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Found 34 matching records:

Displaying record number 61186

HXB2 Location  Gag(18-26)   Gag Epitope Map
View variants at this location
Epitope KIRLRPGGK   Epitope Alignment
Variants
rIRLRPGGK   diminished response; escape documented in this paper; non-susceptible form
Epitope Name KK9
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3692
Epitope Seq.  KIRLRPGGK
Variant Seq.  rIRLRPGGK
Mutations K/R
Epitope Location K1R
HXB2 Location K18R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag KK9 escape variant KRQdILDLWVY did not cross-react to autologous KK9 (KRQEILDLWVY)-specific T cells during acute and chronic infection in A*0301 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61189

HXB2 Location  Gag(20-28)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKQ   Epitope Alignment
Variants
RLRPGGKKk   non-susceptible form
RLRPGGKKr   diminished response; escape documented in this paper; non-susceptible form
Epitope Name RQ9
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3697
Epitope Seq.  RLRPGGKKQ
Variant Seq.  RLRPGGKKk
Mutations Q/K
Epitope Location Q9K
HXB2 Location Q28K
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag RQ9 non-escape variant RLRPGGKKk did not cross-react to autologous RQ9 (RLRPGGKKQ)-specific T cells during acute and chronic infection in A*0301 patients.


Variant ID.  3698
Epitope Seq.  RLRPGGKKQ
Variant Seq.  RLRPGGKKr
Mutations Q/R
Epitope Location Q9R
HXB2 Location Q28R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag RQ9 escape variant RLRPGGKKr did not cross-react to autologous RQ9 (RLRPGGKKQ)-specific T cells during acute infection in A*0301 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61187

HXB2 Location  Gag(20-28)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGKKq   diminished response; escape documented in this paper; non-susceptible form
RLRPGGKKr   diminished response; escape documented in this paper; non-susceptible form
Epitope Name RK9
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3693
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKq
Mutations K/Q
Epitope Location K9Q
HXB2 Location K28Q
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag RK9 escape variant RLRPGGKKq did not cross-react to autologous RK9 (RLRPGGKKK)-specific T cells during acute and chronic infection in A*0301 patients.


Variant ID.  3694
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKr
Mutations K/R
Epitope Location K9R
HXB2 Location K28R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag RK9 escape variant RLRPGGKKr did not cross-react to autologous RK9 (RLRPGGKKK)-specific T cells during acute infection in A*0301 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61177

HXB2 Location  Gag(28-36)   Gag Epitope Map
View variants at this location
Epitope KYKLKHIVW   Epitope Alignment
Variants
KYrLKHIVW   diminished response; escape documented in this paper; non-susceptible form
KYqLKHIVW   diminished response; escape documented in this paper; non-susceptible form; susceptible form
Epitope Name KW9
Species (MHC/HLA human(A*24:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3672
Epitope Seq.  KYKLKHIVW
Variant Seq.  KYrLKHIVW
Mutations K/R
Epitope Location K3R
HXB2 Location K30R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag KW9 escape variant KYrLKHIVW did not cross-react to autologous KW9 (KYKLKHIVW)-specific T cells during acute and chronic infection in A*2402 patients.


Variant ID.  3673
Epitope Seq.  KYKLKHIVW
Variant Seq.  KYqLKHIVW
Mutations K/Q
Epitope Location K3Q
HXB2 Location K30Q
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag KW9 escape variant KYqLKHIVW did not cross-react to autologous KW9 (KYKLKHIVW)-specific T cells during acute infection but did cross-react during chronic infection in A*2402 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61181

HXB2 Location  Gag(84-91)   Gag Epitope Map
View variants at this location
Epitope TMYCVHQK   Epitope Alignment
Variants
TlYCVHQr   diminished response; escape documented in this paper; non-susceptible form
vlYCVHQr   diminished response; escape documented in this paper; non-susceptible form
TlYCVHQK   diminished response; escape documented in this paper; non-susceptible form; susceptible form
Epitope Name TMK11
Species (MHC/HLA human(A*11:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3680
Epitope Seq.  TMYCVHQK
Variant Seq.  TlYCVHQr
Mutations M/L K/R
Epitope Location M2L K8R
HXB2 Location M85L K91R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag TMK11 escape variant TlYCVHQr did not cross-react to autologous TMK11 (TMYCVHQK)-specific T cells during acute and chronic infection in A*1101 patients.


Variant ID.  3681
Epitope Seq.  TMYCVHQK
Variant Seq.  vlYCVHQr
Mutations T/V M/L K/R
Epitope Location T1V M2L K8R
HXB2 Location T84V M85L K91R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag TMK11 escape variant vlYCVHQr did not cross-react to autologous TMK11 (TMYCVHQK)-specific T cells during acute and chronic infection in A*1101 patients.


Variant ID.  3682
Epitope Seq.  TMYCVHQK
Variant Seq.  TlYCVHQK
Mutations M/L
Epitope Location M2L
HXB2 Location M85L
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag TMK11 escape variant TlYCVHQK did not cross-react to autologous TMK11 (TMYCVHQK)-specific T cells during acute infection but did cross-react during chronic infection in A*1101 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61164

HXB2 Location  Gag(298-306)   Gag Epitope Map
View variants at this location
Epitope DRFYKTLRA   Epitope Alignment
Variants
DRFYKvLRA   diminished response; escape documented in this paper; non-susceptible form
DRFYrTLRA   diminished response; escape documented in this paper; non-susceptible form
Epitope Name DA9
Species (MHC/HLA human(B*14:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3623
Epitope Seq.  DRFYKTLRA
Variant Seq.  DRFYKvLRA
Mutations T/V
Epitope Location T6V
HXB2 Location T303V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag DA9 escape variant DRFYKvLRA did not cross-react to autologous DA9(DRFYKTLRA)-specific T cells during acute infection in B*1402 patients.


