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Found 2 matching records:

Displaying record number 62099

HXB2 Location  Gag(28-36)   Gag Epitope Map
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Epitope KYRLKHIVW   Epitope Alignment
Variants
qYRLKHvVW   observed variant
qYRLKHIVW   observed variant
KYRLKHvVW   observed variant
Epitope Name KW9
Species (MHC/HLA human(A*24)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4192
Epitope Seq.  KYRLKHIVW
Variant Seq.  qYRLKHvVW
Mutations K/Q I/V
Epitope Location K1Q I7V
HXB2 Location K28Q I34V
Mutation Type OV: observed variant
Method Sequence
Note Longitudinal deep sequencing in Subject 9213 showed that the double mutant qYRLKHvVW corresponding to positions with the second and third lowest h values, was the infecting strain and stayed at 100% till day 165. On d476 it was 38.5% of the circulating viral population.


Variant ID.  4193
Epitope Seq.  KYRLKHIVW
Variant Seq.  qYRLKHIVW
Mutations K/Q
Epitope Location K1Q
HXB2 Location K28Q
Mutation Type OV: observed variant
Method Sequence
Note Longitudinal deep sequencing in Subject 9213 showed that the mutant qYRLKHIVW corresponding to the position with the lowest h value, appeared by day 476 in 61.5% of the viral population.


Variant ID.  4194
Epitope Seq.  KYRLKHIVW
Variant Seq.  KYRLKHvVW
Mutations I/V
Epitope Location I7V
HXB2 Location I34V
Mutation Type OV: observed variant
Method Sequence
Note Longitudinal deep sequencing in Subject 9213 showed that the mutant KYRLKHvVW corresponding to the position with the third lowest h value, appeared by day 1543 in 20.5% of the viral population, the rest being WT.

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


Displaying record number 62101

HXB2 Location  Gag(78-86)   Gag Epitope Map
View variants at this location
Epitope LYNTVAVLY   Epitope Alignment
Variants
LYNTiAVLY   observed variant
LfNTiAVLY   observed variant
LfNTVAVLY   observed variant
Epitope Name LY9
Species (MHC/HLA human(A*29)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4195
Epitope Seq.  LYNTVAVLY
Variant Seq.  LYNTiAVLY
Mutations V/I
Epitope Location V5I
HXB2 Location V82I
Mutation Type OV: observed variant
Method Other, Relative replication capacity assay
Note Longitudinal deep sequencing in Subject 9213 showed that the mutant LYNTiAVL corresponding to the position with the lowest h value, was the infecting strain (100%) until day 476, but was at 5.4% of the viral population by day 1543.


Variant ID.  4196
Epitope Seq.  LYNTVAVLY
Variant Seq.  LfNTiAVLY
Mutations V/I
Epitope Location V5I
HXB2 Location V82I
Mutation Type OV: observed variant
Method Other, Relative replication capacity assay
Note Longitudinal deep sequencing in Subject 9213 showed that the double mutant LfNTiAVL corresponding to the positions with the two lowest h values, was at 6.3% of the viral population by day 1543.


Variant ID.  4197
Epitope Seq.  LYNTVAVLY
Variant Seq.  LfNTVAVLY
Mutations Y/F
Epitope Location Y2F
HXB2 Location Y79F
Mutation Type OV: observed variant
Method Other, Relative replication capacity assay
Note Longitudinal deep sequencing in Subject 9213 showed that the single mutant LfNTVAVL corresponding to the position with the second lowest h value, was at 57.1% of the viral population by day 1543.

References

Ferguson2013a Andrew L. Ferguson, Jaclyn K. Mann, Saleha Omarjee, Thumbi Ndung'u, Bruce D Walker, and Arup K. Chakraborty. Translating HIV Sequences into Quantitative Fitness Landscapes Predicts Viral Vulnerabilities for Rational Immunogen Design. Immunity, 38(3):606-617, 21 Mar 2013. PubMed ID: 23521886. Show all entries for this paper.


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