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Found 4 matching records:

Displaying record number 1756

HXB2 Location  Gag(28-36)   Gag Epitope Map
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Epitope KYKLKHIVW   Epitope Alignment
Variants
KYKmKHlVW   subtype-specific non-susceptible form
Species (MHC/HLA human(A*24)

Variant Details

Showing all: 1 variant(s).


Variant ID.  87
Epitope Seq.  KYKLKHIVW
Variant Seq.  KYKmKHlVW
Mutations L/M I/L
Epitope Location L4M I7L
HXB2 Location L31M I34L
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype CRF01_AE
Method Chromium-release assay, HLA binding
Note The HLA-A24 subjects tested did not recognize the E clade version KYKmKHlVW, which differs from the previously defined B clade version KYKLKHIVW by two amino acids.

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.


Displaying record number 1757

HXB2 Location  gp160(586-593)   gp160 Epitope Map
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Epitope YLKDQQLL   Epitope Alignment
Variants
rYLKDQkLL   subtype-specific non-susceptible form
Species (MHC/HLA human(A*24)

Variant Details

Showing all: 1 variant(s).


Variant ID.  88
Epitope Seq.  YLKDQQLL
Variant Seq.  rYLKDQkLL
Mutations Y/R L/Y K/L D/K Q/D L/K
Epitope Location Y1R L2Y K3L D4K Q5D L7K
HXB2 Location Y586R L587Y K588L D589K Q590D L592K
Mutation Type SNSF: subtype-specific non-susceptible form
Method Chromium-release assay, HLA binding
Note The HLA-A24 subjects tested did not recognize the E clade version rYLKDQkLL, which differs from the previously defined B clade version YLKDQQLL by one amino acid, with an additional amino acid added on.

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.


Displaying record number 1754

HXB2 Location  Nef(136-145)   Nef Epitope Map
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Epitope PLTFGWCYKL   Epitope Alignment
Variants
PLcFGWCfKL   subtype-specific non-susceptible form
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  89
Epitope Seq.  PLTFGWCYKL
Variant Seq.  PLcFGWCfKL
Mutations T/C Y/F
Epitope Location T3C Y8F
HXB2 Location T138C Y143F
Mutation Type SNSF: subtype-specific non-susceptible form
Epitope Subtype B
Variant Subtype CRF01_AE
Method Chromium-release assay, HLA binding
Note 0/4 HLA-A2 tested subjects recognized the E clade version PLcFGWCfKL, which differs from the previously defined B clade version (PLTFGWCYKL) by two amino acids.

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.


Displaying record number 1755

HXB2 Location  Nef(180-189)   Nef Epitope Map
View variants at this location
Epitope VLEWRFDSRL   Epitope Alignment
Variants
VLiWkFDSaL   subtype-specific non-susceptible form
Species (MHC/HLA human(A*02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  90
Epitope Seq.  VLEWRFDSRL
Variant Seq.  VLiWkFDSaL
Mutations E/I R/K R/A
Epitope Location E3I R5K R9A
HXB2 Location E182I R184K R188A
Mutation Type SNSF: subtype-specific non-susceptible form
Note 0/4 HLA-A2 tested subjects recognized the E clade version VLiWkFDSa, which differs from the previously defined B clade version (VLEWRFDSRL) by three amino acids.

References

Bond2001 K. B. Bond, B. Sriwanthana, T. W. Hodge, A. S. De Groot, T. D. Mastro, N. L. Young, N. Promadej, J. D. Altman, K. Limpakarnjanarat, and J. M. McNicholl. An HLA-directed molecular and bioinformatics approach identifies new HLA-A11 HIV-1 subtype E cytotoxic T lymphocyte epitopes in HIV-1-infected Thais. AIDS Res. Hum. Retroviruses, 17(8):703-17, 20 May 2001. PubMed ID: 11429111. Show all entries for this paper.


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