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HIV Molecular Immunology Database

Patient Detail

Patient Code NIH45 (Donor 45, NIAID 45)
Patient Sex Male
Risk Factor
Infection Country US
Infection City
Infection Year
HLA Type
Patient Ethnicity African-American
Progression Long Term Non-Progressor (LTNP)
Species human
Patient Note Infected with Clade B, yet displayed neutralization activity against all genetic subtypes of HIV-1; diagnosis in 1990; sampled in 2006 (for NIH45-46 and VRC01), [Zhou2013a , PMID: 23911655]. Donor 45 is the source of antibody VRC03 and was studied extensively for VH chain evolution, [Wu2011, PMID: 21835983]. ART-naive donor 45 was a slow progressor with CD4 counts >500 cells/μl and pVL <15,000 copies/ml. PBMCs collected in 2008 were the source of many bnAbs [Rudicell2014, PMID: 25142607].
CTL CD8+ Records
T-Helper CD4+ Records
Antibody Records VRC01 (2163), VRC02 (2164), VRC03 (2165), NIH45-46 (2580), VRC06 (2660), VRC06b (2661), NIH45-46G54W (2821), VRC07 (3059), VRC01-30fH/19fL (3062), VRC01-30fH/10fL (3063), VRC01-8fH/19fL (3065), VRC01-8fH/10fL (3066), VRC01-8fH/6fL (3067), VRC01-5fH/10fL (3068), VRC01-5fH/6fL (3069), VRC01-5fH/0fL (3070), VRC01-0fH/0fL (3071), gVRC-H1dC38/VRC01L (3118), VRC07-523-LS (3156), VRC07-501-LS (3158), VRC07-508-LS (3159), VRC07-544-LS (3160), 45-46m2 (3161), 45-46m7 (3162), NIH45-46G54F (3165), NIH45-46G54Y (3166), 45-46m25 (3167), 45-46m28 (3175), VRC07G54W (3229), VRC08 (3279), VRC01-LS (3313), VRC08c (3318), VRC01b (3338), VRC01c (3339), VRC01d (3341), VRC01e (3342), VRC01f (3343), VRC01g (3344), VRC01h (3345), VRC01i (3346), VRC01j (3347), VRC07b (3348), VRC07c (3349), VRC07d (3350), VRC07e (3351), VRC07f (3352), VRC03b (3353), VRC03d (3354), VRC03e (3355), VRC03f (3356), VRC03g (3357), VRC03h (3358), VRC03i (3359), VRC06c (3360), VRC06d (3361), VRC06e (3362), VRC06f (3363), VRC06g (3364), VRC06h (3365), VRC08d (3366), VRC08e (3367), NIH45-177 (3368), NIH45-243 (3369), VRC07xPG9-16 (3372), VRC07x10E8 (3385), VRC07xPGT121 (3386), VRC07-αCD3 (3469), VRC01-iMab (3568), NIH45-46-iMab (3572), GL-VRC01 (3836), IA-VRC01 (3912), Bi-NAb (3921), VRC01/PGDM1400-10E8v4 (3955), Bi-ScFv (3958), Tri-NAb (3959), polyclonal NIH45 (3967), NIH45-46WPY (4011), NIH45-46WY (4012), DRVIA7H-VRC01L (4091), VRC01H-DRVIA7L (4113), MinVRC01 (4180), VRC01.23LS (4223), VRC07-523-W54-LS.v3 (4235), VRC07-523-F54-LS.v3 (4236), VRC01 UCA (4267), DH651.1 (4268), DH651.2 (4269), DH651.3 (4270), DH651.4 (4271), DH651.5 (4272), DH651.6 (4273), DH651.7 (4274), DH651.8 (4275), DH651.9 (4276), VRC08H/UCAL (4289), VRC01-E28T(HC) (4426), VRC01-E16A(HC) (4427), VRC01-P63K(HC) (4428), VRC01-W68S(LC) (4429), VRC01-Y72F(LC) (4430), VRC01-N73T(LC) (4431), VRC01-I21L(LC) (4432), VRC01-Y28S(LC) (4433), VRC01_FR3-03 (4569), VRC07_FR3-03 (4570), VRC07-523-LS_FR3-03 (4571), VRC07-523-LS-N72Q-R24D (4576), Vc813 (4590), VcT16 (4727), VcT39 (4728), Vc827 (4729), Vc822 (4730), Vc908 (4731), Vc932 (4732), Vc949 (4733), VRC07-523LS.v1 (4757), VRC07-523LS.v11 (4758), VRC07-523LS.v14 (4759), VRC07-523LS.v32 (4760), VRC07-523LS.v34 (4761), VRC01 gHC+gLC (4805)
Sequence Database Patient ID Record 50341
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