HIV molecular immunology database
Found 3 matching records:
| HXB2 Location | Gag(168-175) | Gag Epitope Map
View variants at this location |
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| Epitope |
VIPMSFAL
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | VL8 | |||||
| Species (MHC/HLA) | human(C*01:02) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3107 |
|---|---|
| Epitope Seq. | VIPMSFAL |
| Variant Seq. | VIPMtFAL |
| Mutations | S/T |
| Epitope Location | S5T |
| HXB2 Location | S172T |
| Mutation Type | A: HLA association DR: diminished response E: escape documented in this paper |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy, Intracellular cytokine staining |
| Note | C-mut VIPMtFAL was the result of an S173T substitution in Gag epitope VIPMSFAL (VL8). A peptide containing VIPMtFAL escape was less well recognized than wt VL8 as proved by testing for γ-IFN and TNF-α production with intracellular cytokine staining (ICS) of a VL8-specific CTL cell line and its HLA-Cw*0102-transfected APC. |
Blais2012 Marie-Eve Blais, Yonghong Zhang, Tim Rostron, Harry Griffin, Stephen Taylor, Keyi Xu, Huiping Yan, Hao Wu, Ian James, Mina John, Tao Dong, and Sarah L. Rowland-Jones. High Frequency of HIV Mutations Associated with HLA-C Suggests Enhanced HLA-C-Restricted CTL Selective Pressure Associated with an AIDS-Protective Polymorphism. J. Immunol., 188(9):4663-4670, 1 May 2012. PubMed ID: 22474021. Show all entries for this paper.
| HXB2 Location | Gag(277-285) | Gag Epitope Map
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| Epitope |
YSPTSILDI
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human(C*12) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3109 |
|---|---|
| Epitope Seq. | YSPTSILDI |
| Variant Seq. | YSPvSILDI |
| Mutations | T/V |
| Epitope Location | T4V |
| HXB2 Location | T280V |
| Mutation Type | E: escape documented in this paper |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy |
| Note | C-mut YSPvSILDI that is a variant of Gag YSPTSILDI is restricted by HLA-Cw*12. It is shown to be an escape by EliSpot. |
Blais2012 Marie-Eve Blais, Yonghong Zhang, Tim Rostron, Harry Griffin, Stephen Taylor, Keyi Xu, Huiping Yan, Hao Wu, Ian James, Mina John, Tao Dong, and Sarah L. Rowland-Jones. High Frequency of HIV Mutations Associated with HLA-C Suggests Enhanced HLA-C-Restricted CTL Selective Pressure Associated with an AIDS-Protective Polymorphism. J. Immunol., 188(9):4663-4670, 1 May 2012. PubMed ID: 22474021. Show all entries for this paper.
| HXB2 Location | Pol(464-473) | Pol Epitope Map
View variants at this location |
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| Epitope |
ILKEPVHGVY
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Epitope Alignment | ||||
| Variants |
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| Species (MHC/HLA) | human(C*03:03) | |||||
Showing all: 1 variant(s).
| Variant ID. | 3108 |
|---|---|
| Epitope Seq. | ILKEPVHGVY |
| Variant Seq. | ILrEPVHGVY |
| Mutations | K/R |
| Epitope Location | K3R |
| HXB2 Location | K466R |
| Mutation Type | E: escape documented in this paper |
| Epitope Subtype | B |
| Variant Subtype | B |
| Method | CD8 T-cell Elispot - IFNy |
| Note | C-mut ILrEPVHGVY that is a variant of Pol ILKEPVHGVY is restricted by HLA-Cw*0302. |
Blais2012 Marie-Eve Blais, Yonghong Zhang, Tim Rostron, Harry Griffin, Stephen Taylor, Keyi Xu, Huiping Yan, Hao Wu, Ian James, Mina John, Tao Dong, and Sarah L. Rowland-Jones. High Frequency of HIV Mutations Associated with HLA-C Suggests Enhanced HLA-C-Restricted CTL Selective Pressure Associated with an AIDS-Protective Polymorphism. J. Immunol., 188(9):4663-4670, 1 May 2012. PubMed ID: 22474021. Show all entries for this paper.