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Found 5 matching records:

Displaying record number 61936

HXB2 Location  Gag(146-155)   Gag Epitope Map
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Epitope {P}LSPRTLNAW   Epitope Alignment
Variants
{s}LSPRTLNAW   observed variant
{P}iSPRTLNAW   observed variant
{P}vSPRTLNAW   observed variant
Epitope Name ISW9
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4136
Epitope Seq.  {P}LSPRTLNAW
Variant Seq.  {s}LSPRTLNAW
Mutations P/S
Epitope Location P1S
HXB2 Location P146S
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note Variant {s}LSPRTLNAW, at -1 position of the CRF01_AE ISW9 epitope was seen in donor patient N094 at 86%, 77% and 100%; 8, 20 and 42 mpd respectively. For recipient patient N107, this mutation was seen at 100% and 98% at months 42 and 52 post diagnosis.


Variant ID.  4137
Epitope Seq.  {P}LSPRTLNAW
Variant Seq.  {P}iSPRTLNAW
Mutations L/I
Epitope Location L3I
HXB2 Location L148I
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note Variant {P}iSPRTLNAW, at 1st position of the CRF01_AE ISW9 epitope was seen in donor patient N094 at 1% 8 months post diagnosis; and was never seen in the recipient patient.


Variant ID.  4138
Epitope Seq.  {P}LSPRTLNAW
Variant Seq.  {P}vSPRTLNAW
Mutations L/V
Epitope Location L3V
HXB2 Location L148V
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note Variant {P}vSPRTLNAW, at 1st position of the CRF01_AE ISW9 epitope was seen in donor patient N094 at 10% and 2% 8 and 20 months post diagnosis; this mutation was never seen in the recipient patient, N107.

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.


Displaying record number 61935

HXB2 Location  Gag(162-172)   Gag Epitope Map
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Epitope KGFNPEVIPMF   Epitope Alignment
Variants
KGFNPEVvPMF   observed variant
Epitope Name KF11
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4135
Epitope Seq.  KGFNPEVIPMF
Variant Seq.  KGFNPEVvPMF
Mutations I/V
Epitope Location I8V
HXB2 Location I169V
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note Variant KGFNPEVvPMF, a mutation of CRF01_AE B*57-restricted Gag epitope KF11, KGFNPEVIPMF, was seen in recipient patient N107 at 42 and 52 months post-diagnosis at levels of 15% and 55% respectively.

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.


Displaying record number 59115

HXB2 Location  Gag(240-249)   Gag Epitope Map
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Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSnLQEQIGW   escape documented in this paper; observed variant
Epitope Name TW10
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  3291
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIGW
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type E: escape documented in this paper
OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method CD8 T-cell Elispot - IFNy, Sequence
Note CRF01_AE epitope TSTLQEQIGW had mutated to the T242N variant TSnLQEQIGW in the recipient, N107, by as early as 20 months post diagnosis, and remained stable until at least 52 mpd.

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.


Displaying record number 59114

HXB2 Location  Gag(263-272)   Gag Epitope Map
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Epitope KRWIILGLNK   Epitope Alignment
Variants
KRWIILGLhK   observed variant; susceptible form
KRWIImGLNK   observed variant; susceptible form
KRWIIiGLNK   observed variant
KRWIImGLhK   observed variant
KRWIIvGLhK   observed variant
Epitope Name KK10
Species (MHC/HLA human(B*27)

Variant Details

Showing all: 5 variant(s).


Variant ID.  4130
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIILGLhK
Mutations N/H
Epitope Location N9H
HXB2 Location N271H
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence, Tetramer binding
Note CRF01_AE epitope KRWIILGLNK had mutated to the N271H variant KRWIILGLhK in the recipient, N107, at 100% by as early as 20 months post diagnosis, and was seen at 27% and 56% at 42 and 52 mpd.


Variant ID.  4131
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLNK
Mutations L/M
Epitope Location L6M
HXB2 Location L268M
Mutation Type OV: observed variant
SF: susceptible form
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence, Tetramer binding
Note CRF01_AE epitope KRWIILGLNK had mutated to the L268M variant KRWIImGLNK in the recipient, N107, to 15% by 52 months post diagnosis but response to it, though reduced from WT KK10-response was detected by EliSpot as early as 20 mpd.


Variant ID.  4132
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIIiGLNK
Mutations L/I
Epitope Location L6I
HXB2 Location L268I
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note CRF01_AE epitope KRWIILGLNK had mutated to the L268I variant KRWIIiGLNK in the recipient, N107, to 28% by 52 months post diagnosis.


Variant ID.  4133
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIImGLhK
Mutations L/M N/H
Epitope Location L6M N9H
HXB2 Location L268M N271H
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note CRF01_AE epitope KRWIILGLNK had mutated to the double variant KRWIImGLhK in the recipient, N107, to 61% by 42 months post diagnosis, but was not seen at 52 mpd.


Variant ID.  4134
Epitope Seq.  KRWIILGLNK
Variant Seq.  KRWIIvGLhK
Mutations L/V N/H
Epitope Location L6V N9H
HXB2 Location L268V N271H
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note CRF01_AE epitope KRWIILGLNK had mutated to the double variant KRWIIvGLhK in the recipient, N107, to 8% by 42 months post diagnosis, but was not seen at 52 mpd.

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.


Displaying record number 61929

HXB2 Location  Vpr(31-39)   Vpr Epitope Map
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Epitope VRHFPRLWL   Epitope Alignment
Variants
VRHFPRLWi   observed variant
Epitope Name VL9
Species (MHC/HLA human(B*27)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4129
Epitope Seq.  VRHFPRLWL
Variant Seq.  VRHFPRLWi
Mutations L/I
Epitope Location L9I
HXB2 Location L39I
Mutation Type OV: observed variant
Epitope Subtype CRF01_AE
Variant Subtype CRF01_AE
Method Sequence
Note CRF01_AE epitope VRHFPRLWL had mutated to variant VRHFPRLWi in the recipient, N107, by 52 months post diagnosis.

References

Brener2015 Jacqui Brener, Astrid Gall, Rebecca Batorsky, Lynn Riddell, Soren Buus, Ellen Leitman, Paul Kellam, Todd Allen, Philip Goulder, and Philippa C. Matthews. Disease Progression Despite Protective HLA Expression in an HIV-Infected Transmission Pair. Retrovirology, 12:55, 2015. PubMed ID: 26123575. Show all entries for this paper.


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