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Found 1 matching record:

Displaying record number 58783

HXB2 Location  Gag(209-218)   Gag Epitope Map
View variants at this location
Epitope AAEWDRLHPV   Epitope Alignment
Variants
AAEWDRmHPV   HLA association; diminished HLA binding or increased off-rate
AAEWDRaHPV   HLA association
AAEWDRqHPV   HLA association; diminished HLA binding or increased off-rate
AAEWDRsHPV   HLA association
AAEWDRtHPV   HLA association
AAEWDRvHPV   HLA association
AAEWDRiHPV   HLA association
-AEWDRxHPV   HLA association; diminished HLA binding or increased off-rate
AAEWDRxHP-   HLA association; diminished HLA binding or increased off-rate
Epitope Name p24Gag209-218
Species (MHC/HLA human

Variant Details

Showing all: 9 variant(s).


Variant ID.  3146
Epitope Seq.  AAEWDRLHPV
Variant Seq.  AAEWDRmHPV
Mutations L/M
Epitope Location L7M
HXB2 Location L215M
Mutation Type A: HLA association
DHB: diminished HLA binding or increased off-rate
Epitope Subtype B
Variant Subtype B
Method HLA binding
Note Gag209-218-M, AAEWDRmHPV, binds HLA-Cw*0102 but at a decreased level. 2.9% sequences carried this variation.


Variant ID.  3147
Epitope Seq.  AAEWDRLHPV
Variant Seq.  AAEWDRaHPV
Mutations L/A
Epitope Location L7A
HXB2 Location L215A
Mutation Type A: HLA association
Epitope Subtype B
Variant Subtype B
Method HLA binding
Note Gag209-218-A, AAEWDRaHPV, showed a significant increase in binding to HLA-Cw*0102. 0.9% of sequences carried this variant.


Variant ID.  3148
Epitope Seq.  AAEWDRLHPV
Variant Seq.  AAEWDRqHPV
Mutations L/Q
Epitope Location L7Q
HXB2 Location L215Q
Mutation Type A: HLA association
DHB: diminished HLA binding or increased off-rate
Epitope Subtype B
Variant Subtype B
Method HLA binding
Note Gag209-218-Q, AAEWDRqHPV, showed a slight decrease in binding to HLA-Cw*0102. 0.1% of sequences carried this variant.


Variant ID.  3149
Epitope Seq.  AAEWDRLHPV
Variant Seq.  AAEWDRsHPV
Mutations L/S
Epitope Location L7S
HXB2 Location L215S
Mutation Type A: HLA association
Epitope Subtype B
Variant Subtype B
Method HLA binding
Note Gag209-218-S, AAEWDRsHPV, showed an increase in binding to HLA-Cw*0102. 0.1% of sequences carried this variant.


Variant ID.  3150
Epitope Seq.  AAEWDRLHPV
Variant Seq.  AAEWDRtHPV
Mutations L/T
Epitope Location L7T
HXB2 Location L215T
Mutation Type A: HLA association
Epitope Subtype B
Variant Subtype B
Method HLA binding
Note Gag209-218-T, AAEWDRtHPV, showed a significant increase in binding to HLA-Cw*0102. 5.2% of sequences carried this variant.


Variant ID.  3151
Epitope Seq.  AAEWDRLHPV
Variant Seq.  AAEWDRvHPV
Mutations L/V
Epitope Location L7V
HXB2 Location L215V
Mutation Type A: HLA association
Epitope Subtype B
Variant Subtype B
Method HLA binding
Note Gag209-218-V, AAEWDRvHPV, showed a significant increase in binding to HLA-Cw*0102. 16.3% of sequences carried this variant.


Variant ID.  3152
Epitope Seq.  AAEWDRLHPV
Variant Seq.  AAEWDRiHPV
Mutations L/I
Epitope Location L7I
HXB2 Location L215I
Mutation Type A: HLA association
Epitope Subtype B
Variant Subtype B
Method HLA binding
Note Gag209-218-I, AAEWDRiHPV, showed an increase in binding to HLA-Cw*0102. 3.6% of sequences carried this variant.


Variant ID.  3153
Epitope Seq.  AAEWDRLHPV
Variant Seq.  -AEWDRxHPV
Mutations A/- L/X
Epitope Location A1- L7X
HXB2 Location A209- L215X
Mutation Type A: HLA association
DHB: diminished HLA binding or increased off-rate
Epitope Subtype B
Variant Subtype B
Method HLA binding
Note All sequences with mutations at position 7 and without the N-terminal Alanine were able to bind Cw*0102, but at reduced levels.


Variant ID.  3154
Epitope Seq.  AAEWDRLHPV
Variant Seq.  AAEWDRxHP-
Mutations V/- L/X
Epitope Location V10- L7X
HXB2 Location V218- L215X
Mutation Type A: HLA association
DHB: diminished HLA binding or increased off-rate
Epitope Subtype B
Variant Subtype B
Method HLA binding
Note All sequences with mutations at position 7 and without the C-terminal Valine were unable to bind Cw*0102.

References

Fadda2012 Lena Fadda, Christian Körner, Swati Kumar, Nienke H. van Teijlingen, Alicja Piechocka-Trocha, Mary Carrington, and Marcus Altfeld. HLA-Cw*0102-Restricted HIV-1 p24 Epitope Variants Can Modulate the Binding of the Inhibitory KIR2DL2 Receptor and Primary NK Cell Function. PLoS Pathog., 8(7):e1002805, 2012. PubMed ID: 22807681. Show all entries for this paper.


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