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Found 1 matching record:

Displaying record number 53188

HXB2 Location  Gag(197-205)   Gag Epitope Map
View variants at this location
Epitope ANQMLKDTI   Epitope Alignment
Variants
ANQMLKeTI   subtype-specific susceptible form
Species (MHC/HLA mouse(H-2d)

Variant Details

Showing all: 1 variant(s).


Variant ID.  121
Epitope Seq.  ANQMLKDTI
Variant Seq.  ANQMLKeTI
Mutations D/E
Epitope Location D7E
HXB2 Location D203E
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype C
Variant Subtype B
Method CD4 T-cell Elispot - IFNy, CD8 T-cell Elispot - IFNy, Cytokine production, Cytolytic LDH release assay
Note A cross-clade response to the C clade epitope ANQMLKDTI was observed to the B clade version of this epitope, aNqmlkEti. 66% lysis was observed to the peptide carrying the C clade epitope, only 33% to the B clade variant.

References

Chugh2004 Priti Chugh and Pradeep Seth. Induction of Broad-Based Immune Response against HIV-1 Subtype C gag DNA Vaccine in Mice. Viral Immunol., 17(3):423-435, 2004. Erratum in Viral Immunol. 2004;17(4):620. PubMed ID: 15357908. Show all entries for this paper.


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