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Found 7 matching records:

Displaying record number 59207

HXB2 Location  Gag(147-155)   Gag Epitope Map
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Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   observed variant
ltPRTLNAW   observed variant
ItPRTLNAW   observed variant
IaPRTLNAW   observed variant
IlPRTLNAW   observed variant
Epitope Name ISW9
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 5 variant(s).


Variant ID.  3339
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant lSPRTLNAW, was seen in 2/3 HRPs and 2/3 LRPs. lSPRTLNAW was the only analogous ISW9 in patient P1 and was found in the major viral population in patients P5 and P6 at latter time points.


Variant ID.  3340
Epitope Seq.  ISPRTLNAW
Variant Seq.  ltPRTLNAW
Mutations I/L S/T
Epitope Location I1L S2T
HXB2 Location I147L S148T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant ltPRTLNAW, was seen in 0/3 HRPs and 1/3 LRPs (patient P4) at the last sampling point.


Variant ID.  3341
Epitope Seq.  ISPRTLNAW
Variant Seq.  ItPRTLNAW
Mutations S/T
Epitope Location S2T
HXB2 Location S148T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant ItPRTLNAW, was seen in 0/3 HRPs and 1/3 LRPs. It was the predominant variant in subject P4.


Variant ID.  3342
Epitope Seq.  ISPRTLNAW
Variant Seq.  IaPRTLNAW
Mutations S/A
Epitope Location S2A
HXB2 Location S148A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant ItPRTLNAW, was seen in 1/3 HRPs and 0/3 LRPs. It was the predominant variant in subject P4.


Variant ID.  3343
Epitope Seq.  ISPRTLNAW
Variant Seq.  IlPRTLNAW
Mutations S/L
Epitope Location S2L
HXB2 Location S148L
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant IlPRTLNAW, was seen in 1/3 HRPs and 0/3 LRPs. It was an early variant in Gag that was later lost in subject P3.

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Displaying record number 59208

HXB2 Location  Gag(162-172)   Gag Epitope Map
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Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KAFSPEVIPMs   observed variant
KAFSPEVIPMt   observed variant
KAFSPEiIPMF   observed variant
KAsSPEVIPMF   observed variant
Epitope Name KF11
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 4 variant(s).


Variant ID.  3344
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPEVIPMs
Mutations F/S
Epitope Location F11S
HXB2 Location F172S
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant KAFSPEVIPMs was seen in 1/3 HRP subjects (patient P1).


Variant ID.  3345
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPEVIPMt
Mutations F/T
Epitope Location F11T
HXB2 Location F172T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant KAFSPEVIPMt was seen in 1/3 HRP (patient P1) and 1/3 LRP (patient P6) subjects.


Variant ID.  3346
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAFSPEiIPMF
Mutations V/I
Epitope Location V7I
HXB2 Location V168I
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant KAFSPEiIPMF was seen in 1/3 HRP (patient P1) and 1/3 LRP (patient P6) subjects.


Variant ID.  3347
Epitope Seq.  KAFSPEVIPMF
Variant Seq.  KAsSPEVIPMF
Mutations F/S
Epitope Location F3S
HXB2 Location F164S
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant KAsSPEVIPMF was seen in 1/3 LRP (patient P6) subjects.

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Displaying record number 59210

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSTLrEQIGW   observed variant
TSTLQEQIeW   observed variant
TSsLQEQIGW   observed variant
TSnLQEQIGW   escape documented in this paper; observed variant
TSnLQEQIrW   observed variant
TSnLQEQItW   observed variant
TSnLQEQIaW   escape documented in this paper; observed variant
TSTLQEQIaW   observed variant
Epitope Name TW10
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 8 variant(s).


Variant ID.  3348
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLrEQIGW
Mutations Q/R
Epitope Location Q5R
HXB2 Location Q244R
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSTLrEQIGW was seen in 1/3 HRP (patient P1) subjects.


Variant ID.  3349
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIeW
Mutations Q/R G/E
Epitope Location Q5R G9E
HXB2 Location Q244R G248E
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSTLQEQIeW was seen in 1/3 HRP (patient P1) and 1/3 LRP (patient 5) subjects.


Variant ID.  3350
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSsLQEQIGW
Mutations T/S
Epitope Location T3S
HXB2 Location T242S
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSTLrEQIeW was seen in 1/3 HRP (patient P2) subjects.


Variant ID.  3351
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIGW
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSnLQEQIGW, TW10-3N was seen in all 6 HRP and LRP subjects.


Variant ID.  3352
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIrW
Mutations T/N G/R
Epitope Location T3N G9R
HXB2 Location T242N G248R
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSnLQEQIrW was seen in all 1/3 HRP (patient P2) subjects.


Variant ID.  3353
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQItW
Mutations T/N G/T
Epitope Location T3N G9T
HXB2 Location T242N G248T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSnLQEQItW was seen in all 1/3 HRP (patient P2) subjects.


Variant ID.  3354
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIaW
Mutations T/N G/A
Epitope Location T3N G9A
HXB2 Location T242N G248A
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSnLQEQIaW, TW10-3N-9A, was seen in 1/3 HRP (patient P3) and 1/3 LRP (patient 5) subjects. It was the analogous epitope of the major viral population at the last time point in patient P1, the earliest time point in patients P2 and P3, and the only variant in LRP patients P4 and P6.


Variant ID.  3355
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIaW
Mutations G/A
Epitope Location G9A
HXB2 Location G248A
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant TSTLQEQIaW was seen in 1/3 LRP (patient 5) subjects.

