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Search the Epitope Variant and Escape Mutation Database

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Found 10 matching records:

Displaying record number 55632

HXB2 Location  Gag(11-22)   Gag Epitope Map
View variants at this location
Epitope GKLDSWEKIRLR   Epitope Alignment
Variants
GKLDaWEKIRLR   subtype-specific susceptible form
Species (MHC/HLA)  human

Variant Details

Showing all: 1 variant(s).

Variant ID.  11
Epitope Seq.  GKLDSWEKIRLR
Variant Seq.  GKLDaWEKIRLR
Mutations S/A
Epitope Location S5A
HXB2 Location S15A
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype A, CRF02_AG
Variant Subtype CRF01_AE
Method CD8 T-cell Elispot - IFNy
Note 1 subject responded to peptide GKLDSWEKIRLR from subtypes CRF02_AG and A, and to peptide GKLDaWEKIRLR from subtype CRF01_AE.

References

Aidoo2008 M. Aidoo, S. Sawadogo, E. C. Bile, C. Yang, J. N. Nkengasong, and J. M. McNicholl. Viral, HLA and T Cell Elements in Cross-Reactive Immune Responses to HIV-1 Subtype A, CRF01\_AE and CRF02\_AG Vaccine Sequence in Ivorian Blood Donors. Vaccine, 26(37):4830-4839, 2 Sep 2008. PubMed ID: 18640166. Show all entries for this paper.

Displaying record number 55629

HXB2 Location  Gag(20-31)   Gag Epitope Map
View variants at this location
Epitope RLRPGGKKRYRL   Epitope Alignment
Variants
RLRPGGKKkYRL   subtype-specific susceptible form
Species (MHC/HLA)  human

Variant Details

Showing all: 1 variant(s).

Variant ID.  12
Epitope Seq.  RLRPGGKKRYRL
Variant Seq.  RLRPGGKKkYRL
Mutations R/K
Epitope Location R9K
HXB2 Location R28K
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype CRF02_AG
Variant Subtype A, CRF01_AE
Method CD8 T-cell Elispot - IFNy
Note 1 subject responded to peptide RLRPGGKKRYRL from subtype CRF02_AG and to peptide RLRPGGKKkYRL from subtypes A and CRF01_AE.

References

Aidoo2008 M. Aidoo, S. Sawadogo, E. C. Bile, C. Yang, J. N. Nkengasong, and J. M. McNicholl. Viral, HLA and T Cell Elements in Cross-Reactive Immune Responses to HIV-1 Subtype A, CRF01\_AE and CRF02\_AG Vaccine Sequence in Ivorian Blood Donors. Vaccine, 26(37):4830-4839, 2 Sep 2008. PubMed ID: 18640166. Show all entries for this paper.

Displaying record number 55633

HXB2 Location  Gag(23-34)   Gag Epitope Map
View variants at this location
Epitope PGGKKRYRLKHL   Epitope Alignment
Variants
PGGKKkYRLKHL   subtype-specific susceptible form
Species (MHC/HLA)  human

Variant Details

Showing all: 1 variant(s).

Variant ID.  13
Epitope Seq.  PGGKKRYRLKHL
Variant Seq.  PGGKKkYRLKHL
Mutations R/K
Epitope Location R6K
HXB2 Location R28K
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype CRF02_AG
Variant Subtype A
Method CD8 T-cell Elispot - IFNy
Note 1 subject responded to peptide PGGKKRYRLKHL from subtype CRF02_AG and to peptide PGGKKkYRLKHL from subtype A.

References

Aidoo2008 M. Aidoo, S. Sawadogo, E. C. Bile, C. Yang, J. N. Nkengasong, and J. M. McNicholl. Viral, HLA and T Cell Elements in Cross-Reactive Immune Responses to HIV-1 Subtype A, CRF01\_AE and CRF02\_AG Vaccine Sequence in Ivorian Blood Donors. Vaccine, 26(37):4830-4839, 2 Sep 2008. PubMed ID: 18640166. Show all entries for this paper.

Displaying record number 55634

HXB2 Location  Gag(79-90)   Gag Epitope Map
View variants at this location
Epitope YNIVATLWCVHQ   Epitope Alignment
Variants
YNtVATLWCVHQ   subtype-specific susceptible form
Species (MHC/HLA)  human

Variant Details

Showing all: 1 variant(s).

