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Found 9 matching records:

Displaying record number 23

HXB2 Location  Gag(20-28)   Gag Epitope Map
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Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGKKh   subtype-specific susceptible form
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  98
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKh
Mutations K/H
Epitope Location K9H
HXB2 Location K28H
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype A, B, D
Variant Subtype C
Method Chromium-release assay
Note The consensus peptide of C clade viruses is RLRPGGKKh and is equally reactive.

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 96

HXB2 Location  Gag(77-85)   Gag Epitope Map
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Epitope SLYNTVATL   Epitope Alignment
Variants
SLfNTVATL   subtype-specific susceptible form
Epitope Name SL9
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  99
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, C, D
Variant Subtype A, C
Method Chromium-release assay
Note The consensus peptides of B and D clade viruses and some Cs have the sequence SLYNTVATL. The consensus peptide of A, and some C strains is SLFNTVATL, a form that is cross-reactive.

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 320

HXB2 Location  Gag(298-306)   Gag Epitope Map
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Epitope DRFYKTLRA   Epitope Alignment
Variants
DRFfKTLRA   subtype-specific susceptible form
Species (MHC/HLA human(B14)

Variant Details

Showing all: 1 variant(s).


Variant ID.  110
Epitope Seq.  DRFYKTLRA
Variant Seq.  DRFfKTLRA
Mutations Y/F
Epitope Location Y4F
HXB2 Location Y301F
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, D
Variant Subtype A, C
Method Chromium-release assay
Note The consensus peptide for clades B and D is DRFYKTLRA. The consensus peptide for clades A and C is DRFFKTLRA and it is equally reactive.

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 447

HXB2 Location  Pol(313-321)   Pol Epitope Map
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Epitope AIFQSSMTK   Epitope Alignment
Variants
AIFQaSMTK   diminished response; subtype-specific susceptible form
sIFQSSMTK   subtype-specific susceptible form
Species (MHC/HLA human(A3)

Variant Details

Showing all: 2 variant(s).


Variant ID.  100
Epitope Seq.  AIFQSSMTK
Variant Seq.  AIFQaSMTK
Mutations S/A
Epitope Location S5A
HXB2 Location S317A
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype B, D
Variant Subtype A
Method Chromium-release assay
Note The consensus peptide of B and D clade viruses is AIFQSSMTK. The consensus peptide of a subset of A clade viruses is AIFQASMTK, and it is less able to stimulate the CTL clone.


Variant ID.  101
Epitope Seq.  AIFQSSMTK
Variant Seq.  sIFQSSMTK
Mutations A/S
Epitope Location A1S
HXB2 Location A313S
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, D
Variant Subtype A
Method Chromium-release assay
Note The consensus peptide of B and D clade viruses is AIFQSSMTK. The consensus peptide of a subset of A clade viruses is SIFQSSMTK, and it is as reactive as the originally defined epitope.

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 518

HXB2 Location  Pol(464-472)   Pol Epitope Map
View variants at this location
Epitope ILKEPVHGV   Epitope Alignment
Variants
ILKdPVHGV   subtype-specific non-susceptible form
Species (MHC/HLA human(A2)

Variant Details

Showing all: 1 variant(s).


Variant ID.  109
Epitope Seq.  ILKEPVHGV
Variant Seq.  ILKdPVHGV
Mutations E/D
Epitope Location E4D
HXB2 Location E467D
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype A, B, D
Variant Subtype A
Method Chromium-release assay
Note The consensus peptides of B and D clade viruses and some As have the sequence ILKEPVHGV. The consensus peptide of a subset of A clade viruses, ILKDPVHGV, is not cross-reactive.

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.

Menendez-Arias1998 L. Menendez-Arias, A. Mas, and E. Domingo. Cytotoxic T-Lymphocyte Responses to HIV-1 Reverse Transcriptase. Viral Immunol., 11:167-181, 1998. PubMed ID: 10189185. Show all entries for this paper.


Displaying record number 640

HXB2 Location  gp160(42-52)   gp160 Epitope Map
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Epitope VPVWKEATTTL   Epitope Alignment
Variants
VPVWKEAdTTL   subtype-specific susceptible form
VPVWrdAdTTL   subtype-specific susceptible form
VPVWKdAeTTL   subtype-specific susceptible form
Species (MHC/HLA human(B35)

Variant Details

Showing all: 3 variant(s).


Variant ID.  102
Epitope Seq.  VPVWKEATTTL
Variant Seq.  VPVWKEAdTTL
Mutations T/D
Epitope Location T8D
HXB2 Location T49D
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, D
Variant Subtype C
Method Chromium-release assay
Note VPVWKEATTTL is the consensus sequence for clades B and D.VPVWKEAdTTL is the consensus sequence for clade C and it is cross-reactive.