Variant ID.  3624
Epitope Seq.  DRFYKTLRA
Variant Seq.  DRFYrTLRA
Mutations K/R
Epitope Location K5R
HXB2 Location K302R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method Intracellular cytokine staining, Other
Note Gag DA9 escape variant DRFYrTLRA did not cross-react to autologous DA9(DRFYKTLRA)-specific T cells during acute infection in B*1402 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61182

HXB2 Location  Gag(306-316)   Gag Epitope Map
View variants at this location
Epitope AEQASQEVKNW   Epitope Alignment
Variants
AEQASQdVKNW   non-susceptible form; susceptible form
Epitope Name AEW11
Species (MHC/HLA human(B*44:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3683
Epitope Seq.  AEQASQEVKNW
Variant Seq.  AEQASQdVKNW
Mutations E/D
Epitope Location E7D
HXB2 Location E312D
Mutation Type NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag AEW11 non-escape variant AEQASQdVKNW did not cross-react to autologous AEW11 (AEQASQEVKNW)-specific T cells during acute infection but did cross-react during chronic infection in B*4402 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61178

HXB2 Location  Gag(349-359)   Gag Epitope Map
View variants at this location
Epitope ACQGVGGPGHK   Epitope Alignment
Variants
ACQGVGGPaHK   diminished response; escape documented in this paper; non-susceptible form; susceptible form
ACQGVGGPsHK   diminished response; escape documented in this paper; non-susceptible form
Epitope Name AK11
Species (MHC/HLA human(A*11:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3674
Epitope Seq.  ACQGVGGPGHK
Variant Seq.  ACQGVGGPaHK
Mutations G/A
Epitope Location G9A
HXB2 Location G357A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag AK11 escape variant ACQGVGGPsHK did not cross-react to autologous AK11 (ACQGVGGPGHK)-specific T cells during acute and chronic infectionin A*1101 patients.


Variant ID.  3675
Epitope Seq.  ACQGVGGPGHK
Variant Seq.  ACQGVGGPsHK
Mutations G/S
Epitope Location G9S
HXB2 Location G357S
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Gag AK11 escape variant ACQGVGGPsHK did not cross-react to autologous AK11 (ACQGVGGPGHK)-specific T cells during acute and chronic infectionin A*1101 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61191

HXB2 Location  Pol(90-98)   Pol Epitope Map
View variants at this location
Epitope EDMNLPGRW   Epitope Alignment
Variants
EeMNLPGRW   non-susceptible form
Epitope Name EDW9
Species (MHC/HLA human(B*44:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3701
Epitope Seq.  EDMNLPGRW
Variant Seq.  EeMNLPGRW
Mutations D/E
Epitope Location D2E
HXB2 Location D91E
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol EDW9 non-escape variant EeMNLPGRW did not cross-react to autologous EDW9 (EDMNLPGRW)-specific T cells during acute and chronic infection in B*4402 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61166

HXB2 Location  Pol(124-132)   Pol Epitope Map
View variants at this location
Epitope GHKAIGTVL   Epitope Alignment
Variants
GHKvIGTVL   diminished response; escape documented in this paper; non-susceptible form
GkKAIGTVL   diminished response; escape documented in this paper; non-susceptible form
GHKtIGTVL   diminished response; escape documented in this paper; non-susceptible form
Epitope Name GL9
Species (MHC/HLA human(B*15:03)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3628
Epitope Seq.  GHKAIGTVL
Variant Seq.  GHKvIGTVL
Mutations A/V
Epitope Location A4V
HXB2 Location A127V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol GL9 escape variant GHKvIGTVL did not cross-react to autologous GL9(GHKAIGTVL)-specific T cells during acute infection in B*1503 patients.


Variant ID.  3629
Epitope Seq.  GHKAIGTVL
Variant Seq.  GkKAIGTVL
Mutations A/V
Epitope Location A4V
HXB2 Location A127V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol GL9 escape variant GkKAIGTVL did not cross-react to autologous GL9(GHKAIGTVL)-specific T cells during acute and chronic infection in B*1503 patients.


Variant ID.  3630
Epitope Seq.  GHKAIGTVL
Variant Seq.  GHKtIGTVL
Mutations A/V
Epitope Location A4V
HXB2 Location A127V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol GL9 escape variant GHKtIGTVL did not cross-react to autologous GL9(GHKAIGTVL)-specific T cells during acute infection in B*1503 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61169

HXB2 Location  Pol(283-290)   Pol Epitope Map
View variants at this location
Epitope TAFTIPSI   Epitope Alignment
Variants
TAFTIPSt   diminished response; escape documented in this paper; non-susceptible form
TAFTIPSv   diminished response; escape documented in this paper; non-susceptible form
Epitope Name TI8
Species (MHC/HLA human(B*51:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3641
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSt
Mutations I/T
Epitope Location I8T
HXB2 Location I290T
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol TI8 escape variant TAFTIPSt did not cross-react to autologous TI8 (TAFTIPSI)-specific T cells during acute and chronic infection in B*1501 patients.


Variant ID.  3642
Epitope Seq.  TAFTIPSI
Variant Seq.  TAFTIPSv
Mutations I/V
Epitope Location I8V
HXB2 Location I290V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol TI8 escape variant TAFTIPSv did not cross-react to autologous TI8 (TAFTIPSI)-specific T cells during acute and chronic infection in B*1501 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61179

HXB2 Location  Pol(311-319)   Pol Epitope Map
View variants at this location
Epitope SPAIFQSSM   Epitope Alignment
Variants
SPAIFQcSM   diminished response; escape documented in this paper; non-susceptible form; susceptible form
SPAIFQaSM   diminished response; escape documented in this paper; non-susceptible form; susceptible form
Epitope Name SM9
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3676
Epitope Seq.  SPAIFQSSM
Variant Seq.  SPAIFQcSM
Mutations S/C
Epitope Location S7C
HXB2 Location S317C
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol SM9 escape variant SPAIFQcSM did not cross-react to autologous SM9 (SPAIFQSSM)-specific T cells during acute infection but did cross-react during chronic infection in B*0702 patients.


Variant ID.  3677
Epitope Seq.  SPAIFQSSM
Variant Seq.  SPAIFQaSM
Mutations S/A
Epitope Location S7A
HXB2 Location S317A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol SM9 escape variant SPAIFQaSM did not cross-react to autologous SM9 (SPAIFQSSM)-specific T cells during acute infection but did cross-react during chronic infection in B*0702 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61190

HXB2 Location  Pol(313-321)   Pol Epitope Map
View variants at this location
Epitope AIFQCSMTK   Epitope Alignment
Variants
AIFQsSMTr   diminished response; escape documented in this paper; non-susceptible form
AIFQsSMTK   non-susceptible form
Epitope Name ACK9
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3699
Epitope Seq.  AIFQCSMTK
Variant Seq.  AIFQsSMTr
Mutations C/S K/R
Epitope Location C5S K9R
HXB2 Location C317S K321R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol ACK9 escape variant AIFQsSMTr did not cross-react to autologous ACK9 (AIFQCSMTK)-specific T cells during acute infection in A*0301 patients.


