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Found 5 matching records:

Displaying record number 61936

HXB2 Location Gag(146-155) Gag Epitope Map
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{P}LSPRTLNAW

`{s}LSPRTLNAW`		observed variant
`{P}iSPRTLNAW`		observed variant
`{P}vSPRTLNAW`		observed variant

Epitope Name ISW9

Species (MHC/HLA) human(B*57)

Variant Details

Showing all: 3 variant(s).

Variant ID.	`4136`
Epitope Seq.	`{P}LSPRTLNAW`
Variant Seq.	`{s}LSPRTLNAW`
Mutations	P/S
Epitope Location	P1S
HXB2 Location	P146S
Mutation Type	OV: observed variant
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence
Note	Variant {s}LSPRTLNAW, at -1 position of the CRF01_AE ISW9 epitope was seen in donor patient N094 at 86%, 77% and 100%; 8, 20 and 42 mpd respectively. For recipient patient N107, this mutation was seen at 100% and 98% at months 42 and 52 post diagnosis.

Variant ID.	`4137`
Epitope Seq.	`{P}LSPRTLNAW`
Variant Seq.	`{P}iSPRTLNAW`
Mutations	L/I
Epitope Location	L3I
HXB2 Location	L148I
Mutation Type	OV: observed variant
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence
Note	Variant {P}iSPRTLNAW, at 1st position of the CRF01_AE ISW9 epitope was seen in donor patient N094 at 1% 8 months post diagnosis; and was never seen in the recipient patient.

Variant ID.	`4138`
Epitope Seq.	`{P}LSPRTLNAW`
Variant Seq.	`{P}vSPRTLNAW`
Mutations	L/V
Epitope Location	L3V
HXB2 Location	L148V
Mutation Type	OV: observed variant
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence
Note	Variant {P}vSPRTLNAW, at 1st position of the CRF01_AE ISW9 epitope was seen in donor patient N094 at 10% and 2% 8 and 20 months post diagnosis; this mutation was never seen in the recipient patient, N107.

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.

Displaying record number 61935

HXB2 Location Gag(162-172) Gag Epitope Map
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Epitope

KGFNPEVIPMF

Epitope Alignment

Variants

KGFNPEVvPMF observed variant

Epitope Name KF11

Species (MHC/HLA) human(B*57)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`4135`
Epitope Seq.	`KGFNPEVIPMF`
Variant Seq.	`KGFNPEVvPMF`
Mutations	I/V
Epitope Location	I8V
HXB2 Location	I169V
Mutation Type	OV: observed variant
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence
Note	Variant KGFNPEVvPMF, a mutation of CRF01_AE B*57-restricted Gag epitope KF11, KGFNPEVIPMF, was seen in recipient patient N107 at 42 and 52 months post-diagnosis at levels of 15% and 55% respectively.

References

Displaying record number 59115

HXB2 Location Gag(240-249) Gag Epitope Map
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Epitope

TSTLQEQIGW

Epitope Alignment

Variants

TSnLQEQIGW escape documented in this paper; observed variant

Epitope Name TW10

Species (MHC/HLA) human(B*57)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`3291`
Epitope Seq.	`TSTLQEQIGW`
Variant Seq.	`TSnLQEQIGW`
Mutations	T/N
Epitope Location	T3N
HXB2 Location	T242N
Mutation Type	E: escape documented in this paper OV: observed variant
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	CD8 T-cell Elispot - IFNy, Sequence
Note	CRF01_AE epitope TSTLQEQIGW had mutated to the T242N variant TSnLQEQIGW in the recipient, N107, by as early as 20 months post diagnosis, and remained stable until at least 52 mpd.

References

Displaying record number 59114

HXB2 Location Gag(263-272) Gag Epitope Map
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Epitope

KRWIILGLNK

Epitope Alignment

Variants

`KRWIILGLhK`		observed variant; susceptible form
`KRWIImGLNK`		observed variant; susceptible form
`KRWIIiGLNK`		observed variant
`KRWIImGLhK`		observed variant
`KRWIIvGLhK`		observed variant

Epitope Name KK10

Species (MHC/HLA) human(B*27)

Variant Details

Showing all: 5 variant(s).

Variant ID.	`4130`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIILGLhK`
Mutations	N/H
Epitope Location	N9H
HXB2 Location	N271H
Mutation Type	OV: observed variant SF: susceptible form
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence, Tetramer binding
Note	CRF01_AE epitope KRWIILGLNK had mutated to the N271H variant KRWIILGLhK in the recipient, N107, at 100% by as early as 20 months post diagnosis, and was seen at 27% and 56% at 42 and 52 mpd.

Variant ID.	`4131`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIImGLNK`
Mutations	L/M
Epitope Location	L6M
HXB2 Location	L268M
Mutation Type	OV: observed variant SF: susceptible form
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence, Tetramer binding
Note	CRF01_AE epitope KRWIILGLNK had mutated to the L268M variant KRWIImGLNK in the recipient, N107, to 15% by 52 months post diagnosis but response to it, though reduced from WT KK10-response was detected by EliSpot as early as 20 mpd.

Variant ID.	`4132`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIIiGLNK`
Mutations	L/I
Epitope Location	L6I
HXB2 Location	L268I
Mutation Type	OV: observed variant
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence
Note	CRF01_AE epitope KRWIILGLNK had mutated to the L268I variant KRWIIiGLNK in the recipient, N107, to 28% by 52 months post diagnosis.

Variant ID.	`4133`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIImGLhK`
Mutations	L/M N/H
Epitope Location	L6M N9H
HXB2 Location	L268M N271H
Mutation Type	OV: observed variant
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence
Note	CRF01_AE epitope KRWIILGLNK had mutated to the double variant KRWIImGLhK in the recipient, N107, to 61% by 42 months post diagnosis, but was not seen at 52 mpd.

Variant ID.	`4134`
Epitope Seq.	`KRWIILGLNK`
Variant Seq.	`KRWIIvGLhK`
Mutations	L/V N/H
Epitope Location	L6V N9H
HXB2 Location	L268V N271H
Mutation Type	OV: observed variant
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence
Note	CRF01_AE epitope KRWIILGLNK had mutated to the double variant KRWIIvGLhK in the recipient, N107, to 8% by 42 months post diagnosis, but was not seen at 52 mpd.

References

Displaying record number 61929

HXB2 Location Vpr(31-39) Vpr Epitope Map
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Epitope

VRHFPRLWL

Epitope Alignment

Variants

VRHFPRLWi observed variant

Epitope Name VL9

Species (MHC/HLA) human(B*27)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`4129`
Epitope Seq.	`VRHFPRLWL`
Variant Seq.	`VRHFPRLWi`
Mutations	L/I
Epitope Location	L9I
HXB2 Location	L39I
Mutation Type	OV: observed variant
Epitope Subtype	CRF01_AE
Variant Subtype	CRF01_AE
Method	Sequence
Note	CRF01_AE epitope VRHFPRLWL had mutated to variant VRHFPRLWi in the recipient, N107, by 52 months post diagnosis.