HIV molecular immunology database
Found 2 matching records:
| HXB2 Location | Gag(147-155) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
ISPRTLNAW
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | ISW9 | |||||
| Species (MHC/HLA) | human(B57) | |||||
Showing all: 1 variant(s).
| Variant ID. | 181 |
|---|---|
| Epitope Seq. | ISPRTLNAW |
| Variant Seq. | pSPRTLNAW |
| Mutations | I/P |
| Epitope Location | I1P |
| HXB2 Location | I147P |
| Mutation Type | E: escape documented in this paper P: processing |
| Method | CD8 T-cell Elispot - IFNy, Chromium-release assay |
| Note | The A146P mutation flanking the ISW9 epitope, {p}ISPRTLNAW, is positively selected in HLA-B57+ persons and it prevents trimming of the optimal epitope by the endoplasmic reticulum aminopeptidase I. The A146P processing escape mutation does not influence replicative capacity of the virus in vitro and is accumulated over time in the human population. |
Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.
| HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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|---|---|---|---|---|---|---|
| Epitope |
TSTLQEQIAW
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | TW10 | |||||
| Species (MHC/HLA) | human(B57) | |||||
Showing all: 1 variant(s).
| Variant ID. | 2284 |
|---|---|
| Epitope Seq. | TSTLQEQIAW |
| Variant Seq. | TS*LQEQIAW |
| Mutations | T/* |
| Epitope Location | T3* |
| HXB2 Location | T242* |
| Mutation Type | OV: observed variant |
| Note | 174 people who have C clade infections were studied -- those who carried B57 have 2 positions in which their HIV Gag consensus is different than the C consensus. One mutation is within this epitope, TW10, at position 3, and is believed to be a TCR contact residue. The mutation is not specified in the study. |
Draenert2004a Rika Draenert, Sylvie Le Gall, Katja J. Pfafferott, Alasdair J. Leslie, Polan Chetty, Christian Brander, Edward C. Holmes, Shih-Chung Chang, Margaret E. Feeney, Marylyn M. Addo, Lidia Ruiz, Danni Ramduth, Prakash Jeena, Marcus Altfeld, Stephanie Thomas, Yanhua Tang, Cori L. Verrill, Catherine Dixon, Julia G. Prado, Photini Kiepiela, Javier Martinez-Picado, Bruce D. Walker, and Philip J. R. Goulder. Immune Selection for Altered Antigen Processing Leads to Cytotoxic T Lymphocyte Escape in Chronic HIV-1 Infection. J. Exp. Med., 199(7):905-915, 5 Apr 2004. PubMed ID: 15067030. Show all entries for this paper.