243T |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 249 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSsLQEQIAW |
Mutations | T/S |
Epitope Location | T3S |
HXB2 Location | T242S |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 250 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSTLQEQIrW |
Mutations | A/R |
Epitope Location | A9R |
HXB2 Location | A248R |
Mutation Type | OV: observed variant |
Note | Found in European cohort |
Variant ID. | 251 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSTLaEQIAW |
Mutations | Q/A |
Epitope Location | Q5A |
HXB2 Location | Q244A |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 252 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSTLQEQvAW |
Mutations | I/V |
Epitope Location | I8V |
HXB2 Location | I247V |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 253 |
---|---|
Epitope Seq. | TSTLQEQIAW |
Variant Seq. | TSTLQEQmAW |
Mutations | I/M |
Epitope Location | I8M |
HXB2 Location | I247M |
Mutation Type | OV: observed variant |
Note | Found in African B*5703 cohort |
Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.
HXB2 Location | Gag(263-272) | Gag Epitope Map
View variants at this location |
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Epitope |
KRWIILGLNK
|
Epitope Alignment | ||||||||||||||||
Variants |
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Epitope Name | KK10 | |||||||||||||||||
Species (MHC/HLA) | human(B*27) |
Showing all: 5 variant(s).
Variant ID. | 254 |
---|---|
Epitope Seq. | KRWIILGLNK |
Variant Seq. | KkWIILGLNK |
Mutations | R/K |
Epitope Location | R2K |
HXB2 Location | R264K |
Mutation Type | CE: calculated escape |
Note | The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. |
Variant ID. | 255 |
---|---|
Epitope Seq. | KRWIILGLNK |
Variant Seq. | KRWIImGLNK |
Mutations | L/M |
Epitope Location | L6M |
HXB2 Location | L268M |
Mutation Type | CE: calculated escape |
Note | The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. Leucine at position 6 was under strong positive selection pressure. |
Variant ID. | 256 |
---|---|
Epitope Seq. | KRWIILGLNK |
Variant Seq. | KRWvImGLNK |
Mutations | I/V L/M |
Epitope Location | I4V L6M |
HXB2 Location | I266V L268M |
Mutation Type | OV: observed variant |
Note | Found in European cohort |
Variant ID. | 257 |
---|---|
Epitope Seq. | KRWIILGLNK |
Variant Seq. | KkWIImGLNK |
Mutations | R/K L/M |
Epitope Location | R2K L6M |
HXB2 Location | R264K L268M |
Mutation Type | OV: observed variant |
Note | Found in European cohort |
Variant ID. | 258 |
---|---|
Epitope Seq. | KRWIILGLNK |
Variant Seq. | KRWIIiGLNK |
Mutations | L/I |
Epitope Location | L6I |
HXB2 Location | L268I |
Mutation Type | CE: calculated escape |
Note | The variant was more often found in HLA-matched than in HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. Leucine at position 6 was under strong positive selection pressure. |
Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.
HXB2 Location | Pol(158-167) | Pol Epitope Map
View variants at this location |
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Epitope |
SPIETVPVKL
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Epitope Alignment | |||||||||||||||||||||||||
Variants |
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Epitope Name | SL10 | ||||||||||||||||||||||||||
Species (MHC/HLA) | human(B*81:01) |
Showing all: 8 variant(s).
Variant ID. | 259 |
---|---|
Epitope Seq. | SPIETVPVKL |
Variant Seq. | SsIETVPVKL |
Mutations | P/S |
Epitope Location | P2S |
HXB2 Location | P159S |
Mutation Type | CE: calculated escape |
Note | This variant from an African cohort was more often found in HLA-B*8101 patients, indicating that some favorable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. |
Variant ID. | 260 |
---|---|
Epitope Seq. | SPIETVPVKL |
Variant Seq. | SPIkTVPVKL |
Mutations | E/K |
Epitope Location | E4K |
HXB2 Location | E161K |
Mutation Type | CE: calculated escape |
Note | This variant was more often found in HLA-B*8101 patients, indicating that some favorable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. |
Variant ID. | 262 |
---|---|
Epitope Seq. | SPIETVPVKL |
Variant Seq. | SsIkTVPVKL |
Mutations | P/S E/K |
Epitope Location | P2S E4K |
HXB2 Location | P159S E161K |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 263 |
---|---|
Epitope Seq. | SPIETVPVKL |
Variant Seq. | SsIaTVPVKL |
Mutations | P/S E/A |
Epitope Location | P2S E4A |
HXB2 Location | P159S E161A |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 264 |
---|---|
Epitope Seq. | SPIETVPVKL |
Variant Seq. | SsIdTVPVKL |
Mutations | P/S E/D |
Epitope Location | P2S E4D |
HXB2 Location | P159S E161D |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 265 |
---|---|
Epitope Seq. | SPIETVPVKL |
Variant Seq. | StIETVPVKL |
Mutations | P/T |
Epitope Location | P2T |
HXB2 Location | P159T |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 266 |
---|---|
Epitope Seq. | SPIETVPVKL |
Variant Seq. | SPIETVPVmL |
Mutations | K/M |
Epitope Location | K9M |
HXB2 Location | K166M |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 267 |
---|---|
Epitope Seq. | SPIETVPVKL |
Variant Seq. | SPIaTVPVnL |
Mutations | E/A K/N |
Epitope Location | E4A K9N |
HXB2 Location | E161A K166N |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.
