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Found 9 matching records:

Displaying record number 55770

HXB2 Location  Gag(18-26)   Gag Epitope Map
View variants at this location
Epitope KIRLRPGGK   Epitope Alignment
Variants
KIRLRPGGr   susceptible form
Epitope Name KK9
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  153
Epitope Seq.  KIRLRPGGK
Variant Seq.  KIRLRPGGr
Mutations K/R
Epitope Location K9R
HXB2 Location K26R
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay
Note KIRLRPGGK was recognized by 3 patients. The autologous sequence in one patient was KIRLRPGGr which induced high frequency response.

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


Displaying record number 56296

HXB2 Location  Gag(20-28)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGrKr   susceptible form
RLRPGGKKr   susceptible form
Epitope Name RK9
Species (MHC/HLA human(A3, B7)

Variant Details

Showing all: 2 variant(s).


Variant ID.  154
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGrKr
Mutations K/R K/R
Epitope Location K7R K9R
HXB2 Location K26R K28R
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay
Note RLRPGGKKK was recognized by 3 patients. One patient had variants RLRPGGrKr and RLRPGGKKr, which were well recognized within longer peptides.


Variant ID.  155
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKr
Mutations K/R
Epitope Location K9R
HXB2 Location K28R
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay
Note RLRPGGKKK was recognized by 3 patients. One patient had variants RLRPGGrKr and RLRPGGKKr, which were well recognized within longer peptides.

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


Displaying record number 56297

HXB2 Location  Gag(22-30)   Gag Epitope Map
View variants at this location
Epitope RPGGKKKKYK   Epitope Alignment
Variants
RPGGrKKrYK   susceptible form
RPGGKKKrYK   susceptible form
RPGGKKKKYr   susceptible form
Species (MHC/HLA human(B7)

Variant Details

Showing all: 3 variant(s).


Variant ID.  156
Epitope Seq.  RPGGKKKKYK
Variant Seq.  RPGGrKKrYK
Mutations K/R K/R
Epitope Location K5R K8R
HXB2 Location K26R K29R
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay
Note RPGGKKKKYK was recognized by 3 patients. One patient had variants RPGGrKKrYK, RPGGKKKrYK, RPGGKKKKYr which were well recognized. Variant RPGGKKKKYr was also present and recognized in other 2 patients


Variant ID.  157
Epitope Seq.  RPGGKKKKYK
Variant Seq.  RPGGKKKrYK
Mutations K/R
Epitope Location K8R
HXB2 Location K29R
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay
Note RPGGKKKKYK was recognized by 3 patients. One patient had variants RPGGrKKrYK, RPGGKKKrYK, RPGGKKKKYr which were well recognized. Variant RPGGKKKKYr was also present and recognized in other 2 patients


Variant ID.  158
Epitope Seq.  RPGGKKKKYK
Variant Seq.  RPGGKKKKYr
Mutations K/R
Epitope Location K10R
HXB2 Location K31R
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay
Note RPGGKKKKYK was recognized by 3 patients. One patient had variants RPGGrKKrYK, RPGGKKKrYK, RPGGKKKKYr which were well recognized. Variant RPGGKKKKYr was also present and recognized in other 2 patients

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


Displaying record number 56301

HXB2 Location  Gag(203-212)   Gag Epitope Map
View variants at this location
Epitope ETINEEAAEW   Epitope Alignment
Variants
ETINdEAAEW   susceptible form
Epitope Name EW10
Species (MHC/HLA human(A25)

Variant Details

Showing all: 1 variant(s).


Variant ID.  159
Epitope Seq.  ETINEEAAEW
Variant Seq.  ETINdEAAEW
Mutations E/D
Epitope Location E5D
HXB2 Location E207D
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay
Note ETINEEAAEW, elicited a response in 1 patient with low viremia who also targeted Nef epitopes with high frequency. Patient had both the index epitope and the variant ETINdEAAEW which was recognized.