Variant ID.  3700
Epitope Seq.  AIFQCSMTK
Variant Seq.  AIFQsSMTK
Mutations C/S
Epitope Location C5S
HXB2 Location C317S
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol ACK9 non-escape variant AIFQsSMTK did not cross-react to autologous ACK9 (AIFQCSMTK)-specific T cells during acute and chronic infection in A*0301 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61165

HXB2 Location  Pol(424-432)   Pol Epitope Map
View variants at this location
Epitope QIYAGIKVK   Epitope Alignment
Variants
QIYpGIKVK   diminished response; escape documented in this paper; non-susceptible form
QIYpGIrVK   diminished response; escape documented in this paper; non-susceptible form
QIYpGIKVr   diminished response; escape documented in this paper; non-susceptible form
Epitope Name QK9
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3625
Epitope Seq.  QIYAGIKVK
Variant Seq.  QIYpGIKVK
Mutations A/P
Epitope Location A4P
HXB2 Location A427P
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol QK9 escape variant QIYpGIKVK did not cross-react to autologous QK9(QIYAGIKVK)-specific T cells during acute infection in A*0301 patients.


Variant ID.  3626
Epitope Seq.  QIYAGIKVK
Variant Seq.  QIYpGIrVK
Mutations A/P K/R
Epitope Location A4P K7R
HXB2 Location A427P K430R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol QK9 escape variant QIYpGIrVK did not cross-react to autologous QK9(QIYAGIKVK)-specific T cells during acute infection in A*0301 patients.


Variant ID.  3627
Epitope Seq.  QIYAGIKVK
Variant Seq.  QIYpGIKVr
Mutations A/P K/R
Epitope Location A4P K9R
HXB2 Location A427P K432R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol QK9 escape variant QIYpGIKVr did not cross-react to autologous QK9(QIYAGIKVK)-specific T cells during acute infection in A*0301 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61174

HXB2 Location  Pol(424-432)   Pol Epitope Map
View variants at this location
Epitope QIYPGIKVK   Epitope Alignment
Variants
QIYaGIKVK   non-susceptible form
QIYPGIKVr   diminished response; escape documented in this paper; non-susceptible form
QIYPGIrVK   diminished response; escape documented in this paper; non-susceptible form
Epitope Name QPK9
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3662
Epitope Seq.  QIYPGIKVK
Variant Seq.  QIYaGIKVK
Mutations P/A
Epitope Location P4A
HXB2 Location P427A
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol QPK9 non-escape variant QIYaGIKVK did not cross-react to autologous QPK9 (QIYPGIKVK)-specific T cells during acute and chronic infection in A*0301 patients.


Variant ID.  3663
Epitope Seq.  QIYPGIKVK
Variant Seq.  QIYPGIKVr
Mutations K/R
Epitope Location K9R
HXB2 Location K432R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol QPK9 escape variant QIYPGIKVr did not cross-react to autologous QPK9 (QIYPGIKVK)-specific T cells during acute infection in A*0301 patients.


Variant ID.  3664
Epitope Seq.  QIYPGIKVK
Variant Seq.  QIYPGIrVK
Mutations K/R
Epitope Location K7R
HXB2 Location K430R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol QPK9 escape variant QIYPGIrVK did not cross-react to autologous QPK9 (QIYPGIKVK)-specific T cells during acute infection in A*0301 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61168

HXB2 Location  Pol(464-473)   Pol Epitope Map
View variants at this location
Epitope ILKEPVHGVY   Epitope Alignment
Variants
ILKEPVHGaY   diminished response; escape documented in this paper; non-susceptible form
ILKEtVHGaY   diminished response; escape documented in this paper; non-susceptible form
ILKEsVHGaY   diminished response; escape documented in this paper; non-susceptible form
ILKaPVHGaY   diminished response; escape documented in this paper; non-susceptible form
ILKkPVHGaY   diminished response; escape documented in this paper; non-susceptible form
ILrEPVHGaY   diminished response; escape documented in this paper; non-susceptible form
ILrEPVHGVY   diminished response; escape documented in this paper; non-susceptible form
Epitope Name IY10
Species (MHC/HLA human(B*15:10)

Variant Details

Showing all: 7 variant(s).


Variant ID.  3634
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILKEPVHGaY
Mutations V/A
Epitope Location V9A
HXB2 Location V472A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILKEPVHGaY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute infection in B*1510 patients.


Variant ID.  3635
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILKEtVHGaY
Mutations P/T V/A
Epitope Location P5T V9A
HXB2 Location P468T V472A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILKEtVHGaY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute infection in B*1510 patients.


Variant ID.  3636
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILKEsVHGaY
Mutations P/S V/A
Epitope Location P5S V9A
HXB2 Location P468S V472A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILKEsVHGaY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute infection in B*1510 patients.


Variant ID.  3637
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILKaPVHGaY
Mutations E/A V/A
Epitope Location E4A V9A
HXB2 Location E467A V472A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILKaPVHGaY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute infection in B*1510 patients.


Variant ID.  3638
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILKkPVHGaY
Mutations E/K V/A
Epitope Location E4K V9A
HXB2 Location E467K V472A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILKkPVHGaY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute infection in B*1510 patients.


Variant ID.  3639
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILrEPVHGaY
Mutations E/K V/A
Epitope Location E4K V9A
HXB2 Location E467K V472A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILrEPVHGaY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute infection in B*1510 patients.


Variant ID.  3640
Epitope Seq.  ILKEPVHGVY
Variant Seq.  ILrEPVHGVY
Mutations K/R
Epitope Location K3R
HXB2 Location K466R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IY10 escape variant ILrEPVHGVY did not cross-react to autologous IY10 (ILKEPVHGVY)-specific T cells during acute and chronic infection in B*1510 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61188

HXB2 Location  Pol(530-538)   Pol Epitope Map
View variants at this location
Epitope ITTESIVIW   Epitope Alignment
Variants
IamESIVIW   diminished response; escape documented in this paper; non-susceptible form
IaTESIVIW   diminished response; escape documented in this paper; non-susceptible form
Epitope Name IW9
Species (MHC/HLA human(B*58:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3695
Epitope Seq.  ITTESIVIW
Variant Seq.  IamESIVIW
Mutations T/A T/M
Epitope Location T2A T3M
HXB2 Location T531A T532M
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IW9 escape variant IamESIVIW did not cross-react to autologous IW9 (ITTESIVIW)-specific T cells during acute infection in B*5801 patients.


