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Found 11 matching records:

Displaying record number 52827

HXB2 Location Gag(18-26) Gag Epitope Map
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Epitope

KIRLRPGGK

Epitope Alignment

Variants

KIRLRPGGK{*t} escape documented in this paper; processing

Epitope Name A3-KK9 Gag

Species (MHC/HLA) human(B7)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`2281`
Epitope Seq.	`KIRLRPGGK{*R}`
Variant Seq.	`KIRLRPGGK{*t}`
Mutations	R/T
Epitope Location	R+2T
HXB2 Location	R28T
Mutation Type	E: escape documented in this paper P: processing
Method	CD8 T-cell Elispot - IFNy
Note	Response declined over time; authors suggested that the decline was due to a downstream Arg -> Thr substitution at C+2 that may impair processing.

References

Altfeld2002a Marcus Altfeld, Todd M. Allen, Xu G. Yu, Mary N. Johnston, Deepak Agrawal, Bette T. Korber, David C. Montefiori, David H. O'Connor, Ben T. Davis, Paul K. Lee, Erica L. Maier, Jason Harlow, Philip J. R. Goulder, Christian Brander, Eric S. Rosenberg, and Bruce D. Walker. HIV-1 Superinfection Despite Broad CD8+ T-Cell Responses Containing Replication of the Primary Virus. Nature, 420(6914):434-439, 28 Nov 2002. PubMed ID: 12459786. Show all entries for this paper.

Displaying record number 52824

HXB2 Location Gag(20-28) Gag Epitope Map
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Epitope

RLRPGGKKK

Epitope Alignment

Variants

RLRPGGKKt diminished response

Epitope Name A3-RK9 Ga9

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`43`
Epitope Seq.	`RLRPGGKKK`
Variant Seq.	`RLRPGGKKt`
Mutations	K/T
Epitope Location	K9T
HXB2 Location	K28T
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The second infecting strain had the variant rlrpggkkT. The CTL response declined over time, and the response to the second variant was lower than to the first one

References

Displaying record number 52826

HXB2 Location Pol(313-321) Pol Epitope Map
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Epitope

AIFQSSMTK

Epitope Alignment

Variants

AIFQSSMlK non-susceptible form

Epitope Name A3-AK9 Pol

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`44`
Epitope Seq.	`AIFQSSMTK`
Variant Seq.	`AIFQSSMlK`
Mutations	T/L
Epitope Location	T8L
HXB2 Location	T320L
Mutation Type	NSF: non-susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The second infecting strain had the variant aifqssmIk. The CTL response to the second variant was zero or low at all timepoints. The CTL response to the first variant was also low, and declined over time.

References

Displaying record number 52821

HXB2 Location Pol(424-432) Pol Epitope Map
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Epitope

QIYAGIKVK

Epitope Alignment

Variants

QIYAGIKVr non-susceptible form; susceptible form

Epitope Name A3-QR9 Pol

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`45`
Epitope Seq.	`QIYAGIKVK`
Variant Seq.	`QIYAGIKVr`
Mutations	K/R
Epitope Location	K9R
HXB2 Location	K432R
Mutation Type	NSF: non-susceptible form SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The second infecting strain had the variant qiyagikvR. The initial CTL response to both variants was strong but eventually declined, particularly to the variant in the second strain.

References

Displaying record number 52822

HXB2 Location Pol(511-521) Pol Epitope Map
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Epitope

RTRGAHTNDVK

Epitope Alignment

Variants

RTRGAHTNDVr diminished response

Epitope Name A3-RK11 Pol

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`46`
Epitope Seq.	`RTRGAHTNDVK`
Variant Seq.	`RTRGAHTNDVr`
Mutations	K/R
Epitope Location	K11R
HXB2 Location	K521R
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The second infecting strain had the variant rtrgahtndvR. The CTL response to both variants declined over time, and the response to the second variant was lower than to the first throughout.

