HIV molecular immunology database

 

Patient Detail

Patient Code KI-108
Patient Sex
Risk Factor
Infection Country JP
Infection City
Infection Year
HLA Type A*24:02, B*52:01, C*12:02
Patient Ethnicity Japanese
Progression Progressor (P)
Species human
Patient Note Subtype B-infected patient KI-108 elicits response to and carries HIV-1 Pol epitope LI8, LQKQITKI (Murakoshi2017). KI-108 responds to HIV-1 RT173-181 C*12:02-restricted epitope, KY9, KQNPDIVIY, but weakly to KY9 mutants KQNPDIVIc and KQNPDIVIv (Kuse2015). Murakoshi2019 reports that CTL specific for epitope MQMLKETI(MI8) from WT HIV-1-infected KI-774 were generated into T cell clone lines. Yagita2013 shows that this ART naive patient carries Pol283-8-specific CTL as shown by ICS but does not recognize the same epitope when used as PBMC for EliSpot. The evolution of Gag RI8 escape mutant RMYSPsSI from RMYSPTSI was observed in treatment-naive chronically infected subject KI-108. [Zhang2020, PMID: 32699092]
CTL CD8+ Records 61519, 61523, 61553, 61878, 62484
T-Helper CD4+ Records
Antibody Records
Sequence Database Patient ID Record
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