Variant ID.  3696
Epitope Seq.  ITTESIVIW
Variant Seq.  IaTESIVIW
Mutations T/A
Epitope Location T2A
HXB2 Location T531A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol IW9 escape variant IaTESIVIW did not cross-react to autologous IW9 (ITTESIVIW)-specific T cells during acute and chronic infection in B*5801 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61167

HXB2 Location  Pol(978-986)   Pol Epitope Map
View variants at this location
Epitope RKAKIIRDY   Epitope Alignment
Variants
RKvKIIRDY   diminished response; escape documented in this paper; non-susceptible form
RKAKIlRDY   diminished response; escape documented in this paper; non-susceptible form
RKAKIlRhY   diminished response; escape documented in this paper; non-susceptible form
Epitope Name RY9
Species (MHC/HLA human(B*15:03)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3631
Epitope Seq.  RKAKIIRDY
Variant Seq.  RKvKIIRDY
Mutations A/V
Epitope Location A3V
HXB2 Location A980V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol RY9 escape variant RKvKIIRDY did not cross-react to autologous RY9(RKAKIIRDY)-specific T cells during acute and chronic infection in B*1503 patients.


Variant ID.  3632
Epitope Seq.  RKAKIIRDY
Variant Seq.  RKAKIlRDY
Mutations I/L
Epitope Location I6L
HXB2 Location I983L
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol RY9 escape variant RKAKIlRDY did not cross-react to autologous RY9(RKAKIIRDY)-specific T cells during acute infection in B*1503 patients.


Variant ID.  3633
Epitope Seq.  RKAKIIRDY
Variant Seq.  RKAKIlRhY
Mutations I/L D/H
Epitope Location I6L D8H
HXB2 Location I983L D985H
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Pol RY9 escape variant RKAKIlRhY did not cross-react to autologous RY9(RKAKIIRDY)-specific T cells during acute infection in B*1503 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61173

HXB2 Location  Vif(48-57)   Vif Epitope Map
View variants at this location
Epitope HPRISSEVHI   Epitope Alignment
Variants
HPRvSSEVHI   diminished response; escape documented in this paper; non-susceptible form
HPkISSEVHI   diminished response; escape documented in this paper; non-susceptible form
Epitope Name HI10
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3660
Epitope Seq.  HPRISSEVHI
Variant Seq.  HPRvSSEVHI
Mutations I/V
Epitope Location I4V
HXB2 Location I51V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Vif HI10 escape variant HPRvSSEVHI did not cross-react to autologous HI10 (HPRISSEVHI)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3661
Epitope Seq.  HPRISSEVHI
Variant Seq.  HPkISSEVHI
Mutations R/K
Epitope Location R3K
HXB2 Location R50K
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Vif HI10 escape variant HPkISSEVHI did not cross-react to autologous HI10 (HPRISSEVHI)-specific T cells during acute infection in B*0702 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61162

HXB2 Location  Rev(66-75)   Rev Epitope Map
View variants at this location
Epitope RPAEPVPLQL   Epitope Alignment
Variants
RPtEPVPfQL   diminished response; escape documented in this paper; susceptible form
RPtEPVPLpL   diminished response; escape documented in this paper; susceptible form
RPAEPVPfQL   diminished response; escape documented in this paper; susceptible form
RPtEPVPLQL   diminished response; escape documented in this paper; non-susceptible form
RsAEPVPLQL   diminished response; escape documented in this paper; non-susceptible form
Epitope Name RL10
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3610
Epitope Seq.  RPAEPVPLQL
Variant Seq.  RPtEPVPfQL
Mutations A/T L/F
Epitope Location A3T L8F
HXB2 Location A68T L73F
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Rev RL10 escape variant RPtEPVPfQL cross-reacted to autologous RL10(RPAEPVPLQL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3611
Epitope Seq.  RPAEPVPLQL
Variant Seq.  RPtEPVPLpL
Mutations A/T Q/P
Epitope Location A3T Q9P
HXB2 Location A68T Q74P
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Rev RL10 escape variant RPtEPVPLpL cross-reacted to autologous RL10(RPAEPVPLQL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3612
Epitope Seq.  RPAEPVPLQL
Variant Seq.  RPAEPVPfQL
Mutations L/F
Epitope Location L8F
HXB2 Location L73F
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Rev RL10 escape variant RPAEPVPfQL cross-reacted to autologous RL10(RPAEPVPLQL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3613
Epitope Seq.  RPAEPVPLQL
Variant Seq.  RPtEPVPLQL
Mutations A/T
Epitope Location A3T
HXB2 Location A68T
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Rev RL10 escape variant RPtEPVPLQL did not cross-react to autologous RL10(RPAEPVPLQL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3614
Epitope Seq.  RPAEPVPLQL
Variant Seq.  RsAEPVPLQL
Mutations P/S
Epitope Location P2S
HXB2 Location P67S
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Rev RL10 escape variant RsAEPVPLQL did not cross-react to autologous RL10(RPAEPVPLQL)-specific T cells during acute infection or in acute and chronic infections in different B*0702 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61161

HXB2 Location  gp160(37-46)   gp160 Epitope Map
View variants at this location
Epitope TVYYGVPVWK   Epitope Alignment
Variants
TiYYGVPVWK   diminished response; escape documented in this paper; susceptible form
TiYYGVPVWr   diminished response; escape documented in this paper; susceptible form
TVYYGVPagr   diminished response; escape documented in this paper; susceptible form
TVhYGVPVWr   diminished response; escape documented in this paper; non-susceptible form
Epitope Name TK10
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 4 variant(s).


Variant ID.  3606
Epitope Seq.  TVYYGVPVWK
Variant Seq.  TiYYGVPVWK
Mutations V/I
Epitope Location V2I
HXB2 Location V38I
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Env TK10 escape variant TiYYGVPVWK cross-reacted to autologous TK10(TVYYGVPVWK)-specific T cells during acute infection in A*0301 patients.


Variant ID.  3607
Epitope Seq.  TVYYGVPVWK
Variant Seq.  TiYYGVPVWr
Mutations K/R V/I
Epitope Location K10R V2I
HXB2 Location K46R V38I
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Env TK10 escape variant TiYYGVPVWr cross-reacted to autologous TK10(TVYYGVPVWK)-specific T cells during acute infection in A*0301 patients.


Variant ID.  3608
Epitope Seq.  TVYYGVPVWK
Variant Seq.  TVYYGVPagr
Mutations K/R V/A W/G
Epitope Location K10R V8A W9G
HXB2 Location K46R V44A W45G
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Env TK10 escape variant TVYYGVPagr cross-reacted to autologous TK10(TVYYGVPVWK)-specific T cells during acute infection in A*0301 patients.


