Search T Helper/CD4+ T-Cell Epitope Database

Found 1 matching record:

Displaying record number 363

Download this epitope record as JSON.

HXB2 Location	gp160(92-101) gp120(92-101) DNA(6498..6527)	gp160 Epitope Map
Author Location	gp120(90-100 W6.ID)
Epitope	`YFNMWKNNMV`	Epitope Alignment
Species (MHC/HLA)	human
Immunogen	vaccine
Experimental methods
Keywords

Vaccine Details

Vaccine type	protein
Vaccine strain	B clade W61D
Vaccine component	gp120
Adjuvant	MPL-SE adjuvant, QS21

Notes

An HIV seronegative volunteer was vaccinated with rgp120 and a QS21/MPL adjuvant and HIV-1 specific T-cell lines were isolated.
One T-cell clone reacts with two overlapping peptides, and the region of overlap is: YFNMWKNNMV.
The first 20-mer peptide that this clone reacts with is PQEVVLGNVTEYFNMWKNNMV, and the IIIB version of this peptide does not induce proliferation in the T-cell line that responds to the W61D version: IIIB: pqevvlVnvteNfDmwknDmv.

References

Jones1999 G. J. Jones, P. von Hoegen, J. Weber, and A. D. Rees. Immunization with Human Immunodeficiency Virus Type 1 rgp120W61D in QS21/MPL Adjuvant Primes T Cell Proliferation and C-C Chemokine Production to Multiple Epitopes within Variable and Conserved Domains of gp120W61D. J. Infect. Dis., 179:558-566, 1999. PubMed ID: 9952361. Show all entries for this paper.