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Displaying record number 59209

HXB2 Location  Gag(308-316)   Gag Epitope Map
View variants at this location
Epitope QASQEVKNW   Epitope Alignment
Variants
QASQdVKNW   observed variant
QASQtVKNW   observed variant
Epitope Name QW9
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3356
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQdVKNW
Mutations E/D
Epitope Location E5D
HXB2 Location E312D
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant QASQdVKNW was seen in 2/3 HRP and no LRP subjects. It was the analogous epitope of the major viral population at the last time points in patient P3, the earliest time point in patient P1.


Variant ID.  3357
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQtVKNW
Mutations E/T
Epitope Location E5T
HXB2 Location E312T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant QASQtVKNW was seen in 1/3 HRP and no LRP subjects. It was the only analogous epitope of the major viral population patient P2.

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Displaying record number 59211

HXB2 Location  Nef(82-91)   Nef Epitope Map
View variants at this location
Epitope KAALDLSHFL   Epitope Alignment
Variants
KAALDLSHlL   observed variant
rAALDLSHFL   observed variant
rAALDLSHlL   observed variant
rAAvDLSHFL   observed variant
KgALDLSHFL   observed variant
KAAvDLSHFL   observed variant
Epitope Name KL10
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 6 variant(s).


Variant ID.  3358
Epitope Seq.  KAALDLSHFL
Variant Seq.  KAALDLSHlL
Mutations F/L
Epitope Location F9L
HXB2 Location F90L
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant KAALDLSHlL was seen in 1/3 HRP (patient P2) and 2/3 LRP (patients P4, P6) subjects.


Variant ID.  3359
Epitope Seq.  KAALDLSHFL
Variant Seq.  rAALDLSHFL
Mutations K/R
Epitope Location K1R
HXB2 Location K82R
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant rAALDLSHlL was seen in 1/3 LRP (patient P6) and no HRP subjects.


Variant ID.  3360
Epitope Seq.  KAALDLSHFL
Variant Seq.  rAALDLSHlL
Mutations K/R F/L
Epitope Location K1R F9L
HXB2 Location K82R F90L
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant rAALDLSHlL was seen in no HRP and 1/3 LRP (patient P6) subjects.


Variant ID.  3361
Epitope Seq.  KAALDLSHFL
Variant Seq.  rAAvDLSHFL
Mutations K/R L/V
Epitope Location K1R L4V
HXB2 Location K82R L85V
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant rAAvDLSHFL was seen in no HRP and 1/3 LRP (patient P6) subjects and was the major analogous epitope at later time points.


Variant ID.  3362
Epitope Seq.  KAALDLSHFL
Variant Seq.  KgALDLSHFL
Mutations A/G
Epitope Location A2G
HXB2 Location A83G
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant KgALDLSHFL was seen in 1/3 HRP (patient P3) and 1/3 (patient P4) LRP subjects. It was the autologous epitope of the major viral population in the later time points for the LRP but the only epitope in the HRP.


Variant ID.  3363
Epitope Seq.  KAALDLSHFL
Variant Seq.  KAAvDLSHFL
Mutations L/V
Epitope Location L4V
HXB2 Location L85V
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant KAAvDLSHFL was seen in no HRP and 2/3 LRP subjects. It was the autologous epitope of the major viral population at the first time point for the patient P6 but was then lost.

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Displaying record number 59212

HXB2 Location  Nef(116-125)   Nef Epitope Map
View variants at this location
Epitope HTQGYFPDWQ   Epitope Alignment
Variants
nTQGYFPDWQ   observed variant
Epitope Name HQ10
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3364
Epitope Seq.  HTQGYFPDWQ
Variant Seq.  nTQGYFPDWQ
Mutations H/N
Epitope Location H1N
HXB2 Location H116N
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant nTQGYFPDWQ was seen in 2/3 HRP and all 3 LRP subjects. It was the autologous epitope of the major viral population in patients P2, P3 and P6; and it was the only form in patients P4 and P5.

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


Displaying record number 59213

HXB2 Location  Nef(120-128)   Nef Epitope Map
View variants at this location
Epitope YFPDWQNYT   Epitope Alignment
Variants
YFPDWQcYT   observed variant
YFPDWQchT   observed variant
Epitope Name YT9
Species (MHC/HLA human(B*57:01)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3365
Epitope Seq.  YFPDWQNYT
Variant Seq.  YFPDWQcYT
Mutations N/C
Epitope Location N7C
HXB2 Location N126C
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant YFPDWQcYT was an autologous epitope found in 1/3 HRP (patient P2) and 1/3 LRP (patient P4).


Variant ID.  3366
Epitope Seq.  YFPDWQNYT
Variant Seq.  YFPDWQchT
Mutations N/C Y/H
Epitope Location N7C Y8H
HXB2 Location N126C Y127H
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method HLA binding, Intracellular cytokine staining, Sequence
Note Variant YFPDWQchT was an autologous epitope found in no HRP and 1/3 LRP (patient P4).

References

Buggert2014 Marcus Buggert, Melissa M. Norström, Marco Salemi, Frederick M. Hecht, and Annika C. Karlsson. Functional Avidity and IL-2/Perforin Production Is Linked to the Emergence of Mutations within HLA-B*5701-Restricted Epitopes and HIV-1 Disease Progression. J. Immunol., 192(10):4685-4696, 15 May 2014. PubMed ID: 24740510. Show all entries for this paper.


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