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Found 8 matching records:

Displaying record number 62276

HXB2 Location  Gag(146-155)   Gag Epitope Map
View variants at this location
Epitope AISPRTLNAW   Epitope Alignment
Variants
plSPRTLNAW   escape documented in this paper
AlSPRTLNAW   escape documented in this paper
pISPRTLNAW   escape documented in this paper
Epitope Name AW10, IW9
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4382
Epitope Seq.  AISPRTLNAW
Variant Seq.  plSPRTLNAW
Mutations A/P I/L
Epitope Location A1P I2L
HXB2 Location A146P I147L
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Double mutation, plSPRTLNAW, was seen at all times in patient2.


Variant ID.  4383
Epitope Seq.  AISPRTLNAW
Variant Seq.  AlSPRTLNAW
Mutations I/L
Epitope Location I2L
HXB2 Location I147L
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Mutation AlSPRTLNAW, was seen in patient4 before 30/47 months post infection.


Variant ID.  4384
Epitope Seq.  AISPRTLNAW
Variant Seq.  pISPRTLNAW
Mutations A/P
Epitope Location A1P
HXB2 Location A146P
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Mutation pISPRTLNAW, was seen in patients 3 and 4 30/47 months post infection.

References

Bansal2007 Anju Bansal, Ling Yue, Joan Conway, Karina Yusim, Jianming Tang, John Kappes, Richard A. Kaslow, Craig M. Wilson, and Paul A. Goepfert. Immunological Control of Chronic HIV-1 Infection: HLA-Mediated Immune Function and Viral Evolution in Adolescents. AIDS, 21(18):2387-2397, 30 Nov 2007. PubMed ID: 18025875. Show all entries for this paper.


Displaying record number 62280

HXB2 Location  Gag(180-188)   Gag Epitope Map
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Epitope TPQDLNTML   Epitope Alignment
Variants
TPhDLNTML   observed variant
Epitope Name Gag-TL9
Species (MHC/HLA human(B*35, B*53)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4392
Epitope Seq.  TPQDLNTML
Variant Seq.  TPhDLNTML
Mutations Q/H
Epitope Location Q3H
HXB2 Location Q182H
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Mutation TPhDLNTML was seen in patient 7 after 30 or 47 months.

References

Bansal2007 Anju Bansal, Ling Yue, Joan Conway, Karina Yusim, Jianming Tang, John Kappes, Richard A. Kaslow, Craig M. Wilson, and Paul A. Goepfert. Immunological Control of Chronic HIV-1 Infection: HLA-Mediated Immune Function and Viral Evolution in Adolescents. AIDS, 21(18):2387-2397, 30 Nov 2007. PubMed ID: 18025875. Show all entries for this paper.


Displaying record number 62277

HXB2 Location  Gag(240-250)   Gag Epitope Map
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Epitope TSTLQEQIGWM   Epitope Alignment
Variants
TSnLQEQIGWM   escape documented in this paper
TSnLQEQItWM   escape documented in this paper
TSTpQEQIaWM   escape documented in this paper
Epitope Name TW10
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4385
Epitope Seq.  TSTLQEQIGWM
Variant Seq.  TSnLQEQIGWM
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Escape TSnLQEQIGW was seen in patient2 before 30/47 months.


Variant ID.  4386
Epitope Seq.  TSTLQEQIGWM
Variant Seq.  TSnLQEQItWM
Mutations T/N G/T
Epitope Location T3N G9T
HXB2 Location T242N G248T
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Escape TSnLQEQIaW was seen in patient4 at all times sampled.


Variant ID.  4387
Epitope Seq.  TSTLQEQIGWM
Variant Seq.  TSTpQEQIaWM
Mutations L/P G/A
Epitope Location L4P G9A
HXB2 Location L243P G248A
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Escape TSTpQEQIaWM was seen in patient3 after 30/47 months.

References

Bansal2007 Anju Bansal, Ling Yue, Joan Conway, Karina Yusim, Jianming Tang, John Kappes, Richard A. Kaslow, Craig M. Wilson, and Paul A. Goepfert. Immunological Control of Chronic HIV-1 Infection: HLA-Mediated Immune Function and Viral Evolution in Adolescents. AIDS, 21(18):2387-2397, 30 Nov 2007. PubMed ID: 18025875. Show all entries for this paper.


