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Found 6 matching records:

Displaying record number 55068

HXB2 Location  Gag(156-164)   Gag Epitope Map
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Epitope VKVVEEKAF   Epitope Alignment
Variants
VKViEEKAF   subtype-specific susceptible form
Species (MHC/HLA human(B*15:03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  213
Epitope Seq.  VKVVEEKAF
Variant Seq.  VKViEEKAF
Mutations V/I
Epitope Location V4I
HXB2 Location V159I
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype C
Note VKVVEEKAF epitope is found in subtype B, while the variant is found in subtype C. Both are frequently targeted by B*1503 positive individuals.

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.


Displaying record number 55070

HXB2 Location  Pol(147-155)   Pol Epitope Map
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Epitope TQIGCTLNF   Epitope Alignment
Variants
TQlGCTLNF   subtype-specific non-susceptible form
Species (MHC/HLA human(B*15:03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  214
Epitope Seq.  TQIGCTLNF
Variant Seq.  TQlGCTLNF
Mutations I/L
Epitope Location I3L
HXB2 Location I149L
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype C
Note TQIGCTLNF epitope is found in subtype B, while the variant is found in subtype C. Only subtype B epitope is frequently recognized by B*1503 positive individuals.

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.


Displaying record number 55071

HXB2 Location  Pol(328-336)   Pol Epitope Map
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Epitope KQNPDIVIY   Epitope Alignment
Variants
KQNPeIVIY   subtype-specific non-susceptible form
Species (MHC/HLA human(B*15:03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  215
Epitope Seq.  KQNPDIVIY
Variant Seq.  KQNPeIVIY
Mutations D/E
Epitope Location D5E
HXB2 Location D332E
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype C
Note KQNPDIVIY epitope is found in subtype B, while the variant is found in subtype C. Only subtype B epitope is frequently recognized by B*1503 positive individuals.

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.


Displaying record number 55073

HXB2 Location  Pol(933-942)   Pol Epitope Map
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Epitope TKIQNFRVYY   Epitope Alignment
Variants
iKIQNFRVYY   subtype-specific non-susceptible form
Species (MHC/HLA human(B*15:03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  216
Epitope Seq.  TKIQNFRVYY
Variant Seq.  iKIQNFRVYY
Mutations T/I
Epitope Location T1I
HXB2 Location T933I
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype C
Note TKIQNFRVYY epitope is found in subtype B, while the variant is found in subtype C. Subtype B epitope is significantly more frequently recognized by B*1503 positive individuals than the variant C epitope.

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.


Displaying record number 55077

HXB2 Location  Pol(978-986)   Pol Epitope Map
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Epitope RKAKIIRDY   Epitope Alignment
Variants
RKAKIIkDY   subtype-specific non-susceptible form
Species (MHC/HLA human(B*15:03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  217
Epitope Seq.  RKAKIIRDY
Variant Seq.  RKAKIIkDY
Mutations R/K
Epitope Location R7K
HXB2 Location R984K
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype C
Note RKAKIIRDY epitope is found in subtype B, while the variant is found in subtype C. Subtype B epitope is significantly more frequently recognized by B*1503 positive individuals than the variant C epitope.

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.


Displaying record number 55075

HXB2 Location  Nef(183-191)   Nef Epitope Map
View variants at this location
Epitope WKFDSRLAF   Epitope Alignment
Variants
WKFDSqLAF   subtype-specific non-susceptible form
Species (MHC/HLA human(B*15:03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  218
Epitope Seq.  WKFDSRLAF
Variant Seq.  WKFDSqLAF
Mutations R/Q
Epitope Location R6Q
HXB2 Location R188Q
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype C
Note WKFDSRLAF epitope is found in subtype B, while the variant is found in subtype C, Subtype B epitope is significantly more frequently recognized by B*1503 positive individuals than the variant C epitope.

References

Frahm2006 Nicole Frahm, Photini Kiepiela, Sharon Adams, Caitlyn H. Linde, Hannah S. Hewitt, Kaori Sango, Margaret E. Feeney, Marylyn M. Addo, Mathias Lichterfeld, Matthew P. Lahaie, Eunice Pae, Alysse G. Wurcel, Timothy Roach, M Anne. St. John, Marcus Altfeld, Francesco M. Marincola, Corey Moore, Simon Mallal, Mary Carrington, David Heckerman, Todd M. Allen, James I. Mullins, Bette T. Korber, Philip J. R. Goulder, Bruce D. Walker, and Christian Brander. Control of Human Immunodeficiency Virus Replication by Cytotoxic T Lymphocytes Targeting Subdominant Epitopes. Nat. Immunol., 7(2):173-178, Feb 2006. PubMed ID: 16369537. Show all entries for this paper.


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