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Found 1 matching record:

Displaying record number 57381

HXB2 Location  Gag(77-85)   Gag Epitope Map
View variants at this location
Epitope SLYNTVATL   Epitope Alignment
Variants
SLYNTiAvL   literature escape
SLfNTVATL   literature escape
SLYNTiATL   literature escape
Epitope Name SL9
Species (MHC/HLA human(A*02:01)

Variant Details

Showing all: 3 variant(s).


Variant ID.  2340
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiAvL
Mutations V/I T/V
Epitope Location V6I T8V
HXB2 Location V82I T84V
Mutation Type LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note SL9 variant V82I/T84V, SLYNTiAvL, was recognized by different TCR mutants with differing functional avidities.


Variant ID.  2341
Epitope Seq.  SLYNTVATL
Variant Seq.  SLfNTVATL
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note SL9 variant Y79F, SLfNTVATL, was recognized by different TCR mutants with differing functional avidities.


Variant ID.  2342
Epitope Seq.  SLYNTVATL
Variant Seq.  SLYNTiATL
Mutations V/I
Epitope Location V6I
HXB2 Location V82I
Mutation Type LE: literature escape
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Chromium-release assay
Note SL9 variant V82I, SLYNTiATL, was recognized by different TCR mutants with differing functional avidities.

References

Bennett2010 Michael S. Bennett, Aviva Joseph, Hwee L. Ng, Harris Goldstein, and Otto O. Yang. Fine-Tuning of T-Cell Receptor Avidity to Increase HIV Epitope Variant Recognition by Cytotoxic T Lymphocytes. AIDS, 24(17):2619-2628, 13 Nov 2010. PubMed ID: 20881472. Show all entries for this paper.


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