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Found 7 matching records:

Displaying record number 55064

HXB2 Location  Gag(77-85)   Gag Epitope Map
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Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTVAvL   diminished response
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  183
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTVAvL
Mutations T/V
Epitope Location T8V
HXB2 Location T84V
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. SLYNTVAvL variant arose in one twin and not the other. Response to the variant was diminished.

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.


Displaying record number 55060

HXB2 Location  Pol(160-167)   Pol Epitope Map
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Epitope IETVPVKL   Epitope Alignment
Variants
IdTVPVKL   diminished response
IETVPVrL   diminished response
Epitope Name IL8
Species (MHC/HLA human(B*40:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  184
Epitope Seq.  IETVPVKL
Variant Seq.  IdTVPVKL
Mutations E/D
Epitope Location E2D
HXB2 Location E161D
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. IdTVPVKL variant arose in one twin; IETVPVrL variant arose in the other. Response to the both variants was diminished.


Variant ID.  185
Epitope Seq.  IETVPVKL
Variant Seq.  IETVPVrL
Mutations K/R
Epitope Location K7R
HXB2 Location K166R
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. IdTVPVKL variant arose in one twin; IETVPVrL variant arose in the other. Response to both variants was diminished.

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.


Displaying record number 55063

HXB2 Location  Pol(282-290)   Pol Epitope Map
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Epitope YTAFTIPSV   Epitope Alignment
Variants
YTAFTIPSi   diminished response
Epitope Name YV9
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  186
Epitope Seq.  YTAFTIPSV
Variant Seq.  YTAFTIPSi
Mutations V/I
Epitope Location V9I
HXB2 Location V290I
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. YTAFTIPSi variant arose in one twin and not the other. Response to the variant was diminished.

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.


Displaying record number 55059

HXB2 Location  Pol(357-365)   Pol Epitope Map
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Epitope IEELRQHLL   Epitope Alignment
Variants
vEELReHLL   diminished response
IEELReHLL   diminished response
Epitope Name IL9
Species (MHC/HLA human(B*40:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  187
Epitope Seq.  IEELRQHLL
Variant Seq.  vEELReHLL
Mutations I/V Q/E
Epitope Location I1V Q6E
HXB2 Location I357V Q362E
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. vEELReHLL variant arose in one twin; IEELReHLL variant arose in the other. Response to both variants was diminished.


Variant ID.  188
Epitope Seq.  IEELRQHLL
Variant Seq.  IEELReHLL
Mutations Q/E
Epitope Location Q6E
HXB2 Location Q362E
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. vEELReHLL variant arose in one twin; IEELReHLL variant arose in the other. Response to both variants was diminished.

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.


Displaying record number 55062

HXB2 Location  gp160(805-814)   gp160 Epitope Map
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Epitope QELKNSAVSL   Epitope Alignment
Variants
QELKkSAVSL   diminished response
Epitope Name QL10
Species (MHC/HLA human(B*40:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  189
Epitope Seq.  QELKNSAVSL
Variant Seq.  QELKkSAVSL
Mutations N/K
Epitope Location N5K
HXB2 Location N809K
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. QELKkSAVSL variant arose in one twin and not the other. Response to the variant was diminished.

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.


Displaying record number 55066

HXB2 Location  Nef(37-45)   Nef Epitope Map
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Epitope LEKHGAITS   Epitope Alignment
Variants
LdKHGAITS   diminished response
LEKHGAvTS   susceptible form
Epitope Name LS9
Species (MHC/HLA human(B*40:01, B50)

Variant Details

Showing all: 2 variant(s).


Variant ID.  190
Epitope Seq.  LEKHGAITS
Variant Seq.  LdKHGAITS
Mutations E/D
Epitope Location E2D
HXB2 Location E38D
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. LdKHGAITS variant arose in one twin; LEKHGAvTS variant arose in the other. Response to LdKHGAITS variant was diminished, while response to LEKHGAvTS was as strong as to LEKHGAITS.


Variant ID.  191
Epitope Seq.  LEKHGAITS
Variant Seq.  LEKHGAvTS
Mutations I/V
Epitope Location I7V
HXB2 Location I43V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. LdKHGAITS variant arose in one twin; LEKHGAvTS variant arose in the other. Response to LdKHGAITS variant was diminished, while response to LEKHGAvTS was as strong as to LEKHGAITS

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.


Displaying record number 55065

HXB2 Location  Nef(83-91)   Nef Epitope Map
View variants at this location
Epitope AALDMSHFL   Epitope Alignment
Variants
AALDiSHFL   susceptible form
gALDMSHFL   diminished response
Epitope Name AL9
Species (MHC/HLA human(Cw3)

Variant Details

Showing all: 2 variant(s).


Variant ID.  192
Epitope Seq.  AALDMSHFL
Variant Seq.  AALDiSHFL
Mutations M/I
Epitope Location M5I
HXB2 Location M87I
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. AALDiSHFL variant arose in one twin; gALDMSHFL variant arose in the other. Response to AALDiSHFL variant was as strong as to AALDMSHFL, while response to gALDMSHFL was diminished.


Variant ID.  193
Epitope Seq.  AALDMSHFL
Variant Seq.  gALDMSHFL
Mutations A/G
Epitope Location A1G
HXB2 Location A83G
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy, Intracellular cytokine staining
Note Immune responses were examined in monozygotic male twins infected simultaneously with the same virus. AALDiSHFL variant arose in one twin; gALDMSHFL variant arose in the other. Response to AALDiSHFL variant was as strong as to AALDMSHFL, while response to gALDMSHFL was diminished.

References

Draenert2006 Rika Draenert, Todd M. Allen, Yang Liu, Terri Wrin, Colombe Chappey, Cori L. Verrill, Guillem Sirera, Robert L. Eldridge, Matthew P. Lahaie, Lidia Ruiz, Bonaventura Clotet, Christos J. Petropoulos, Bruce D. Walker, and Javier Martinez-Picado. Constraints on HIV-1 Evolution and Immunodominance Revealed in Monozygotic Adult Twins Infected with the Same Virus. J. Exp. Med., 203(3):529-539, 20 Mar 2006. PubMed ID: 16533886. Show all entries for this paper.


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