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Found 13 matching records:

Displaying record number 58746

HXB2 Location  Gag(17-31)   Gag Epitope Map
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Epitope EKIRLRPGGKKKYKL   Epitope Alignment
Variants
EKIRLRPGGKKKYqL   non-susceptible form; susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  3135
Epitope Seq.  EKIRLRPGGKKKYKL
Variant Seq.  EKIRLRPGGKKKYqL
Mutations K/Q
Epitope Location K14Q
HXB2 Location K162Q
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Variant EKIRLRPGGKKKYqL was detected in CP2 and ES2 HIV-1 sequences, but is only recognized by CTL from subject CP2.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58743

HXB2 Location  Gag(147-155)   Gag Epitope Map
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Epitope ISPRTLNAW   Epitope Alignment
Variants
lSPRTLNAW   non-susceptible form; susceptible form
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3131
Epitope Seq.  ISPRTLNAW
Variant Seq.  lSPRTLNAW
Mutations I/L
Epitope Location I1L
HXB2 Location I147L
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Mutant epitope lSPRTLNAW is recognized only by subject ES38 as seen by EliSpot; though it is found in both ES38 and CP2 HIV-1.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58741

HXB2 Location  Gag(162-172)   Gag Epitope Map
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Epitope KAFSPEVIPMF   Epitope Alignment
Variants
KAFSPEVIPMF{t}   literature escape; non-susceptible form; susceptible form
Epitope Name KF11
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3130
Epitope Seq.  KAFSPEVIPMF{S}
Variant Seq.  KAFSPEVIPMF{t}
Mutations S/T
Epitope Location S+1T
HXB2 Location S173T
Mutation Type LE: literature escape
NSF: non-susceptible form
SF: susceptible form
Method CD4 T-cell Elispot - IFNy, Sequence
Note The S173T mutation to epitope KF11 is seen and recognized in HLA-B*57 individuals like ES38, but in this case was present in both ES38 as well as non-B*57-subject, CP2.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58728

HXB2 Location  Gag(213-227)   Gag Epitope Map
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Epitope DRLHPVHAGPIAPGQ   Epitope Alignment
Variants
DRvHPVHAGPIAPGQ   susceptible form
Epitope Name DQ15
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  3128
Epitope Seq.  DRLHPVHAGPIAPGQ
Variant Seq.  DRvHPVHAGPIAPGQ
Mutations L/V
Epitope Location L3V
HXB2 Location L215V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Epitope DQ15 was seen to mutate to DRvHPVHAGPIAPGQ in subject CP1 but not in the controller, VC1. Subject CP1 recognizes DRvHPVHAGPIAPGQ as shown by EliSpot.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58744

HXB2 Location  Gag(240-249)   Gag Epitope Map
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Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSTLQEQIaW   susceptible form
TSTLQEQvaW   non-susceptible form
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 2 variant(s).


Variant ID.  3132
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQIaW
Mutations G/A
Epitope Location G9A
HXB2 Location G248A
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Mutant TSTLQEQIaW was seen in and recognized by subject ES38.


Variant ID.  3133
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSTLQEQvaW
Mutations I/V G/A
Epitope Location I8V G9A
HXB2 Location I247V G248A
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Mutant TSTLQEQvaW was seen in CP2 Gag sequences even though CP2 does not carry the HLA-B*57 allele. Subject CP2 was not able to recognize this sequence by EliSpot.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58747

HXB2 Location  Gag(249-263)   Gag Epitope Map
View variants at this location
Epitope WMTNNPPIPVGEIYK   Epitope Alignment
Variants
WMTsNPPvPVGEIYK   non-susceptible form; susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  3136
Epitope Seq.  WMTNNPPIPVGEIYK
Variant Seq.  WMTsNPPvPVGEIYK
Mutations N/S I/V
Epitope Location N4S I8V
HXB2 Location N252S I256V
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, CTL suppression of replication, Intracellular cytokine staining
Note WMTsNPPvPVGEIYK was a variant found in both CP2 and ES38 HIV-1 sequences even though it was recognized by subject CP2 and not ES38.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58745

HXB2 Location  Gag(308-316)   Gag Epitope Map
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Epitope QASQEVKNW   Epitope Alignment
Variants
QASQdVKNW   non-susceptible form
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3134
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQdVKNW
Mutations E/D
Epitope Location E5D
HXB2 Location E312D
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Variant QASQdVKNW is seen in both ES38 and CP2 HIV-1 sequences even though CP2 does not carry HLA-B*57 allele. Neither subject can recognize this variant.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58729