Displaying record number 62275

HXB2 Location  Gag(308-316)   Gag Epitope Map
View variants at this location
Epitope QASQEVKNW   Epitope Alignment
Variants
QASQdVKNW   observed variant
QASQdVKsW   observed variant
QAtQEVKNW   observed variant
Epitope Name QW9
Species (MHC/HLA human(B*35, B*57)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4379
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQdVKNW
Mutations E/D
Epitope Location E5D
HXB2 Location E312D
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note The E to D change in QW9 is a common non-selection-driven mutation seen in B*57 and B*35/43 carriers. It was seen in patients 3 and 4 at all times and patients 2, 5 after 30/47 months, while it was observed in patient 9 only before 30/47 months.


Variant ID.  4380
Epitope Seq.  QASQEVKNW
Variant Seq.  QASQdVKsW
Mutations E/D N/S
Epitope Location E5D N8S
HXB2 Location E312D N315S
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note The QW9 mutation, QASQdVKsW, was seen in patient 11 at all times sampled.


Variant ID.  4381
Epitope Seq.  QASQEVKNW
Variant Seq.  QAtQEVKNW
Mutations S/T
Epitope Location S3T
HXB2 Location S310T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note The QW9 mutation, QAtQEVKNW, was seen in patient7 at all times sampled, but in patient10 after 30/47 months' infection.

References

Bansal2007 Anju Bansal, Ling Yue, Joan Conway, Karina Yusim, Jianming Tang, John Kappes, Richard A. Kaslow, Craig M. Wilson, and Paul A. Goepfert. Immunological Control of Chronic HIV-1 Infection: HLA-Mediated Immune Function and Viral Evolution in Adolescents. AIDS, 21(18):2387-2397, 30 Nov 2007. PubMed ID: 18025875. Show all entries for this paper.


Displaying record number 62281

HXB2 Location  Nef(74-81)   Nef Epitope Map
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Epitope VPLRPMTY   Epitope Alignment
Variants
VPLRPMTf   escape documented in this paper
lPLRPMTY   observed variant
VPLRPiTY   observed variant
VPLRPMTt   observed variant
VPLRPMnY   observed variant
Epitope Name VY8
Species (MHC/HLA human(B*35, B*53)

Variant Details

Showing all: 5 variant(s).


Variant ID.  4393
Epitope Seq.  VPLRPMTY
Variant Seq.  VPLRPMTf
Mutations Y/F
Epitope Location Y8F
HXB2 Location Y81F
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Escape Y81F, VPLRPMTf, was seen in patient8 after 30/47 months.


Variant ID.  4394
Epitope Seq.  VPLRPMTY
Variant Seq.  lPLRPMTY
Mutations V/L
Epitope Location V1L
HXB2 Location V74L
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Mutation lPLRPMTY, was seen in patient8 before 30/47 months.


Variant ID.  4395
Epitope Seq.  VPLRPMTY
Variant Seq.  VPLRPiTY
Mutations M/I
Epitope Location M6I
HXB2 Location M79I
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Mutation VPLRPiTY, was seen in patient6 before 30/47 months and patient10 after 30/47 months.


Variant ID.  4396
Epitope Seq.  VPLRPMTY
Variant Seq.  VPLRPMTt
Mutations Y/T
Epitope Location Y8T
HXB2 Location Y81T
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Mutation VPLRPMTt, was seen in patient7 at all times sampled.


Variant ID.  4397
Epitope Seq.  VPLRPMTY
Variant Seq.  VPLRPMnY
Mutations T/N
Epitope Location T7N
HXB2 Location T80N
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Mutation VPLRPMnY, was seen in patient6 after 30/47 months.

References

Bansal2007 Anju Bansal, Ling Yue, Joan Conway, Karina Yusim, Jianming Tang, John Kappes, Richard A. Kaslow, Craig M. Wilson, and Paul A. Goepfert. Immunological Control of Chronic HIV-1 Infection: HLA-Mediated Immune Function and Viral Evolution in Adolescents. AIDS, 21(18):2387-2397, 30 Nov 2007. PubMed ID: 18025875. Show all entries for this paper.


Displaying record number 62278

HXB2 Location  Nef(82-90)   Nef Epitope Map
View variants at this location
Epitope KAAVDLSHF   Epitope Alignment
Variants
KAAVDiSHF   observed variant
KAAVnLSHF   observed variant
KgAlDLSHF   observed variant
Epitope Name KF9
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4388
Epitope Seq.  KAAVDLSHF
Variant Seq.  KAAVDiSHF
Mutations L/I
Epitope Location L6I
HXB2 Location L87I
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note This mutation, KAAVDiSHF, was seen in patient1 at all times sampled and in patient3 before 30/47 months.