References

Displaying record number 52828

HXB2 Location Pol(894-903) Pol Epitope Map
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Epitope

AVFIHNFKRK

Epitope Alignment

Variants

AVFvHNFKRK non-susceptible form

Epitope Name A3-AK10 Pol

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`47`
Epitope Seq.	`AVFIHNFKRK`
Variant Seq.	`AVFvHNFKRK`
Mutations	I/V
Epitope Location	I4V
HXB2 Location	I897V
Mutation Type	NSF: non-susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The second infecting strain had the variant avfVhnfkrk. The CTL response to the second variant was zero at all timepoints. The CTL response to the first variant was low and declined over time.

References

Displaying record number 52813

HXB2 Location Vif(17-26) Vif Epitope Map
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Epitope

RIRTWKSLVK

Epitope Alignment

Variants

RIsTWKSLVK susceptible form

Epitope Name A3-RK10 Vif

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`48`
Epitope Seq.	`RIRTWKSLVK`
Variant Seq.	`RIsTWKSLVK`
Mutations	R/S
Epitope Location	R3S
HXB2 Location	R19S
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The second infecting strain had the variant riStwkslvk. The initial CTL response persisted against both variants after the superinfection was established.

References

Displaying record number 52823

HXB2 Location Vif(48-57) Vif Epitope Map
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Epitope

HPRISSEVHI

Epitope Alignment

Variants

HPkISSEVHI susceptible form

Epitope Name B7-HM0 Vif

Species (MHC/HLA) human(B7)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`49`
Epitope Seq.	`HPRISSEVHI`
Variant Seq.	`HPkISSEVHI`
Mutations	R/K
Epitope Location	R3K
HXB2 Location	R50K
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The second infecting strain had the variant hpKissevhi. The CTL response was equal against both variants, and declined over time.

References

Displaying record number 52814

HXB2 Location Vif(158-168) Vif Epitope Map
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Epitope

RRKPPLPSIAK

Epitope Alignment

Variants

RtKPPLPSvtK susceptible form

Species (MHC/HLA) human(A3)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`50`
Epitope Seq.	`RRKPPLPSIAK`
Variant Seq.	`RtKPPLPSvtK`
Mutations	A/T R/T I/V
Epitope Location	A10T R2T I9V
HXB2 Location	A167T R159T I166V
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The second infecting strain had the variant rTkpplpsVTk. The patient maintained persistent reactive CTL against both variants after the superinfection was established.

References

Displaying record number 52825

HXB2 Location Vpr(34-42) Vpr Epitope Map
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Epitope

FPRTWLHGL

Epitope Alignment

Variants

FPwTWLHGL diminished response

Epitope Name B7-FL9 Vpr

Species (MHC/HLA) human(B7)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`51`
Epitope Seq.	`FPRTWLHGL`
Variant Seq.	`FPwTWLHGL`
Mutations	R/W
Epitope Location	R3W
HXB2 Location	R36W
Mutation Type	DR: diminished response
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The second infecting strain had the variant fpWtwlhgl. The CTL response declined over time and the response to the second variant was lower than to the first one all the time points.

References

Displaying record number 52830

HXB2 Location gp160(298-307) gp160 Epitope Map
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Epitope

RPNNNTRRGI

Epitope Alignment

Variants

RPsNNTRksI susceptible form

Epitope Name B7-RI10 Env

Species (MHC/HLA) human(B7)

Variant Details

Showing all: 1 variant(s).

Variant ID.	`52`
Epitope Seq.	`RPNNNTRRGI`
Variant Seq.	`RPsNNTRksI`
Mutations	N/S R/K G/S
Epitope Location	N3S R8K G9S
HXB2 Location	N300S R305K G306S
Mutation Type	SF: susceptible form
Method	CD8 T-cell Elispot - IFNy
Note	Superinfection. The first infecting strain had the variant rpSnntrKSi, and the CTL response was higher to the second variant, RPNNNTRRGI.