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


Displaying record number 56298

HXB2 Location  Gag(266-273)   Gag Epitope Map
View variants at this location
Epitope IILGLNKI   Epitope Alignment
Variants
ImLGLNKI   observed variant
Species (MHC/HLA human(A2, A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  160
Epitope Seq.  IILGLNKI
Variant Seq.  ImLGLNKI
Mutations I/M
Epitope Location I2M
HXB2 Location I267M
Mutation Type OV: observed variant
Method Flow cytometric T-cell cytokine assay
Note IILGLNKI, elicited a response in 1 patient. The patient autologous sequence was ImLGLNKI.

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


Displaying record number 56302

HXB2 Location  Nef(101-109)   Nef Epitope Map
View variants at this location
Epitope IHSQRRQDI   Epitope Alignment
Variants
IySQkRQDI   susceptible form
Species (MHC/HLA human(A24)

Variant Details

Showing all: 1 variant(s).


Variant ID.  161
Epitope Seq.  IHSQRRQDI
Variant Seq.  IySQkRQDI
Mutations H/Y R/K
Epitope Location H2Y R5K
HXB2 Location H102Y R105K
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay
Note IHSQRRQDI, elicited a response in 1 patient. Patient autologous sequence was IySQkRQDI, which was exclusively targeted over the consensus form IHSQRRQDI.

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


Displaying record number 56303

HXB2 Location  Nef(106-114)   Nef Epitope Map
View variants at this location
Epitope RQDILDLWI   Epitope Alignment
Variants
RQDILDLWv   observed variant
Species (MHC/HLA human(B7)

Variant Details

Showing all: 1 variant(s).


Variant ID.  162
Epitope Seq.  RQDILDLWI
Variant Seq.  RQDILDLWv
Mutations I/V
Epitope Location I9V
HXB2 Location I114V
Mutation Type OV: observed variant
Method Flow cytometric T-cell cytokine assay
Note HLA-B7-restricted epitope, RQDILDLWI, elicited a response in 1 patient. Patient autologous sequence was RQDILDLWv.

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


Displaying record number 56304

HXB2 Location  Nef(107-115)   Nef Epitope Map
View variants at this location
Epitope QDILDLWIY   Epitope Alignment
Variants
QDILDLWvY   susceptible form
Species (MHC/HLA human(B18)

Variant Details

Showing all: 1 variant(s).


Variant ID.  163
Epitope Seq.  QDILDLWIY
Variant Seq.  QDILDLWvY
Mutations I/V
Epitope Location I8V
HXB2 Location I114V
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay
Note QDILDLWIY elicited a response in 1 patient. Patient autologous sequence was QDILDLWvY, which was exclusively targeted over the consensus form QDILDLWIY.

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


Displaying record number 56305

HXB2 Location  Nef(108-115)   Nef Epitope Map
View variants at this location
Epitope DILDLWIY   Epitope Alignment
Variants
DILDLWvY   susceptible form
Species (MHC/HLA human(Cw7)

Variant Details

Showing all: 1 variant(s).


Variant ID.  164
Epitope Seq.  DILDLWIY
Variant Seq.  DILDLWvY
Mutations I/V
Epitope Location I7V
HXB2 Location I114V
Mutation Type SF: susceptible form
Method Flow cytometric T-cell cytokine assay
Note DILDLWIY elicited a response in 1 patient. Patient autologous sequence was DILDLWvY, which was exclusively targeted over the consensus form DILDLWIY.

References

Daucher2008 Marybeth Daucher, David A. Price, Jason M. Brenchley, Laurie Lamoreaux, Julia A. Metcalf, Catherine Rehm, Elizabeth Nies-Kraske, Elizabeth Urban, Christian Yoder, Diane Rock, Julie Gumkowski, Michael R. Betts, Mark R. Dybul, and Daniel C. Douek. Virological Outcome after Structured Interruption of Antiretroviral Therapy for Human Immunodeficiency Virus Infection Is Associated with the Functional Profile of Virus-Specific CD8+ T Cells. J. Virol., 82(8):4102-4114, Apr 2008. PubMed ID: 18234797. Show all entries for this paper.


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