Search T Helper/CD4+ T-Cell Epitope Database

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Displaying record number 303

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HXB2 Location	gp160(586-598) gp41(75-87) DNA(7980..8018)	gp160 Epitope Map
Author Location	Env(586-598)
Epitope	YLRDQQLLGIWGC	Epitope Alignment
Species (MHC/HLA)	macaque, mouse
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Notes

• Synthetic peptide derived from conserved region of the HIV-1 envelope that stimulates a proliferative response in mice.
• Proliferative response to this peptide was observed in 1/3 immunized rhesus monkeys, with a weak transient response in the other two.

References

Nehete1993 P. N. Nehete, W. C. Satterfield, C. M. Matherne, R. B. Arlinghaus, and K. J. Sastry. Induction of Human Immunodeficiency Virus-Specific T Cell Responses in Rhesus Monkeys by Synthetic Peptides from gp160. AIDS Res. Hum. Retroviruses, 9:235-240, 1993. Notes: Three rhesus monkeys were immunized with eight synthetic peptides that induce T cell activity in mice. PBMCs from these monkeys were monitored every 2 weeks for 34 weeks for proliferative responses against individual peptides and gp160. PubMed ID: 8471313. Show all entries for this paper.