Variant ID.  14
Epitope Seq.  YNIVATLWCVHQ
Variant Seq.  YNtVATLWCVHQ
Mutations I/T
Epitope Location I3T
HXB2 Location I81T
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype CRF02_AG
Variant Subtype CRF01_AE
Method CD8 T-cell Elispot - IFNy
Note 1 subject responded to peptide YNIVATLWCVHQ from subtype CRF02_AG and to peptide YNtVATLWCVHQ from subtype CRF01_AE.

References

Aidoo2008 M. Aidoo, S. Sawadogo, E. C. Bile, C. Yang, J. N. Nkengasong, and J. M. McNicholl. Viral, HLA and T Cell Elements in Cross-Reactive Immune Responses to HIV-1 Subtype A, CRF01\_AE and CRF02\_AG Vaccine Sequence in Ivorian Blood Donors. Vaccine, 26(37):4830-4839, 2 Sep 2008. PubMed ID: 18640166. Show all entries for this paper.

Displaying record number 55635

HXB2 Location  Gag(83-94)   Gag Epitope Map
View variants at this location
Epitope ATLWCVHQRIDI   Epitope Alignment
Variants
ATLWCVHQRIev   subtype-specific susceptible form
Species (MHC/HLA)  human

Variant Details

Showing all: 1 variant(s).

Variant ID.  15
Epitope Seq.  ATLWCVHQRIDI
Variant Seq.  ATLWCVHQRIev
Mutations D/E I/V
Epitope Location D11E I12V
HXB2 Location D93E I94V
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype CRF02_AG
Variant Subtype CRF01_AE
Method CD8 T-cell Elispot - IFNy
Note 1 subject responded to peptide ATLWCVHQRIDI from subtype CRF02_AG and to peptide ATLWCVHQRIev from subtype CRF01_AE.

References

Aidoo2008 M. Aidoo, S. Sawadogo, E. C. Bile, C. Yang, J. N. Nkengasong, and J. M. McNicholl. Viral, HLA and T Cell Elements in Cross-Reactive Immune Responses to HIV-1 Subtype A, CRF01\_AE and CRF02\_AG Vaccine Sequence in Ivorian Blood Donors. Vaccine, 26(37):4830-4839, 2 Sep 2008. PubMed ID: 18640166. Show all entries for this paper.

Displaying record number 55639

HXB2 Location  Gag(142-155)   Gag Epitope Map
View variants at this location
Epitope MVHQSMSPRTLNAW   Epitope Alignment
Variants
MVHQplSPRTLNAW   subtype-specific susceptible form
Species (MHC/HLA)  human

Variant Details

Showing all: 1 variant(s).

Variant ID.  16
Epitope Seq.  MVHQSMSPRTLNAW
Variant Seq.  MVHQplSPRTLNAW
Mutations S/P M/L
Epitope Location S5P M6L
HXB2 Location S146P M147L
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype CRF02_AG
Variant Subtype A
Method CD8 T-cell Elispot - IFNy
Note 2 subjects responded to peptide MVHQSMSPRTLNAW from subtype CRF02_AG, and 1 of the 2 responded to peptide MVHQplSPRTLNAW from subtype A.

References

Aidoo2008 M. Aidoo, S. Sawadogo, E. C. Bile, C. Yang, J. N. Nkengasong, and J. M. McNicholl. Viral, HLA and T Cell Elements in Cross-Reactive Immune Responses to HIV-1 Subtype A, CRF01\_AE and CRF02\_AG Vaccine Sequence in Ivorian Blood Donors. Vaccine, 26(37):4830-4839, 2 Sep 2008. PubMed ID: 18640166. Show all entries for this paper.

Displaying record number 55648

HXB2 Location  Gag(158-172)   Gag Epitope Map
View variants at this location
Epitope VIEEKAFSPEVIPMF   Epitope Alignment
Variants
VvEEKgFnPEVIPMF   subtype-specific susceptible form
Species (MHC/HLA)  human

Variant Details

Showing all: 1 variant(s).

Variant ID.  17
Epitope Seq.  VIEEKAFSPEVIPMF
Variant Seq.  VvEEKgFnPEVIPMF
Mutations I/V A/G S/N
Epitope Location I2V A6G S8N
HXB2 Location I159V A163G S165N
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype A, CRF02_AG
Variant Subtype CRF01_AE
Method CD8 T-cell Elispot - IFNy
Note 1 subject responded to peptide VIEEKAFSPEVIPMF from subtypes A and CRF02_AG; and to peptide VvEEKgFnPEVIPMF from subtype CRF01_AE.