Variant ID.  103
Epitope Seq.  VPVWKEATTTL
Variant Seq.  VPVWrdAdTTL
Mutations K/R E/D T/D
Epitope Location K5R E6D T8D
HXB2 Location K46R E47D T49D
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, D
Variant Subtype C
Method Chromium-release assay
Note VPVWKEATTTL is the consensus sequence for clades B and D. VPVWrdAdTTL is the consensus sequence for clade E and even with three substitutions still retains some cross-reactivity.


Variant ID.  2932
Epitope Seq.  VPVWKEATTTL
Variant Seq.  VPVWKdAeTTL
Mutations E/D T/E
Epitope Location E6D T8E
HXB2 Location E47D T49E
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, D
Variant Subtype C
Method Chromium-release assay
Note VPVWKEATTTL is the consensus sequence for clades B and D. VPVWKdAeTTL is the consensus sequence for clade A and it is cross-reactive.

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 818

HXB2 Location  gp160(584-592)   gp160 Epitope Map
View variants at this location
Epitope ERYLKDQQL   Epitope Alignment
Variants
ERYLrDQQL   subtype-specific susceptible form
ERYLKDQQf   subtype-specific non-susceptible form
Species (MHC/HLA human(B14)

Variant Details

Showing all: 2 variant(s).


Variant ID.  104
Epitope Seq.  ERYLKDQQL
Variant Seq.  ERYLrDQQL
Mutations K/R
Epitope Location K5R
HXB2 Location K588R
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype B, C, D
Variant Subtype A
Method Chromium-release assay
Note The consensus sequence for clades B, C, and D is ERYLKDQQL. The consensus sequence for clade A is ERYLRDQQL and it is equally reactive.


Variant ID.  2255
Epitope Seq.  ERYLKDQQL
Variant Seq.  ERYLKDQQf
Mutations L/F
Epitope Location L9F
HXB2 Location L592F
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B, C, D
Variant Subtype CRF01_AE
Method Chromium-release assay
Note The consensus sequence for clades B, C, and D is ERYLKDQQL. The consensus sequence for clade E is ERYLKDQKF and it is not reactive.

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 864

HXB2 Location  gp160(770-780)   gp160 Epitope Map
View variants at this location
Epitope RLRDLLLIVTR   Epitope Alignment
Variants
RLRDfiLIVTR   diminished response; subtype-specific susceptible form
SLRDLLLIVTR   diminished response; subtype-specific susceptible form
Species (MHC/HLA human(A3)

Variant Details

Showing all: 2 variant(s).


Variant ID.  106
Epitope Seq.  RLRDLLLIVTR
Variant Seq.  RLRDfiLIVTR
Mutations L/F L/I
Epitope Location L5F L6I
HXB2 Location L774F L775I
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype A, C, CRF01_AE
Method Chromium-release assay
Note The consensus peptide of clade B is RLRDLLLIVTR. The consensus peptide of clades A, C and E is RLRDFILIVTR and it is less reactive.


Variant ID.  107
Epitope Seq.  RLRDLLLIVTR
Variant Seq.  SLRDLLLIVTR
Mutations R/S
Epitope Location R1S
HXB2 Location R770S
Mutation Type DR: diminished response
SSF: subtype-specific susceptible form
Epitope Subtype B
Variant Subtype D
Method Chromium-release assay
Note The consensus peptide of clade B is RLRDLLLIVTR. The consensus peptide of clade D is SLRDLLLIVTR and it is less reactive.

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


Displaying record number 895

HXB2 Location  gp160(843-851)   gp160 Epitope Map
View variants at this location
Epitope IPRRIRQGL   Epitope Alignment
Variants
IPRRIRQGf   subtype-specific susceptible form
Species (MHC/HLA human(B7)

Variant Details

Showing all: 1 variant(s).


Variant ID.  108
Epitope Seq.  IPRRIRQGL
Variant Seq.  IPRRIRQGf
Mutations L/F
Epitope Location L9F
HXB2 Location L851F
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype A, B, D, F
Variant Subtype C
Method Chromium-release assay
Note The consensus peptide of clades A, B, D, and F is IPRRIRQGL. The consensus peptide of clade C is iprrirqgF, and it is equally reactive.

References

Cao1997a H. Cao, P. Kanki, J. L. Sankale, A. Dieng-Sarr, Gail P. Mazzara, S. Kalams, B. Korber, S. M'Boup, and B. D. Walker. CTL Cross-Reactivity among Different HIV-1 Clades: Implications for Vaccine Development. J. Virol., 71:8615-8623, 1997. PubMed ID: 9343219. Show all entries for this paper.


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