HIV molecular immunology database
Found 3 matching records:
| HXB2 Location | Gag(180-188) | Gag Epitope Map
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| Epitope |
TPQDLNMML
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human(B53) | |||||
Showing all: 1 variant(s).
| Variant ID. | 176 |
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| Epitope Seq. | TPQDLNMML |
| Variant Seq. | TPQDLNtML |
| Mutations | M/T |
| Epitope Location | M7T |
| HXB2 Location | M186T |
| Mutation Type | SNSF: subtype-specific non-susceptible form TCR: TCR related mutation |
| Epitope Subtype | A |
| Variant Subtype | B, C, D |
| Method | CD8 T-cell Elispot - IFNy, Cytotoxicity assay, Tetramer binding |
| Note | TPQDLNMML was subtype A-specific with no cross-recognition of the subtype B, C, and D variant, TPQDLNTML, although the B/C/D variant bound more efficiently to B53 in vitro. Position 7 shows great positional variation in crystal structures of two HLA-B53 complexes, suggesting that variation here might significantly alter the position of the peptide in the binding groove and thus affect TCR interactions. |
Dorrell2001 L. Dorrell, B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, A. McMichael, H. Whittle, and S. Rowland-Jones. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur. J. Immunol., 31(6):1747-56, Jun 2001. PubMed ID: 11385619. Show all entries for this paper.
| HXB2 Location | Gag(203-212) | Gag Epitope Map
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| Epitope |
DTINEEAAEW
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human(B53) | |||||
Showing all: 1 variant(s).
| Variant ID. | 2210 |
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| Epitope Seq. | DTINEEAAEW |
| Variant Seq. | eTINEEAAEW |
| Mutations | D/E |
| Epitope Location | D1E |
| HXB2 Location | D203E |
| Mutation Type | DR: diminished response SSF: subtype-specific susceptible form |
| Epitope Subtype | A |
| Variant Subtype | B, C, D |
| Method | CD8 T-cell Elispot - IFNy, Cytotoxicity assay, Tetramer binding |
| Note | DTINEEAAEW was not subtype A-specific and there was cross-recognition, although diminished, of the subtype B, C, and D variant, ETINEEAAEW. |
Dorrell2001 L. Dorrell, B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, A. McMichael, H. Whittle, and S. Rowland-Jones. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur. J. Immunol., 31(6):1747-56, Jun 2001. PubMed ID: 11385619. Show all entries for this paper.
| HXB2 Location | Gag(308-316) | Gag Epitope Map
View variants at this location |
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| Epitope |
QATQEVKNM
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human(B53) | |||||
Showing all: 1 variant(s).
| Variant ID. | 177 |
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| Epitope Seq. | QATQEVKNM |
| Variant Seq. | QAsQdVKNw |
| Mutations | T/S E/D M/W |
| Epitope Location | T3S E5D M9W |
| HXB2 Location | T310S E312D M316W |
| Mutation Type | OV: observed variant |
| Epitope Subtype | A |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Cytotoxicity assay, Tetramer binding |
| Note | Cross-recognition of QATQEVKNM was not studied here, but it was noted that both the subtype A version (QATQEVKNM) and subtype B version (QASQDVKNW) of this epitope are also presented by HLA-B57 and B58, common HLA alleles in Africans. |
Dorrell2001 L. Dorrell, B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, A. McMichael, H. Whittle, and S. Rowland-Jones. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur. J. Immunol., 31(6):1747-56, Jun 2001. PubMed ID: 11385619. Show all entries for this paper.