Variant ID.  3609
Epitope Seq.  TVYYGVPVWK
Variant Seq.  TVhYGVPVWr
Mutations K/R Y/H
Epitope Location K10R Y3H
HXB2 Location K46R Y39H
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Env TK10 escape variant TVhYGVPVWr did not cross-react to autologous TK10(TVYYGVPVWK)-specific T cells during acute infection in A*0301 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61171

HXB2 Location  Nef(68-76)   Nef Epitope Map
View variants at this location
Epitope FPVRPQVPL   Epitope Alignment
Variants
FPVkPQVPL   diminished response; escape documented in this paper; non-susceptible form
FPVkPQVPv   diminished response; escape documented in this paper; non-susceptible form
FPVkPrVPL   diminished response; escape documented in this paper; non-susceptible form
FPVkPQVsL   diminished response; escape documented in this paper; non-susceptible form
FPVtPQVPL   diminished response; escape documented in this paper; non-susceptible form
FPVtPQVPv   diminished response; escape documented in this paper; non-susceptible form
FPVtPrVPL   diminished response; escape documented in this paper; non-susceptible form
Epitope Name FL9
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 7 variant(s).


Variant ID.  3648
Epitope Seq.  FPVRPQVPL
Variant Seq.  FPVkPQVPL
Mutations R/K
Epitope Location R4K
HXB2 Location R71K
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FL9 escape variant FPVkPQVPL did not cross-react to autologous FL9 (FPVRPQVPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3649
Epitope Seq.  FPVRPQVPL
Variant Seq.  FPVkPQVPv
Mutations R/K L/V
Epitope Location R4K L9V
HXB2 Location R71K L76V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FL9 escape variant FPVkPQVPv did not cross-react to autologous FL9 (FPVRPQVPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3650
Epitope Seq.  FPVRPQVPL
Variant Seq.  FPVkPrVPL
Mutations R/K Q/R
Epitope Location R4K Q6R
HXB2 Location R71K Q73R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FL9 escape variant FPVkPrVPL did not cross-react to autologous FL9 (FPVRPQVPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3651
Epitope Seq.  FPVRPQVPL
Variant Seq.  FPVkPQVsL
Mutations R/K P/S
Epitope Location R4K P8S
HXB2 Location R71K P75S
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FL9 escape variant FPVkPQVsL did not cross-react to autologous FL9 (FPVRPQVPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3652
Epitope Seq.  FPVRPQVPL
Variant Seq.  FPVtPQVPL
Mutations R/T
Epitope Location R4T
HXB2 Location R71T
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FL9 escape variant FPVtPQVPL did not cross-react to autologous FL9 (FPVRPQVPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3653
Epitope Seq.  FPVRPQVPL
Variant Seq.  FPVtPQVPv
Mutations R/T L/V
Epitope Location R4T L9V
HXB2 Location R71T L76V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FL9 escape variant FPVtPQVPv did not cross-react to autologous FL9 (FPVRPQVPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3654
Epitope Seq.  FPVRPQVPL
Variant Seq.  FPVtPrVPL
Mutations R/T Q/R
Epitope Location R4T Q6R
HXB2 Location R71T Q73R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FL9 escape variant FPVtPrVPL did not cross-react to autologous FL9 (FPVRPQVPL)-specific T cells during acute infection in B*0702 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61175

HXB2 Location  Nef(68-76)   Nef Epitope Map
View variants at this location
Epitope FPVKPQVPL   Epitope Alignment
Variants
FPVrPQVPL   non-susceptible form; susceptible form
FPVtPQVPL   diminished response; escape documented in this paper; non-susceptible form; susceptible form
Epitope Name FKL9
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3665
Epitope Seq.  FPVKPQVPL
Variant Seq.  FPVrPQVPL
Mutations K/R
Epitope Location K4R
HXB2 Location K71R
Mutation Type NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FKL9 non-escape variant FPVrPQVPL did not cross-react to autologous FKL9 (FPVKPQVPL)-specific T cells during acute infection but did cross-react during chronic infection in B*0702 patients.


Variant ID.  3666
Epitope Seq.  FPVKPQVPL
Variant Seq.  FPVtPQVPL
Mutations K/T
Epitope Location K4T
HXB2 Location K71T
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FKL9 escape variant FPVtPQVPL did not cross-react to autologous FKL9 (FPVKPQVPL)-specific T cells during acute infection but did cross-react during chronic infection in B*0702 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61192

HXB2 Location  Nef(68-77)   Nef Epitope Map
View variants at this location
Epitope FPVKPQVPLR   Epitope Alignment
Variants
FPVrPQVPLR   non-susceptible form
FPVtPQVPLR   diminished response; escape documented in this paper; non-susceptible form
Epitope Name FKR10
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3702
Epitope Seq.  FPVKPQVPLR
Variant Seq.  FPVrPQVPLR
Mutations K/R
Epitope Location K4R
HXB2 Location K71R
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FKR10 non-escape variant FPVrPQVPLR did not cross-react to autologous FKR10 (FPVKPQVPLR)-specific T cells during acute and chronic infection in B*0702 patients.


Variant ID.  3703
Epitope Seq.  FPVKPQVPLR
Variant Seq.  FPVtPQVPLR
Mutations K/R
Epitope Location K4R
HXB2 Location K71R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FKR10 escape variant FPVtPQVPLR did not cross-react to autologous FKR10 (FPVKPQVPLR)-specific T cells during acute and chronic infection in B*0702 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61172

HXB2 Location  Nef(68-77)   Nef Epitope Map
View variants at this location
Epitope FPVRPQVPLR   Epitope Alignment
Variants
FPVkPQVPLR   diminished response; escape documented in this paper; non-susceptible form
FPVkPQVPvR   diminished response; escape documented in this paper; non-susceptible form
FPVkPQePLi   diminished response; escape documented in this paper; non-susceptible form
FPVtPQVPLR   diminished response; escape documented in this paper; non-susceptible form
FPVtPQVPLt   diminished response; escape documented in this paper; non-susceptible form
Epitope Name FR10
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3655
Epitope Seq.  FPVRPQVPLR
Variant Seq.  FPVkPQVPLR
Mutations R/K
Epitope Location R4K
HXB2 Location R71K
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FR10 escape variant FPVkPQVPLR did not cross-react to autologous FR10 (FPVRPQVPLR)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3656
Epitope Seq.  FPVRPQVPLR
Variant Seq.  FPVkPQVPvR
Mutations R/K L/V
Epitope Location R4K L9V
HXB2 Location R71K L76V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FR10 escape variant FPVkPQVPvR did not cross-react to autologous FR10 (FPVRPQVPLR)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3657
Epitope Seq.  FPVRPQVPLR
Variant Seq.  FPVkPQePLi
Mutations R/I R/K V/E
Epitope Location R10I R4K V7E
HXB2 Location R77I R71K V74E
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FR10 escape variant FPVkPQePLi did not cross-react to autologous FR10 (FPVRPQVPLR)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3658
Epitope Seq.  FPVRPQVPLR
Variant Seq.  FPVtPQVPLR
Mutations R/T
Epitope Location R4T
HXB2 Location R71T
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FR10 escape variant FPVtPQVPLR did not cross-react to autologous FR10 (FPVRPQVPLR)-specific T cells during acute infection or acute and chronic infections in different B*0702 patients.


