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Found 13 matching records:

Displaying record number 58746

HXB2 Location Gag(17-31) Gag Epitope Map
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Epitope

EKIRLRPGGKKKYKL

Epitope Alignment

Variants

EKIRLRPGGKKKYqL non-susceptible form; susceptible form

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3135`
Epitope Seq.	`EKIRLRPGGKKKYKL`
Variant Seq.	`EKIRLRPGGKKKYqL`
Mutations	K/Q
Epitope Location	K14Q
HXB2 Location	K162Q
Mutation Type	NSF: non-susceptible form SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Variant EKIRLRPGGKKKYqL was detected in CP2 and ES2 HIV-1 sequences, but is only recognized by CTL from subject CP2.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.

Displaying record number 58743

HXB2 Location Gag(147-155) Gag Epitope Map
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Epitope

ISPRTLNAW

Epitope Alignment

Variants

lSPRTLNAW non-susceptible form; susceptible form

Species (MHC/HLA) human(B*57)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3131`
Epitope Seq.	`ISPRTLNAW`
Variant Seq.	`lSPRTLNAW`
Mutations	I/L
Epitope Location	I1L
HXB2 Location	I147L
Mutation Type	NSF: non-susceptible form SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Mutant epitope lSPRTLNAW is recognized only by subject ES38 as seen by EliSpot; though it is found in both ES38 and CP2 HIV-1.

References

Displaying record number 58741

HXB2 Location Gag(162-172) Gag Epitope Map
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Epitope

KAFSPEVIPMF

Epitope Alignment

Variants

KAFSPEVIPMF{t} literature escape; non-susceptible form; susceptible form

Epitope Name KF11

Species (MHC/HLA) human(B*57)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3130`
Epitope Seq.	`KAFSPEVIPMF{S}`
Variant Seq.	`KAFSPEVIPMF{t}`
Mutations	S/T
Epitope Location	S+1T
HXB2 Location	S173T
Mutation Type	LE: literature escape NSF: non-susceptible form SF: susceptible form
Method	CD4 T-cell Elispot - IFNy, Sequence
Note	The S173T mutation to epitope KF11 is seen and recognized in HLA-B57 individuals like ES38, but in this case was present in both ES38 as well as non-B57-subject, CP2.

References

Displaying record number 58728

HXB2 Location Gag(213-227) Gag Epitope Map
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Epitope

DRLHPVHAGPIAPGQ

Epitope Alignment

Variants

DRvHPVHAGPIAPGQ susceptible form

Epitope Name DQ15

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3128`
Epitope Seq.	`DRLHPVHAGPIAPGQ`
Variant Seq.	`DRvHPVHAGPIAPGQ`
Mutations	L/V
Epitope Location	L3V
HXB2 Location	L215V
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Epitope DQ15 was seen to mutate to DRvHPVHAGPIAPGQ in subject CP1 but not in the controller, VC1. Subject CP1 recognizes DRvHPVHAGPIAPGQ as shown by EliSpot.

References

Displaying record number 58744

HXB2 Location Gag(240-249) Gag Epitope Map
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Epitope

TSTLQEQIGW

Epitope Alignment

Variants

`TSTLQEQIaW`		susceptible form
`TSTLQEQvaW`		non-susceptible form

Species (MHC/HLA) human(B*57)

Variant Details

Showing all: 2 variant(s).

Variant ID.	`3132`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSTLQEQIaW`
Mutations	G/A
Epitope Location	G9A
HXB2 Location	G248A
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Mutant TSTLQEQIaW was seen in and recognized by subject ES38.

Variant ID.	`3133`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSTLQEQvaW`
Mutations	I/V G/A
Epitope Location	I8V G9A
HXB2 Location	I247V G248A
Mutation Type	NSF: non-susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Mutant TSTLQEQvaW was seen in CP2 Gag sequences even though CP2 does not carry the HLA-B*57 allele. Subject CP2 was not able to recognize this sequence by EliSpot.

References

Displaying record number 58747

HXB2 Location Gag(249-263) Gag Epitope Map
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Epitope

WMTNNPPIPVGEIYK

Epitope Alignment

Variants

WMTsNPPvPVGEIYK non-susceptible form; susceptible form

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3136`
Epitope Seq.	`WMTNNPPIPVGEIYK`
Variant Seq.	`WMTsNPPvPVGEIYK`
Mutations	N/S I/V
Epitope Location	N4S I8V
HXB2 Location	N252S I256V
Mutation Type	NSF: non-susceptible form SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, CTL suppression of replication, Intracellular cytokine staining
Note	WMTsNPPvPVGEIYK was a variant found in both CP2 and ES38 HIV-1 sequences even though it was recognized by subject CP2 and not ES38.

