Search T Helper/CD4+ T-Cell Epitope Database

Found 2 matching records:

Displaying record number 201534

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HXB2 Location	Gag(301-315) p24(169-183) DNA(1690..1734)	Gag Epitope Map
Author Location	Gag(301-315 HXB2)
Epitope	YKTLRAEQASQEVKN	Epitope Alignment
Subtype	B
Species (MHC/HLA)	transgenic mouse(DRB1*01:01)
Immunogen	vaccine
Experimental methods	T-cell Elispot
Keywords	vaccine-induced immune responses, dendritic cells

Vaccine Details

Notes

• Dendritic cell mediated immunization of DNA plasmid constructs was studied in BALB/c (H-2d) and HLA-DR4 (DRA1*0101, DRB1*0401) transgenic mice. Most peptide-specific T-cell responses in the HLA-DR4 transgenic mice corresponded to human HLA-DR4 epitopes listed in HIV Immunology Database.
• Gag peptide YKTLRAEQASQEVKN elicited CD4 T-cell responses in HLA-DR4 (DRB1*0401) transgenic mice immunized with pLAMP/gag-based prime and boost formulations.

References

Simon2010 Gregory G. Simon, Yongli Hu, Asif M. Khan, Jingshi Zhou, Jerome Salmon, Priya R. Chikhlikar, Keun-Ok Jung, Ernesto T. A. Marques, and J. Thomas August. Dendritic Cell Mediated Delivery of Plasmid DNA Encoding LAMP/HIV-1 Gag Fusion Immunogen Enhances T Cell Epitope Responses in HLA DR4 Transgenic Mice. PLoS One, 5(1):e8574, 2010. PubMed ID: 20052293. Show all entries for this paper.

Displaying record number 201092

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HXB2 Location	Gag(301-315) p24(169-183) DNA(1690..1734)	Gag Epitope Map
Author Location
Epitope	YKTLRAEQASQEVKN	Epitope Alignment
Epitope Name	G076
Species (MHC/HLA)	human
Immunogen	HIV-1 infection
Country	Canada
Experimental methods	Flow cytometric T-cell cytokine assay, Proliferation
Keywords	memory cells

Notes

• HIV-1-specific CD4+ T-cell responses were analyzed for 6 years since primary infection, in 10 aviremic and 8 viremic patients.
• CD4+ T cells proliferating responses were correlated with the frequency of CD4+ T cells secreting IL-2 in aviremic patients. In viremic patients, CD4+ T cell proliferative response was impaired despite of the high frequencies of IFN-γ, but not IL-2-producing CD4+ T cells in periods of elevated viremia, suggesting that long-term CD4+ memory depends on IL-2-producing CD4+ T cells and that IFN-γ only-producing cells are short lived.

References

Younes2003 Souheil-Antoine Younes, Bader Yassine-Diab, Alain R. Dumont, Mohamed-Rachid Boulassel, Zvi Grossman, Jean-Pierre Routy, and Rafick-Pierre Sékaly. HIV-1 Viremia Prevents the Establishment of Interleukin 2-Producing HIV-Specific memory CD4+ T Cells Endowed with Proliferative Capacity. J. Exp. Med., 198(12):1909-1922, 15 Dec 2003. PubMed ID: 14676302. Show all entries for this paper.