HIV molecular immunology database

 

Search the Epitope Variant and Escape Mutation Database

Help


Found 2 matching records:

Displaying record number 52917

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
pSPRTLNAW   escape documented in this paper; processing
Epitope Name ISW9
Species (MHC/HLA human(B57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  181
Epitope Seq.  ISPRTLNAW
Variant Seq.  pSPRTLNAW
Mutations I/P
Epitope Location I1P
HXB2 Location I147P
Mutation Type E: escape documented in this paper
P: processing
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note The A146P mutation flanking the ISW9 epitope, {p}ISPRTLNAW, is positively selected in HLA-B57+ persons and it prevents trimming of the optimal epitope by the endoplasmic reticulum aminopeptidase I. The A146P processing escape mutation does not influence replicative capacity of the virus in vitro and is accumulated over time in the human population.

References

Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.


Displaying record number 52918

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIAW   Epitope Alignment
Variants
TS*LQEQIAW   observed variant
Epitope Name TW10
Species (MHC/HLA human(B57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2284
Epitope Seq.  TSTLQEQIAW
Variant Seq.  TS*LQEQIAW
Mutations T/*
Epitope Location T3*
HXB2 Location T242*
Mutation Type OV: observed variant
Note 174 people who have C clade infections were studied -- those who carried B57 have 2 positions in which their HIV Gag consensus is different than the C consensus. One mutation is within this epitope, TW10, at position 3, and is believed to be a TCR contact residue. The mutation is not specified in the study.

References

Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.


Questions or comments? Contact us at immuno@lanl.gov
 
Managed by Triad National Security, LLC for the U.S. Department of Energy’s National Nuclear Security Administration
Copyright © 2022 Triad National Security, LLC | Disclaimer/Privacy

Dept of Health & Human Services Los Alamos National Institutes of Health