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Found 4 matching records:

Displaying record number 60505

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
pLYNTVATL   HLA association; TCR related mutation
SLfNTVATL   HLA association; TCR related mutation
SLYNTiATL   HLA association; TCR related mutation
SLfNTVAvL   HLA association; TCR related mutation
SLfNaVAvL   HLA association; TCR related mutation
Epitope Name A2-SL9
Species (MHC/HLA human

Variant Details

Showing all: 5 variant(s).


Variant ID.  3502
Epitope Seq.  SLYNTVATL
Variant Seq.  pLYNTVATL
Mutations S/P
Epitope Location S1P
HXB2 Location S77P
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 6 (ACS 18840) carried 5.3% pLYNTVATL.


Variant ID.  3503
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note By t2, subject 5 (ACS 19342) carried 100% SLfNTVATL, and at t1 subject 7 (ACS 19453) carried 51.7% of this variant that was lost by t2.


Variant ID.  3504
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t2, subject 1 (ACS 19957) carried 100% SLYNTiATL while subject 7 (AC 18839) had 9.7% of this variant by t2.


Variant ID.  3505
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVAvL
Mutations Y/F T/V
Epitope Location Y3F T8V
HXB2 Location Y79F T84V
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t2, subject 2 (ACS 19957) carried 93.8% SLfNTVAvL.


Variant ID.  3506
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNaVAvL
Mutations Y/F T/A T/V
Epitope Location Y3F T5A T8V
HXB2 Location Y79F T81A T84V
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 2 (ACS 19957) carried 100% SLfNaVAvL, which decreased to 6.3% with reversion of T81A to T at t2.

References

Costa2015 Ana I. Costa, Dan Koning, Kristin Ladell, James E. McLaren, Bart P. X. Grady, Ingrid M. M. Schellens, Petra van Ham, Monique Nijhuis, José A. M. Borghans, Can Keşmir, David A. Price, and Debbie van Baarle. Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1. J. Virol., 89(1):110-119, Jan 2015. PubMed ID: 25320304. Show all entries for this paper.


Displaying record number 60506

HXB2 Location  Gag(260-267)   Gag Epitope Map
View variants at this location
Epitope EIYKRWII   Epitope Alignment
Variants
dIYKRWII   HLA association; TCR related mutation
EIYeRWII   HLA association; TCR related mutation
EIYKRWIv   HLA association; TCR related mutation
EIYrRWII   HLA association; TCR related mutation
Epitope Name B8-EI8
Species (MHC/HLA human

Variant Details

Showing all: 4 variant(s).


Variant ID.  3507
Epitope Seq.  EIYKRWII
Variant Seq.  dIYKRWII
Mutations E/D
Epitope Location E1D
HXB2 Location E128D
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t2, subject 5 (ACS 19342) carried 100% dIYKRWII.


Variant ID.  3508
Epitope Seq.  EIYKRWII
Variant Seq.  EIYeRWII
Mutations K/E
Epitope Location K4E
HXB2 Location K131E
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 5 (ACS 19342) carried 3.2% EIYeRWII which was completely lost by t2.


Variant ID.  3509
Epitope Seq.  EIYKRWII
Variant Seq.  EIYKRWIv
Mutations I/V
Epitope Location I8V
HXB2 Location I135V
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t2, subject 5 (ACS 19342) carried 14.3% EIYKRWIv.


Variant ID.  3510
Epitope Seq.  EIYKRWII
Variant Seq.  EIYrRWII
Mutations K/R
Epitope Location K4R
HXB2 Location K131R
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t2, subject 7 (ACS 18839) carried 14.3% EIYKRWIv.

References

Costa2015 Ana I. Costa, Dan Koning, Kristin Ladell, James E. McLaren, Bart P. X. Grady, Ingrid M. M. Schellens, Petra van Ham, Monique Nijhuis, José A. M. Borghans, Can Keşmir, David A. Price, and Debbie van Baarle. Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1. J. Virol., 89(1):110-119, Jan 2015. PubMed ID: 25320304. Show all entries for this paper.


Displaying record number 60508

HXB2 Location  Gag(263-272)   Gag Epitope Map
View variants at this location
Epitope KRWIILGLNK   Epitope Alignment
Variants
eRWIILGLNK   HLA association; TCR related mutation
rRWIILGLNK   HLA association; TCR related mutation
KRWIIpGLNK   HLA association; TCR related mutation
KRWIImGLNK   HLA association; TCR related mutation
KRWIvmGLNK   HLA association; TCR related mutation
KRWIIiGLNK   HLA association; TCR related mutation
Epitope Name B27-KK10
Species (MHC/HLA human

Variant Details

Showing all: 6 variant(s).


