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Found 11 matching records:

Displaying record number 52827

HXB2 Location  Gag(18-26)   Gag Epitope Map
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Epitope KIRLRPGGK   Epitope Alignment
Variants
KIRLRPGGK{*t}   escape documented in this paper; processing
Epitope Name A3-KK9 Gag
Species (MHC/HLA human(B7)

Variant Details

Showing all: 1 variant(s).


Variant ID.  2281
Epitope Seq.  KIRLRPGGK{*R}
Variant Seq.  KIRLRPGGK{*t}
Mutations R/T
Epitope Location R+2T
HXB2 Location R28T
Mutation Type E: escape documented in this paper
P: processing
Method CD8 T-cell Elispot - IFNy
Note Response declined over time; authors suggested that the decline was due to a downstream Arg -> Thr substitution at C+2 that may impair processing.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 52824

HXB2 Location  Gag(20-28)   Gag Epitope Map
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Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGKKt   diminished response
Epitope Name A3-RK9 Ga9
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  43
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKKt
Mutations K/T
Epitope Location K9T
HXB2 Location K28T
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant rlrpggkkT. The CTL response declined over time, and the response to the second variant was lower than to the first one

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 52826

HXB2 Location  Pol(313-321)   Pol Epitope Map
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Epitope AIFQSSMTK   Epitope Alignment
Variants
AIFQSSMlK   non-susceptible form
Epitope Name A3-AK9 Pol
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  44
Epitope Seq.  AIFQSSMTK
Variant Seq.  AIFQSSMlK
Mutations T/L
Epitope Location T8L
HXB2 Location T320L
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant aifqssmIk. The CTL response to the second variant was zero or low at all timepoints. The CTL response to the first variant was also low, and declined over time.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 52821

HXB2 Location  Pol(424-432)   Pol Epitope Map
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Epitope QIYAGIKVK   Epitope Alignment
Variants
QIYAGIKVr   non-susceptible form; susceptible form
Epitope Name A3-QR9 Pol
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  45
Epitope Seq.  QIYAGIKVK
Variant Seq.  QIYAGIKVr
Mutations K/R
Epitope Location K9R
HXB2 Location K432R
Mutation Type NSF: non-susceptible form
SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant qiyagikvR. The initial CTL response to both variants was strong but eventually declined, particularly to the variant in the second strain.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 52822

HXB2 Location  Pol(511-521)   Pol Epitope Map
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Epitope RTRGAHTNDVK   Epitope Alignment
Variants
RTRGAHTNDVr   diminished response
Epitope Name A3-RK11 Pol
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  46
Epitope Seq.  RTRGAHTNDVK
Variant Seq.  RTRGAHTNDVr
Mutations K/R
Epitope Location K11R
HXB2 Location K521R
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant rtrgahtndvR. The CTL response to both variants declined over time, and the response to the second variant was lower than to the first throughout.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 52828

HXB2 Location  Pol(894-903)   Pol Epitope Map
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Epitope AVFIHNFKRK   Epitope Alignment
Variants
AVFvHNFKRK   non-susceptible form
Epitope Name A3-AK10 Pol
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  47
Epitope Seq.  AVFIHNFKRK
Variant Seq.  AVFvHNFKRK
Mutations I/V
Epitope Location I4V
HXB2 Location I897V
Mutation Type NSF: non-susceptible form
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant avfVhnfkrk. The CTL response to the second variant was zero at all timepoints. The CTL response to the first variant was low and declined over time.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 52813

HXB2 Location  Vif(17-26)   Vif Epitope Map
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Epitope RIRTWKSLVK   Epitope Alignment
Variants
RIsTWKSLVK   susceptible form
Epitope Name A3-RK10 Vif
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  48
Epitope Seq.  RIRTWKSLVK
Variant Seq.  RIsTWKSLVK
Mutations R/S
Epitope Location R3S
HXB2 Location R19S
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant riStwkslvk. The initial CTL response persisted against both variants after the superinfection was established.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 52823

HXB2 Location  Vif(48-57)   Vif Epitope Map
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Epitope HPRISSEVHI   Epitope Alignment
Variants
HPkISSEVHI   susceptible form
Epitope Name B7-HM0 Vif
Species (MHC/HLA human(B7)

Variant Details

Showing all: 1 variant(s).


Variant ID.  49
Epitope Seq.  HPRISSEVHI
Variant Seq.  HPkISSEVHI
Mutations R/K
Epitope Location R3K
HXB2 Location R50K
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant hpKissevhi. The CTL response was equal against both variants, and declined over time.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 52814

HXB2 Location  Vif(158-168)   Vif Epitope Map
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Epitope RRKPPLPSIAK   Epitope Alignment
Variants
RtKPPLPSvtK   susceptible form
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  50
Epitope Seq.  RRKPPLPSIAK
Variant Seq.  RtKPPLPSvtK
Mutations A/T R/T I/V
Epitope Location A10T R2T I9V
HXB2 Location A167T R159T I166V
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant rTkpplpsVTk. The patient maintained persistent reactive CTL against both variants after the superinfection was established.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 52825

HXB2 Location  Vpr(34-42)   Vpr Epitope Map
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Epitope FPRTWLHGL   Epitope Alignment
Variants
FPwTWLHGL   diminished response
Epitope Name B7-FL9 Vpr
Species (MHC/HLA human(B7)

Variant Details

Showing all: 1 variant(s).


Variant ID.  51
Epitope Seq.  FPRTWLHGL
Variant Seq.  FPwTWLHGL
Mutations R/W
Epitope Location R3W
HXB2 Location R36W
Mutation Type DR: diminished response
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The second infecting strain had the variant fpWtwlhgl. The CTL response declined over time and the response to the second variant was lower than to the first one all the time points.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


Displaying record number 52830

HXB2 Location  gp160(298-307)   gp160 Epitope Map
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Epitope RPNNNTRRGI   Epitope Alignment
Variants
RPsNNTRksI   susceptible form
Epitope Name B7-RI10 Env
Species (MHC/HLA human(B7)

Variant Details

Showing all: 1 variant(s).


Variant ID.  52
Epitope Seq.  RPNNNTRRGI
Variant Seq.  RPsNNTRksI
Mutations N/S R/K G/S
Epitope Location N3S R8K G9S
HXB2 Location N300S R305K G306S
Mutation Type SF: susceptible form
Method CD8 T-cell Elispot - IFNy
Note Superinfection. The first infecting strain had the variant rpSnntrKSi, and the CTL response was higher to the second variant, RPNNNTRRGI.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.


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