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Found 2 matching records:

Displaying record number 53636

HXB2 Location  Gag(147-155)   Gag Epitope Map
View variants at this location
Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   observed variant
Epitope Name IW9
Species (MHC/HLA human(B57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  138
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy
Note ISPRTLNAW had a variant lSPRTLNAW in 7/10 B57+ subjects, and 4/9 B57- subjects; 2 other variants were observed, but there was no apparent sequence selection in this epitope.

References

Currier2005 Jeffrey R. Currier, Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. Immunodominance and Cross-Reactivity of B5703-Restricted CD8 T Lymphocytes from HIV Type 1 Subtype C-Infected Ethiopians. AIDS Res. Hum. Retroviruses, 21(3):239-245, Mar 2005. PubMed ID: 15795531. Show all entries for this paper.


Displaying record number 53635

HXB2 Location  Gag(162-172)   Gag Epitope Map
View variants at this location
Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KnFSPEVIPMF   non-susceptible form; susceptible form
rAFSPEVIPMF   non-susceptible form; susceptible form
KgFnPEVIPMF   non-susceptible form; susceptible form
Epitope Name KF11
Species (MHC/HLA human(B*57:03)

Variant Details

Showing all: 3 variant(s).


Variant ID.  139
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KnFSPEVIPMF
Mutations A/N
Epitope Location A2N
HXB2 Location A163N
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note 5 variants of the epitope were observed: KAFSPEVIPMF, KnFSPEVIPMF, rAFSPEVIPMF, and KgFnPEVIPMF. Depending on the subject, different versions of these variants were more or less susceptible to their CD8+ T cells, i.e., one person's escape form was another person's susceptible form. Responses against KnFSPEVIPMF were strong but subdominant in subjects carrying KAFSPEVIPMF and KnFSPEVIPMF and there was little or no response in subjects carrying KgFnPEVIPMF.


Variant ID.  140
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  rAFSPEVIPMF
Mutations K/R
Epitope Location K1R
HXB2 Location K162R
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note 5 variants of the epitope were observed: KAFSPEVIPMF, KnFSPEVIPMF, rAFSPEVIPMF, and KgFnPEVIPMF. Depending on the subject, different versions of these variants were more or less susceptible to their CD8+ T cells, i.e., one person's escape form was another person's susceptible form. Responses against rAFSPEVIPMF were among maximal in subjects carrying KAFSPEVIPMF, KnFSPEVIPMF and rAFSPEVIPMF but there was little or no response in subjects carrying KgFnPEVIPMF.


Variant ID.  141
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KgFnPEVIPMF
Mutations A/G S/N
Epitope Location A2G S4N
HXB2 Location A163G S165N
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note 5 variants of the epitope were observed: KAFSPEVIPMF, KnFSPEVIPMF, rAFSPEVIPMF, and KgFnPEVIPMF. Depending on the subject, different versions of these variants were more or less susceptible to their CD8+ T cells, i.e., one person's escape form was another person's susceptible form. Responses against KgFnPEVIPMF were strong but subdominant in subjects carrying KAFSPEVIPMF and KnFSPEVIPMF. In subjects carrying KgFnPEVIPMF there was a strong response against the index peptide but little or no response against other peptides. Subject carrying provirus with rAFSPEVIPMF showed dramatic nonrecognition of KgFnPEVIPMF.

References

Currier2005 Jeffrey R. Currier, Matthew E. Harris, Josephine H. Cox, Francine E. McCutchan, Deborah L. Birx, Shlomo Maayan, and Guido Ferrari. Immunodominance and Cross-Reactivity of B5703-Restricted CD8 T Lymphocytes from HIV Type 1 Subtype C-Infected Ethiopians. AIDS Res. Hum. Retroviruses, 21(3):239-245, Mar 2005. PubMed ID: 15795531. Show all entries for this paper.


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