Variant ID.  3659
Epitope Seq.  FPVRPQVPLR
Variant Seq.  FPVtPQVPLt
Mutations R/T R/T
Epitope Location R10T R4T
HXB2 Location R77T R71T
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef FR10 escape variant FPVtPQVPLt did not cross-react to autologous FR10 (FPVRPQVPLR)-specific T cells during acute infection in B*0702 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61136

HXB2 Location  Nef(77-85)   Nef Epitope Map
View variants at this location
Epitope RPMTYKGAL   Epitope Alignment
Variants
RPMTYKaAL   diminished response; escape documented in this paper; non-susceptible form; susceptible form
RPMTYKaAv   diminished response; escape documented in this paper; non-susceptible form; susceptible form
RPMTYKaAf   diminished response; escape documented in this paper; susceptible form
RPMTYKaAi   diminished response; escape documented in this paper; susceptible form
RPMTfKaAL   diminished response; escape documented in this paper; non-susceptible form
RPMTfKaAv   diminished response; escape documented in this paper; non-susceptible form
RPMTYKgAv   diminished response; escape documented in this paper; susceptible form
Epitope Name RL9
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 7 variant(s).


Variant ID.  3565
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYKaAL
Mutations G/A
Epitope Location G7A
HXB2 Location G83A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RL9 escape variant RPMTYKaAL did cross-react to autologous RL9(RPMTYKGAL)-specific T cells during acute infection in a B*0702 patient, however in another patient RPMTYKaAL did not cross-react during acute infection but did cross-react during chronic infection. In yet another B*0702 subject, this escape epitope did not cross-react either during acute or chronic infection.


Variant ID.  3566
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYKaAv
Mutations G/A L/V
Epitope Location G7A L9V
HXB2 Location G83A L85V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RL9 escape variant RPMTYKaAv did cross-react to autologous RL9(RPMTYKGAL)-specific T cells during acute infection in B*0702 patients, however in another patient RPMTYKaAV did not cross-react during acute infection but did cross-react during chronic infection.


Variant ID.  3568
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYKaAf
Mutations G/A L/F
Epitope Location G7A L9F
HXB2 Location G83A L85F
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RL9 escape variant RPMTYKaAf did cross-react to autologous RL9(RPMTYKGAL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3569
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYKaAi
Mutations G/A L/I
Epitope Location G7A L9I
HXB2 Location G83A L85I
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RL9 escape variant RPMTYKaAi did cross-react to autologous RL9(RPMTYKGAL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3570
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTfKaAL
Mutations Y/F G/A
Epitope Location Y5F G7A
HXB2 Location Y81F G83A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RL9 escape variant RPMTfKaAL did not cross-react to autologous RL9(RPMTYKGAL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3571
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTfKaAv
Mutations Y/F G/A L/V
Epitope Location Y5F G7A L9V
HXB2 Location Y81F G83A L85V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RL9 escape variant RPMTfKaAv did not cross-react to autologous RL9(RPMTYKGAL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3686
Epitope Seq.  RPMTYKGAL
Variant Seq.  RPMTYKgAv
Mutations L/V
Epitope Location L9V
HXB2 Location L85V
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RL9 escape variant RPMTYKgAv did cross-react to autologous RL9(RPMTYKGAL)-specific T cells during acute infection in B*0702 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61163

HXB2 Location  Nef(77-85)   Nef Epitope Map
View variants at this location
Epitope RPMTFKGAL   Epitope Alignment
Variants
RPMTFKaAv   diminished response; escape documented in this paper; non-susceptible form
RPMTFKaAL   diminished response; escape documented in this paper; non-susceptible form
RPMTyKaAi   diminished response; escape documented in this paper; non-susceptible form
RPMTyKaAf   diminished response; escape documented in this paper; non-susceptible form
RPMTyKGAv   diminished response; escape documented in this paper; non-susceptible form
RPMTyKaAv   diminished response; escape documented in this paper; non-susceptible form
RPMTyKaAL   diminished response; escape documented in this paper; non-susceptible form
RPMTyKGAL   susceptible form
Epitope Name RFL9
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 8 variant(s).


Variant ID.  3615
Epitope Seq.  RPMTFKGAL
Variant Seq.  RPMTFKaAv
Mutations G/A L/V
Epitope Location G7A L9V
HXB2 Location G83A L85V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RFL9 escape variant RPMTFKaAv did not cross-react to autologous RFL9(RPMTFKGAL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3616
Epitope Seq.  RPMTFKGAL
Variant Seq.  RPMTFKaAL
Mutations G/A
Epitope Location G7A
HXB2 Location G83A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RFL9 escape variant RPMTFKaAL did not cross-react to autologous RFL9(RPMTFKGAL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3617
Epitope Seq.  RPMTFKGAL
Variant Seq.  RPMTyKaAi
Mutations F/Y G/A L/I
Epitope Location F5Y G7A L9I
HXB2 Location F81Y G83A L85I
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RFL9 escape variant RPMTyKaAi did not cross-react to autologous RFL9(RPMTFKGAL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3618
Epitope Seq.  RPMTFKGAL
Variant Seq.  RPMTyKaAf
Mutations F/Y G/A L/F
Epitope Location F5Y G7A L9F
HXB2 Location F81Y G83A L85F
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RFL9 escape variant RPMTyKaAf did not cross-react to autologous RFL9(RPMTFKGAL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3619
Epitope Seq.  RPMTFKGAL
Variant Seq.  RPMTyKGAv
Mutations F/Y L/V
Epitope Location F5Y L9V
HXB2 Location F81Y L85V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RFL9 escape variant RPMTyKGAv did not cross-react to autologous RFL9(RPMTFKGAL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3620
Epitope Seq.  RPMTFKGAL
Variant Seq.  RPMTyKaAv
Mutations F/Y L/V
Epitope Location F5Y L9V
HXB2 Location F81Y L85V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RFL9 escape variant RPMTyKaAv did not cross-react to autologous RFL9(RPMTFKGAL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3621
Epitope Seq.  RPMTFKGAL
Variant Seq.  RPMTyKaAL
Mutations F/Y G/A
Epitope Location F5Y G7A
HXB2 Location F81Y G83A
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RFL9 escape variant RPMTyKaAL did not cross-react to autologous RFL9(RPMTFKGAL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3622
Epitope Seq.  RPMTFKGAL
Variant Seq.  RPMTyKGAL
Mutations F/Y
Epitope Location F5Y
HXB2 Location F81Y
Mutation Type SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RFL9 non-escape variant RPMTyKGAL (RL9) cross-reacted to autologous RFL9(RPMTFKGAL)-specific T cells during acute infection in B*0702 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61183