References

Displaying record number 58745

HXB2 Location Gag(308-316) Gag Epitope Map
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Epitope

QASQEVKNW

Epitope Alignment

Variants

QASQdVKNW non-susceptible form

Species (MHC/HLA) human(B*57)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3134`
Epitope Seq.	`QASQEVKNW`
Variant Seq.	`QASQdVKNW`
Mutations	E/D
Epitope Location	E5D
HXB2 Location	E312D
Mutation Type	NSF: non-susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Variant QASQdVKNW is seen in both ES38 and CP2 HIV-1 sequences even though CP2 does not carry HLA-B*57 allele. Neither subject can recognize this variant.

References

Displaying record number 58729

HXB2 Location Gag(325-339) Gag Epitope Map
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Epitope

NANPDCKTILKALGP

Epitope Alignment

Variants

NsNPDCKTILKALGP inferred escape; non-susceptible form; susceptible form

Epitope Name NP15

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3129`
Epitope Seq.	`NANPDCKTILKALGP`
Variant Seq.	`NsNPDCKTILKALGP`
Mutations	A/S
Epitope Location	A2S
HXB2 Location	A326S
Mutation Type	IE: inferred escape NSF: non-susceptible form SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Subject VC1, the controller, carried a mutation in NP15, NsNPDCKTILKALGP, that the authors predict to be an escape though it was recognized by VC1 by EliSpot. CP2 also carried the mutation but did not recognize it.

References

Displaying record number 58750

HXB2 Location Nef(81-95) Nef Epitope Map
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Epitope

FKAALDLSHFLNEKG

Epitope Alignment

Variants

FKAAvDLSHFLNEKG non-susceptible form

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3139`
Epitope Seq.	`FKAALDLSHFLNEKG`
Variant Seq.	`FKAAvDLSHFLNEKG`
Mutations	L/V
Epitope Location	L5V
HXB2 Location	L85V
Mutation Type	NSF: non-susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Variant FKAAvDLSHFLNEKG is seen in CP2 sequence but not recognized.

References

Displaying record number 58749

HXB2 Location Nef(101-116) Nef Epitope Map
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Epitope

IYSQKRQDILDLWVYH

Epitope Alignment

Variants

vwSQKRQDILDLWVYn non-susceptible form; susceptible form

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3138`
Epitope Seq.	`IYSQKRQDILDLWVYH`
Variant Seq.	`vwSQKRQDILDLWVYn`
Mutations	I/V H/N Y/W
Epitope Location	I1V H16N Y2W
HXB2 Location	I101V H116N Y102W
Mutation Type	NSF: non-susceptible form SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Variant vwSQKRQDILDLWVYn was seen in both ES38 and CP2 even though it was recognized only by subject ES38.

References

Displaying record number 58748

HXB2 Location Nef(116-124) Nef Epitope Map
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Epitope

HTQGYFPDW

Epitope Alignment

Variants

nTQGYFPDW non-susceptible form

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3137`
Epitope Seq.	`HTQGYFPDW`
Variant Seq.	`nTQGYFPDW`
Mutations	H/N
Epitope Location	H1N
HXB2 Location	H116N
Mutation Type	NSF: non-susceptible form
Method	Sequence
Note	nTQGYFPDW, a variant of epitope HTQGYFPDW was seen in both ES38 and CP2 HIV-1 sequences though neither subject could recognize the variant by EliSpot.

References

Displaying record number 58751

HXB2 Location Nef(129-143) Nef Epitope Map
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Epitope

PGPGIRYPLTFGWCF

Epitope Alignment

Variants

PGPGpRYPLTFGWCF non-susceptible form; susceptible form

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3140`
Epitope Seq.	`PGPGIRYPLTFGWCF`
Variant Seq.	`PGPGpRYPLTFGWCF`
Mutations	I/P
Epitope Location	I5P
HXB2 Location	I133P
Mutation Type	NSF: non-susceptible form SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Variant PGPGpRYPLTFGWCF is seen in both ES38 and CP2 HIV-1, though the variant epitope is recognized only by subject CP2 and not ES38.

References

Displaying record number 58753

HXB2 Location Nef(133-147) Nef Epitope Map
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Epitope

IRYPLTFGWCFKLVP

Epitope Alignment

Variants

pRYPLTFGWCFKLVP non-susceptible form; susceptible form

Species (MHC/HLA) human

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3141`
Epitope Seq.	`IRYPLTFGWCFKLVP`
Variant Seq.	`pRYPLTFGWCFKLVP`
Mutations	I/P
Epitope Location	I1P
HXB2 Location	I133P
Mutation Type	NSF: non-susceptible form SF: susceptible form
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	Variant pRYPLTFGWCFKLVP is seen in both ES38 and CP2, though it is recognized only by subject CP2 in EliSpot.