Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 324

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HXB2 Location	gp160(821-838) gp41(310-327) DNA(8685..8738)	gp160 Epitope Map
Author Location	gp41(827-843)
Epitope	YVAEGTDRVIEVVQGACR	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Experimental methods
Keywords	rate of progression

Notes

• As HIV-1-infected individuals progress to disease, T-cells show reduced ability to proliferate in response to HIV antigen, but retain the ability to express the activation antigens CD25 and CD71.
• The ability to express activation markers in response to HIV is retained, but the response to tetanus toxoid recall antigen is lost.
• This study investigated CD25 and CD71 expression in PBMC from patients at various stages of progression, measuring the response to in vitro stimulation by peptide cocktail containing four antigenic Env peptides, or p17 and p24.

References

Caruso1997 A. Caruso, S. Licenziati, A. D. Canaris, M. Corulli, M. A. De Francesco, A. Cantalamessa, F. Fallacara, S. Fiorentini, A. Balsari, and A. Turano. T Cells from Individuals in Advanced Stages of HIV-1 Infection Do not Proliferate but Express Activation Antigens in Response to HIV-1-Specific Antigens. J. Acquir. Immune Defic. Syndr. Hum. Retrovirol., 15:61-69, 1997. PubMed ID: 9215656. Show all entries for this paper.