HIV molecular immunology database
Found 3 matching records:
| HXB2 Location | Gag(18-26) | Gag Epitope Map
View variants at this location |
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| Epitope |
KIRLRPGGK
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | KK9 | |||||
| Species (MHC/HLA) | human(A3) | |||||
Showing all: 1 variant(s).
| Variant ID. | 31 |
|---|---|
| Epitope Seq. | KIRLRPGGK |
| Variant Seq. | KIRLRPGGq |
| Mutations | K/Q |
| Epitope Location | K9Q |
| HXB2 Location | K26Q |
| Mutation Type | E: escape documented in this paper P: processing |
| Method | CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay |
| Note | Variant inhibits processing, resulting in rapid decline in the KK9 specific CD8+ T-cell response. |
Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.
| HXB2 Location | Gag(20-28) | Gag Epitope Map
View variants at this location |
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| Epitope |
RLRPGGKKK
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | RK9 | |||||
| Species (MHC/HLA) | human(A3) | |||||
Showing all: 1 variant(s).
| Variant ID. | 32 |
|---|---|
| Epitope Seq. | RLRPGGKKK |
| Variant Seq. | RLRPGGKqK |
| Mutations | K/Q |
| Epitope Location | K8Q |
| HXB2 Location | K27Q |
| Mutation Type | E: escape documented in this paper |
| Method | CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay |
| Note | Variant abrogates the response. |
Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.
| HXB2 Location | Gag(240-249) | Gag Epitope Map
View variants at this location |
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| Epitope |
TSTLQEQIGW
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Epitope Alignment | ||||
| Variants |
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| Epitope Name | TW10 | |||||
| Species (MHC/HLA) | human(B57) | |||||
Showing all: 1 variant(s).
| Variant ID. | 33 |
|---|---|
| Epitope Seq. | TSTLQEQIGW |
| Variant Seq. | TSnLQEQIGW |
| Mutations | T/N |
| Epitope Location | T3N |
| HXB2 Location | T242N |
| Mutation Type | E: escape documented in this paper |
| Method | CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay |
| Note | The acute immunodominant response was to TSTLQEQIGW. The response declined following viral escape to TSnLQEQIGW by day 64. |
Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.