HXB2 Location  Nef(84-92)   Nef Epitope Map
View variants at this location
Epitope ALDLSHFLR   Epitope Alignment
Variants
AvDLSHFLk   non-susceptible form; susceptible form
ALDLSHFLk   diminished response; escape documented in this paper; non-susceptible form; susceptible form
Epitope Name ALR9
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3684
Epitope Seq.  ALDLSHFLR
Variant Seq.  AvDLSHFLk
Mutations L/V R/K
Epitope Location L2V R9K
HXB2 Location L85V R92K
Mutation Type NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef ALR9 non-escape variant AvDLSHFLk did not cross-react to autologous ALR9 (ALDLSHFLR)-specific T cells during acute infection but did cross-react during chronic infection in A*0301 patients.


Variant ID.  3685
Epitope Seq.  ALDLSHFLR
Variant Seq.  ALDLSHFLk
Mutations R/K
Epitope Location R9K
HXB2 Location R92K
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef ALR9 escape variant ALDLSHFLk did not cross-react to autologous ALR9 (ALDLSHFLR)-specific T cells during acute infection but did cross-react during chronic infection in A*0301 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61170

HXB2 Location  Nef(84-92)   Nef Epitope Map
View variants at this location
Epitope AVDLSHFLK   Epitope Alignment
Variants
AlDLSHFLK   diminished response; escape documented in this paper; non-susceptible form
AlDLSHFLr   diminished response; escape documented in this paper; non-susceptible form
AlDiSHFLK   diminished response; escape documented in this paper; non-susceptible form
AlnLSHFLK   diminished response; escape documented in this paper; non-susceptible form
AlDmSHFLK   diminished response; escape documented in this paper; non-susceptible form
Epitope Name AK9
Species (MHC/HLA human(A*03:01)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3643
Epitope Seq.  AVDLSHFLK
Variant Seq.  AlDLSHFLK
Mutations V/L
Epitope Location V2L
HXB2 Location V85L
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef AK9 escape variant AlDLSHFLK did not cross-react to autologous AK9 (AVDLSHFLK)-specific T cells during acute and chronic infection in A*0301 patients.


Variant ID.  3644
Epitope Seq.  AVDLSHFLK
Variant Seq.  AlDLSHFLr
Mutations V/L K/R
Epitope Location V2L K9R
HXB2 Location V85L K92R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef AK9 escape variant AlDLSHFLr did not cross-react to autologous AK9 (AVDLSHFLK)-specific T cells during acute and chronic infection in A*0301 patients.


Variant ID.  3645
Epitope Seq.  AVDLSHFLK
Variant Seq.  AlDiSHFLK
Mutations V/L L/I
Epitope Location V2L L4I
HXB2 Location V85L L87I
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef AK9 escape variant AlDiSHFLK did not cross-react to autologous AK9 (AVDLSHFLK)-specific T cells during acute infection in A*0301 patients.


Variant ID.  3646
Epitope Seq.  AVDLSHFLK
Variant Seq.  AlnLSHFLK
Mutations V/L D/N
Epitope Location V2L D3N
HXB2 Location V85L D86N
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef AK9 escape variant AlnLSHFLK did not cross-react to autologous AK9 (AVDLSHFLK)-specific T cells during acute infection in A*0301 patients.


Variant ID.  3647
Epitope Seq.  AVDLSHFLK
Variant Seq.  AlDmSHFLK
Mutations V/L L/M
Epitope Location V2L L4M
HXB2 Location V85L L87M
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef AK9 escape variant AlDmSHFLK did not cross-react to autologous AK9 (AVDLSHFLK)-specific T cells during acute infection in A*0301 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61176

HXB2 Location  Nef(84-92)   Nef Epitope Map
View variants at this location
Epitope ALDLSHFLK   Epitope Alignment
Variants
AvDLSHFLK   non-susceptible form
ALDLSHFLr   diminished response; escape documented in this paper; non-susceptible form
ALDiSHFLK   diminished response; escape documented in this paper; non-susceptible form
ALnLSHFLK   diminished response; escape documented in this paper; non-susceptible form
ALDmSHFLK   diminished response; escape documented in this paper; non-susceptible form
Epitope Name ALK9
Species (MHC/HLA human(A*11:01)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3667
Epitope Seq.  ALDLSHFLK
Variant Seq.  AvDLSHFLK
Mutations L/V
Epitope Location L2V
HXB2 Location L85V
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef ALK9 non-escape variant AvDLSHFLK did not cross-react to autologous FKL9 (ALDLSHFLK)-specific T cells during acute and chronic infection in A*1101 patients.


Variant ID.  3668
Epitope Seq.  ALDLSHFLK
Variant Seq.  ALDLSHFLr
Mutations K/R
Epitope Location K9R
HXB2 Location K92R
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef ALK9 escape variant ALDLSHFLr did not cross-react to autologous FKL9 (ALDLSHFLK)-specific T cells during acute and chronic infection in A*1101 patients.


Variant ID.  3669
Epitope Seq.  ALDLSHFLK
Variant Seq.  ALDiSHFLK
Mutations L/I
Epitope Location L4I
HXB2 Location L87I
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef ALK9 escape variant ALDiSHFLK did not cross-react to autologous FKL9 (ALDLSHFLK)-specific T cells during acute and chronic infection in A*1101 patients.


Variant ID.  3670
Epitope Seq.  ALDLSHFLK
Variant Seq.  ALnLSHFLK
Mutations D/N
Epitope Location D3N
HXB2 Location D86N
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef ALK9 escape variant ALnLSHFLK did not cross-react to autologous FKL9 (ALDLSHFLK)-specific T cells during acute and chronic infection in A*1101 patients.


