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Found 3 matching records:

Displaying record number 1712

HXB2 Location  Gag(180-188)   Gag Epitope Map
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Epitope TPQDLNMML   Epitope Alignment
Variants
TPQDLNtML   subtype-specific non-susceptible form; TCR related mutation
Species (MHC/HLA human(B53)

Variant Details

Showing all: 1 variant(s).


Variant ID.  176
Epitope Seq.  TPQDLNMML
Variant Seq.  TPQDLNtML
Mutations M/T
Epitope Location M7T
HXB2 Location M186T
Mutation Type SNSF: subtype-specific non-susceptible form
TCR: TCR related mutation
Epitope Subtype A
Variant Subtype B, C, D
Method CD8 T-cell Elispot - IFNy, Cytotoxicity assay, Tetramer binding
Note TPQDLNMML was subtype A-specific with no cross-recognition of the subtype B, C, and D variant, TPQDLNTML, although the B/C/D variant bound more efficiently to B53 in vitro. Position 7 shows great positional variation in crystal structures of two HLA-B53 complexes, suggesting that variation here might significantly alter the position of the peptide in the binding groove and thus affect TCR interactions.

References

Dorrell2001 L. Dorrell, B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, A. McMichael, H. Whittle, and S. Rowland-Jones. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur. J. Immunol., 31(6):1747-56, Jun 2001. PubMed ID: 11385619. Show all entries for this paper.


Displaying record number 1713

HXB2 Location  Gag(203-212)   Gag Epitope Map
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Epitope DTINEEAAEW   Epitope Alignment
Variants
eTINEEAAEW   diminished response; subtype-specific susceptible form
Species (MHC/HLA human(B53)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2210
Epitope Seq.  DTINEEAAEW
Variant Seq.  eTINEEAAEW
Mutations D/E
Epitope Location D1E
HXB2 Location D203E
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype A
Variant Subtype B, C, D
Method CD8 T-cell Elispot - IFNy, Cytotoxicity assay, Tetramer binding
Note DTINEEAAEW was not subtype A-specific and there was cross-recognition, although diminished, of the subtype B, C, and D variant, ETINEEAAEW.

References

Dorrell2001 L. Dorrell, B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, A. McMichael, H. Whittle, and S. Rowland-Jones. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur. J. Immunol., 31(6):1747-56, Jun 2001. PubMed ID: 11385619. Show all entries for this paper.


Displaying record number 1714

HXB2 Location  Gag(308-316)   Gag Epitope Map
View variants at this location
Epitope QATQEVKNM   Epitope Alignment
Variants
QAsQdVKNw   observed variant
Species (MHC/HLA human(B53)

Variant Details

Showing all: 1 variant(s).


Variant ID.  177
Epitope Seq.  QATQEVKNM
Variant Seq.  QAsQdVKNw
Mutations T/S E/D M/W
Epitope Location T3S E5D M9W
HXB2 Location T310S E312D M316W
Mutation Type OV: observed variant
Epitope Subtype A
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Cytotoxicity assay, Tetramer binding
Note Cross-recognition of QATQEVKNM was not studied here, but it was noted that both the subtype A version (QATQEVKNM) and subtype B version (QASQDVKNW) of this epitope are also presented by HLA-B57 and B58, common HLA alleles in Africans.

References

Dorrell2001 L. Dorrell, B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, A. McMichael, H. Whittle, and S. Rowland-Jones. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur. J. Immunol., 31(6):1747-56, Jun 2001. PubMed ID: 11385619. Show all entries for this paper.


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