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Found 3 matching records:

Displaying record number 53201

HXB2 Location  Gag(18-26)   Gag Epitope Map
View variants at this location
Epitope KIRLRPGGK   Epitope Alignment
Variants
KIRLRPGGq   escape documented in this paper; processing
Epitope Name KK9
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  31
Epitope Seq.  KIRLRPGGK
Variant Seq.  KIRLRPGGq
Mutations K/Q
Epitope Location K9Q
HXB2 Location K26Q
Mutation Type E: escape documented in this paper
P: processing
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay
Note Variant inhibits processing, resulting in rapid decline in the KK9 specific CD8+ T-cell response.

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.


Displaying record number 53202

HXB2 Location  Gag(20-28)   Gag Epitope Map
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Epitope RLRPGGKKK   Epitope Alignment
Variants
RLRPGGKqK   escape documented in this paper
Epitope Name RK9
Species (MHC/HLA human(A3)

Variant Details

Showing all: 1 variant(s).


Variant ID.  32
Epitope Seq.  RLRPGGKKK
Variant Seq.  RLRPGGKqK
Mutations K/Q
Epitope Location K8Q
HXB2 Location K27Q
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay
Note Variant abrogates the response.

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.


Displaying record number 53203

HXB2 Location  Gag(240-249)   Gag Epitope Map
View variants at this location
Epitope TSTLQEQIGW   Epitope Alignment
Variants
TSnLQEQIGW   escape documented in this paper
Epitope Name TW10
Species (MHC/HLA human(B57)

Variant Details

Showing all: 1 variant(s).


Variant ID.  33
Epitope Seq.  TSTLQEQIGW
Variant Seq.  TSnLQEQIGW
Mutations T/N
Epitope Location T3N
HXB2 Location T242N
Mutation Type E: escape documented in this paper
Method CD8 T-cell Elispot - IFNy, Flow cytometric T-cell cytokine assay
Note The acute immunodominant response was to TSTLQEQIGW. The response declined following viral escape to TSnLQEQIGW by day 64.

References

Allen2004 Todd M Allen, Marcus Altfeld, Xu G. Yu, Kristin M. O'Sullivan, Mathias Lichterfeld, Sylvie Le Gall, Mina John, Bianca R. Mothe, Paul K. Lee, Elizabeth T. Kalife, Daniel E. Cohen, Kenneth A. Freedberg, Daryld A. Strick, Mary N. Johnston, Alessandro Sette, Eric S. Rosenberg, Simon A. Mallal, Philip J. R. Goulder, Christian Brander, and Bruce D. Walker. Selection, Transmission, and Reversion of an Antigen-Processing Cytotoxic T-Lymphocyte Escape Mutation in Human Immunodeficiency Virus Type 1 Infection. J. Virol., 78(13):7069-7078, Jul 2004. PubMed ID: 15194783. Show all entries for this paper.


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