Variant ID.  4389
Epitope Seq.  KAAVDLSHF
Variant Seq.  KAAVnLSHF
Mutations D/N
Epitope Location D5N
HXB2 Location D86N
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note This mutation, KAAVnLSHF, was seen in patient2 before 30/47 months.


Variant ID.  4390
Epitope Seq.  KAAVDLSHF
Variant Seq.  KgAlDLSHF
Mutations A/G V/L
Epitope Location A2G V4L
HXB2 Location A83G V85L
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note This mutation, KgAlDLSHF, was seen in patient4 at all times sampled and in patient3 after 30/47 months.

References

Bansal2007 Anju Bansal, Ling Yue, Joan Conway, Karina Yusim, Jianming Tang, John Kappes, Richard A. Kaslow, Craig M. Wilson, and Paul A. Goepfert. Immunological Control of Chronic HIV-1 Infection: HLA-Mediated Immune Function and Viral Evolution in Adolescents. AIDS, 21(18):2387-2397, 30 Nov 2007. PubMed ID: 18025875. Show all entries for this paper.


Displaying record number 62279

HXB2 Location  Nef(116-125)   Nef Epitope Map
View variants at this location
Epitope HTQGYFPDWQ   Epitope Alignment
Variants
nTQGYFPDWQ   escape documented in this paper
Epitope Name Nef-HQ10
Species (MHC/HLA human(B*57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  4391
Epitope Seq.  HTQGYFPDWQ
Variant Seq.  nTQGYFPDWQ
Mutations H/N
Epitope Location H1N
HXB2 Location H116N
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Mutation nTQGYFPDWQ was seen n patient 4 at all times sampled and in pateitn3 after 30/47 months.

References

Bansal2007 Anju Bansal, Ling Yue, Joan Conway, Karina Yusim, Jianming Tang, John Kappes, Richard A. Kaslow, Craig M. Wilson, and Paul A. Goepfert. Immunological Control of Chronic HIV-1 Infection: HLA-Mediated Immune Function and Viral Evolution in Adolescents. AIDS, 21(18):2387-2397, 30 Nov 2007. PubMed ID: 18025875. Show all entries for this paper.


Displaying record number 62274

HXB2 Location  Nef(135-143)   Nef Epitope Map
View variants at this location
Epitope YPLTFGWCY   Epitope Alignment
Variants
fPLTFGWCY   observed variant
YPLTlGWCY   escape documented in this paper
YPLcFGWCY   escape documented in this paper
Epitope Name YY9
Species (MHC/HLA human(B*35)

Variant Details

Showing all: 3 variant(s).


Variant ID.  4376
Epitope Seq.  YPLTFGWCY
Variant Seq.  fPLTFGWCY
Mutations Y/F
Epitope Location Y1F
HXB2 Location Y135F
Mutation Type OV: observed variant
Epitope Subtype B
Variant Subtype B
Method Longitudinal study, Other
Note Y135F was a mutation observed in B*35/B*53-Subjects 5 (before 30 months) and 6 (after 30/47 months).


Variant ID.  4377
Epitope Seq.  YPLTFGWCY
Variant Seq.  YPLTlGWCY
Mutations F/L
Epitope Location F5L
HXB2 Location F139L
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study, Other
Note F139L was a mutation observed in B*35/B*53-Subject7 that tested with poor recognition by EliSpot. It was observed in patient5 earlier than 30 months post-infection and patient6, after 30/47 months.


Variant ID.  4378
Epitope Seq.  YPLTFGWCY
Variant Seq.  YPLcFGWCY
Mutations T/C
Epitope Location T4C
HXB2 Location T138C
Mutation Type E: escape documented in this paper
Epitope Subtype B
Variant Subtype B
Method CD8 T-cell Elispot - IFNy, Longitudinal study, Other
Note T138C was a mutation observed in B*35/B*53-Subjects 9 and 11 (after 30/47 months) that tested with poor recognition by EliSpot.

References

Bansal2007 Anju Bansal, Ling Yue, Joan Conway, Karina Yusim, Jianming Tang, John Kappes, Richard A. Kaslow, Craig M. Wilson, and Paul A. Goepfert. Immunological Control of Chronic HIV-1 Infection: HLA-Mediated Immune Function and Viral Evolution in Adolescents. AIDS, 21(18):2387-2397, 30 Nov 2007. PubMed ID: 18025875. Show all entries for this paper.


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