References

Aidoo2008 M. Aidoo, S. Sawadogo, E. C. Bile, C. Yang, J. N. Nkengasong, and J. M. McNicholl. Viral, HLA and T Cell Elements in Cross-Reactive Immune Responses to HIV-1 Subtype A, CRF01\_AE and CRF02\_AG Vaccine Sequence in Ivorian Blood Donors. Vaccine, 26(37):4830-4839, 2 Sep 2008. PubMed ID: 18640166. Show all entries for this paper.

Displaying record number 55640

HXB2 Location  Gag(198-211)   Gag Epitope Map
View variants at this location
Epitope MQMLKDTINEEAAE   Epitope Alignment
Variants
MQMLKeTINEEAAE   subtype-specific susceptible form
Species (MHC/HLA)  human

Variant Details

Showing all: 1 variant(s).

Variant ID.  18
Epitope Seq.  MQMLKDTINEEAAE
Variant Seq.  MQMLKeTINEEAAE
Mutations D/E
Epitope Location D6E
HXB2 Location D203E
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype A
Variant Subtype CRF01_AE
Method CD8 T-cell Elispot - IFNy
Note 2 subjects responded to peptide MQMLKDTINEEAAE from subtype A and 1 of the 2 responded to peptide MQMLKeTINEEAAE of subtype CRF01_AE.

References

Aidoo2008 M. Aidoo, S. Sawadogo, E. C. Bile, C. Yang, J. N. Nkengasong, and J. M. McNicholl. Viral, HLA and T Cell Elements in Cross-Reactive Immune Responses to HIV-1 Subtype A, CRF01\_AE and CRF02\_AG Vaccine Sequence in Ivorian Blood Donors. Vaccine, 26(37):4830-4839, 2 Sep 2008. PubMed ID: 18640166. Show all entries for this paper.

Displaying record number 55630

HXB2 Location  Gag(305-319)   Gag Epitope Map
View variants at this location
Epitope RAEQATQEVKNWMTE   Epitope Alignment
Variants
RAEQATQdVKNWMTd   subtype-specific susceptible form
Species (MHC/HLA)  human

Variant Details

Showing all: 1 variant(s).

Variant ID.  20
Epitope Seq.  RAEQATQEVKNWMTE
Variant Seq.  RAEQATQdVKNWMTd
Mutations E/D E/D
Epitope Location E15D E8D
HXB2 Location E319D E312D
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype CRF01_AE, CRF02_AG
Variant Subtype A
Method CD8 T-cell Elispot - IFNy
Note 3 subjects responded to peptide RAEQATQEVKNWMTE from subtypes CRF01_AE and CRF02_AG; 1 of the 3 subjects also responded to peptide RAEQATQdVKNWMTd from subtype A.

References

Aidoo2008 M. Aidoo, S. Sawadogo, E. C. Bile, C. Yang, J. N. Nkengasong, and J. M. McNicholl. Viral, HLA and T Cell Elements in Cross-Reactive Immune Responses to HIV-1 Subtype A, CRF01\_AE and CRF02\_AG Vaccine Sequence in Ivorian Blood Donors. Vaccine, 26(37):4830-4839, 2 Sep 2008. PubMed ID: 18640166. Show all entries for this paper.

Displaying record number 55627

HXB2 Location  Gag(349-363)   Gag Epitope Map
View variants at this location
Epitope ACQGVGGPSHKARIL   Epitope Alignment
Variants
ACQGVGGPSHKARvL   subtype-specific susceptible form
Species (MHC/HLA)  human

Variant Details

Showing all: 1 variant(s).

Variant ID.  19
Epitope Seq.  ACQGVGGPSHKARIL
Variant Seq.  ACQGVGGPSHKARvL
Mutations I/V
Epitope Location I14V
HXB2 Location I362V
Mutation Type SSF: subtype-specific susceptible form
Epitope Subtype A
Variant Subtype CRF01_AE
Method CD8 T-cell Elispot - IFNy
Note 1 subject responded to peptide ACQGVGGPSHKARIL from subtype A and to peptide ACQGVGGPSHKARvL from subtype CRF01_AE.

References

Aidoo2008 M. Aidoo, S. Sawadogo, E. C. Bile, C. Yang, J. N. Nkengasong, and J. M. McNicholl. Viral, HLA and T Cell Elements in Cross-Reactive Immune Responses to HIV-1 Subtype A, CRF01\_AE and CRF02\_AG Vaccine Sequence in Ivorian Blood Donors. Vaccine, 26(37):4830-4839, 2 Sep 2008. PubMed ID: 18640166. Show all entries for this paper.

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