Variant ID.  3516
Epitope Seq.  KRWIILGLNK
Variant Seq.  eRWIILGLNK
Mutations K/E
Epitope Location K1E
HXB2 Location K131E
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 2 (ACS 19885) carried 3.2% eRWIILGLNK.


Variant ID.  3517
Epitope Seq.  KRWIILGLNK
Variant Seq.  rRWIILGLNK
Mutations K/R
Epitope Location K1R
HXB2 Location K131R
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t2, subject 7 (ACS 18839) carried 5.3% rRWIILGLNK.


Variant ID.  3518
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIIpGLNK
Mutations L/P
Epitope Location L6P
HXB2 Location L136P
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 2 (ACS 19885) carried 3.2% KRWIIpGLNK.


Variant ID.  3519
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L136M
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 6 (ACS 18840) carried 68% KRWIImGLNK. Subject 7 (ACS 18839) carried 100% of this variant at t1 and 42.1% at t2.


Variant ID.  3520
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIvmGLNK
Mutations I/V L/M
Epitope Location I5V L6M
HXB2 Location I135V L136M
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t2, subject 2 (ACS 19885) carried 14.3% KRWIvmGLNK.


Variant ID.  3521
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIIiGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L136M
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 6 (ACS 18840) carried 4% KRWIIiGLNK.

References

Costa2015 Ana I. Costa, Dan Koning, Kristin Ladell, James E. McLaren, Bart P. X. Grady, Ingrid M. M. Schellens, Petra van Ham, Monique Nijhuis, José A. M. Borghans, Can Keşmir, David A. Price, and Debbie van Baarle. Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1. J. Virol., 89(1):110-119, Jan 2015. PubMed ID: 25320304. Show all entries for this paper.


Displaying record number 60507

HXB2 Location  Nef(90-97)   Nef Epitope Map
View variants at this location
Epitope FLKEKGGL   Epitope Alignment
Variants
FLKErGGL   HLA association; TCR related mutation
FLKEmGGL   HLA association; TCR related mutation
FLKEtGGL   HLA association; TCR related mutation
FLKEeGGL   HLA association; TCR related mutation
FLrEKGGL   HLA association; TCR related mutation
Epitope Name B8-FL8
Species (MHC/HLA human

Variant Details

Showing all: 5 variant(s).


Variant ID.  3511
Epitope Seq.  FLKEKGGL
Variant Seq.  FLKErGGL
Mutations K/R
Epitope Location K5R
HXB2 Location K94R
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 1 (ACS 19957) carried 1.6% FLKErGGL; subject 7 carried 36% of this variant at t1, and 97.6% at t2.


Variant ID.  3512
Epitope Seq.  FLKEKGGL
Variant Seq.  FLKEmGGL
Mutations K/M
Epitope Location K5M
HXB2 Location K94M
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t2, subject 1 (ACS 19957) carried 93.4% FLKEmGGL and subject 4 (ACS 19453) carried 86.7%.


Variant ID.  3513
Epitope Seq.  FLKEKGGL
Variant Seq.  FLKEtGGL
Mutations K/T
Epitope Location K5T
HXB2 Location K94T
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 1 (ACS 19957) carried 79.2% FLKEtGGL.


Variant ID.  3514
Epitope Seq.  FLKEKGGL
Variant Seq.  FLKEeGGL
Mutations K/E
Epitope Location K5E
HXB2 Location K94E
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 8 (ACS 18785) carried 14% FLKEeGGL that was lost by t2; at t2 subjects 5 (ACS 19342) and 7 (ACS 18839) carried 100% and 2.4% of this variant respectively.


Variant ID.  3515
Epitope Seq.  FLKEKGGL
Variant Seq.  FLrEKGGL
Mutations K/R
Epitope Location K3R
HXB2 Location K92R
Mutation Type A: HLA association
TCR: TCR related mutation
Method Other, Tetramer binding
Note At t1, subject 2 (ACS 19885) carried 100% FLrEKGGL.

References

Costa2015 Ana I. Costa, Dan Koning, Kristin Ladell, James E. McLaren, Bart P. X. Grady, Ingrid M. M. Schellens, Petra van Ham, Monique Nijhuis, José A. M. Borghans, Can Keşmir, David A. Price, and Debbie van Baarle. Complex T-Cell Receptor Repertoire Dynamics Underlie the CD8+ T-Cell Response to HIV-1. J. Virol., 89(1):110-119, Jan 2015. PubMed ID: 25320304. Show all entries for this paper.


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