Variant ID.  3671
Epitope Seq.  ALDLSHFLK
Variant Seq.  ALDmSHFLK
Mutations L/M
Epitope Location L4M
HXB2 Location L87M
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef ALK9 escape variant ALDmSHFLK did not cross-react to autologous FKL9 (ALDLSHFLK)-specific T cells during acute and chronic infection in A*1101 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61185

HXB2 Location  Nef(105-115)   Nef Epitope Map
View variants at this location
Epitope KRQEILDLWVY   Epitope Alignment
Variants
qRQdILDLWVY   diminished response; escape documented in this paper; non-susceptible form; susceptible form
KRQdILDLWVY   non-susceptible form
Epitope Name KEY11
Species (MHC/HLA human(C*07:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3690
Epitope Seq.  KRQEILDLWVY
Variant Seq.  qRQdILDLWVY
Mutations K/Q E/D
Epitope Location K1Q E4D
HXB2 Location K105Q E108D
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef KEY11 escape variant qRQdILDLWVY did not cross-react to autologous KEY11 (KRQEILDLWVY)-specific T cells during acute infection but did cross-react during chronic infection in Cw*0701 patients.


Variant ID.  3691
Epitope Seq.  KRQEILDLWVY
Variant Seq.  KRQdILDLWVY
Mutations E/D
Epitope Location E4D
HXB2 Location E108D
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef KEY11 non-escape variant KRQdILDLWVY did not cross-react to autologous KEY11 (KRQEILDLWVY)-specific T cells during acute and chronic infection in Cw*0701 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61160

HXB2 Location  Nef(128-137)   Nef Epitope Map
View variants at this location
Epitope TPGPGIRYPL   Epitope Alignment
Variants
TPGPGvRYPL   diminished response; escape documented in this paper; susceptible form
TPGPGvRfPL   diminished response; escape documented in this paper; susceptible form
TPGPGvRwPL   diminished response; escape documented in this paper; susceptible form
TPGPGvRlPL   diminished response; escape documented in this paper; susceptible form
TPGPGtRfPL   diminished response; escape documented in this paper; susceptible form
Epitope Name TL10
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3601
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRYPL
Mutations I/V
Epitope Location I6V
HXB2 Location I133V
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TL10 escape variant TPGPGvRYPL cross-reacted to autologous TL10(TPGPGIRYPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3602
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRfPL
Mutations I/V Y/F
Epitope Location I6V Y8F
HXB2 Location I133V Y135F
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TL10 escape variant TPGPGvRfPL cross-reacted to autologous TL10(TPGPGIRYPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3603
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRwPL
Mutations I/V Y/W
Epitope Location I6V Y8W
HXB2 Location I133V Y135W
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TL10 escape variant TPGPGvRwPL cross-reacted to autologous TL10(TPGPGIRYPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3604
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGvRlPL
Mutations I/V Y/L
Epitope Location I6V Y8L
HXB2 Location I133V Y135L
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TL10 escape variant TPGPGvRlPL did not cross-react to autologous TL10(TPGPGIRYPL)-specific T cells during acute infection in B*0702 patients.


Variant ID.  3605
Epitope Seq.  TPGPGIRYPL
Variant Seq.  TPGPGtRfPL
Mutations I/T Y/F
Epitope Location I6T Y8F
HXB2 Location I133T Y135F
Mutation Type DR: diminished response
E: escape documented in this paper
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TL10 escape variant TPGPGtRfPL did not cross-react to autologous TL10(TPGPGIRYPL)-specific T cells during acute infection in B*0702 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61184

HXB2 Location  Nef(128-137)   Nef Epitope Map
View variants at this location
Epitope TPGPGTRYPL   Epitope Alignment
Variants
TPGPGiRYPL   non-susceptible form
TPGPGvRYPL   diminished response; escape documented in this paper; non-susceptible form; susceptible form
TPGPGTRfPL   diminished response; escape documented in this paper; non-susceptible form; susceptible form
Epitope Name TTL10
Species (MHC/HLA human(B*07:02)

Variant Details

Showing all: 3 variant(s).


Variant ID.  3687
Epitope Seq.  TPGPGTRYPL
Variant Seq.  TPGPGiRYPL
Mutations T/I
Epitope Location T6I
HXB2 Location T133I
Mutation Type NSF: non-susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TTL10 non-escape variant TPGPGiRYPL did not cross-react to autologous TTL10 (TPGPGTRYPL)-specific T cells during acute and chronic infection in B*0702 patients.


Variant ID.  3688
Epitope Seq.  TPGPGTRYPL
Variant Seq.  TPGPGvRYPL
Mutations T/V
Epitope Location T6V
HXB2 Location T133V
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TTL10 escape variant TPGPGvRYPL did not cross-react to autologous TTL10 (TPGPGTRYPL)-specific T cells during acute and chronic infection in B*0702 patients.


Variant ID.  3689
Epitope Seq.  TPGPGTRYPL
Variant Seq.  TPGPGTRfPL
Mutations Y/F
Epitope Location Y8F
HXB2 Location Y135F
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef TTL10 escape variant TPGPGTRfPL did not cross-react to autologous TTL10 (TPGPGTRYPL)-specific T cells during acute infection but did cross-react during chronic infection in B*0702 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


Displaying record number 61180

HXB2 Location  Nef(134-141)   Nef Epitope Map
View variants at this location
Epitope RYPLTFGW   Epitope Alignment
Variants
RfPLTFGW   diminished response; escape documented in this paper; non-susceptible form; susceptible form
RYPLcFGW   diminished response; escape documented in this paper; non-susceptible form; susceptible form
Epitope Name RW8
Species (MHC/HLA human(A*24:02)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3678
Epitope Seq.  RYPLTFGW
Variant Seq.  RfPLTFGW
Mutations Y/F
Epitope Location Y2F
HXB2 Location Y135F
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RW8 escape variant RfPLTFGW did not cross-react to autologous RW8 (RYPLTFGW)-specific T cells during acute infection but did cross-react during chronic infection in A*2402 patients.


Variant ID.  3679
Epitope Seq.  RYPLTFGW
Variant Seq.  RYPLcFGW
Mutations T/C
Epitope Location T5C
HXB2 Location T138C
Mutation Type DR: diminished response
E: escape documented in this paper
NSF: non-susceptible form
SF: susceptible form
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining, Other
Note Nef RW8 escape variant RYPLcFGW did not cross-react to autologous RW8 (RYPLTFGW)-specific T cells during acute infection but did cross-react during chronic infection in A*2402 patients.

References

Du2016 Victor Y. Du, Anju Bansal, Jonathan Carlson, Jesus F. Salazar-Gonzalez, Maria G. Salazar, Kristin Ladell, Stephanie Gras, Tracy M. Josephs, Sonya L. Heath, David A. Price, Jamie Rossjohn, Eric Hunter, and Paul A. Goepfert. HIV-1-Specific CD8 T Cells Exhibit Limited Cross-Reactivity during Acute Infection. J. Immunol., 196(8):3276-3286, 15 Apr 2016. PubMed ID: 26983786. Show all entries for this paper.


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