HIV molecular immunology database

 

Search T Helper/CD4+ T-Cell Epitope Database

Found 6 matching records:

Displaying record number 201760

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HXB2 Location Nef(81-97)
DNA(9037..9087)
Nef Epitope Map
Author Location Nef
Epitope YKAAVDLSHFLKEKGGL Epitope Alignment
YKAAVDLSHFLKEKGGL epitope logo
Epitope Name OLP-78
Species (MHC/HLA) human(DRB1*07:01, DRB1*08:04)
Immunogen HIV-1 infection
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ, HLA binding
Keywords binding affinity, immunodominance, HLA cross-presentation

Notes

References

Ranasinghe2013 Srinika Ranasinghe, Sam Cutler, Isaiah Davis, Richard Lu, Damien Z. Soghoian, Ying Qi, John Sidney, Gregory Kranias, Michael D. Flanders, Madelene Lindqvist, Bjorn Kuhl, Galit Alter, Steven G. Deeks, Bruce D. Walker, Xiaojiang Gao, Alessandro Sette, Mary Carrington, and Hendrik Streeck. Association of HLA-DRB1-Restricted CD4+ T Cell Responses with HIV Immune Control. Nat. Med., 19(7):930-933, Jul 2013. PubMed ID: 23793098. Show all entries for this paper.


Displaying record number 201026

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HXB2 Location Nef(81-97)
DNA(9037..9087)
Nef Epitope Map
Author Location Nef(81-97 B Consensus)
Epitope YKAAVDLSHFLKEKGGL Epitope Alignment
YKAAVDLSHFLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ, HLA binding, Intracellular cytokine staining
Keywords supervised treatment interruptions (STI), rate of progression, immunodominance, acute/early infection

Notes

References

Kaufmann2004 Daniel E. Kaufmann, Paul M. Bailey, John Sidney, Bradford Wagner, Philip J. Norris, Mary N. Johnston, Lisa A. Cosimi, Marylyn M. Addo, Mathias Lichterfeld, Marcus Altfeld, Nicole Frahm, Christian Brander, Alessandro Sette, Bruce D. Walker, and Eric S. Rosenberg. Comprehensive Analysis of Human Immunodeficiency Virus Type 1-Specific CD4 Responses Reveals Marked Immunodominance of gag and nef and the Presence of Broadly Recognized Peptides. J. Virol., 78(9):4463-4477, May 2004. PubMed ID: 15078927. Show all entries for this paper.


Displaying record number 201253

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HXB2 Location Nef(81-97)
DNA(9037..9087)
Nef Epitope Map
Author Location ( clade B consensus)
Epitope YKAAVDLSHFLKEKGGL Epitope Alignment
YKAAVDLSHFLKEKGGL epitope logo
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Patient MHC/HLA A*02:01, A*29:02:01, B*15:01, B*44:03, C*03:04, C*16:01, DRB1*04:01, DRB1*07:01
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords escape

Notes

References

Rychert2007 Jenna Rychert, Suzanne Saindon, Sarah Placek, Demetre Daskalakis, and Eric Rosenberg. Sequence Variation Occurs in CD4 Epitopes During Early HIV Infection. J. Acquir. Immune Defic. Syndr., 46(3):261-267, 1 Nov 2007. PubMed ID: 18167642. Show all entries for this paper.


Displaying record number 201387

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HXB2 Location Nef(81-97)
DNA(9037..9087)
Nef Epitope Map
Author Location Nef(81-97)
Epitope YKAAVDLSHFLKEKGGL Epitope Alignment
YKAAVDLSHFLKEKGGL epitope logo
Species (MHC/HLA) human
Immunogen vaccine
Country Russia
Experimental methods T-cell Elispot
Keywords vaccine antigen design

Vaccine Details

Vaccine type DNA, virus-like particle (VLP), HIV infected-cell lysate, polyepitope
Vaccine component Env, Gag, Nef, Pol

Notes

References

Bazhan2008 Sergei I. Bazhan, Larisa I. Karpenko, Leonid R. Lebedev, Roman V. Uzhachenko, Pavel A. Belavin, Alexey M. Eroshkin, and Alexander A. Ilyichev. A Synergistic Effect of a Combined Bivalent DNA-Protein Anti-HIV-1 Vaccine Containing Multiple T- and B-Cell Epitopes of HIV-1 Proteins. Mol. Immunol., 45(3):661-669, Feb 2008. PubMed ID: 17869341. Show all entries for this paper.


Displaying record number 201639

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HXB2 Location Nef(81-97)
DNA(9037..9087)
Nef Epitope Map
Author Location Nef(81-97)
Epitope YKAAVDLSHFLKEKGGL Epitope Alignment
YKAAVDLSHFLKEKGGL epitope logo
Epitope Name OLP 78
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country United States
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords immunodominance, novel epitope

Notes

References

Ranasinghe2012 Srinika Ranasinghe, Michael Flanders, Sam Cutler, Damien Z. Soghoian, Musie Ghebremichael, Isaiah Davis, Madelene Lindqvist, Florencia Pereyra, Bruce D. Walker, David Heckerman, and Hendrik Streeck. HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome. J. Virol., 86(1):277-283, Jan 2012. PubMed ID: 22031937. Show all entries for this paper.


Displaying record number 201868

Download this epitope record as JSON.

HXB2 Location Nef(81-97)
DNA(9037..9087)
Nef Epitope Map
Author Location Nef
Epitope YKAAVDLSHFLKEKGGL Epitope Alignment
YKAAVDLSHFLKEKGGL epitope logo
Epitope Name Peptide 78
Subtype B
Species (MHC/HLA) human
Immunogen HIV-1 infection
Country Germany, United States
Experimental methods CD4 T-cell Elispot - IFNγ
Keywords immunodominance, acute/early infection, chronic infection

Notes

References

Schieffer2014 Miriam Schieffer, Heiko K. Jessen, Alexander F. Oster, Franco Pissani, Damien Z. Soghoian, Richard Lu, Arne B. Jessen, Carmen Zedlack, Bruce T. Schultz, Isaiah Davis, Srinika Ranasinghe, Eric S. Rosenberg, Galit Alter, Ralf R. Schumann, and Hendrik Streeck. Induction of Gag-specific CD4 T Cell Responses during Acute HIV Infection Is Associated with Improved Viral Control. J. Virol., 88(13):7357-7366, Jul 2014. PubMed ID: 24741089. Show all entries for this paper.


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