HXB2 Location | Pol(283-290) | Pol Epitope Map
View variants at this location |
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Epitope |
TAFTIPSI
|
Epitope Alignment | |||||||||||||
Variants |
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Epitope Name | TI8 | ||||||||||||||
Species (MHC/HLA) | human(B*51) |
Showing all: 4 variant(s).
Variant ID. | 268 |
---|---|
Epitope Seq. | TAFTIPSI |
Variant Seq. | TAFTIPSt |
Mutations | I/T |
Epitope Location | I8T |
HXB2 Location | I290T |
Mutation Type | CE: calculated escape |
Note | The variant appears very soon after seroconversion, and was present in 7/8 HLA-matched and 21/57 HLA-unmatched patients. Position 8 was under strong positive selection pressure. |
Variant ID. | 269 |
---|---|
Epitope Seq. | TAFTIPSI |
Variant Seq. | TAFTIPSm |
Mutations | I/M |
Epitope Location | I8M |
HXB2 Location | I290M |
Mutation Type | OV: observed variant |
Note | Found in European cohort |
Variant ID. | 270 |
---|---|
Epitope Seq. | TAFTIPSI |
Variant Seq. | TAFTIPSr |
Mutations | I/R |
Epitope Location | I8R |
HXB2 Location | I290R |
Mutation Type | OV: observed variant |
Note | Found in European cohort |
Variant ID. | 271 |
---|---|
Epitope Seq. | TAFTIPSI |
Variant Seq. | TAFTvPSt |
Mutations | I/V I/T |
Epitope Location | I5V I8T |
HXB2 Location | I287V I290T |
Mutation Type | OV: observed variant |
Note | Found in European cohort |
Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.
HXB2 Location | Nef(71-79) | Nef Epitope Map
View variants at this location |
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Epitope |
RPQVPLRPM
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Epitope Alignment | ||||||||||||||||||||||
Variants |
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Epitope Name | RM9 | |||||||||||||||||||||||
Species (MHC/HLA) | human(B*81:01) |
Showing all: 7 variant(s).
Variant ID. | 272 |
---|---|
Epitope Seq. | RPQVPLRPM |
Variant Seq. | RPQVPvRPM |
Mutations | L/V |
Epitope Location | L6V |
HXB2 Location | L76V |
Mutation Type | CE: calculated escape |
Note | This variant was more often found in HLA-B*8101 patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. |
Variant ID. | 273 |
---|---|
Epitope Seq. | RPQVPLRPM |
Variant Seq. | RPQVPtRPM |
Mutations | L/T |
Epitope Location | L6T |
HXB2 Location | L76T |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 274 |
---|---|
Epitope Seq. | RPQVPLRPM |
Variant Seq. | RPQVPmRPM |
Mutations | L/M |
Epitope Location | L6M |
HXB2 Location | L76M |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 275 |
---|---|
Epitope Seq. | RPQVPLRPM |
Variant Seq. | RPQmPLRPM |
Mutations | V/M |
Epitope Location | V4M |
HXB2 Location | V74M |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 276 |
---|---|
Epitope Seq. | RPQVPLRPM |
Variant Seq. | kPQVPvRPM |
Mutations | R/K L/V |
Epitope Location | R1K L6V |
HXB2 Location | R71K L76V |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 277 |
---|---|
Epitope Seq. | RPQVPLRPM |
Variant Seq. | RPQVPiRPM |
Mutations | L/I |
Epitope Location | L6I |
HXB2 Location | L76I |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Variant ID. | 278 |
---|---|
Epitope Seq. | RPQVPLRPM |
Variant Seq. | tPQVPIRPM |
Mutations | R/T L/I |
Epitope Location | R1T L6I |
HXB2 Location | R71T L76I |
Mutation Type | OV: observed variant |
Note | Found in African cohort |
Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.
HXB2 Location | Nef(116-125) | Nef Epitope Map
View variants at this location |
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Epitope |
HTQGYFPDWQ
|
Epitope Alignment | ||||
Variants |
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Epitope Name | HQ10 | |||||
Species (MHC/HLA) | human(B*57) |
Showing all: 1 variant(s).
Variant ID. | 279 |
---|---|
Epitope Seq. | HTQGYFPDWQ |
Variant Seq. | nTQGYFPDWQ |
Mutations | H/N |
Epitope Location | H1N |
HXB2 Location | H116N |
Mutation Type | CE: calculated escape |
Note | The variant was found in 100% of HLA-matched and in 28.8% of HLA-unmatched patients, indicating that some favourable HLA alleles induce strong pressure, resulting in escape variants with high fitness cost and low viral loads. |
Frater2007 A. J. Frater, H. Brown, A. Oxenius, H. F. Günthard, B. Hirschel, N. Robinson, A. J. Leslie, R. Payne, H. Crawford, A. Prendergast, C. Brander, P. Kiepiela, B. D. Walker, P. J. R. Goulder, A. McLean, and R. E. Phillips. Effective T-Cell Responses Select Human Immunodeficiency Virus Mutants and Slow Disease Progression. J. Virol., 81(12):6742-6751, Jun 2007. PubMed ID: 17409157. Show all entries for this paper.