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Found 5 matching records:

Displaying record number 53611

HXB2 Location  Gag(21-35)   Gag Epitope Map
View variants at this location
Epitope LRPGGKKKYRLKHLV   Epitope Alignment
Variants
LRPGGKKKYkLKHLV   observed variant
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  63
Epitope Seq.  LRPGGKKKYRLKHLV
Variant Seq.  LRPGGKKKYkLKHLV
Mutations R/K
Epitope Location R10K
HXB2 Location R30K
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy
Note The sequence contains a known B8 epitope, but the subjects recognizing it were B8-negative. The autologous viral sequence was lrpggkkkyKlkhlv, and the index peptide was recognized.

References

Barugahare2005 Banson Barugahare, Chris Baker, Okumu K'Aluoch, Richard Donovan, Mohamed Elrefaei, Mark Eggena, Norman Jones, Steven Mutalya, Cissy Kityo, Peter Mugyenyi, and Huyen Cao. Human Immunodeficiency Virus-Specific Responses in Adult Ugandans: Patterns of Cross-Clade Recognition. J. Virol., 79(7):4132-4139, Apr 2005. PubMed ID: 15767414. Show all entries for this paper.


Displaying record number 53612

HXB2 Location  Gag(77-91)   Gag Epitope Map
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Epitope SLYNTVATLYCVHQR   Epitope Alignment
Variants
SLfNTVATLYCVHQR   susceptible form
Species (MHC/HLA human(A*02:01, A*30:02)

Variant Details

Showing all: 1 variant(s).


Variant ID.  64
Epitope Seq.  SLYNTVATLYCVHQR
Variant Seq.  SLfNTVATLYCVHQR
Mutations Y/F
Epitope Location Y3F
HXB2 Location Y79F
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note The sequence contains a known A2 epitope and a known A*3002 epitope, and the subjects recognizing it each carry an HLA with a previously-defined restriction. The viral sequence isolated from the subjects was slFntvatlycvhqr, and was reactive.

References

Barugahare2005 Banson Barugahare, Chris Baker, Okumu K'Aluoch, Richard Donovan, Mohamed Elrefaei, Mark Eggena, Norman Jones, Steven Mutalya, Cissy Kityo, Peter Mugyenyi, and Huyen Cao. Human Immunodeficiency Virus-Specific Responses in Adult Ugandans: Patterns of Cross-Clade Recognition. J. Virol., 79(7):4132-4139, Apr 2005. PubMed ID: 15767414. Show all entries for this paper.


Displaying record number 53613

HXB2 Location  Gag(141-155)   Gag Epitope Map
View variants at this location
Epitope QMVHQSLSPRTLNAW   Epitope Alignment
Variants
QMtHQnLSPRTLNAW   observed variant
QMVHQaLSPRTLNAW   observed variant
Species (MHC/HLA human

Variant Details

Showing all: 2 variant(s).


Variant ID.  65
Epitope Seq.  QMVHQSLSPRTLNAW
Variant Seq.  QMtHQnLSPRTLNAW
Mutations V/T S/N
Epitope Location V3T S6N
HXB2 Location V143T S146N
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy
Note The sequence contains a known B7/B8 epitope, but the subjects recognizing it are B7- and B8-negative. The viral sequences isolated from the subjects were qmThqNlsprtlnaw and qmvhqAlsprtlnaw, and the index peptide was recognized.


Variant ID.  66
Epitope Seq.  QMVHQSLSPRTLNAW
Variant Seq.  QMVHQaLSPRTLNAW
Mutations S/A
Epitope Location S6A
HXB2 Location S146A
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy
Note The sequence contains a known B7/B8 epitope, but the subjects recognizing it are B7- and B8-negative. The viral sequences isolated from the subjects were qmThqNlsprtlnaw and qmvhqAlsprtlnaw, and the index peptide was recognized.

References

Barugahare2005 Banson Barugahare, Chris Baker, Okumu K'Aluoch, Richard Donovan, Mohamed Elrefaei, Mark Eggena, Norman Jones, Steven Mutalya, Cissy Kityo, Peter Mugyenyi, and Huyen Cao. Human Immunodeficiency Virus-Specific Responses in Adult Ugandans: Patterns of Cross-Clade Recognition. J. Virol., 79(7):4132-4139, Apr 2005. PubMed ID: 15767414. Show all entries for this paper.


Displaying record number 53615

HXB2 Location  Gag(293-307)   Gag Epitope Map
View variants at this location
Epitope FRDYVDRFYKTLRAE   Epitope Alignment
Variants
FRDYVDRFYKvLRAE   observed variant
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  67
Epitope Seq.  FRDYVDRFYKTLRAE
Variant Seq.  FRDYVDRFYKvLRAE
Mutations T/V
Epitope Location T11V
HXB2 Location T303V
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy
Note The sequence contains a known epitope (FRDYVDRFYKTL), but the subject recognizing it does not carry HLAs of the previously-defined restriction. The isolated viral sequence was frdyvdrfykVlrae, from the patient that could recognize the peptide.

References

Barugahare2005 Banson Barugahare, Chris Baker, Okumu K'Aluoch, Richard Donovan, Mohamed Elrefaei, Mark Eggena, Norman Jones, Steven Mutalya, Cissy Kityo, Peter Mugyenyi, and Huyen Cao. Human Immunodeficiency Virus-Specific Responses in Adult Ugandans: Patterns of Cross-Clade Recognition. J. Virol., 79(7):4132-4139, Apr 2005. PubMed ID: 15767414. Show all entries for this paper.


Displaying record number 53616

HXB2 Location  Nef(103-117)   Nef Epitope Map
View variants at this location
Epitope SKKRQEILDLWVYHT   Epitope Alignment
Variants
SKKRQkILDLWVYHT   observed variant
Species (MHC/HLA human

Variant Details

Showing all: 1 variant(s).


Variant ID.  68
Epitope Seq.  SKKRQEILDLWVYHT
Variant Seq.  SKKRQkILDLWVYHT
Mutations E/K
Epitope Location E6K
HXB2 Location E108K
Mutation Type OV: observed variant
Method CD8 T-cell Elispot - IFNy
Note The sequence contains a previously-defined epitope (KRQEILDLWVY) of unknown HLA restriction. The viral sequence from the subjects that recognized the peptide was skkrqKildlwvyNt.

References

Barugahare2005 Banson Barugahare, Chris Baker, Okumu K'Aluoch, Richard Donovan, Mohamed Elrefaei, Mark Eggena, Norman Jones, Steven Mutalya, Cissy Kityo, Peter Mugyenyi, and Huyen Cao. Human Immunodeficiency Virus-Specific Responses in Adult Ugandans: Patterns of Cross-Clade Recognition. J. Virol., 79(7):4132-4139, Apr 2005. PubMed ID: 15767414. Show all entries for this paper.


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