HXB2 Location  Gag(325-339)   Gag Epitope Map
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Epitope NANPDCKTILKALGP   Epitope Alignment
Variants
NsNPDCKTILKALGP   inferred escape; non-susceptible form; susceptible form
Epitope Name NP15
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  3129
Epitope Seq.  NANPDCKTILKALGP
Variant Seq.  NsNPDCKTILKALGP
Mutations A/S
Epitope Location A2S
HXB2 Location A326S
Mutation Type IE: inferred escape
NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Subject VC1, the controller, carried a mutation in NP15, NsNPDCKTILKALGP, that the authors predict to be an escape though it was recognized by VC1 by EliSpot. CP2 also carried the mutation but did not recognize it.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58750

HXB2 Location  Nef(81-95)   Nef Epitope Map
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Epitope FKAALDLSHFLNEKG   Epitope Alignment
Variants
FKAAvDLSHFLNEKG   non-susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  3139
Epitope Seq.  FKAALDLSHFLNEKG
Variant Seq.  FKAAvDLSHFLNEKG
Mutations L/V
Epitope Location L5V
HXB2 Location L85V
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note Variant FKAAvDLSHFLNEKG is seen in CP2 sequence but not recognized.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58749

HXB2 Location  Nef(101-116)   Nef Epitope Map
View variants at this location
Epitope IYSQKRQDILDLWVYH   Epitope Alignment
Variants
vwSQKRQDILDLWVYn   non-susceptible form; susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  3138
Epitope Seq.  IYSQKRQDILDLWVYH
Variant Seq.  vwSQKRQDILDLWVYn
Mutations I/V H/N Y/W
Epitope Location I1V H16N Y2W
HXB2 Location I101V H116N Y102W
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Variant vwSQKRQDILDLWVYn was seen in both ES38 and CP2 even though it was recognized only by subject ES38.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58748

HXB2 Location  Nef(116-124)   Nef Epitope Map
View variants at this location
Epitope HTQGYFPDW   Epitope Alignment
Variants
nTQGYFPDW   non-susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  3137
Epitope Seq.  HTQGYFPDW
Variant Seq.  nTQGYFPDW
Mutations H/N
Epitope Location H1N
HXB2 Location H116N
Mutation Type NSF: non-susceptible form
Method Sequence
Note nTQGYFPDW, a variant of epitope HTQGYFPDW was seen in both ES38 and CP2 HIV-1 sequences though neither subject could recognize the variant by EliSpot.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58751

HXB2 Location  Nef(129-143)   Nef Epitope Map
View variants at this location
Epitope PGPGIRYPLTFGWCF   Epitope Alignment
Variants
PGPGpRYPLTFGWCF   non-susceptible form; susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  3140
Epitope Seq.  PGPGIRYPLTFGWCF
Variant Seq.  PGPGpRYPLTFGWCF
Mutations I/P
Epitope Location I5P
HXB2 Location I133P
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Variant PGPGpRYPLTFGWCF is seen in both ES38 and CP2 HIV-1, though the variant epitope is recognized only by subject CP2 and not ES38.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


Displaying record number 58753

HXB2 Location  Nef(133-147)   Nef Epitope Map
View variants at this location
Epitope IRYPLTFGWCFKLVP   Epitope Alignment
Variants
pRYPLTFGWCFKLVP   non-susceptible form; susceptible form
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  3141
Epitope Seq.  IRYPLTFGWCFKLVP
Variant Seq.  pRYPLTFGWCFKLVP
Mutations I/P
Epitope Location I1P
HXB2 Location I133P
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy, Sequence
Note Variant pRYPLTFGWCFKLVP is seen in both ES38 and CP2, though it is recognized only by subject CP2 in EliSpot.

References

Buckheit2012 Robert W. Buckheit, III, Tracy G. Allen, Angela Alme, Maria Salgado, Karen A. O'Connell, Sarah Huculak, Oluwaseun Falade-Nwulia, Thomas M. Williams, Joel E. Gallant, Robert F. Siliciano, and Joel N. Blankson. Host Factors Dictate Control of Viral Replication in Two HIV-1 Controller/Chronic Progressor Transmission Pairs. Nat Commun, 3:716, 2012. PubMed ID: 22395607. Show all entries for this paper.


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