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Found 3 matching records:

Displaying record number 55051

HXB2 Location  Gag(77-85)   Gag Epitope Map
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Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTiATL   subtype-specific non-susceptible form; subtype-specific susceptible form
Species (MHC/HLA human(A*02:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  142
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTiATL
Mutations Y/F V/I
Epitope Location Y3F V6I
HXB2 Location Y79F V82I
Mutation Type SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, C
Variant Subtype A, D
Note SLYNTVATL within peptide SLYNTVATLYC from A consensus and C isolate was recognized by 5/9 HLA A*0201 carriers from subtype A Kenyan cohort. The variant SLfNTiATL within peptide SLfNTiATLYC from A isolate and peptide SLfNTiATLWC from D isolate was recognized by 3 out 5 subjects that recognized SLYNTVATL and not recognized by 2 subjects.

References

Currier2006 Jeffrey R. Currier, Unchalee Visawapoka, Sodsai Tovanabutra, Carl J. Mason, Deborah L. Birx, Francine E. McCutchan, and Josephine H. Cox. CTL Epitope Distribution Patterns in the Gag and Nef Proteins of HIV-1 from Subtype A Infected Subjects in Kenya: Use of Multiple Peptide Sets Increases the Detectable Breadth of the CTL Response. BMC Immunol, 7:8, 2006. PubMed ID: 16620386. Show all entries for this paper.


Displaying record number 55053

HXB2 Location  Gag(162-172)   Gag Epitope Map
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Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KgFnPEVIPMF   subtype-specific non-susceptible form; subtype-specific susceptible form
Species (MHC/HLA human(B*57:01, B*57:03)

Variant Details

Showing all: 1 variant(s).


Variant ID.  143
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFnPEVIPMF
Mutations A/G S/N
Epitope Location A2G S4N
HXB2 Location A163G S165N
Mutation Type SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Epitope Subtype A, C, D
Variant Subtype A
Note KAFSPEVIPMF within peptide EKAFSPEVIPMFSAL from A consensus, C isolate and D isolate was recognized by 5/5 HLA B*5701/B*5703 carriers from subtype A Kenyan cohort. The variant KgFnPEVIPMF within peptide EKgFnPEVIPMFSAL from A isolate was recognized by 3 out 5 subjects that recognized KAFSPEVIPMF and not recognized by 2 subjects.

References

Currier2006 Jeffrey R. Currier, Unchalee Visawapoka, Sodsai Tovanabutra, Carl J. Mason, Deborah L. Birx, Francine E. McCutchan, and Josephine H. Cox. CTL Epitope Distribution Patterns in the Gag and Nef Proteins of HIV-1 from Subtype A Infected Subjects in Kenya: Use of Multiple Peptide Sets Increases the Detectable Breadth of the CTL Response. BMC Immunol, 7:8, 2006. PubMed ID: 16620386. Show all entries for this paper.


Displaying record number 55054

HXB2 Location  Gag(180-188)   Gag Epitope Map
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Epitope TPQDLNMML   Epitope Alignment
Variants
TPQDLNtML   subtype-specific non-susceptible form; subtype-specific susceptible form
Species (MHC/HLA human(B*42:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  144
Epitope Seq.  TPQDLNMML
Variant Seq.  TPQDLNtML
Mutations M/T
Epitope Location M7T
HXB2 Location M186T
Mutation Type SNSF: subtype-specific non-susceptible form
SSF: subtype-specific susceptible form
Note TPQDLNMML within peptide EGATPQDLNMMLNIV from A consensus and A isolate was recognized by 4 HLA B*4202 carriers from subtype A Kenyan cohort. The variant TPQDLNtML within peptide EGATPQDLNtMLNtV from C and D isolates was recognized by only 1 out 4 subjects that recognized TPQDLNMML.

References

Currier2006 Jeffrey R. Currier, Unchalee Visawapoka, Sodsai Tovanabutra, Carl J. Mason, Deborah L. Birx, Francine E. McCutchan, and Josephine H. Cox. CTL Epitope Distribution Patterns in the Gag and Nef Proteins of HIV-1 from Subtype A Infected Subjects in Kenya: Use of Multiple Peptide Sets Increases the Detectable Breadth of the CTL Response. BMC Immunol, 7:8, 2006. PubMed ID: 16620386. Show all entries for this paper.


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